Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01018:Speer4a3'

53583

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Speer4a3

Ensembl Gene

ENSMUSG00000095550

Gene Name

spermatogenesis associated glutamate (E)-rich protein 4A3

Synonyms

Gm21671

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.057) question?

Stock #

IGL01018

Quality Score

Status

Chromosome

Chromosomal Location

26154795-26159342 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

G to T at 26155721 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Histidine to Asparagine at position 208 (H208N)

Ref Sequence

ENSEMBL: ENSMUSP00000133924 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000162387]

AlphaFold

G3UY31

Predicted Effect

probably benign
Transcript: ENSMUST00000162387
AA Change: H208N

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)

SMART Domains

Protein: ENSMUSP00000133924
Gene: ENSMUSG00000095550
AA Change: H208N

Domain	Start	End	E-Value	Type
Pfam:Takusan	50	134	2.4e-25	PFAM
low complexity region	154	168	N/A	INTRINSIC
low complexity region	235	259	N/A	INTRINSIC

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 51 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
5530400C23Rik	G	T	6: 133,271,460 (GRCm39)	R168I	probably benign	Het
5530400C23Rik	A	T	6: 133,271,461 (GRCm39)	R168S	probably benign	Het
Armt1	T	A	10: 4,400,732 (GRCm39)	S160T	probably benign	Het
Armt1	C	T	10: 4,404,237 (GRCm39)		probably benign	Het
Ccdc170	T	C	10: 4,462,788 (GRCm39)	W35R	probably benign	Het
Ccdc170	T	C	10: 4,464,114 (GRCm39)	V31A	probably benign	Het
Ccdc170	G	T	10: 4,464,155 (GRCm39)	A99S	probably benign	Het
Glp2r	C	A	11: 67,600,470 (GRCm39)	V460F	probably benign	Het
Gm21411	C	T	4: 146,977,067 (GRCm39)	S69N	possibly damaging	Het
Gm21411	T	C	4: 146,977,034 (GRCm39)	Q80R	probably benign	Het
Gm21738	G	A	14: 19,418,856 (GRCm38)	P24L	probably benign	Het
H2-M10.6	C	T	17: 37,123,112 (GRCm39)	A15V	probably benign	Het
H60c	T	C	10: 3,209,766 (GRCm39)	M174V	probably benign	Het
H60c	A	C	10: 3,210,343 (GRCm39)	F69V	probably benign	Het
Ipcef1	G	A	10: 6,840,551 (GRCm39)	A382V	probably benign	Het
Ipcef1	C	T	10: 6,869,968 (GRCm39)	R144Q	probably damaging	Het
Mapk8ip3	T	G	17: 25,118,693 (GRCm39)		probably benign	Het
Mthfd1l	T	C	10: 3,928,708 (GRCm39)	V100A	probably benign	Het
Mthfd1l	T	C	10: 3,957,800 (GRCm39)	V279A	probably benign	Het
Mthfd1l	T	C	10: 3,982,345 (GRCm39)		probably benign	Het
Mtrf1l	A	G	10: 5,764,180 (GRCm39)		probably benign	Het
Myo18b	T	C	5: 112,957,613 (GRCm39)	E1450G	probably damaging	Het
Obscn	C	T	11: 59,018,895 (GRCm39)	V973M	probably damaging	Het
Oprm1	T	C	10: 6,987,170 (GRCm39)		probably benign	Het
Or6p1	G	A	1: 174,258,908 (GRCm39)	V305I	probably benign	Het
Pou5f2	A	G	13: 78,174,057 (GRCm39)		probably benign	Het
Ralgapa2	G	A	2: 146,252,113 (GRCm39)	H891Y	probably benign	Het
Ralgapa2	T	G	2: 146,252,112 (GRCm39)	H806P	probably benign	Het
Rmnd1	A	G	10: 4,377,392 (GRCm39)	W96R	probably benign	Het
Rmnd1	A	T	10: 4,377,290 (GRCm39)	S130T	probably benign	Het
Spata31e2	T	C	1: 26,721,991 (GRCm39)	E1063G	probably damaging	Het
Trappc12	A	C	12: 28,741,853 (GRCm39)		probably benign	Het
Ulbp3	G	A	10: 3,075,031 (GRCm39)		noncoding transcript	Het
Ulbp3	C	T	10: 3,075,193 (GRCm39)		noncoding transcript	Het
Ulbp3	A	G	10: 3,070,231 (GRCm39)		noncoding transcript	Het
Ulbp3	A	G	10: 3,070,209 (GRCm39)		noncoding transcript	Het
Vip	A	G	10: 5,592,480 (GRCm39)	D40G	probably benign	Het
Vmn2r125	T	C	4: 156,702,907 (GRCm39)		probably benign	Het
Vmn2r125	A	G	4: 156,703,140 (GRCm39)	N173D	probably damaging	Het
Vmn2r125	C	A	4: 156,703,194 (GRCm39)	Q191K	probably benign	Het
Vmn2r125	A	C	4: 156,703,195 (GRCm39)	Q191P	probably benign	Het
Vmn2r125	A	T	4: 156,703,332 (GRCm39)	T237S	probably benign	Het
Vmn2r125	T	A	4: 156,703,521 (GRCm39)	L300M	probably benign	Het
Vmn2r125	C	T	4: 156,703,333 (GRCm39)	T237I	probably benign	Het
Vmn2r129	C	A	4: 156,690,730 (GRCm39)		noncoding transcript	Het
Vmn2r129	A	T	4: 156,690,441 (GRCm39)		noncoding transcript	Het
Vmn2r129	G	A	4: 156,686,900 (GRCm39)		noncoding transcript	Het
Vmn2r129	T	C	4: 156,687,885 (GRCm39)		noncoding transcript	Het
Vmn2r129	T	C	4: 156,686,558 (GRCm39)		noncoding transcript	Het
Vmn2r40	G	A	7: 8,911,175 (GRCm39)	S706F	probably damaging	Het
Zfp14	T	A	7: 29,737,526 (GRCm39)	R486S	probably damaging	Het

Other mutations in Speer4a3

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00990:Speer4a3	APN	5	26,159,222 (GRCm39)	missense	probably benign
IGL02487:Speer4a3	APN	5	26,156,605 (GRCm39)	missense	probably benign	0.00
IGL02612:Speer4a3	APN	5	26,156,614 (GRCm39)	missense	probably benign	0.32
IGL02654:Speer4a3	APN	5	26,158,205 (GRCm39)	missense	probably benign	0.00
R1344:Speer4a3	UTSW	5	26,158,107 (GRCm39)	missense	probably benign	0.07
R1462:Speer4a3	UTSW	5	26,156,623 (GRCm39)	missense	possibly damaging	0.94
R1462:Speer4a3	UTSW	5	26,156,623 (GRCm39)	missense	possibly damaging	0.94
R2213:Speer4a3	UTSW	5	26,158,175 (GRCm39)	missense	probably benign
R6856:Speer4a3	UTSW	5	26,155,843 (GRCm39)	missense	probably benign
R7069:Speer4a3	UTSW	5	26,154,842 (GRCm39)	missense	possibly damaging	0.94
R7165:Speer4a3	UTSW	5	26,155,849 (GRCm39)	small deletion	probably benign
R7737:Speer4a3	UTSW	5	26,155,849 (GRCm39)	small deletion	probably benign
R8393:Speer4a3	UTSW	5	26,158,076 (GRCm39)	missense	probably damaging	1.00
R8729:Speer4a3	UTSW	5	26,158,178 (GRCm39)	missense	probably damaging	0.99
R8815:Speer4a3	UTSW	5	26,158,191 (GRCm39)	missense	probably damaging	1.00
R8901:Speer4a3	UTSW	5	26,155,857 (GRCm39)	small deletion	probably benign
R8922:Speer4a3	UTSW	5	26,156,594 (GRCm39)	missense	possibly damaging	0.89
R9125:Speer4a3	UTSW	5	26,156,596 (GRCm39)	missense	possibly damaging	0.78
R9156:Speer4a3	UTSW	5	26,155,857 (GRCm39)	small deletion	probably benign
R9451:Speer4a3	UTSW	5	26,156,569 (GRCm39)	nonsense	probably null
R9474:Speer4a3	UTSW	5	26,158,136 (GRCm39)	missense	probably damaging	1.00
R9498:Speer4a3	UTSW	5	26,155,849 (GRCm39)	small deletion	probably benign
R9685:Speer4a3	UTSW	5	26,155,849 (GRCm39)	small deletion	probably benign
R9717:Speer4a3	UTSW	5	26,154,829 (GRCm39)	missense	probably damaging	0.99
R9766:Speer4a3	UTSW	5	26,155,849 (GRCm39)	small deletion	probably benign
RF039:Speer4a3	UTSW	5	26,155,857 (GRCm39)	small deletion	probably benign

Posted On

2013-06-28