Incidental Mutation 'R6868:Adgrg7'
| ID |
536051 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Adgrg7
|
| Ensembl Gene |
ENSMUSG00000022755 |
| Gene Name |
adhesion G protein-coupled receptor G7 |
| Synonyms |
9130020O16Rik, Gpr128 |
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R6868 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Not validated
|
| Chromosome |
16 |
| Chromosomal Location |
56544972-56616218 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 56593839 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Phenylalanine to Leucine
at position 126
(F126L)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000023437
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000023437]
|
| AlphaFold |
Q8BM96 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000023437
AA Change: F126L
PolyPhen 2
Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
|
| SMART Domains |
Protein: ENSMUSP00000023437
Gene: ENSMUSG00000022755
AA Change: F126L
| Domain | Start | End | E-Value | Type |
|---|
|
transmembrane domain
|
12 |
34 |
N/A |
INTRINSIC |
|
SCOP:d1edmb_
|
52 |
76 |
1e-3 |
SMART |
|
GPS
|
376 |
424 |
6.16e-8 |
SMART |
|
Pfam:7tm_2
|
428 |
712 |
4.5e-40 |
PFAM |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.4%
- 20x: 98.0%
|
| Validation Efficiency |
|
| MGI Phenotype |
PHENOTYPE: Mice homozygous for a knock-out allele exhibit reduced body weight gain and increased frequency of peristalsis and slow wave potential in the small intestine. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 60 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| A630010A05Rik |
A |
T |
16: 14,436,559 (GRCm39) |
N204I |
probably damaging |
Het |
| Aasdh |
C |
T |
5: 77,039,527 (GRCm39) |
V261M |
probably damaging |
Het |
| Agxt2 |
T |
C |
15: 10,373,855 (GRCm39) |
L87P |
probably damaging |
Het |
| Alcam |
G |
A |
16: 52,088,748 (GRCm39) |
S554F |
probably damaging |
Het |
| Ambra1 |
T |
C |
2: 91,747,878 (GRCm39) |
S1205P |
possibly damaging |
Het |
| Bst2 |
A |
C |
8: 71,987,404 (GRCm39) |
V150G |
unknown |
Het |
| C3 |
T |
C |
17: 57,511,029 (GRCm39) |
Y1659C |
possibly damaging |
Het |
| Cacna1s |
G |
A |
1: 136,020,432 (GRCm39) |
R823Q |
probably benign |
Het |
| Cdk4 |
T |
C |
10: 126,900,870 (GRCm39) |
V174A |
probably benign |
Het |
| Ces2h |
T |
A |
8: 105,745,055 (GRCm39) |
N396K |
probably benign |
Het |
| Cfap144 |
C |
T |
11: 58,683,732 (GRCm39) |
D113N |
probably damaging |
Het |
| Chd7 |
T |
C |
4: 8,811,501 (GRCm39) |
|
probably null |
Het |
| Cnih4 |
A |
G |
1: 180,993,762 (GRCm39) |
I76V |
probably null |
Het |
| Csmd2 |
G |
A |
4: 128,336,633 (GRCm39) |
V1404I |
probably benign |
Het |
| Ctrb1 |
T |
C |
8: 112,416,035 (GRCm39) |
D53G |
probably benign |
Het |
| Cul9 |
C |
A |
17: 46,833,109 (GRCm39) |
R1323L |
possibly damaging |
Het |
| Dchs1 |
A |
G |
7: 105,412,710 (GRCm39) |
V1230A |
possibly damaging |
Het |
| Dgat2 |
T |
C |
7: 98,807,513 (GRCm39) |
D219G |
probably benign |
Het |
| Dgkh |
T |
C |
14: 78,862,293 (GRCm39) |
T225A |
probably damaging |
Het |
| Dock9 |
G |
T |
14: 121,823,676 (GRCm39) |
A1412E |
probably benign |
Het |
| Dscam |
C |
T |
16: 96,631,140 (GRCm39) |
V292M |
probably damaging |
Het |
| Fras1 |
T |
A |
5: 96,830,237 (GRCm39) |
V1509E |
probably benign |
Het |
| Fryl |
T |
C |
5: 73,226,146 (GRCm39) |
Q1839R |
probably damaging |
Het |
| Gcat |
A |
G |
15: 78,919,566 (GRCm39) |
D177G |
probably damaging |
Het |
| Gss |
T |
C |
2: 155,409,732 (GRCm39) |
T235A |
possibly damaging |
Het |
| Ints10 |
T |
A |
8: 69,250,450 (GRCm39) |
M114K |
probably damaging |
Het |
| Ints5 |
T |
G |
19: 8,874,750 (GRCm39) |
L903R |
probably damaging |
Het |
| Lipo2 |
G |
T |
19: 33,725,862 (GRCm39) |
P130Q |
possibly damaging |
Het |
| Megf11 |
G |
A |
9: 64,587,591 (GRCm39) |
C494Y |
probably damaging |
Het |
| Milr1 |
T |
C |
11: 106,654,747 (GRCm39) |
Y162H |
probably damaging |
Het |
| Mrc2 |
T |
A |
11: 105,219,244 (GRCm39) |
I278N |
probably damaging |
Het |
| Mst1r |
T |
A |
9: 107,793,132 (GRCm39) |
|
probably null |
Het |
| Myh15 |
G |
A |
16: 48,889,766 (GRCm39) |
C119Y |
probably damaging |
Het |
| Nap1l1 |
G |
A |
10: 111,330,669 (GRCm39) |
G358D |
probably damaging |
Het |
| Nav3 |
T |
C |
10: 109,529,027 (GRCm39) |
I2178V |
possibly damaging |
Het |
| Nkx2-5 |
T |
C |
17: 27,060,268 (GRCm39) |
E21G |
probably damaging |
Het |
| Nos2 |
C |
T |
11: 78,848,332 (GRCm39) |
R967C |
probably benign |
Het |
| Or6c215 |
T |
C |
10: 129,638,037 (GRCm39) |
D119G |
probably damaging |
Het |
| Parp10 |
T |
C |
15: 76,127,306 (GRCm39) |
R44G |
probably damaging |
Het |
| Pced1b |
A |
G |
15: 97,282,222 (GRCm39) |
H87R |
probably damaging |
Het |
| Ppfia3 |
T |
A |
7: 45,003,036 (GRCm39) |
L524F |
probably damaging |
Het |
| Ppp1r12b |
T |
C |
1: 134,814,176 (GRCm39) |
T376A |
probably benign |
Het |
| Ppp4r4 |
T |
C |
12: 103,557,111 (GRCm39) |
L449P |
probably damaging |
Het |
| Prkd1 |
T |
C |
12: 50,472,320 (GRCm39) |
R198G |
probably damaging |
Het |
| Pth2r |
C |
A |
1: 65,427,638 (GRCm39) |
A437E |
probably benign |
Het |
| Ptprh |
A |
T |
7: 4,604,864 (GRCm39) |
I60N |
probably benign |
Het |
| Pxmp2 |
C |
T |
5: 110,433,846 (GRCm39) |
R9Q |
probably damaging |
Het |
| Scarb2 |
T |
C |
5: 92,633,168 (GRCm39) |
K55E |
probably benign |
Het |
| Slc18b1 |
T |
C |
10: 23,680,132 (GRCm39) |
V109A |
possibly damaging |
Het |
| Slx4ip |
T |
A |
2: 136,842,130 (GRCm39) |
D18E |
probably damaging |
Het |
| Stk40 |
A |
G |
4: 126,017,607 (GRCm39) |
R45G |
probably damaging |
Het |
| Tbxas1 |
A |
T |
6: 39,061,240 (GRCm39) |
Q513L |
probably damaging |
Het |
| Tcf4 |
A |
T |
18: 69,790,721 (GRCm39) |
|
probably null |
Het |
| Tmc6 |
T |
A |
11: 117,665,143 (GRCm39) |
I377F |
probably benign |
Het |
| Tmem131l |
T |
C |
3: 83,868,938 (GRCm39) |
I146V |
probably damaging |
Het |
| Trac |
T |
A |
14: 54,458,049 (GRCm39) |
|
probably benign |
Het |
| Trpm7 |
T |
C |
2: 126,679,334 (GRCm39) |
D409G |
probably damaging |
Het |
| Usp39 |
A |
T |
6: 72,314,734 (GRCm39) |
V224E |
possibly damaging |
Het |
| Vmn1r184 |
A |
C |
7: 25,966,727 (GRCm39) |
M158L |
probably benign |
Het |
| Vmn2r120 |
T |
A |
17: 57,852,218 (GRCm39) |
I33L |
probably benign |
Het |
|
| Other mutations in Adgrg7 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01783:Adgrg7
|
APN |
16 |
56,568,282 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL03122:Adgrg7
|
APN |
16 |
56,590,725 (GRCm39) |
splice site |
probably benign |
|
|
orchard
|
UTSW |
16 |
56,545,342 (GRCm39) |
missense |
probably damaging |
1.00 |
|
sevin
|
UTSW |
16 |
56,562,769 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0632:Adgrg7
|
UTSW |
16 |
56,562,952 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R0673:Adgrg7
|
UTSW |
16 |
56,593,849 (GRCm39) |
missense |
possibly damaging |
0.48 |
|
R1690:Adgrg7
|
UTSW |
16 |
56,615,993 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R2009:Adgrg7
|
UTSW |
16 |
56,582,236 (GRCm39) |
missense |
probably benign |
0.08 |
|
R2017:Adgrg7
|
UTSW |
16 |
56,553,169 (GRCm39) |
missense |
probably benign |
0.02 |
|
R2132:Adgrg7
|
UTSW |
16 |
56,588,281 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2153:Adgrg7
|
UTSW |
16 |
56,572,791 (GRCm39) |
missense |
possibly damaging |
0.75 |
|
R2229:Adgrg7
|
UTSW |
16 |
56,572,766 (GRCm39) |
missense |
probably benign |
|
|
R2436:Adgrg7
|
UTSW |
16 |
56,582,308 (GRCm39) |
missense |
possibly damaging |
0.78 |
|
R2878:Adgrg7
|
UTSW |
16 |
56,570,817 (GRCm39) |
missense |
probably benign |
0.14 |
|
R2981:Adgrg7
|
UTSW |
16 |
56,570,769 (GRCm39) |
critical splice donor site |
probably null |
|
|
R4014:Adgrg7
|
UTSW |
16 |
56,562,651 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4023:Adgrg7
|
UTSW |
16 |
56,550,661 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4024:Adgrg7
|
UTSW |
16 |
56,550,661 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4026:Adgrg7
|
UTSW |
16 |
56,550,661 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4551:Adgrg7
|
UTSW |
16 |
56,568,375 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4834:Adgrg7
|
UTSW |
16 |
56,553,232 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5041:Adgrg7
|
UTSW |
16 |
56,550,711 (GRCm39) |
missense |
probably benign |
0.21 |
|
R5145:Adgrg7
|
UTSW |
16 |
56,562,682 (GRCm39) |
missense |
probably benign |
0.04 |
|
R5377:Adgrg7
|
UTSW |
16 |
56,550,669 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
R5549:Adgrg7
|
UTSW |
16 |
56,570,790 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5915:Adgrg7
|
UTSW |
16 |
56,550,748 (GRCm39) |
splice site |
probably null |
|
|
R5957:Adgrg7
|
UTSW |
16 |
56,593,790 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R6146:Adgrg7
|
UTSW |
16 |
56,593,829 (GRCm39) |
missense |
probably benign |
0.21 |
|
R6198:Adgrg7
|
UTSW |
16 |
56,597,556 (GRCm39) |
missense |
possibly damaging |
0.64 |
|
R6233:Adgrg7
|
UTSW |
16 |
56,599,005 (GRCm39) |
missense |
possibly damaging |
0.52 |
|
R6337:Adgrg7
|
UTSW |
16 |
56,572,788 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R6633:Adgrg7
|
UTSW |
16 |
56,550,649 (GRCm39) |
missense |
probably benign |
0.05 |
|
R6693:Adgrg7
|
UTSW |
16 |
56,590,587 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R6812:Adgrg7
|
UTSW |
16 |
56,616,161 (GRCm39) |
start gained |
probably benign |
|
|
R6841:Adgrg7
|
UTSW |
16 |
56,570,787 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7076:Adgrg7
|
UTSW |
16 |
56,562,769 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7146:Adgrg7
|
UTSW |
16 |
56,550,605 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7232:Adgrg7
|
UTSW |
16 |
56,597,515 (GRCm39) |
splice site |
probably null |
|
|
R7266:Adgrg7
|
UTSW |
16 |
56,590,674 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7376:Adgrg7
|
UTSW |
16 |
56,545,342 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7390:Adgrg7
|
UTSW |
16 |
56,553,207 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R7401:Adgrg7
|
UTSW |
16 |
56,562,781 (GRCm39) |
missense |
probably benign |
0.43 |
|
R7496:Adgrg7
|
UTSW |
16 |
56,553,220 (GRCm39) |
missense |
probably benign |
|
|
R7540:Adgrg7
|
UTSW |
16 |
56,570,792 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8147:Adgrg7
|
UTSW |
16 |
56,562,876 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8354:Adgrg7
|
UTSW |
16 |
56,616,045 (GRCm39) |
start gained |
probably benign |
|
|
R8372:Adgrg7
|
UTSW |
16 |
56,616,114 (GRCm39) |
start gained |
probably benign |
|
|
R8393:Adgrg7
|
UTSW |
16 |
56,582,477 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8454:Adgrg7
|
UTSW |
16 |
56,616,045 (GRCm39) |
start gained |
probably benign |
|
|
R8723:Adgrg7
|
UTSW |
16 |
56,582,282 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8891:Adgrg7
|
UTSW |
16 |
56,572,762 (GRCm39) |
missense |
probably benign |
0.03 |
|
R9017:Adgrg7
|
UTSW |
16 |
56,553,211 (GRCm39) |
missense |
probably benign |
0.01 |
|
R9570:Adgrg7
|
UTSW |
16 |
56,570,813 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9604:Adgrg7
|
UTSW |
16 |
56,597,570 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9628:Adgrg7
|
UTSW |
16 |
56,553,193 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- TTTGCTAAGCTACCATTTGCTG -3'
(R):5'- TTGGCTACAGCACCTCAATCC -3'
Sequencing Primer
(F):5'- TGTCAACATTAAAGAGATGTCGAC -3'
(R):5'- AGCAGTACATTGTCTCCCAGTATCAG -3'
|
| Posted On |
2018-10-18 |
Incidental Mutation