Incidental Mutation 'R6864:Vmn2r24'
| ID |
535805 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn2r24
|
| Ensembl Gene |
ENSMUSG00000072780 |
| Gene Name |
vomeronasal 2, receptor 24 |
| Synonyms |
EG243628 |
| MMRRC Submission |
044964-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.055)
|
| Stock # |
R6864 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Validated
|
| Chromosome |
6 |
| Chromosomal Location |
123755930-123793239 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to T
at 123756117 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Aspartic acid to Valine
at position 63
(D63V)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000074602
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000075095]
|
| AlphaFold |
D3YUI0 |
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000075095
AA Change: D63V
PolyPhen 2
Score 0.887 (Sensitivity: 0.82; Specificity: 0.94)
|
| SMART Domains |
Protein: ENSMUSP00000074602
Gene: ENSMUSG00000072780
AA Change: D63V
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
22 |
N/A |
INTRINSIC |
|
Pfam:ANF_receptor
|
82 |
469 |
1.6e-32 |
PFAM |
|
Pfam:NCD3G
|
518 |
571 |
1.1e-22 |
PFAM |
|
Pfam:7tm_3
|
602 |
839 |
1.1e-54 |
PFAM |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.2%
- 20x: 97.2%
|
| Validation Efficiency |
100% (60/60) |
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 57 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Adgre1 |
C |
T |
17: 57,785,879 (GRCm39) |
T875I |
probably damaging |
Het |
| Anln |
A |
T |
9: 22,293,545 (GRCm39) |
S33T |
probably benign |
Het |
| Anxa6 |
T |
C |
11: 54,877,011 (GRCm39) |
T541A |
probably benign |
Het |
| Atxn2 |
C |
T |
5: 121,917,557 (GRCm39) |
R334W |
probably damaging |
Het |
| AU040320 |
T |
A |
4: 126,741,612 (GRCm39) |
V940D |
probably damaging |
Het |
| Bcl2 |
A |
T |
1: 106,471,011 (GRCm39) |
Y232N |
probably damaging |
Het |
| Bmp7 |
A |
G |
2: 172,781,855 (GRCm39) |
V3A |
probably benign |
Het |
| Calr |
A |
T |
8: 85,571,557 (GRCm39) |
H145Q |
probably damaging |
Het |
| Camta2 |
T |
A |
11: 70,562,792 (GRCm39) |
T976S |
probably benign |
Het |
| Ccnk |
G |
A |
12: 108,168,473 (GRCm39) |
|
probably benign |
Het |
| Cntln |
T |
C |
4: 85,015,029 (GRCm39) |
S1107P |
probably damaging |
Het |
| Cradd |
T |
C |
10: 95,011,789 (GRCm39) |
D117G |
probably damaging |
Het |
| Dcaf7 |
C |
T |
11: 105,937,647 (GRCm39) |
T90I |
probably damaging |
Het |
| Defb30 |
T |
A |
14: 63,273,552 (GRCm39) |
|
probably null |
Het |
| Dock4 |
T |
A |
12: 40,795,745 (GRCm39) |
I854N |
probably damaging |
Het |
| Dym |
T |
A |
18: 75,189,809 (GRCm39) |
Y132* |
probably null |
Het |
| Eef1a2 |
T |
C |
2: 180,791,477 (GRCm39) |
T341A |
probably benign |
Het |
| Eml2 |
T |
C |
7: 18,930,206 (GRCm39) |
V309A |
probably damaging |
Het |
| Flnb |
C |
T |
14: 7,905,640 (GRCm38) |
P1130L |
possibly damaging |
Het |
| Hivep3 |
C |
A |
4: 119,952,085 (GRCm39) |
Q134K |
possibly damaging |
Het |
| Kbtbd2 |
T |
A |
6: 56,757,011 (GRCm39) |
K242* |
probably null |
Het |
| Kel |
A |
G |
6: 41,680,694 (GRCm39) |
|
probably null |
Het |
| Lcorl |
T |
A |
5: 45,904,546 (GRCm39) |
K177N |
probably damaging |
Het |
| Mbd3l2 |
A |
G |
9: 18,354,795 (GRCm39) |
|
probably benign |
Het |
| Mcm3ap |
A |
G |
10: 76,343,313 (GRCm39) |
D1735G |
probably damaging |
Het |
| Ms4a1 |
C |
A |
19: 11,230,542 (GRCm39) |
|
probably null |
Het |
| Muc5ac |
C |
T |
7: 141,363,481 (GRCm39) |
|
probably benign |
Het |
| Mylk |
C |
A |
16: 34,694,520 (GRCm39) |
P193Q |
probably benign |
Het |
| Or1j11 |
T |
A |
2: 36,311,832 (GRCm39) |
C141S |
probably damaging |
Het |
| Or2y16 |
G |
T |
11: 49,334,767 (GRCm39) |
A30S |
probably benign |
Het |
| Or2y17 |
A |
T |
11: 49,231,580 (GRCm39) |
T74S |
probably damaging |
Het |
| Or4d10b |
A |
T |
19: 12,036,777 (GRCm39) |
F113Y |
probably damaging |
Het |
| Or4f52 |
C |
T |
2: 111,061,542 (GRCm39) |
V199I |
probably benign |
Het |
| Otogl |
C |
T |
10: 107,663,667 (GRCm39) |
S968N |
probably damaging |
Het |
| Oxr1 |
T |
G |
15: 41,686,783 (GRCm39) |
V555G |
probably damaging |
Het |
| Parp12 |
T |
C |
6: 39,088,670 (GRCm39) |
I189V |
probably benign |
Het |
| Peg3 |
T |
C |
7: 6,715,761 (GRCm39) |
Y103C |
probably damaging |
Het |
| Plekhh2 |
T |
C |
17: 84,925,427 (GRCm39) |
V1408A |
probably benign |
Het |
| Prkacb |
T |
C |
3: 146,451,133 (GRCm39) |
Y204C |
probably damaging |
Het |
| Prkch |
A |
G |
12: 73,806,391 (GRCm39) |
E546G |
probably damaging |
Het |
| Prss12 |
C |
A |
3: 123,241,033 (GRCm39) |
H76N |
probably benign |
Het |
| Rai14 |
G |
T |
15: 10,633,254 (GRCm39) |
S45R |
possibly damaging |
Het |
| Samd9l |
T |
A |
6: 3,374,750 (GRCm39) |
D837V |
probably benign |
Het |
| Slc22a6 |
G |
T |
19: 8,595,805 (GRCm39) |
C49F |
probably damaging |
Het |
| Slc2a2 |
T |
A |
3: 28,775,874 (GRCm39) |
I328N |
probably damaging |
Het |
| Slc35f4 |
T |
C |
14: 49,556,310 (GRCm39) |
I148V |
possibly damaging |
Het |
| Stk32b |
A |
T |
5: 37,606,149 (GRCm39) |
|
probably null |
Het |
| Tasor |
T |
A |
14: 27,183,115 (GRCm39) |
F525I |
probably damaging |
Het |
| Tktl2 |
T |
C |
8: 66,964,991 (GRCm39) |
I183T |
probably damaging |
Het |
| Tmem175 |
A |
C |
5: 108,793,845 (GRCm39) |
H325P |
probably damaging |
Het |
| Tns3 |
A |
G |
11: 8,443,196 (GRCm39) |
V389A |
probably damaging |
Het |
| Trappc9 |
A |
T |
15: 72,809,011 (GRCm39) |
|
probably null |
Het |
| Trim28 |
T |
A |
7: 12,763,385 (GRCm39) |
F509I |
possibly damaging |
Het |
| Vmn1r210 |
T |
A |
13: 23,011,713 (GRCm39) |
Q191L |
probably benign |
Het |
| Zfp536 |
A |
G |
7: 37,267,940 (GRCm39) |
L492P |
probably damaging |
Het |
| Zfp831 |
C |
A |
2: 174,488,533 (GRCm39) |
N1069K |
possibly damaging |
Het |
| Zfp943 |
T |
A |
17: 22,211,593 (GRCm39) |
H226Q |
probably damaging |
Het |
|
| Other mutations in Vmn2r24 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00954:Vmn2r24
|
APN |
6 |
123,792,596 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01382:Vmn2r24
|
APN |
6 |
123,763,938 (GRCm39) |
missense |
possibly damaging |
0.62 |
|
IGL01592:Vmn2r24
|
APN |
6 |
123,764,445 (GRCm39) |
missense |
probably benign |
0.30 |
|
IGL01754:Vmn2r24
|
APN |
6 |
123,781,120 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01939:Vmn2r24
|
APN |
6 |
123,764,404 (GRCm39) |
missense |
probably benign |
|
|
IGL02140:Vmn2r24
|
APN |
6 |
123,757,631 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL02272:Vmn2r24
|
APN |
6 |
123,763,843 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
IGL02568:Vmn2r24
|
APN |
6 |
123,792,812 (GRCm39) |
missense |
probably benign |
0.36 |
|
IGL02748:Vmn2r24
|
APN |
6 |
123,793,057 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
IGL03022:Vmn2r24
|
APN |
6 |
123,755,967 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL03343:Vmn2r24
|
APN |
6 |
123,793,070 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0357:Vmn2r24
|
UTSW |
6 |
123,792,369 (GRCm39) |
frame shift |
probably null |
|
|
R0453:Vmn2r24
|
UTSW |
6 |
123,757,350 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R0538:Vmn2r24
|
UTSW |
6 |
123,793,012 (GRCm39) |
missense |
probably benign |
0.32 |
|
R0607:Vmn2r24
|
UTSW |
6 |
123,763,893 (GRCm39) |
missense |
probably benign |
|
|
R1381:Vmn2r24
|
UTSW |
6 |
123,763,692 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1589:Vmn2r24
|
UTSW |
6 |
123,783,479 (GRCm39) |
splice site |
probably benign |
|
|
R1848:Vmn2r24
|
UTSW |
6 |
123,793,183 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2035:Vmn2r24
|
UTSW |
6 |
123,793,019 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2077:Vmn2r24
|
UTSW |
6 |
123,792,358 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2122:Vmn2r24
|
UTSW |
6 |
123,792,353 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R2145:Vmn2r24
|
UTSW |
6 |
123,755,972 (GRCm39) |
missense |
probably benign |
|
|
R2483:Vmn2r24
|
UTSW |
6 |
123,792,997 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2512:Vmn2r24
|
UTSW |
6 |
123,763,985 (GRCm39) |
missense |
probably benign |
0.01 |
|
R3001:Vmn2r24
|
UTSW |
6 |
123,781,231 (GRCm39) |
missense |
probably benign |
0.00 |
|
R3002:Vmn2r24
|
UTSW |
6 |
123,781,231 (GRCm39) |
missense |
probably benign |
0.00 |
|
R3236:Vmn2r24
|
UTSW |
6 |
123,755,984 (GRCm39) |
nonsense |
probably null |
|
|
R3623:Vmn2r24
|
UTSW |
6 |
123,792,997 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3624:Vmn2r24
|
UTSW |
6 |
123,792,997 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3835:Vmn2r24
|
UTSW |
6 |
123,764,412 (GRCm39) |
missense |
probably benign |
0.33 |
|
R4074:Vmn2r24
|
UTSW |
6 |
123,764,374 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R4075:Vmn2r24
|
UTSW |
6 |
123,764,374 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R4812:Vmn2r24
|
UTSW |
6 |
123,756,144 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4825:Vmn2r24
|
UTSW |
6 |
123,792,739 (GRCm39) |
missense |
probably benign |
0.02 |
|
R5351:Vmn2r24
|
UTSW |
6 |
123,793,223 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R5665:Vmn2r24
|
UTSW |
6 |
123,763,938 (GRCm39) |
missense |
possibly damaging |
0.62 |
|
R5790:Vmn2r24
|
UTSW |
6 |
123,792,499 (GRCm39) |
missense |
probably benign |
|
|
R5808:Vmn2r24
|
UTSW |
6 |
123,792,597 (GRCm39) |
nonsense |
probably null |
|
|
R5879:Vmn2r24
|
UTSW |
6 |
123,764,226 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R5923:Vmn2r24
|
UTSW |
6 |
123,792,751 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R5969:Vmn2r24
|
UTSW |
6 |
123,755,981 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6050:Vmn2r24
|
UTSW |
6 |
123,792,691 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6171:Vmn2r24
|
UTSW |
6 |
123,764,205 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R6174:Vmn2r24
|
UTSW |
6 |
123,793,236 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6356:Vmn2r24
|
UTSW |
6 |
123,783,368 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R6562:Vmn2r24
|
UTSW |
6 |
123,757,386 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6563:Vmn2r24
|
UTSW |
6 |
123,781,137 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R6584:Vmn2r24
|
UTSW |
6 |
123,792,764 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R6630:Vmn2r24
|
UTSW |
6 |
123,763,981 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6803:Vmn2r24
|
UTSW |
6 |
123,755,960 (GRCm39) |
missense |
possibly damaging |
0.64 |
|
R7252:Vmn2r24
|
UTSW |
6 |
123,764,191 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R7369:Vmn2r24
|
UTSW |
6 |
123,792,638 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7646:Vmn2r24
|
UTSW |
6 |
123,793,169 (GRCm39) |
missense |
probably benign |
0.20 |
|
R7799:Vmn2r24
|
UTSW |
6 |
123,757,422 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7803:Vmn2r24
|
UTSW |
6 |
123,757,438 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7959:Vmn2r24
|
UTSW |
6 |
123,755,949 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R8215:Vmn2r24
|
UTSW |
6 |
123,756,077 (GRCm39) |
missense |
probably benign |
0.10 |
|
R8796:Vmn2r24
|
UTSW |
6 |
123,757,500 (GRCm39) |
missense |
probably benign |
|
|
R9172:Vmn2r24
|
UTSW |
6 |
123,783,432 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9300:Vmn2r24
|
UTSW |
6 |
123,793,030 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R9369:Vmn2r24
|
UTSW |
6 |
123,792,357 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9375:Vmn2r24
|
UTSW |
6 |
123,792,542 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9523:Vmn2r24
|
UTSW |
6 |
123,763,950 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R9546:Vmn2r24
|
UTSW |
6 |
123,764,266 (GRCm39) |
missense |
probably damaging |
0.98 |
|
RF006:Vmn2r24
|
UTSW |
6 |
123,783,378 (GRCm39) |
missense |
probably damaging |
1.00 |
|
RF016:Vmn2r24
|
UTSW |
6 |
123,781,174 (GRCm39) |
missense |
probably benign |
0.04 |
|
X0023:Vmn2r24
|
UTSW |
6 |
123,764,359 (GRCm39) |
missense |
probably damaging |
0.99 |
|
Z1088:Vmn2r24
|
UTSW |
6 |
123,781,155 (GRCm39) |
missense |
probably benign |
0.00 |
|
Z1177:Vmn2r24
|
UTSW |
6 |
123,763,719 (GRCm39) |
missense |
probably benign |
0.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- GCTGATGTGCTTTCAGAGTCG -3'
(R):5'- ACAGTGATACAGAGACAGAGACT -3'
Sequencing Primer
(F):5'- GCTTTCAGAGTCGATTAGCTCAAG -3'
(R):5'- TTAATGAATTTGAAGACAGGAGACAC -3'
|
| Posted On |
2018-10-18 |
Incidental Mutation