Incidental Mutation 'R6850:Trim45'
ID 535583
Institutional Source Beutler Lab
Gene Symbol Trim45
Ensembl Gene ENSMUSG00000033233
Gene Name tripartite motif-containing 45
Synonyms 4921530N01Rik
MMRRC Submission 044954-MU
Accession Numbers
Essential gene? Essential (E-score: 1.000) question?
Stock # R6850 (G1)
Quality Score 225.009
Status Validated
Chromosome 3
Chromosomal Location 100829518-100844236 bp(+) (GRCm39)
Type of Mutation nonsense
DNA Base Change (assembly) T to A at 100830541 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Leucine to Stop codon at position 105 (L105*)
Ref Sequence ENSEMBL: ENSMUSP00000115669 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000037409] [ENSMUST00000094048] [ENSMUST00000106980] [ENSMUST00000134993]
AlphaFold Q6PFY8
Predicted Effect probably null
Transcript: ENSMUST00000037409
AA Change: L105*
SMART Domains Protein: ENSMUSP00000043389
Gene: ENSMUSG00000033233
AA Change: L105*

DomainStartEndE-ValueType
RING 29 97 5.35e-5 SMART
BBOX 130 176 1.03e-1 SMART
BBOX 186 227 4.34e-5 SMART
BBC 234 360 3.55e-9 SMART
IG_FLMN 398 500 7.63e-33 SMART
low complexity region 532 549 N/A INTRINSIC
Predicted Effect probably null
Transcript: ENSMUST00000094048
AA Change: L56*
SMART Domains Protein: ENSMUSP00000091590
Gene: ENSMUSG00000033233
AA Change: L56*

DomainStartEndE-ValueType
BBOX 81 127 1.03e-1 SMART
BBOX 137 178 4.34e-5 SMART
BBC 185 311 3.55e-9 SMART
IG_FLMN 349 451 7.63e-33 SMART
low complexity region 483 500 N/A INTRINSIC
Predicted Effect probably null
Transcript: ENSMUST00000106980
AA Change: L105*
SMART Domains Protein: ENSMUSP00000102593
Gene: ENSMUSG00000033233
AA Change: L105*

DomainStartEndE-ValueType
RING 29 97 5.35e-5 SMART
BBOX 130 176 1.03e-1 SMART
BBOX 186 227 4.34e-5 SMART
BBC 234 360 3.55e-9 SMART
IG_FLMN 398 500 7.63e-33 SMART
low complexity region 532 549 N/A INTRINSIC
Predicted Effect probably null
Transcript: ENSMUST00000134993
AA Change: L105*
SMART Domains Protein: ENSMUSP00000115669
Gene: ENSMUSG00000033233
AA Change: L105*

DomainStartEndE-ValueType
RING 29 97 5.35e-5 SMART
BBOX 130 176 1.03e-1 SMART
BBOX 186 227 4.34e-5 SMART
BBC 234 360 3.55e-9 SMART
IG_FLMN 398 500 7.63e-33 SMART
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.6%
  • 20x: 98.7%
Validation Efficiency 98% (54/55)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the tripartite motif family. The encoded protein may function as a transcriptional repressor of the mitogen-activated protein kinase pathway. Alternatively spliced transcript variants have been described.[provided by RefSeq, Mar 2009]
Allele List at MGI
Other mutations in this stock
Total: 54 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adgb T C 10: 10,270,318 (GRCm39) M927V probably benign Het
Agr2 A G 12: 36,045,558 (GRCm39) I15V probably benign Het
Alpk1 A G 3: 127,523,012 (GRCm39) I10T possibly damaging Het
Art5 A G 7: 101,747,302 (GRCm39) V159A possibly damaging Het
Asz1 G A 6: 18,108,942 (GRCm39) R32W probably benign Het
Atp8b1 A C 18: 64,689,923 (GRCm39) M603R possibly damaging Het
Cacna1s G A 1: 136,020,432 (GRCm39) R823Q probably benign Het
Car9 A G 4: 43,507,321 (GRCm39) E3G probably damaging Het
Cpne3 A T 4: 19,535,231 (GRCm39) I267N possibly damaging Het
Cyp2c65 T A 19: 39,057,535 (GRCm39) F57I probably benign Het
D430041D05Rik T C 2: 104,031,604 (GRCm39) K980R probably damaging Het
Dnhd1 G T 7: 105,369,137 (GRCm39) G4303W possibly damaging Het
Dnmt3a A G 12: 3,947,600 (GRCm39) N485D probably benign Het
Dusp4 A T 8: 35,283,651 (GRCm39) K166* probably null Het
Ect2 T C 3: 27,193,034 (GRCm39) D344G probably damaging Het
Eif2b1 T C 5: 124,717,069 (GRCm39) D3G probably benign Het
Ermp1 A G 19: 29,594,041 (GRCm39) Y710H probably damaging Het
Gar1 T C 3: 129,623,038 (GRCm39) N117S probably damaging Het
H2-T10 A G 17: 36,430,152 (GRCm39) L263P probably damaging Het
Iqcn A T 8: 71,163,425 (GRCm39) N873Y probably damaging Het
Itga7 A T 10: 128,781,385 (GRCm39) I621F probably damaging Het
Kcna3 A T 3: 106,944,475 (GRCm39) D246V probably damaging Het
Kctd12 C T 14: 103,219,414 (GRCm39) G155S probably benign Het
Lrtm1 T C 14: 28,749,407 (GRCm39) V256A probably benign Het
Mcf2l T C 8: 13,059,476 (GRCm39) F629L possibly damaging Het
Mphosph9 A G 5: 124,399,019 (GRCm39) F999L probably damaging Het
Mtres1 ACTGCACCACCT ACT 10: 43,408,721 (GRCm39) probably benign Het
Obscn C T 11: 58,958,950 (GRCm39) V3643M possibly damaging Het
Obscn C T 11: 58,892,955 (GRCm39) A6764T possibly damaging Het
Or4c102 T A 2: 88,422,650 (GRCm39) C167* probably null Het
Or8g18 T C 9: 39,149,271 (GRCm39) I150V probably benign Het
Pdhx T C 2: 102,871,445 (GRCm39) H195R probably damaging Het
Pdilt A T 7: 119,086,182 (GRCm39) V511E probably damaging Het
Prima1 C T 12: 103,163,594 (GRCm39) D126N probably benign Het
Prrc2c TTGCTGCTGCTGCTGCTGCTGCTGCTGC TTGCTGCTGCTGCTGCTGCTGCTGC 1: 162,536,630 (GRCm39) probably benign Het
Prune2 C A 19: 17,099,552 (GRCm39) D1685E probably benign Het
Ptgs2 A T 1: 149,981,291 (GRCm39) I525F probably damaging Het
Rab11fip2 A T 19: 59,925,441 (GRCm39) F259I possibly damaging Het
Ranbp3l C A 15: 9,058,808 (GRCm39) D216E probably damaging Het
Scn5a A T 9: 119,330,815 (GRCm39) L1240Q possibly damaging Het
Sohlh2 A T 3: 55,099,707 (GRCm39) T160S probably benign Het
Sorbs1 G C 19: 40,365,244 (GRCm39) R180G probably benign Het
Spata31h1 A C 10: 82,128,888 (GRCm39) M1374R possibly damaging Het
Tank A G 2: 61,480,346 (GRCm39) E294G probably benign Het
Tars1 T A 15: 11,392,885 (GRCm39) Y187F probably benign Het
Tas2r144 T A 6: 42,192,857 (GRCm39) M199K possibly damaging Het
Tdrd3 T C 14: 87,695,515 (GRCm39) probably benign Het
Tecta T A 9: 42,255,134 (GRCm39) D1683V probably benign Het
Tln2 A G 9: 67,165,817 (GRCm39) I2098T probably damaging Het
Tmie A G 9: 110,695,980 (GRCm39) I137T possibly damaging Het
Trpv3 G A 11: 73,182,519 (GRCm39) G568S probably damaging Het
Wdr75 A G 1: 45,853,758 (GRCm39) T390A probably benign Het
Wdr97 A G 15: 76,241,996 (GRCm39) Y763C probably damaging Het
Zfp35 G A 18: 24,135,839 (GRCm39) R61H possibly damaging Het
Other mutations in Trim45
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00802:Trim45 APN 3 100,839,042 (GRCm39) intron probably benign
IGL01472:Trim45 APN 3 100,835,381 (GRCm39) missense probably benign 0.00
IGL01996:Trim45 APN 3 100,835,425 (GRCm39) nonsense probably null 0.00
IGL02392:Trim45 APN 3 100,832,621 (GRCm39) missense probably benign 0.04
IGL03229:Trim45 APN 3 100,830,385 (GRCm39) missense probably damaging 1.00
IGL02837:Trim45 UTSW 3 100,838,943 (GRCm39) intron probably benign
R0021:Trim45 UTSW 3 100,832,736 (GRCm39) missense probably damaging 1.00
R0243:Trim45 UTSW 3 100,837,160 (GRCm39) missense probably benign 0.05
R0501:Trim45 UTSW 3 100,830,535 (GRCm39) missense probably damaging 1.00
R1222:Trim45 UTSW 3 100,834,614 (GRCm39) missense probably benign 0.14
R1418:Trim45 UTSW 3 100,834,614 (GRCm39) missense probably benign 0.14
R1813:Trim45 UTSW 3 100,830,283 (GRCm39) missense probably benign 0.16
R2148:Trim45 UTSW 3 100,839,360 (GRCm39) nonsense probably null
R2383:Trim45 UTSW 3 100,832,543 (GRCm39) missense probably damaging 0.97
R4368:Trim45 UTSW 3 100,830,502 (GRCm39) missense probably damaging 1.00
R4769:Trim45 UTSW 3 100,839,050 (GRCm39) intron probably benign
R4840:Trim45 UTSW 3 100,832,804 (GRCm39) missense possibly damaging 0.95
R5030:Trim45 UTSW 3 100,835,388 (GRCm39) missense probably damaging 1.00
R5272:Trim45 UTSW 3 100,837,235 (GRCm39) missense probably damaging 1.00
R5298:Trim45 UTSW 3 100,832,787 (GRCm39) missense probably damaging 1.00
R5498:Trim45 UTSW 3 100,832,457 (GRCm39) missense possibly damaging 0.67
R5589:Trim45 UTSW 3 100,837,257 (GRCm39) missense probably damaging 1.00
R6537:Trim45 UTSW 3 100,832,712 (GRCm39) missense probably benign 0.39
R7009:Trim45 UTSW 3 100,839,195 (GRCm39) intron probably benign
R7122:Trim45 UTSW 3 100,839,353 (GRCm39) missense unknown
R7583:Trim45 UTSW 3 100,832,339 (GRCm39) missense probably damaging 1.00
R8358:Trim45 UTSW 3 100,834,634 (GRCm39) missense probably damaging 0.98
R8368:Trim45 UTSW 3 100,830,672 (GRCm39) missense possibly damaging 0.61
R8924:Trim45 UTSW 3 100,835,394 (GRCm39) missense probably damaging 1.00
R8998:Trim45 UTSW 3 100,838,960 (GRCm39) missense unknown
R8999:Trim45 UTSW 3 100,838,960 (GRCm39) missense unknown
R9069:Trim45 UTSW 3 100,832,440 (GRCm39) nonsense probably null
R9368:Trim45 UTSW 3 100,832,319 (GRCm39) missense possibly damaging 0.51
R9594:Trim45 UTSW 3 100,830,265 (GRCm39) missense probably benign 0.00
R9634:Trim45 UTSW 3 100,839,306 (GRCm39) missense unknown
R9651:Trim45 UTSW 3 100,832,705 (GRCm39) nonsense probably null
X0066:Trim45 UTSW 3 100,839,083 (GRCm39) intron probably benign
Z1088:Trim45 UTSW 3 100,832,956 (GRCm39) missense probably benign 0.11
Predicted Primers PCR Primer
(F):5'- TTGCCTTGCTTGCACACAG -3'
(R):5'- CTTACGCCACAATAAACGGG -3'

Sequencing Primer
(F):5'- GTGTGCACCACGTGTCTG -3'
(R):5'- TCTTTACCTATGAGCCTGGCAG -3'
Posted On 2018-09-12