Incidental Mutation 'R6867:Zfp703'
ID 535976
Institutional Source Beutler Lab
Gene Symbol Zfp703
Ensembl Gene ENSMUSG00000085795
Gene Name zinc finger protein 703
Synonyms Zeppo1, 1110032O19Rik, Csmn1, End2
MMRRC Submission 045028-MU
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.364) question?
Stock # R6867 (G1)
Quality Score 218.009
Status Validated
Chromosome 8
Chromosomal Location 27467364-27471490 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to A at 27468668 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Proline to Threonine at position 111 (P111T)
Ref Sequence ENSEMBL: ENSMUSP00000128757 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000127097] [ENSMUST00000154256] [ENSMUST00000209411] [ENSMUST00000209610]
AlphaFold P0CL69
Predicted Effect probably benign
Transcript: ENSMUST00000127097
SMART Domains Protein: ENSMUSP00000132801
Gene: ENSMUSG00000085795

DomainStartEndE-ValueType
low complexity region 15 29 N/A INTRINSIC
low complexity region 32 47 N/A INTRINSIC
Predicted Effect probably damaging
Transcript: ENSMUST00000154256
AA Change: P111T

PolyPhen 2 Score 0.970 (Sensitivity: 0.77; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000128757
Gene: ENSMUSG00000085795
AA Change: P111T

DomainStartEndE-ValueType
low complexity region 15 29 N/A INTRINSIC
low complexity region 32 47 N/A INTRINSIC
low complexity region 133 145 N/A INTRINSIC
low complexity region 164 191 N/A INTRINSIC
low complexity region 212 231 N/A INTRINSIC
low complexity region 261 275 N/A INTRINSIC
Pfam:nlz1 315 369 3.6e-24 PFAM
low complexity region 426 442 N/A INTRINSIC
ZnF_C2H2 460 488 1.16e1 SMART
low complexity region 497 541 N/A INTRINSIC
Predicted Effect unknown
Transcript: ENSMUST00000209411
AA Change: A34D
Predicted Effect probably benign
Transcript: ENSMUST00000209610
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.4%
  • 20x: 98.0%
Validation Efficiency 100% (43/43)
Allele List at MGI
Other mutations in this stock
Total: 42 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Apold1 T C 6: 134,961,019 (GRCm39) S158P possibly damaging Het
Cep162 A T 9: 87,099,134 (GRCm39) L788* probably null Het
Cyp7b1 T C 3: 18,151,394 (GRCm39) Y273C probably damaging Het
Dlx1 C A 2: 71,361,353 (GRCm39) N122K probably damaging Het
Dock10 A T 1: 80,508,976 (GRCm39) I1605K probably damaging Het
Enox1 T C 14: 77,936,739 (GRCm39) probably null Het
F3 T C 3: 121,523,020 (GRCm39) S77P possibly damaging Het
Fam186a T A 15: 99,843,731 (GRCm39) I838L unknown Het
Flrt2 T C 12: 95,746,156 (GRCm39) F165L probably damaging Het
Gcgr T A 11: 120,427,295 (GRCm39) V135E possibly damaging Het
Gm6741 T C 17: 91,544,339 (GRCm39) L34P probably benign Het
Gna13 T C 11: 109,286,948 (GRCm39) M257T possibly damaging Het
Hsd11b2 G A 8: 106,248,949 (GRCm39) R147H probably benign Het
Hydin A G 8: 111,266,434 (GRCm39) Y2865C probably benign Het
Igdcc3 A G 9: 65,090,320 (GRCm39) N610D probably damaging Het
Ipp T A 4: 116,367,606 (GRCm39) probably null Het
Kdm5d A G Y: 927,425 (GRCm39) T682A probably benign Het
Megf8 A G 7: 25,030,460 (GRCm39) Y471C probably benign Het
Mprip T C 11: 59,640,456 (GRCm39) probably null Het
Mtres1 ACTGCACCACCT ACT 10: 43,408,721 (GRCm39) probably benign Het
Myrfl T A 10: 116,684,187 (GRCm39) R179* probably null Het
Nek1 C A 8: 61,525,364 (GRCm39) Q601K possibly damaging Het
Neurod4 C G 10: 130,106,583 (GRCm39) K230N probably damaging Het
Or1ab2 C T 8: 72,863,707 (GRCm39) T99I possibly damaging Het
Or8u10 A G 2: 85,916,082 (GRCm39) I13T possibly damaging Het
Orc3 A G 4: 34,605,539 (GRCm39) L114P probably damaging Het
Rag1 T C 2: 101,472,292 (GRCm39) D950G probably damaging Het
Rasgrp2 G A 19: 6,463,213 (GRCm39) S504N probably benign Het
Rgl2 A G 17: 34,151,661 (GRCm39) D235G probably benign Het
Slc35e2 A G 4: 155,703,157 (GRCm39) E390G probably benign Het
Slc39a1 T A 3: 90,156,759 (GRCm39) V105E probably damaging Het
Tesk2 T A 4: 116,658,995 (GRCm39) C291S probably damaging Het
Tmco3 T A 8: 13,363,927 (GRCm39) F83Y probably damaging Het
Trim25 T C 11: 88,901,713 (GRCm39) I336T probably benign Het
Ush2a A G 1: 188,643,170 (GRCm39) I4177M probably damaging Het
Veph1 T A 3: 66,162,458 (GRCm39) T67S probably damaging Het
Vmn2r43 A G 7: 8,258,125 (GRCm39) F363L probably benign Het
Vps28 A T 15: 76,506,871 (GRCm39) I109N probably damaging Het
Vps50 A G 6: 3,517,835 (GRCm39) D91G probably benign Het
Wdr20 T C 12: 110,760,133 (GRCm39) F340L probably benign Het
Wdr95 A G 5: 149,504,388 (GRCm39) probably null Het
Zfand6 A G 7: 84,265,122 (GRCm39) V193A probably damaging Het
Other mutations in Zfp703
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02441:Zfp703 APN 8 27,470,036 (GRCm39) missense probably damaging 0.98
R1524:Zfp703 UTSW 8 27,469,401 (GRCm39) missense probably damaging 1.00
R2082:Zfp703 UTSW 8 27,469,016 (GRCm39) missense probably benign 0.01
R4049:Zfp703 UTSW 8 27,469,113 (GRCm39) missense possibly damaging 0.70
R4570:Zfp703 UTSW 8 27,468,981 (GRCm39) missense probably benign 0.10
R4884:Zfp703 UTSW 8 27,468,729 (GRCm39) missense probably benign 0.03
R4929:Zfp703 UTSW 8 27,468,879 (GRCm39) missense possibly damaging 0.66
R4938:Zfp703 UTSW 8 27,469,801 (GRCm39) missense probably damaging 1.00
R4943:Zfp703 UTSW 8 27,469,619 (GRCm39) missense probably benign 0.35
R5117:Zfp703 UTSW 8 27,469,233 (GRCm39) missense probably damaging 1.00
R5118:Zfp703 UTSW 8 27,469,233 (GRCm39) missense probably damaging 1.00
R5297:Zfp703 UTSW 8 27,469,233 (GRCm39) missense probably damaging 1.00
R5465:Zfp703 UTSW 8 27,469,233 (GRCm39) missense probably damaging 1.00
R5466:Zfp703 UTSW 8 27,469,233 (GRCm39) missense probably damaging 1.00
R5467:Zfp703 UTSW 8 27,469,233 (GRCm39) missense probably damaging 1.00
R5492:Zfp703 UTSW 8 27,469,233 (GRCm39) missense probably damaging 1.00
R5493:Zfp703 UTSW 8 27,469,233 (GRCm39) missense probably damaging 1.00
R5494:Zfp703 UTSW 8 27,469,233 (GRCm39) missense probably damaging 1.00
R5757:Zfp703 UTSW 8 27,469,233 (GRCm39) missense probably damaging 1.00
R5758:Zfp703 UTSW 8 27,469,233 (GRCm39) missense probably damaging 1.00
R5802:Zfp703 UTSW 8 27,469,233 (GRCm39) missense probably damaging 1.00
R5828:Zfp703 UTSW 8 27,469,233 (GRCm39) missense probably damaging 1.00
R5850:Zfp703 UTSW 8 27,469,233 (GRCm39) missense probably damaging 1.00
R5854:Zfp703 UTSW 8 27,469,233 (GRCm39) missense probably damaging 1.00
R5856:Zfp703 UTSW 8 27,469,233 (GRCm39) missense probably damaging 1.00
R5959:Zfp703 UTSW 8 27,469,233 (GRCm39) missense probably damaging 1.00
R6464:Zfp703 UTSW 8 27,469,355 (GRCm39) missense probably damaging 1.00
R7067:Zfp703 UTSW 8 27,469,044 (GRCm39) missense probably damaging 0.96
R7812:Zfp703 UTSW 8 27,469,906 (GRCm39) missense probably damaging 1.00
R7880:Zfp703 UTSW 8 27,468,718 (GRCm39) missense unknown
R8167:Zfp703 UTSW 8 27,469,782 (GRCm39) missense probably damaging 1.00
R8966:Zfp703 UTSW 8 27,468,302 (GRCm39) missense possibly damaging 0.83
R9686:Zfp703 UTSW 8 27,469,044 (GRCm39) missense probably damaging 0.96
Predicted Primers PCR Primer
(F):5'- CCACAAGGCAAGTGTCATTC -3'
(R):5'- CGAGTTTGATGAGGTGGAGACC -3'

Sequencing Primer
(F):5'- AAGTGTCATTCCGCCCAG -3'
(R):5'- ACGAGGAGCCGCTGTCTTTG -3'
Posted On 2018-10-18