Mutagenetix > Incidental Mutation

Incidental Mutation 'R6846:Ighg2c'

534779

Institutional Source

Beutler Lab

Gene Symbol

Ighg2c

Ensembl Gene

ENSMUSG00000076612

Gene Name

immunoglobulin heavy constant gamma 2C

Synonyms

MMRRC Submission

044952-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.085) question?

Stock #

R6846 (G1)

Quality Score

225.009

Status

Not validated

Chromosome

Chromosomal Location

113251009-113252552 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 113251930 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Isoleucine to Threonine at position 102 (I102T)

Gene Model

predicted gene model for transcript(s):

AlphaFold

no structure available at present

Predicted Effect

unknown
Transcript: ENSMUST00000103416
AA Change: I102T

SMART Domains

Protein: ENSMUSP00000100212
Gene: ENSMUSG00000076612
AA Change: I102T

Domain	Start	End	E-Value	Type
IGc1	21	91	2.4e-15	SMART
IG_like	143	218	1.64e-2	SMART
IGc1	249	322	1.97e-34	SMART
transmembrane domain	350	372	N/A	INTRINSIC

Predicted Effect

unknown
Transcript: ENSMUST00000195192
AA Change: I102T

Coding Region Coverage

1x: 100.0%
3x: 99.9%
10x: 99.4%
20x: 97.9%

Validation Efficiency

100% (42/42)

Allele List at MGI

Other mutations in this stock

Total: 42 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Ahnak	A	G	19: 8,989,221 (GRCm39)	N3502D	possibly damaging	Het
Ambn	T	A	5: 88,609,574 (GRCm39)	I94K	possibly damaging	Het
Ank3	A	G	10: 69,660,179 (GRCm39)	H227R	probably damaging	Het
Arhgap42	G	T	9: 9,006,446 (GRCm39)	P650Q	probably damaging	Het
Bahcc1	A	G	11: 120,162,422 (GRCm39)	E240G	possibly damaging	Het
Cd19	T	C	7: 126,010,025 (GRCm39)	E408G	probably benign	Het
Cdh11	G	A	8: 103,391,276 (GRCm39)	T320I	probably damaging	Het
Cep131	G	A	11: 119,956,517 (GRCm39)	R944W	probably damaging	Het
Dgkd	T	G	1: 87,853,413 (GRCm39)		probably null	Het
Dnaaf1	T	A	8: 120,309,401 (GRCm39)	L163Q	probably damaging	Het
Ecpas	A	G	4: 58,814,081 (GRCm39)	C1342R	possibly damaging	Het
Etl4	T	A	2: 20,748,919 (GRCm39)	L550Q	possibly damaging	Het
Evpl	T	C	11: 116,114,633 (GRCm39)	E1019G	probably damaging	Het
Fam120b	T	C	17: 15,635,091 (GRCm39)	L601P	probably damaging	Het
Fhit	C	A	14: 9,763,762 (GRCm38)	R172L	possibly damaging	Het
Hoxa6	T	C	6: 52,183,523 (GRCm39)	H174R	possibly damaging	Het
Htra4	A	G	8: 25,520,561 (GRCm39)	F367L	probably damaging	Het
Iws1	T	C	18: 32,219,326 (GRCm39)		probably benign	Het
Lats2	A	G	14: 57,933,591 (GRCm39)	V842A	probably damaging	Het
Limd2	C	T	11: 106,050,213 (GRCm39)	M1I	probably null	Het
Lrp2	T	A	2: 69,348,787 (GRCm39)	Q728L	probably damaging	Het
Mcc	T	A	18: 44,606,707 (GRCm39)	T400S	possibly damaging	Het
Mthfd1l	A	G	10: 3,997,898 (GRCm39)	D623G	probably damaging	Het
Myocos	T	C	1: 162,484,665 (GRCm39)		probably benign	Het
Nat1	G	T	8: 67,943,995 (GRCm39)	A124S	probably benign	Het
Nfya	A	T	17: 48,702,715 (GRCm39)	M62K	probably benign	Het
Nlgn1	A	G	3: 25,490,506 (GRCm39)	V378A	probably damaging	Het
Or52r1c	T	A	7: 102,735,265 (GRCm39)	I175N	possibly damaging	Het
Or5ak22	A	T	2: 85,230,861 (GRCm39)	N5K	probably damaging	Het
Pitpnm2	T	C	5: 124,269,234 (GRCm39)	S463G	probably benign	Het
Serpinb3b	T	C	1: 107,082,403 (GRCm39)	E287G	probably benign	Het
Slc16a13	T	C	11: 70,108,661 (GRCm39)	T390A	probably benign	Het
Slc7a14	A	G	3: 31,278,372 (GRCm39)	M411T	probably damaging	Het
Strn	A	G	17: 79,043,886 (GRCm39)	F11L	probably damaging	Het
Swap70	T	A	7: 109,854,956 (GRCm39)	F85L	possibly damaging	Het
Tanc2	T	A	11: 105,689,479 (GRCm39)	W214R	probably benign	Het
Tenm3	T	C	8: 48,729,773 (GRCm39)	K1411R	probably benign	Het
Tmem176a	G	T	6: 48,820,759 (GRCm39)	R116L	probably damaging	Het
Trim71	G	T	9: 114,354,115 (GRCm39)	H296Q	probably damaging	Het
Vmn1r67	A	T	7: 10,180,840 (GRCm39)	I35L	probably benign	Het
Vnn3	A	G	10: 23,727,620 (GRCm39)	T47A	probably benign	Het
Zscan10	A	T	17: 23,824,581 (GRCm39)	Q12H	probably damaging	Het

Other mutations in Ighg2c

Allele	Source	Chr	Coord	Type	Predicted Effect
IGL02087:Ighg2c	APN	12	113,248,986 (GRCm39)	unclassified	probably benign
IGL02560:Ighg2c	APN	12	113,251,504 (GRCm39)	missense	unknown
IGL03339:Ighg2c	APN	12	113,251,614 (GRCm39)	missense	unknown
R0047:Ighg2c	UTSW	12	113,251,788 (GRCm39)	splice site	probably benign
R0047:Ighg2c	UTSW	12	113,251,788 (GRCm39)	splice site	probably benign
R0415:Ighg2c	UTSW	12	113,251,530 (GRCm39)	missense	unknown
R0571:Ighg2c	UTSW	12	113,252,382 (GRCm39)	nonsense	probably null
R0634:Ighg2c	UTSW	12	113,251,584 (GRCm39)	missense	unknown
R0893:Ighg2c	UTSW	12	113,251,053 (GRCm39)	missense	unknown
R1169:Ighg2c	UTSW	12	113,249,572 (GRCm39)	unclassified	probably benign
R3895:Ighg2c	UTSW	12	113,251,278 (GRCm39)	missense	unknown
R5065:Ighg2c	UTSW	12	113,251,708 (GRCm39)	missense	unknown
R6407:Ighg2c	UTSW	12	113,252,271 (GRCm39)	missense	unknown
R7052:Ighg2c	UTSW	12	113,252,343 (GRCm39)	missense
R7231:Ighg2c	UTSW	12	113,251,636 (GRCm39)	missense
R7513:Ighg2c	UTSW	12	113,252,471 (GRCm39)	missense
R8783:Ighg2c	UTSW	12	113,252,412 (GRCm39)	missense
R9175:Ighg2c	UTSW	12	113,252,499 (GRCm39)	missense
R9419:Ighg2c	UTSW	12	113,251,015 (GRCm39)	critical splice donor site	probably benign
Z1177:Ighg2c	UTSW	12	113,251,300 (GRCm39)	missense

Predicted Primers

Posted On

2018-09-12