Incidental Mutation 'R6854:Or5h19'
ID 535165
Institutional Source Beutler Lab
Gene Symbol Or5h19
Ensembl Gene ENSMUSG00000043357
Gene Name olfactory receptor family 5 subfamily H member 19
Synonyms Olfr187, GA_x54KRFPKG5P-55265713-55264787, MOR183-8
MMRRC Submission 044957-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.060) question?
Stock # R6854 (G1)
Quality Score 225.009
Status Validated
Chromosome 16
Chromosomal Location 58856143-58860112 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to C at 58856428 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Serine at position 224 (I224S)
Ref Sequence ENSEMBL: ENSMUSP00000147035 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000206428] [ENSMUST00000207673]
AlphaFold no structure available at present
Predicted Effect possibly damaging
Transcript: ENSMUST00000206428
AA Change: I224S

PolyPhen 2 Score 0.753 (Sensitivity: 0.85; Specificity: 0.92)
Predicted Effect possibly damaging
Transcript: ENSMUST00000207673
AA Change: I224S

PolyPhen 2 Score 0.753 (Sensitivity: 0.85; Specificity: 0.92)
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.6%
  • 20x: 98.6%
Validation Efficiency 100% (44/44)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 43 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Ahnak T C 19: 8,992,599 (GRCm39) S4628P probably damaging Het
Aspm G A 1: 139,390,920 (GRCm39) R735H possibly damaging Het
Atp4a T C 7: 30,414,433 (GRCm39) V152A probably benign Het
BC035947 G A 1: 78,475,125 (GRCm39) T469I probably damaging Het
Bicra A T 7: 15,722,687 (GRCm39) S277T probably benign Het
Catsperg1 A T 7: 28,881,127 (GRCm39) N1142K possibly damaging Het
Ccnd3 T C 17: 47,889,645 (GRCm39) probably benign Het
Cdc25a A G 9: 109,708,995 (GRCm39) K79E probably damaging Het
Cfap44 A G 16: 44,269,391 (GRCm39) probably null Het
Chd5 C A 4: 152,467,395 (GRCm39) N1644K probably damaging Het
Flrt3 C T 2: 140,502,638 (GRCm39) R330H probably damaging Het
Gm6034 T A 17: 36,368,110 (GRCm39) probably null Het
Hivep1 A G 13: 42,309,983 (GRCm39) E741G probably damaging Het
Iqgap3 T C 3: 88,004,258 (GRCm39) V448A probably damaging Het
Itsn2 A G 12: 4,702,382 (GRCm39) R679G probably benign Het
Klrb1c A G 6: 128,765,381 (GRCm39) S70P possibly damaging Het
Maml2 C T 9: 13,617,131 (GRCm39) T159I possibly damaging Het
Mroh2a G A 1: 88,171,672 (GRCm39) R770Q probably damaging Het
Mycl G A 4: 122,894,039 (GRCm39) D280N probably damaging Het
Nlrp1b G A 11: 71,119,259 (GRCm39) T12I possibly damaging Het
Or4f14c T C 2: 111,940,992 (GRCm39) N202D probably benign Het
Palmd A G 3: 116,717,112 (GRCm39) S462P probably benign Het
Phyhd1 A C 2: 30,159,773 (GRCm39) I36L possibly damaging Het
Plcd1 T C 9: 118,903,389 (GRCm39) probably null Het
Pml G C 9: 58,127,189 (GRCm39) A806G probably damaging Het
Ppp6r1 C A 7: 4,635,395 (GRCm39) A838S probably benign Het
Prkdc C T 16: 15,469,402 (GRCm39) T169I probably damaging Het
Prr23a1 G T 9: 98,724,988 (GRCm39) V117L possibly damaging Het
Pus7 T C 5: 23,973,845 (GRCm39) silent Het
Rdh7 T C 10: 127,724,250 (GRCm39) E78G probably benign Het
Repin1 G T 6: 48,570,825 (GRCm39) probably benign Het
Rptn A G 3: 93,305,430 (GRCm39) N921S possibly damaging Het
Sema4f A G 6: 82,894,983 (GRCm39) L404P probably damaging Het
Serinc4 T A 2: 121,287,031 (GRCm39) M2L probably benign Het
Siglecf T C 7: 43,001,604 (GRCm39) V138A probably benign Het
Slc66a3 G A 12: 17,049,830 (GRCm39) L43F probably damaging Het
Speer2 T A 16: 69,655,775 (GRCm39) Q106L probably damaging Het
Sptb G A 12: 76,650,254 (GRCm39) P1821L probably damaging Het
St3gal3 C A 4: 117,815,727 (GRCm39) M107I probably benign Het
Tmem25 T C 9: 44,707,305 (GRCm39) K265E possibly damaging Het
Ttll3 CAAAGTAA CAAAGTAAAGTAA 6: 113,376,118 (GRCm39) probably null Het
Vsig10 G A 5: 117,476,472 (GRCm39) V309I probably benign Het
Zfp318 G GAAGAAA 17: 46,723,468 (GRCm39) probably benign Het
Other mutations in Or5h19
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01333:Or5h19 APN 16 58,856,269 (GRCm39) missense probably damaging 1.00
R0218:Or5h19 UTSW 16 58,856,456 (GRCm39) missense probably benign 0.00
R1023:Or5h19 UTSW 16 58,856,178 (GRCm39) missense probably benign 0.00
R1086:Or5h19 UTSW 16 58,856,626 (GRCm39) missense probably damaging 1.00
R1472:Or5h19 UTSW 16 58,856,920 (GRCm39) missense probably damaging 1.00
R4710:Or5h19 UTSW 16 58,856,638 (GRCm39) missense possibly damaging 0.94
R4738:Or5h19 UTSW 16 58,856,558 (GRCm39) missense probably benign 0.00
R5265:Or5h19 UTSW 16 58,856,506 (GRCm39) missense possibly damaging 0.94
R6053:Or5h19 UTSW 16 58,856,351 (GRCm39) missense probably damaging 1.00
R6704:Or5h19 UTSW 16 58,856,225 (GRCm39) missense probably damaging 1.00
R7178:Or5h19 UTSW 16 58,856,296 (GRCm39) missense probably benign 0.06
R7198:Or5h19 UTSW 16 58,856,456 (GRCm39) missense probably benign 0.00
R7404:Or5h19 UTSW 16 58,856,603 (GRCm39) missense possibly damaging 0.81
R7462:Or5h19 UTSW 16 58,856,379 (GRCm39) nonsense probably null
R7938:Or5h19 UTSW 16 58,856,325 (GRCm39) nonsense probably null
R8785:Or5h19 UTSW 16 58,856,530 (GRCm39) missense probably damaging 1.00
R8790:Or5h19 UTSW 16 58,856,580 (GRCm39) missense possibly damaging 0.96
R8912:Or5h19 UTSW 16 58,856,263 (GRCm39) missense probably benign 0.21
R9198:Or5h19 UTSW 16 58,856,263 (GRCm39) missense probably benign 0.21
R9234:Or5h19 UTSW 16 58,856,789 (GRCm39) missense probably benign 0.05
R9368:Or5h19 UTSW 16 58,856,678 (GRCm39) missense probably benign 0.04
R9568:Or5h19 UTSW 16 58,856,213 (GRCm39) missense probably damaging 1.00
R9679:Or5h19 UTSW 16 58,856,521 (GRCm39) missense possibly damaging 0.87
Predicted Primers PCR Primer
(F):5'- ACCCAAATGTAACAGAGAGTTGC -3'
(R):5'- CTACCCAGTAGTTATGACCAATGG -3'

Sequencing Primer
(F):5'- TTGCCAGTGAATCTATAACTTGC -3'
(R):5'- GCTGGAATTATTCATGCTTTGATTC -3'
Posted On 2018-09-12