Mutagenetix > Incidental Mutation

Incidental Mutation 'R6876:Qng1'

536431

Institutional Source

Beutler Lab

Gene Symbol

Qng1

Ensembl Gene

ENSMUSG00000021550

Gene Name

Q-nucleotide N-glycosylase 1

Synonyms

2210016F16Rik

MMRRC Submission

044972-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.124) question?

Stock #

R6876 (G1)

Quality Score

152.008

Status

Not validated

Chromosome

Chromosomal Location

58527860-58533039 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 58532910 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Aspartic acid to Glycine at position 20 (D20G)

Ref Sequence

ENSEMBL: ENSMUSP00000022032 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000022032]

AlphaFold

G3X8U3

Predicted Effect

probably damaging
Transcript: ENSMUST00000022032
AA Change: D20G

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000022032
Gene: ENSMUSG00000021550
AA Change: D20G

Domain	Start	End	E-Value	Type
low complexity region	31	41	N/A	INTRINSIC
Pfam:Q_salvage	53	338	9.7e-122	PFAM

Coding Region Coverage

1x: 100.0%
3x: 99.9%
10x: 99.4%
20x: 98.0%

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 37 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Aasdh	T	C	5: 77,044,288 (GRCm39)	T201A	probably damaging	Het
Abca12	T	A	1: 71,302,667 (GRCm39)	D2184V	probably damaging	Het
Abcf1	C	T	17: 36,270,136 (GRCm39)	D641N	probably benign	Het
Adgrv1	C	A	13: 81,303,273 (GRCm39)		probably null	Het
Aftph	T	C	11: 20,659,744 (GRCm39)	E693G	probably damaging	Het
Ahnak	A	G	19: 8,991,484 (GRCm39)	D4256G	probably damaging	Het
Arv1	A	G	8: 125,457,651 (GRCm39)	K185R	probably damaging	Het
Ces4a	T	A	8: 105,871,624 (GRCm39)	V258D	possibly damaging	Het
Col6a5	T	C	9: 105,814,506 (GRCm39)	D502G	unknown	Het
Diaph1	A	T	18: 38,029,426 (GRCm39)	H335Q	unknown	Het
Dtna	G	A	18: 23,744,167 (GRCm39)	V404I	probably benign	Het
Ephb1	T	C	9: 101,861,319 (GRCm39)	D615G	probably damaging	Het
Gimap3	A	T	6: 48,742,855 (GRCm39)	I25N	probably damaging	Het
Hao1	A	G	2: 134,343,069 (GRCm39)	V274A	probably benign	Het
Hirip3	T	C	7: 126,463,321 (GRCm39)	S426P	probably damaging	Het
Igkv4-69	T	C	6: 69,260,818 (GRCm39)	D103G	probably damaging	Het
Kdm8	T	C	7: 125,051,830 (GRCm39)	V141A	probably benign	Het
Mink1	G	T	11: 70,498,261 (GRCm39)	A553S	probably benign	Het
Mpl	T	A	4: 118,314,317 (GRCm39)	Y60F	probably damaging	Het
Muc5ac	C	T	7: 141,363,481 (GRCm39)		probably benign	Het
Myo5a	C	A	9: 75,067,772 (GRCm39)	R609S	probably benign	Het
Myo5b	A	T	18: 74,841,026 (GRCm39)	H969L	probably benign	Het
Or1n2	T	A	2: 36,797,834 (GRCm39)	I292N	probably damaging	Het
Or2h2c	G	C	17: 37,422,098 (GRCm39)	Q259E	probably damaging	Het
Or2y16	T	C	11: 49,335,068 (GRCm39)	L130P	probably damaging	Het
Peg10	T	TCCA	6: 4,756,451 (GRCm39)		probably benign	Het
Prodh2	T	A	7: 30,205,925 (GRCm39)	W207R	probably damaging	Het
Rfx6	A	G	10: 51,596,087 (GRCm39)	K457E	probably damaging	Het
Sim1	A	G	10: 50,859,791 (GRCm39)	E551G	possibly damaging	Het
Soat2	T	C	15: 102,069,049 (GRCm39)	F358S	probably damaging	Het
Tes3-ps	A	G	13: 49,647,195 (GRCm39)	K24E	probably benign	Het
Txndc16	A	G	14: 45,400,497 (GRCm39)	F335L	possibly damaging	Het
Unc45b	T	C	11: 82,813,738 (GRCm39)	Y382H	probably benign	Het
Vmn2r60	A	G	7: 41,785,087 (GRCm39)	T100A	probably null	Het
Vmn2r93	T	A	17: 18,525,450 (GRCm39)	H369Q	probably benign	Het
Yy1	A	G	12: 108,772,518 (GRCm39)	I265V	probably benign	Het
Zfp54	A	T	17: 21,654,239 (GRCm39)	K244N	probably damaging	Het

Other mutations in Qng1

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01160:Qng1	APN	13	58,529,790 (GRCm39)	missense	probably damaging	1.00
IGL02302:Qng1	APN	13	58,529,749 (GRCm39)	missense	probably damaging	1.00
PIT1430001:Qng1	UTSW	13	58,532,827 (GRCm39)	nonsense	probably null
R0055:Qng1	UTSW	13	58,531,980 (GRCm39)	missense	probably damaging	1.00
R0055:Qng1	UTSW	13	58,531,980 (GRCm39)	missense	probably damaging	1.00
R2874:Qng1	UTSW	13	58,530,384 (GRCm39)	missense	probably damaging	1.00
R3954:Qng1	UTSW	13	58,532,203 (GRCm39)	missense	probably damaging	0.97
R3956:Qng1	UTSW	13	58,532,203 (GRCm39)	missense	probably damaging	0.97
R4012:Qng1	UTSW	13	58,529,800 (GRCm39)	nonsense	probably null
R4212:Qng1	UTSW	13	58,529,805 (GRCm39)	missense	probably damaging	1.00
R4469:Qng1	UTSW	13	58,530,239 (GRCm39)	missense	probably damaging	1.00
R4712:Qng1	UTSW	13	58,529,617 (GRCm39)	missense	probably benign	0.06
R5401:Qng1	UTSW	13	58,530,405 (GRCm39)	missense	probably benign
R6957:Qng1	UTSW	13	58,529,775 (GRCm39)	missense	probably damaging	1.00
R7285:Qng1	UTSW	13	58,532,199 (GRCm39)	missense	probably damaging	1.00
R7599:Qng1	UTSW	13	58,529,649 (GRCm39)	missense	probably damaging	0.99
R8553:Qng1	UTSW	13	58,532,694 (GRCm39)	missense	probably damaging	0.96
R8939:Qng1	UTSW	13	58,532,875 (GRCm39)	missense	probably damaging	1.00

Predicted Primers

PCR Primer
(F):5'- AGCACCCACCCAGGTTTAAG -3'
(R):5'- AAGCCTTCCTCAAAGACGG -3'

Sequencing Primer
(F):5'- TTTAAGGCTGGCACCCAC -3'
(R):5'- GGCCGAACACAAGGAGTCC -3'

Posted On

2018-10-18