Incidental Mutation 'R6872:Or5ac19'
ID 536233
Institutional Source Beutler Lab
Gene Symbol Or5ac19
Ensembl Gene ENSMUSG00000074995
Gene Name olfactory receptor family 5 subfamily AC member 19
Synonyms Olfr201, MOR182-2, GA_x54KRFPKG5P-55483936-55483010
MMRRC Submission 044969-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.166) question?
Stock # R6872 (G1)
Quality Score 225.009
Status Not validated
Chromosome 16
Chromosomal Location 59089102-59090028 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 59089961 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Leucine to Proline at position 23 (L23P)
Ref Sequence ENSEMBL: ENSMUSP00000150660 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000099656] [ENSMUST00000216834]
AlphaFold Q7TS38
Predicted Effect probably benign
Transcript: ENSMUST00000099656
AA Change: L23P

PolyPhen 2 Score 0.200 (Sensitivity: 0.92; Specificity: 0.88)
SMART Domains Protein: ENSMUSP00000097248
Gene: ENSMUSG00000074995
AA Change: L23P

DomainStartEndE-ValueType
Pfam:7tm_4 31 308 1.2e-46 PFAM
Pfam:7tm_1 41 290 8e-18 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000216834
AA Change: L23P

PolyPhen 2 Score 0.200 (Sensitivity: 0.92; Specificity: 0.88)
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.4%
  • 20x: 98.0%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 55 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aadacl4 G A 4: 144,349,750 (GRCm39) V336I probably benign Het
Aadacl4fm4 A T 4: 144,397,216 (GRCm39) L172* probably null Het
Abcg3 T C 5: 105,083,860 (GRCm39) T637A probably benign Het
Ap3d1 G A 10: 80,550,156 (GRCm39) R692* probably null Het
Aqp2 C T 15: 99,481,885 (GRCm39) H260Y probably benign Het
Btbd2 C A 10: 80,480,166 (GRCm39) R383L probably damaging Het
Ccdc196 T A 12: 78,244,141 (GRCm39) D31E probably damaging Het
Ccdc24 T C 4: 117,727,123 (GRCm39) T196A probably benign Het
Cdc20b G A 13: 113,220,509 (GRCm39) G463S probably damaging Het
Ceacam5 A T 7: 17,486,212 (GRCm39) R570* probably null Het
Col12a1 A T 9: 79,584,516 (GRCm39) N1357K probably damaging Het
Cpa5 A T 6: 30,614,053 (GRCm39) Q65L probably benign Het
Ddo A C 10: 40,513,414 (GRCm39) M119L possibly damaging Het
Dnah8 G T 17: 30,981,653 (GRCm39) L3058F probably damaging Het
Dnajb8 A G 6: 88,200,022 (GRCm39) N186S probably damaging Het
Dock4 T C 12: 40,862,325 (GRCm39) probably null Het
Ear6 A G 14: 52,091,885 (GRCm39) Y144C probably damaging Het
Eng T A 2: 32,563,287 (GRCm39) I281N probably damaging Het
Fgf2 A G 3: 37,458,860 (GRCm39) K85E probably damaging Het
Fubp1 A T 3: 151,931,783 (GRCm39) Q37L probably benign Het
Gabra2 G T 5: 71,251,882 (GRCm39) P22T probably damaging Het
Gm10401 T C 5: 115,236,245 (GRCm39) probably benign Het
Gsdmc T C 15: 63,650,556 (GRCm39) D275G possibly damaging Het
Iglv3 A G 16: 19,060,034 (GRCm39) I98T probably damaging Het
Lmod1 G T 1: 135,292,879 (GRCm39) R578L probably damaging Het
Mindy2 A G 9: 70,524,044 (GRCm39) probably null Het
Neb G T 2: 52,183,657 (GRCm39) Q1004K probably damaging Het
Nkx2-9 T G 12: 56,658,674 (GRCm39) N180T probably benign Het
Nlrp2 C T 7: 5,311,709 (GRCm39) R922H probably benign Het
Nol4l T C 2: 153,325,737 (GRCm39) E116G probably damaging Het
Or1af1 A T 2: 37,109,989 (GRCm39) M163L possibly damaging Het
Pcdhb20 A C 18: 37,639,218 (GRCm39) E581D probably benign Het
Pidd1 G T 7: 141,019,331 (GRCm39) T750K probably benign Het
Rab44 A G 17: 29,358,784 (GRCm39) E324G probably benign Het
Ramp3 T C 11: 6,624,768 (GRCm39) C21R possibly damaging Het
Rpap1 A C 2: 119,605,850 (GRCm39) M345R probably damaging Het
Serpina3k A C 12: 104,310,519 (GRCm39) K350Q probably benign Het
St13 C T 15: 81,250,547 (GRCm39) probably null Het
Stard9 A T 2: 120,544,549 (GRCm39) K4497* probably null Het
Tbx19 A T 1: 164,975,202 (GRCm39) probably null Het
Tgoln1 A G 6: 72,592,538 (GRCm39) V314A possibly damaging Het
Them4 A T 3: 94,231,678 (GRCm39) I172F probably damaging Het
Tmc7 T A 7: 118,146,846 (GRCm39) Y477F probably benign Het
Tmem132a A G 19: 10,840,669 (GRCm39) L421P probably damaging Het
Trim69 A G 2: 121,998,391 (GRCm39) E121G probably damaging Het
Vmn2r11 T G 5: 109,194,976 (GRCm39) R783S possibly damaging Het
Vmn2r62 T A 7: 42,438,412 (GRCm39) L141F probably benign Het
Zbtb7a A G 10: 80,983,905 (GRCm39) N449S possibly damaging Het
Zfhx3 C T 8: 109,527,273 (GRCm39) R1057W probably damaging Het
Zfp180 G T 7: 23,805,306 (GRCm39) C575F probably damaging Het
Zfp462 G A 4: 55,012,326 (GRCm39) A1431T probably benign Het
Zfp592 T C 7: 80,673,576 (GRCm39) V180A probably benign Het
Zfp605 C T 5: 110,275,311 (GRCm39) P143L probably benign Het
Zfp646 T C 7: 127,482,505 (GRCm39) S1561P probably benign Het
Zfp706 T C 15: 37,002,190 (GRCm39) T46A possibly damaging Het
Other mutations in Or5ac19
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01734:Or5ac19 APN 16 59,089,213 (GRCm39) missense probably benign 0.07
IGL01985:Or5ac19 APN 16 59,089,442 (GRCm39) missense probably benign
IGL02618:Or5ac19 APN 16 59,089,290 (GRCm39) missense probably damaging 1.00
IGL02830:Or5ac19 APN 16 59,089,416 (GRCm39) missense possibly damaging 0.94
PIT4449001:Or5ac19 UTSW 16 59,089,493 (GRCm39) missense probably damaging 1.00
R0047:Or5ac19 UTSW 16 59,089,574 (GRCm39) missense probably damaging 1.00
R0047:Or5ac19 UTSW 16 59,089,574 (GRCm39) missense probably damaging 1.00
R1035:Or5ac19 UTSW 16 59,089,307 (GRCm39) missense probably damaging 1.00
R1037:Or5ac19 UTSW 16 59,089,307 (GRCm39) missense probably damaging 1.00
R1163:Or5ac19 UTSW 16 59,089,518 (GRCm39) missense probably benign 0.23
R1225:Or5ac19 UTSW 16 59,089,587 (GRCm39) missense probably benign
R1519:Or5ac19 UTSW 16 59,089,307 (GRCm39) missense probably damaging 1.00
R1583:Or5ac19 UTSW 16 59,089,394 (GRCm39) missense probably benign 0.00
R2075:Or5ac19 UTSW 16 59,089,274 (GRCm39) missense possibly damaging 0.60
R4591:Or5ac19 UTSW 16 59,089,776 (GRCm39) missense possibly damaging 0.94
R5547:Or5ac19 UTSW 16 59,089,479 (GRCm39) missense probably benign 0.35
R6132:Or5ac19 UTSW 16 59,089,367 (GRCm39) missense probably damaging 0.97
R6737:Or5ac19 UTSW 16 59,089,175 (GRCm39) missense possibly damaging 0.60
R8001:Or5ac19 UTSW 16 59,089,472 (GRCm39) missense probably benign 0.01
R8525:Or5ac19 UTSW 16 59,089,571 (GRCm39) missense probably benign 0.07
R9003:Or5ac19 UTSW 16 59,089,263 (GRCm39) missense probably benign 0.05
R9260:Or5ac19 UTSW 16 59,089,677 (GRCm39) missense probably damaging 0.98
R9584:Or5ac19 UTSW 16 59,089,580 (GRCm39) missense probably benign 0.05
Predicted Primers PCR Primer
(F):5'- ACTCAACCAGGGTTATCTCATG -3'
(R):5'- CTGGCATTAGAAATTTCCATTTGGG -3'

Sequencing Primer
(F):5'- TGAGAATCATTCTGGGAGTCAC -3'
(R):5'- CCATTTGGGATAGTGACAGTGATAAC -3'
Posted On 2018-10-18