Incidental Mutation 'IGL01021:Tas2r123'
| ID |
53631 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Tas2r123
|
| Ensembl Gene |
ENSMUSG00000057381 |
| Gene Name |
taste receptor, type 2, member 123 |
| Synonyms |
mt2r55, mGR23, STC 9-2, T2R23, Tas2r23 |
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.055)
|
| Stock # |
IGL01021
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
6 |
| Chromosomal Location |
132824105-132825106 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
G to A
at 132824369 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Alanine to Threonine
at position 89
(A89T)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000071615
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000071696]
|
| AlphaFold |
P59528 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000071696
AA Change: A89T
PolyPhen 2
Score 0.006 (Sensitivity: 0.97; Specificity: 0.75)
|
| SMART Domains |
Protein: ENSMUSP00000071615
Gene: ENSMUSG00000057381
AA Change: A89T
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:TAS2R
|
7 |
322 |
4.6e-79 |
PFAM |
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 33 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 4930533L02Rik |
T |
C |
7: 124,917,848 (GRCm39) |
V80A |
unknown |
Het |
| Adam28 |
A |
G |
14: 68,879,563 (GRCm39) |
S162P |
probably benign |
Het |
| Adamts14 |
G |
T |
10: 61,061,152 (GRCm39) |
S426Y |
probably damaging |
Het |
| Ankrd24 |
A |
G |
10: 81,470,995 (GRCm39) |
|
probably null |
Het |
| B3galt5 |
C |
A |
16: 96,116,923 (GRCm39) |
H185Q |
probably benign |
Het |
| Bod1l |
A |
G |
5: 41,995,516 (GRCm39) |
|
probably benign |
Het |
| Ddx46 |
T |
A |
13: 55,814,145 (GRCm39) |
Y700* |
probably null |
Het |
| Dph7 |
T |
G |
2: 24,861,935 (GRCm39) |
|
probably null |
Het |
| Eif1ad9 |
G |
A |
12: 88,296,042 (GRCm39) |
G7R |
unknown |
Het |
| Fcho1 |
A |
T |
8: 72,166,167 (GRCm39) |
Y354* |
probably null |
Het |
| Fnbp4 |
A |
G |
2: 90,608,013 (GRCm39) |
M912V |
probably benign |
Het |
| Fpgt |
T |
A |
3: 154,797,129 (GRCm39) |
E42V |
possibly damaging |
Het |
| Frmd3 |
A |
G |
4: 73,992,357 (GRCm39) |
I75V |
possibly damaging |
Het |
| Gm3278 |
G |
T |
14: 16,082,261 (GRCm39) |
V159L |
possibly damaging |
Het |
| Gmds |
T |
C |
13: 32,311,013 (GRCm39) |
I205V |
possibly damaging |
Het |
| Gprin1 |
T |
A |
13: 54,888,182 (GRCm39) |
S31C |
probably damaging |
Het |
| Igkv4-68 |
T |
C |
6: 69,281,865 (GRCm39) |
E102G |
probably damaging |
Het |
| Itga1 |
T |
A |
13: 115,133,536 (GRCm39) |
Y458F |
probably benign |
Het |
| Kif20b |
T |
C |
19: 34,915,660 (GRCm39) |
V479A |
possibly damaging |
Het |
| Megf8 |
T |
A |
7: 25,037,799 (GRCm39) |
W772R |
probably benign |
Het |
| Muc6 |
T |
A |
7: 141,217,075 (GRCm39) |
I2533F |
possibly damaging |
Het |
| Npas3 |
T |
C |
12: 54,050,343 (GRCm39) |
S258P |
probably damaging |
Het |
| Padi3 |
T |
C |
4: 140,523,645 (GRCm39) |
|
probably benign |
Het |
| Pmfbp1 |
G |
T |
8: 110,264,625 (GRCm39) |
R897L |
possibly damaging |
Het |
| Rims1 |
A |
T |
1: 22,525,701 (GRCm39) |
W407R |
probably damaging |
Het |
| Scnn1b |
G |
T |
7: 121,517,259 (GRCm39) |
D632Y |
probably damaging |
Het |
| Tbk1 |
T |
C |
10: 121,387,177 (GRCm39) |
E706G |
probably benign |
Het |
| Thra |
A |
G |
11: 98,653,754 (GRCm39) |
D195G |
possibly damaging |
Het |
| Tpp2 |
T |
A |
1: 43,973,347 (GRCm39) |
Y33* |
probably null |
Het |
| Usp6nl |
T |
A |
2: 6,429,198 (GRCm39) |
M220K |
probably damaging |
Het |
| Vmn2r112 |
C |
T |
17: 22,837,885 (GRCm39) |
T782I |
probably damaging |
Het |
| Zbtb43 |
T |
C |
2: 33,343,771 (GRCm39) |
T485A |
probably benign |
Het |
| Zfat |
T |
C |
15: 68,042,015 (GRCm39) |
I840V |
possibly damaging |
Het |
|
| Other mutations in Tas2r123 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01547:Tas2r123
|
APN |
6 |
132,824,421 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02576:Tas2r123
|
APN |
6 |
132,824,703 (GRCm39) |
missense |
possibly damaging |
0.96 |
|
IGL03303:Tas2r123
|
APN |
6 |
132,824,401 (GRCm39) |
missense |
probably damaging |
1.00 |
|
G1patch:Tas2r123
|
UTSW |
6 |
132,824,801 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R0068:Tas2r123
|
UTSW |
6 |
132,824,955 (GRCm39) |
missense |
possibly damaging |
0.66 |
|
R0068:Tas2r123
|
UTSW |
6 |
132,824,955 (GRCm39) |
missense |
possibly damaging |
0.66 |
|
R0110:Tas2r123
|
UTSW |
6 |
132,824,295 (GRCm39) |
missense |
probably benign |
0.01 |
|
R0364:Tas2r123
|
UTSW |
6 |
132,824,644 (GRCm39) |
missense |
probably benign |
|
|
R0415:Tas2r123
|
UTSW |
6 |
132,824,801 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R0469:Tas2r123
|
UTSW |
6 |
132,824,295 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1791:Tas2r123
|
UTSW |
6 |
132,824,528 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1976:Tas2r123
|
UTSW |
6 |
132,824,295 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R2328:Tas2r123
|
UTSW |
6 |
132,824,279 (GRCm39) |
missense |
probably benign |
0.02 |
|
R4282:Tas2r123
|
UTSW |
6 |
132,825,008 (GRCm39) |
missense |
possibly damaging |
0.75 |
|
R4283:Tas2r123
|
UTSW |
6 |
132,825,008 (GRCm39) |
missense |
possibly damaging |
0.75 |
|
R4939:Tas2r123
|
UTSW |
6 |
132,824,808 (GRCm39) |
missense |
probably benign |
0.32 |
|
R5079:Tas2r123
|
UTSW |
6 |
132,824,681 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5241:Tas2r123
|
UTSW |
6 |
132,824,181 (GRCm39) |
missense |
probably benign |
0.06 |
|
R5288:Tas2r123
|
UTSW |
6 |
132,824,190 (GRCm39) |
missense |
probably benign |
0.17 |
|
R5851:Tas2r123
|
UTSW |
6 |
132,824,271 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6725:Tas2r123
|
UTSW |
6 |
132,824,801 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R6895:Tas2r123
|
UTSW |
6 |
132,824,133 (GRCm39) |
missense |
probably benign |
|
|
R7017:Tas2r123
|
UTSW |
6 |
132,824,513 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7183:Tas2r123
|
UTSW |
6 |
132,824,661 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R8972:Tas2r123
|
UTSW |
6 |
132,824,333 (GRCm39) |
missense |
probably benign |
0.30 |
|
R9321:Tas2r123
|
UTSW |
6 |
132,825,095 (GRCm39) |
missense |
probably benign |
|
|
| Posted On |
2013-06-28 |
Incidental Mutation