Incidental Mutation 'R6846:Vnn3'
ID |
534771 |
Institutional Source |
Beutler Lab
|
Gene Symbol |
Vnn3
|
Ensembl Gene |
ENSMUSG00000020010 |
Gene Name |
vanin 3 |
Synonyms |
|
MMRRC Submission |
044952-MU
|
Accession Numbers |
|
Essential gene? |
Probably non essential
(E-score: 0.055)
|
Stock # |
R6846 (G1)
|
Quality Score |
225.009 |
Status
|
Validated
|
Chromosome |
10 |
Chromosomal Location |
23727360-23745741 bp(+) (GRCm39) |
Type of Mutation |
missense |
DNA Base Change (assembly) |
A to G
at 23727620 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
Threonine to Alanine
at position 47
(T47A)
|
Ref Sequence |
ENSEMBL: ENSMUSP00000020190
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000020190]
|
AlphaFold |
Q9QZ25 |
Predicted Effect |
probably benign
Transcript: ENSMUST00000020190
AA Change: T47A
PolyPhen 2
Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
|
SMART Domains |
Protein: ENSMUSP00000020190 Gene: ENSMUSG00000020010 AA Change: T47A
Domain | Start | End | E-Value | Type |
signal peptide
|
1 |
22 |
N/A |
INTRINSIC |
Pfam:CN_hydrolase
|
51 |
296 |
6.9e-19 |
PFAM |
|
Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.4%
- 20x: 97.9%
|
Validation Efficiency |
100% (42/42) |
Allele List at MGI |
|
Other mutations in this stock |
Total: 42 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
Ahnak |
A |
G |
19: 8,989,221 (GRCm39) |
N3502D |
possibly damaging |
Het |
Ambn |
T |
A |
5: 88,609,574 (GRCm39) |
I94K |
possibly damaging |
Het |
Ank3 |
A |
G |
10: 69,660,179 (GRCm39) |
H227R |
probably damaging |
Het |
Arhgap42 |
G |
T |
9: 9,006,446 (GRCm39) |
P650Q |
probably damaging |
Het |
Bahcc1 |
A |
G |
11: 120,162,422 (GRCm39) |
E240G |
possibly damaging |
Het |
Cd19 |
T |
C |
7: 126,010,025 (GRCm39) |
E408G |
probably benign |
Het |
Cdh11 |
G |
A |
8: 103,391,276 (GRCm39) |
T320I |
probably damaging |
Het |
Cep131 |
G |
A |
11: 119,956,517 (GRCm39) |
R944W |
probably damaging |
Het |
Dgkd |
T |
G |
1: 87,853,413 (GRCm39) |
|
probably null |
Het |
Dnaaf1 |
T |
A |
8: 120,309,401 (GRCm39) |
L163Q |
probably damaging |
Het |
Ecpas |
A |
G |
4: 58,814,081 (GRCm39) |
C1342R |
possibly damaging |
Het |
Etl4 |
T |
A |
2: 20,748,919 (GRCm39) |
L550Q |
possibly damaging |
Het |
Evpl |
T |
C |
11: 116,114,633 (GRCm39) |
E1019G |
probably damaging |
Het |
Fam120b |
T |
C |
17: 15,635,091 (GRCm39) |
L601P |
probably damaging |
Het |
Fhit |
C |
A |
14: 9,763,762 (GRCm38) |
R172L |
possibly damaging |
Het |
Hoxa6 |
T |
C |
6: 52,183,523 (GRCm39) |
H174R |
possibly damaging |
Het |
Htra4 |
A |
G |
8: 25,520,561 (GRCm39) |
F367L |
probably damaging |
Het |
Ighg2c |
A |
G |
12: 113,251,930 (GRCm39) |
I102T |
unknown |
Het |
Iws1 |
T |
C |
18: 32,219,326 (GRCm39) |
|
probably benign |
Het |
Lats2 |
A |
G |
14: 57,933,591 (GRCm39) |
V842A |
probably damaging |
Het |
Limd2 |
C |
T |
11: 106,050,213 (GRCm39) |
M1I |
probably null |
Het |
Lrp2 |
T |
A |
2: 69,348,787 (GRCm39) |
Q728L |
probably damaging |
Het |
Mcc |
T |
A |
18: 44,606,707 (GRCm39) |
T400S |
possibly damaging |
Het |
Mthfd1l |
A |
G |
10: 3,997,898 (GRCm39) |
D623G |
probably damaging |
Het |
Myocos |
T |
C |
1: 162,484,665 (GRCm39) |
|
probably benign |
Het |
Nat1 |
G |
T |
8: 67,943,995 (GRCm39) |
A124S |
probably benign |
Het |
Nfya |
A |
T |
17: 48,702,715 (GRCm39) |
M62K |
probably benign |
Het |
Nlgn1 |
A |
G |
3: 25,490,506 (GRCm39) |
V378A |
probably damaging |
Het |
Or52r1c |
T |
A |
7: 102,735,265 (GRCm39) |
I175N |
possibly damaging |
Het |
Or5ak22 |
A |
T |
2: 85,230,861 (GRCm39) |
N5K |
probably damaging |
Het |
Pitpnm2 |
T |
C |
5: 124,269,234 (GRCm39) |
S463G |
probably benign |
Het |
Serpinb3b |
T |
C |
1: 107,082,403 (GRCm39) |
E287G |
probably benign |
Het |
Slc16a13 |
T |
C |
11: 70,108,661 (GRCm39) |
T390A |
probably benign |
Het |
Slc7a14 |
A |
G |
3: 31,278,372 (GRCm39) |
M411T |
probably damaging |
Het |
Strn |
A |
G |
17: 79,043,886 (GRCm39) |
F11L |
probably damaging |
Het |
Swap70 |
T |
A |
7: 109,854,956 (GRCm39) |
F85L |
possibly damaging |
Het |
Tanc2 |
T |
A |
11: 105,689,479 (GRCm39) |
W214R |
probably benign |
Het |
Tenm3 |
T |
C |
8: 48,729,773 (GRCm39) |
K1411R |
probably benign |
Het |
Tmem176a |
G |
T |
6: 48,820,759 (GRCm39) |
R116L |
probably damaging |
Het |
Trim71 |
G |
T |
9: 114,354,115 (GRCm39) |
H296Q |
probably damaging |
Het |
Vmn1r67 |
A |
T |
7: 10,180,840 (GRCm39) |
I35L |
probably benign |
Het |
Zscan10 |
A |
T |
17: 23,824,581 (GRCm39) |
Q12H |
probably damaging |
Het |
|
Other mutations in Vnn3 |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL00675:Vnn3
|
APN |
10 |
23,743,066 (GRCm39) |
missense |
possibly damaging |
0.77 |
IGL01300:Vnn3
|
APN |
10 |
23,740,263 (GRCm39) |
missense |
possibly damaging |
0.87 |
IGL01349:Vnn3
|
APN |
10 |
23,727,814 (GRCm39) |
missense |
probably damaging |
0.99 |
IGL02491:Vnn3
|
APN |
10 |
23,741,816 (GRCm39) |
missense |
probably benign |
0.11 |
IGL03256:Vnn3
|
APN |
10 |
23,727,698 (GRCm39) |
splice site |
probably benign |
|
IGL03289:Vnn3
|
APN |
10 |
23,741,735 (GRCm39) |
missense |
possibly damaging |
0.92 |
IGL02799:Vnn3
|
UTSW |
10 |
23,727,869 (GRCm39) |
missense |
possibly damaging |
0.64 |
R0599:Vnn3
|
UTSW |
10 |
23,741,603 (GRCm39) |
missense |
possibly damaging |
0.94 |
R1703:Vnn3
|
UTSW |
10 |
23,741,828 (GRCm39) |
missense |
probably benign |
|
R1753:Vnn3
|
UTSW |
10 |
23,741,718 (GRCm39) |
missense |
probably benign |
0.27 |
R2119:Vnn3
|
UTSW |
10 |
23,740,311 (GRCm39) |
missense |
probably damaging |
1.00 |
R2288:Vnn3
|
UTSW |
10 |
23,740,354 (GRCm39) |
missense |
probably benign |
0.03 |
R4255:Vnn3
|
UTSW |
10 |
23,741,720 (GRCm39) |
missense |
probably benign |
0.18 |
R4458:Vnn3
|
UTSW |
10 |
23,741,567 (GRCm39) |
missense |
probably benign |
0.23 |
R4518:Vnn3
|
UTSW |
10 |
23,743,124 (GRCm39) |
missense |
possibly damaging |
0.77 |
R4545:Vnn3
|
UTSW |
10 |
23,732,224 (GRCm39) |
missense |
probably benign |
0.00 |
R4723:Vnn3
|
UTSW |
10 |
23,727,589 (GRCm39) |
missense |
possibly damaging |
0.88 |
R4791:Vnn3
|
UTSW |
10 |
23,740,519 (GRCm39) |
missense |
probably benign |
|
R4921:Vnn3
|
UTSW |
10 |
23,740,473 (GRCm39) |
missense |
probably benign |
0.01 |
R5152:Vnn3
|
UTSW |
10 |
23,740,237 (GRCm39) |
missense |
probably benign |
0.01 |
R5390:Vnn3
|
UTSW |
10 |
23,727,483 (GRCm39) |
start codon destroyed |
probably null |
1.00 |
R5545:Vnn3
|
UTSW |
10 |
23,742,992 (GRCm39) |
missense |
probably benign |
0.00 |
R6197:Vnn3
|
UTSW |
10 |
23,732,187 (GRCm39) |
missense |
probably damaging |
1.00 |
R6751:Vnn3
|
UTSW |
10 |
23,745,523 (GRCm39) |
missense |
probably benign |
0.00 |
R6917:Vnn3
|
UTSW |
10 |
23,741,832 (GRCm39) |
missense |
possibly damaging |
0.50 |
R7073:Vnn3
|
UTSW |
10 |
23,740,311 (GRCm39) |
missense |
probably damaging |
1.00 |
R7100:Vnn3
|
UTSW |
10 |
23,741,840 (GRCm39) |
missense |
probably damaging |
1.00 |
R7152:Vnn3
|
UTSW |
10 |
23,727,513 (GRCm39) |
missense |
possibly damaging |
0.88 |
R7336:Vnn3
|
UTSW |
10 |
23,727,806 (GRCm39) |
missense |
probably benign |
0.42 |
R7421:Vnn3
|
UTSW |
10 |
23,741,666 (GRCm39) |
missense |
probably benign |
0.06 |
R7875:Vnn3
|
UTSW |
10 |
23,743,146 (GRCm39) |
missense |
possibly damaging |
0.80 |
R8353:Vnn3
|
UTSW |
10 |
23,745,443 (GRCm39) |
missense |
probably benign |
0.01 |
R8453:Vnn3
|
UTSW |
10 |
23,745,443 (GRCm39) |
missense |
probably benign |
0.01 |
R8465:Vnn3
|
UTSW |
10 |
23,741,780 (GRCm39) |
missense |
possibly damaging |
0.67 |
R9105:Vnn3
|
UTSW |
10 |
23,740,461 (GRCm39) |
missense |
probably damaging |
1.00 |
R9261:Vnn3
|
UTSW |
10 |
23,741,607 (GRCm39) |
missense |
probably damaging |
0.97 |
R9441:Vnn3
|
UTSW |
10 |
23,740,498 (GRCm39) |
missense |
possibly damaging |
0.94 |
R9718:Vnn3
|
UTSW |
10 |
23,745,454 (GRCm39) |
nonsense |
probably null |
|
R9737:Vnn3
|
UTSW |
10 |
23,741,813 (GRCm39) |
missense |
probably benign |
0.02 |
|
Predicted Primers |
PCR Primer
(F):5'- ATATATTCACAGGCAGCTGGC -3'
(R):5'- TGTGCACCCTGCTCAAAACAG -3'
Sequencing Primer
(F):5'- CTGAGATACAGTAGAAGAACCTTCTG -3'
(R):5'- CTGCTCAAAACAGACATGGAAAG -3'
|
Posted On |
2018-09-12 |