Incidental Mutation 'R6854:Cdc25a'
ID 535155
Institutional Source Beutler Lab
Gene Symbol Cdc25a
Ensembl Gene ENSMUSG00000032477
Gene Name cell division cycle 25A
Synonyms D9Ertd393e
MMRRC Submission 044957-MU
Accession Numbers
Essential gene? Essential (E-score: 1.000) question?
Stock # R6854 (G1)
Quality Score 225.009
Status Validated
Chromosome 9
Chromosomal Location 109704647-109722963 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 109708995 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Lysine to Glutamic Acid at position 79 (K79E)
Ref Sequence ENSEMBL: ENSMUSP00000142958 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000094324] [ENSMUST00000198308] [ENSMUST00000198848]
AlphaFold P48964
Predicted Effect probably damaging
Transcript: ENSMUST00000094324
AA Change: K140E

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000091882
Gene: ENSMUSG00000032477
AA Change: K140E

DomainStartEndE-ValueType
Pfam:M-inducer_phosp 85 318 3.6e-69 PFAM
RHOD 356 469 2.6e-25 SMART
Predicted Effect probably damaging
Transcript: ENSMUST00000198308
AA Change: K79E

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000142958
Gene: ENSMUSG00000032477
AA Change: K79E

DomainStartEndE-ValueType
Pfam:M-inducer_phosp 24 258 1.2e-88 PFAM
RHOD 295 408 5.97e-25 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000198848
Predicted Effect probably benign
Transcript: ENSMUST00000199787
Meta Mutation Damage Score 0.3785 question?
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.6%
  • 20x: 98.6%
Validation Efficiency 100% (44/44)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] CDC25A is a member of the CDC25 family of phosphatases. CDC25A is required for progression from G1 to the S phase of the cell cycle. It activates the cyclin-dependent kinase CDC2 by removing two phosphate groups. CDC25A is specifically degraded in response to DNA damage, which prevents cells with chromosomal abnormalities from progressing through cell division. CDC25A is an oncogene, although its exact role in oncogenesis has not been demonstrated. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
PHENOTYPE: Homozygotes for a spontaneous mutation exhibit elevated levels of early erythroid progenitor cell cycling but erythropoiesis is normally unaffected. Homozygous deletion of this gene is lethal and male heterozygotes display decreased vertebral trabecular bone. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 43 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Ahnak T C 19: 8,992,599 (GRCm39) S4628P probably damaging Het
Aspm G A 1: 139,390,920 (GRCm39) R735H possibly damaging Het
Atp4a T C 7: 30,414,433 (GRCm39) V152A probably benign Het
BC035947 G A 1: 78,475,125 (GRCm39) T469I probably damaging Het
Bicra A T 7: 15,722,687 (GRCm39) S277T probably benign Het
Catsperg1 A T 7: 28,881,127 (GRCm39) N1142K possibly damaging Het
Ccnd3 T C 17: 47,889,645 (GRCm39) probably benign Het
Cfap44 A G 16: 44,269,391 (GRCm39) probably null Het
Chd5 C A 4: 152,467,395 (GRCm39) N1644K probably damaging Het
Flrt3 C T 2: 140,502,638 (GRCm39) R330H probably damaging Het
Gm6034 T A 17: 36,368,110 (GRCm39) probably null Het
Hivep1 A G 13: 42,309,983 (GRCm39) E741G probably damaging Het
Iqgap3 T C 3: 88,004,258 (GRCm39) V448A probably damaging Het
Itsn2 A G 12: 4,702,382 (GRCm39) R679G probably benign Het
Klrb1c A G 6: 128,765,381 (GRCm39) S70P possibly damaging Het
Maml2 C T 9: 13,617,131 (GRCm39) T159I possibly damaging Het
Mroh2a G A 1: 88,171,672 (GRCm39) R770Q probably damaging Het
Mycl G A 4: 122,894,039 (GRCm39) D280N probably damaging Het
Nlrp1b G A 11: 71,119,259 (GRCm39) T12I possibly damaging Het
Or4f14c T C 2: 111,940,992 (GRCm39) N202D probably benign Het
Or5h19 A C 16: 58,856,428 (GRCm39) I224S possibly damaging Het
Palmd A G 3: 116,717,112 (GRCm39) S462P probably benign Het
Phyhd1 A C 2: 30,159,773 (GRCm39) I36L possibly damaging Het
Plcd1 T C 9: 118,903,389 (GRCm39) probably null Het
Pml G C 9: 58,127,189 (GRCm39) A806G probably damaging Het
Ppp6r1 C A 7: 4,635,395 (GRCm39) A838S probably benign Het
Prkdc C T 16: 15,469,402 (GRCm39) T169I probably damaging Het
Prr23a1 G T 9: 98,724,988 (GRCm39) V117L possibly damaging Het
Pus7 T C 5: 23,973,845 (GRCm39) silent Het
Rdh7 T C 10: 127,724,250 (GRCm39) E78G probably benign Het
Repin1 G T 6: 48,570,825 (GRCm39) probably benign Het
Rptn A G 3: 93,305,430 (GRCm39) N921S possibly damaging Het
Sema4f A G 6: 82,894,983 (GRCm39) L404P probably damaging Het
Serinc4 T A 2: 121,287,031 (GRCm39) M2L probably benign Het
Siglecf T C 7: 43,001,604 (GRCm39) V138A probably benign Het
Slc66a3 G A 12: 17,049,830 (GRCm39) L43F probably damaging Het
Speer2 T A 16: 69,655,775 (GRCm39) Q106L probably damaging Het
Sptb G A 12: 76,650,254 (GRCm39) P1821L probably damaging Het
St3gal3 C A 4: 117,815,727 (GRCm39) M107I probably benign Het
Tmem25 T C 9: 44,707,305 (GRCm39) K265E possibly damaging Het
Ttll3 CAAAGTAA CAAAGTAAAGTAA 6: 113,376,118 (GRCm39) probably null Het
Vsig10 G A 5: 117,476,472 (GRCm39) V309I probably benign Het
Zfp318 G GAAGAAA 17: 46,723,468 (GRCm39) probably benign Het
Other mutations in Cdc25a
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01658:Cdc25a APN 9 109,705,194 (GRCm39) splice site probably null
IGL01761:Cdc25a APN 9 109,720,933 (GRCm39) intron probably benign
IGL02808:Cdc25a APN 9 109,712,667 (GRCm39) splice site probably null
IGL03241:Cdc25a APN 9 109,713,267 (GRCm39) splice site probably null
P4748:Cdc25a UTSW 9 109,713,176 (GRCm39) splice site probably benign
R1472:Cdc25a UTSW 9 109,705,157 (GRCm39) missense probably benign 0.00
R1571:Cdc25a UTSW 9 109,710,614 (GRCm39) missense possibly damaging 0.56
R1598:Cdc25a UTSW 9 109,708,961 (GRCm39) frame shift probably null
R4135:Cdc25a UTSW 9 109,710,585 (GRCm39) missense possibly damaging 0.62
R4301:Cdc25a UTSW 9 109,718,810 (GRCm39) missense probably benign 0.23
R4386:Cdc25a UTSW 9 109,718,801 (GRCm39) missense probably damaging 1.00
R5074:Cdc25a UTSW 9 109,713,208 (GRCm39) missense possibly damaging 0.46
R5171:Cdc25a UTSW 9 109,706,229 (GRCm39) missense probably benign 0.25
R5896:Cdc25a UTSW 9 109,713,433 (GRCm39) missense probably benign 0.00
R5928:Cdc25a UTSW 9 109,718,861 (GRCm39) missense probably damaging 1.00
R6223:Cdc25a UTSW 9 109,718,842 (GRCm39) missense possibly damaging 0.85
R6240:Cdc25a UTSW 9 109,713,226 (GRCm39) missense probably damaging 1.00
R6440:Cdc25a UTSW 9 109,710,566 (GRCm39) missense probably benign
R7219:Cdc25a UTSW 9 109,718,154 (GRCm39) missense probably damaging 0.99
R7980:Cdc25a UTSW 9 109,708,949 (GRCm39) missense probably damaging 1.00
R8506:Cdc25a UTSW 9 109,720,820 (GRCm39) missense probably damaging 0.99
R8790:Cdc25a UTSW 9 109,716,416 (GRCm39) critical splice donor site probably null
R8807:Cdc25a UTSW 9 109,708,303 (GRCm39) missense probably benign 0.01
Predicted Primers PCR Primer
(F):5'- TGAACCCCTGGGCACTTATG -3'
(R):5'- CTCCAGCATCACAAAGCTAGGTAG -3'

Sequencing Primer
(F):5'- GGTCATCTCAAGTTCAAGGCCAG -3'
(R):5'- CATCACAAAGCTAGGTAGAAGAAGC -3'
Posted On 2018-09-12