Incidental Mutation 'R6874:Or8k24'
ID 536291
Institutional Source Beutler Lab
Gene Symbol Or8k24
Ensembl Gene ENSMUSG00000075186
Gene Name olfactory receptor family 8 subfamily K member 24
Synonyms MOR190-2, Olfr1058, GA_x6K02T2Q125-47855818-47854868
MMRRC Submission 045029-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.160) question?
Stock # R6874 (G1)
Quality Score 225.009
Status Not validated
Chromosome 2
Chromosomal Location 86215810-86216760 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to T at 86215872 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Isoleucine at position 297 (V297I)
Ref Sequence ENSEMBL: ENSMUSP00000151037 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000102631] [ENSMUST00000213998]
AlphaFold Q7TR74
Predicted Effect possibly damaging
Transcript: ENSMUST00000102631
AA Change: V297I

PolyPhen 2 Score 0.953 (Sensitivity: 0.79; Specificity: 0.95)
SMART Domains Protein: ENSMUSP00000099691
Gene: ENSMUSG00000075186
AA Change: V297I

DomainStartEndE-ValueType
Pfam:7tm_4 31 308 1e-49 PFAM
Pfam:7tm_1 41 290 1.1e-19 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000213998
AA Change: V297I

PolyPhen 2 Score 0.953 (Sensitivity: 0.79; Specificity: 0.95)
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.5%
  • 20x: 98.3%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 57 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca14 A G 7: 119,851,428 (GRCm39) D802G possibly damaging Het
Acsl5 A G 19: 55,280,295 (GRCm39) T523A probably damaging Het
Adamts7 A T 9: 90,070,784 (GRCm39) D635V probably damaging Het
Akr1c12 C A 13: 4,322,959 (GRCm39) G217C probably benign Het
Astn1 C A 1: 158,491,644 (GRCm39) S1007* probably null Het
Cntln T C 4: 84,985,996 (GRCm39) L988P probably damaging Het
Dcps A T 9: 35,087,263 (GRCm39) M1K probably null Het
Dnai1 T A 4: 41,632,412 (GRCm39) L582Q probably damaging Het
Dst A T 1: 34,328,732 (GRCm39) Q7118L probably benign Het
Ehd2 T A 7: 15,684,363 (GRCm39) T479S probably benign Het
Fbxl7 T C 15: 26,553,028 (GRCm39) I80V probably benign Het
Fry T C 5: 150,360,768 (GRCm39) V125A probably benign Het
Gm12695 A T 4: 96,673,306 (GRCm39) I31K probably benign Het
Gm5591 T C 7: 38,219,715 (GRCm39) E386G probably damaging Het
Helz G T 11: 107,554,460 (GRCm39) R1219S probably damaging Het
Hes3 G T 4: 152,371,695 (GRCm39) P85T possibly damaging Het
Igkv3-2 A T 6: 70,675,822 (GRCm39) R44* probably null Het
Igsf9 A G 1: 172,322,096 (GRCm39) T496A probably benign Het
Irf2bp1 G T 7: 18,739,142 (GRCm39) A261S possibly damaging Het
Jph2 G A 2: 163,181,407 (GRCm39) P586S probably benign Het
Klhl11 T C 11: 100,363,031 (GRCm39) H175R probably benign Het
Ksr2 G T 5: 117,894,401 (GRCm39) E847* probably null Het
Lats1 T A 10: 7,586,615 (GRCm39) Y926N probably damaging Het
Lmbr1 A T 5: 29,497,904 (GRCm39) L33H probably damaging Het
Lrp10 T C 14: 54,705,670 (GRCm39) S287P possibly damaging Het
Map3k6 G A 4: 132,977,967 (GRCm39) E976K probably benign Het
Mfsd6 T A 1: 52,699,868 (GRCm39) D760V probably benign Het
Muc16 G T 9: 18,570,065 (GRCm39) S818* probably null Het
Muc5ac C T 7: 141,363,481 (GRCm39) probably benign Het
Nagpa T C 16: 5,013,921 (GRCm39) T306A probably benign Het
Nisch G T 14: 30,898,641 (GRCm39) probably benign Het
Nrxn3 T C 12: 90,298,964 (GRCm39) V1028A probably damaging Het
Nucb1 T C 7: 45,152,618 (GRCm39) N75S probably benign Het
Or11a4 T C 17: 37,536,238 (GRCm39) V74A probably benign Het
Or1e1d-ps1 T G 11: 73,819,068 (GRCm39) M6R probably null Het
Or51a43 T A 7: 103,717,396 (GRCm39) I281F possibly damaging Het
Or5h23 T A 16: 58,906,312 (GRCm39) Y178F probably benign Het
Or7g19 T A 9: 18,856,777 (GRCm39) Y278N possibly damaging Het
Or8b57 A G 9: 40,004,022 (GRCm39) V80A probably benign Het
Pik3c2a A G 7: 115,993,540 (GRCm39) L409S probably damaging Het
Pkhd1l1 T A 15: 44,452,923 (GRCm39) D3949E probably benign Het
Prune2 C A 19: 17,100,592 (GRCm39) P2032Q probably damaging Het
Ptms T C 6: 124,891,194 (GRCm39) probably benign Het
Ptp4a3 A G 15: 73,595,259 (GRCm39) probably benign Het
Ptprq T C 10: 107,554,460 (GRCm39) I88M possibly damaging Het
Radil T A 5: 142,492,557 (GRCm39) D357V probably damaging Het
Runx2 G A 17: 45,125,079 (GRCm39) P80L probably damaging Het
Supt20 A G 3: 54,635,175 (GRCm39) probably null Het
Thoc5 T C 11: 4,851,261 (GRCm39) I69T probably damaging Het
Trib2 G C 12: 15,865,338 (GRCm39) S79W probably damaging Het
Trpc6 A G 9: 8,680,439 (GRCm39) D889G probably damaging Het
Usf3 T C 16: 44,040,103 (GRCm39) S1528P probably benign Het
Vax1 A T 19: 59,156,955 (GRCm39) V126E unknown Het
Vgf A G 5: 137,060,386 (GRCm39) probably benign Het
Vmn2r1 T A 3: 64,012,376 (GRCm39) C746S probably damaging Het
Vmn2r77 A G 7: 86,451,286 (GRCm39) T391A probably benign Het
Zfp738 C A 13: 67,818,382 (GRCm39) E536D possibly damaging Het
Other mutations in Or8k24
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01353:Or8k24 APN 2 86,216,365 (GRCm39) nonsense probably null
R0413:Or8k24 UTSW 2 86,216,058 (GRCm39) missense probably benign 0.02
R1315:Or8k24 UTSW 2 86,216,518 (GRCm39) missense possibly damaging 0.86
R1609:Or8k24 UTSW 2 86,215,838 (GRCm39) missense probably benign 0.07
R1951:Or8k24 UTSW 2 86,215,855 (GRCm39) missense probably benign 0.03
R2184:Or8k24 UTSW 2 86,216,489 (GRCm39) missense probably benign 0.05
R2351:Or8k24 UTSW 2 86,216,471 (GRCm39) missense probably damaging 0.99
R4067:Or8k24 UTSW 2 86,216,431 (GRCm39) nonsense probably null
R4706:Or8k24 UTSW 2 86,216,732 (GRCm39) missense probably benign 0.29
R5164:Or8k24 UTSW 2 86,215,815 (GRCm39) missense probably benign
R5224:Or8k24 UTSW 2 86,216,193 (GRCm39) missense possibly damaging 0.91
R5254:Or8k24 UTSW 2 86,216,484 (GRCm39) missense possibly damaging 0.65
R5424:Or8k24 UTSW 2 86,216,184 (GRCm39) nonsense probably null
R5907:Or8k24 UTSW 2 86,216,218 (GRCm39) missense probably damaging 0.97
R5980:Or8k24 UTSW 2 86,216,141 (GRCm39) nonsense probably null
R6348:Or8k24 UTSW 2 86,216,513 (GRCm39) missense probably benign
R6897:Or8k24 UTSW 2 86,216,024 (GRCm39) missense possibly damaging 0.91
R7060:Or8k24 UTSW 2 86,216,569 (GRCm39) missense possibly damaging 0.95
R7516:Or8k24 UTSW 2 86,216,328 (GRCm39) missense probably benign 0.35
R7530:Or8k24 UTSW 2 86,216,515 (GRCm39) missense probably damaging 1.00
R8130:Or8k24 UTSW 2 86,215,911 (GRCm39) missense probably benign 0.14
R9147:Or8k24 UTSW 2 86,216,324 (GRCm39) missense probably benign 0.00
R9148:Or8k24 UTSW 2 86,216,324 (GRCm39) missense probably benign 0.00
Z1088:Or8k24 UTSW 2 86,216,523 (GRCm39) missense probably damaging 1.00
Z1088:Or8k24 UTSW 2 86,216,100 (GRCm39) missense probably benign 0.43
Predicted Primers PCR Primer
(F):5'- TCTTCAGTAAAAGGGATTGAGTTCC -3'
(R):5'- AGGCTTTCTCTACCTGTGGG -3'

Sequencing Primer
(F):5'- AAGGGATTGAGTTCCATTGATTTC -3'
(R):5'- TGGGTCCCACCTGACAATG -3'
Posted On 2018-10-18