Incidental Mutation 'R6877:Or10g3b'
ID 536479
Institutional Source Beutler Lab
Gene Symbol Or10g3b
Ensembl Gene ENSMUSG00000095030
Gene Name olfactory receptor family 10 subfamily G member 3B
Synonyms GA_x6K02T2RJGY-644134-645075, Olfr1513, MOR223-10, MOR223-7P
MMRRC Submission 044973-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.107) question?
Stock # R6877 (G1)
Quality Score 225.009
Status Validated
Chromosome 14
Chromosomal Location 52586560-52587501 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 52587270 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Phenylalanine at position 78 (I78F)
Ref Sequence ENSEMBL: ENSMUSP00000149216 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000089739] [ENSMUST00000215147]
AlphaFold L7N457
Predicted Effect possibly damaging
Transcript: ENSMUST00000089739
AA Change: I78F

PolyPhen 2 Score 0.951 (Sensitivity: 0.79; Specificity: 0.95)
SMART Domains Protein: ENSMUSP00000087171
Gene: ENSMUSG00000095030
AA Change: I78F

DomainStartEndE-ValueType
Pfam:7tm_4 31 307 5.2e-49 PFAM
Pfam:7tm_1 41 291 1.6e-20 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000215147
AA Change: I78F

PolyPhen 2 Score 0.951 (Sensitivity: 0.79; Specificity: 0.95)
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.5%
  • 20x: 98.2%
Validation Efficiency 94% (47/50)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 50 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adam34l T C 8: 44,078,274 (GRCm39) H650R probably benign Het
Adgrl2 T C 3: 148,522,922 (GRCm39) Y1367C probably damaging Het
Aqr A T 2: 113,947,052 (GRCm39) C1043* probably null Het
Arhgef17 A G 7: 100,530,548 (GRCm39) S1413P probably damaging Het
AU041133 A G 10: 81,987,405 (GRCm39) T352A probably benign Het
Bcl7a A G 5: 123,489,958 (GRCm39) T41A probably damaging Het
Btbd10 A T 7: 112,921,967 (GRCm39) F298Y probably damaging Het
Ccdc57 G A 11: 120,764,528 (GRCm39) T749I probably benign Het
Clcnkb T C 4: 141,132,143 (GRCm39) N646S probably benign Het
Dcst1 T C 3: 89,257,667 (GRCm39) D701G probably benign Het
Dnah14 C A 1: 181,455,997 (GRCm39) T1001K possibly damaging Het
Dnah8 G T 17: 30,965,933 (GRCm39) G2422W probably damaging Het
Dyrk2 A T 10: 118,696,328 (GRCm39) I310N probably damaging Het
Eif5b A T 1: 38,089,320 (GRCm39) N1099Y probably damaging Het
Elp2 T A 18: 24,768,033 (GRCm39) N762K probably benign Het
Esco2 A G 14: 66,068,494 (GRCm39) V272A probably benign Het
Fat3 A C 9: 15,910,564 (GRCm39) S1813A probably benign Het
Igf2r A G 17: 12,916,228 (GRCm39) V1710A probably damaging Het
Iqgap3 GGAGAG GGAG 3: 88,020,078 (GRCm39) probably null Het
Kcnk5 T C 14: 20,194,784 (GRCm39) T185A possibly damaging Het
Litafd G A 16: 8,501,173 (GRCm39) V10I unknown Het
Muc5ac C T 7: 141,363,481 (GRCm39) probably benign Het
Nol4 A T 18: 22,852,186 (GRCm39) C460S probably benign Het
Ntaq1 C A 15: 58,017,074 (GRCm39) P163Q probably damaging Het
Or4f14b T C 2: 111,775,184 (GRCm39) I206V probably benign Het
Ovch2 G A 7: 107,389,315 (GRCm39) A371V probably benign Het
Pcdhb4 A G 18: 37,442,625 (GRCm39) D645G probably damaging Het
Pcnt A C 10: 76,269,851 (GRCm39) S207A possibly damaging Het
Pex1 A T 5: 3,685,505 (GRCm39) Q1211L probably benign Het
Pnn A G 12: 59,115,553 (GRCm39) E99G probably damaging Het
Prkrip1 A T 5: 136,218,478 (GRCm39) probably null Het
Rnf133 A G 6: 23,649,486 (GRCm39) F191L probably benign Het
Scn10a T C 9: 119,438,848 (GRCm39) T1674A probably damaging Het
Sdccag8 G A 1: 176,839,501 (GRCm39) V682M probably damaging Het
Spi1 T C 2: 90,944,741 (GRCm39) L162P probably damaging Het
Sptan1 C G 2: 29,920,985 (GRCm39) N2432K probably damaging Het
Stx2 A G 5: 129,064,884 (GRCm39) V271A probably benign Het
Sumf2 G A 5: 129,878,867 (GRCm39) D68N probably damaging Het
Tsc22d4 A G 5: 137,760,855 (GRCm39) E92G possibly damaging Het
Ube3c G T 5: 29,792,316 (GRCm39) R37L probably benign Het
Ubr5 A G 15: 38,002,814 (GRCm39) S1446P probably damaging Het
Veph1 T C 3: 66,162,505 (GRCm39) N51S probably damaging Het
Vmn1r82 T C 7: 12,039,290 (GRCm39) F70L possibly damaging Het
Vmn2r92 A G 17: 18,389,084 (GRCm39) N466S probably damaging Het
Vwf T A 6: 125,634,164 (GRCm39) V2153D possibly damaging Het
Yeats2 A G 16: 19,998,344 (GRCm39) T300A probably benign Het
Zc3h12d G T 10: 7,715,735 (GRCm39) R46L probably damaging Het
Zfp516 T C 18: 82,973,916 (GRCm39) I38T probably damaging Het
Zic5 G A 14: 122,697,100 (GRCm39) T505I unknown Het
Zpld1 C T 16: 55,072,034 (GRCm39) G75E probably damaging Het
Other mutations in Or10g3b
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00309:Or10g3b APN 14 52,587,167 (GRCm39) missense probably benign 0.00
IGL02485:Or10g3b APN 14 52,587,501 (GRCm39) start codon destroyed possibly damaging 0.89
IGL02828:Or10g3b APN 14 52,586,799 (GRCm39) missense probably benign 0.02
R0744:Or10g3b UTSW 14 52,586,835 (GRCm39) missense probably benign 0.00
R0833:Or10g3b UTSW 14 52,586,835 (GRCm39) missense probably benign 0.00
R2316:Or10g3b UTSW 14 52,587,395 (GRCm39) missense probably benign 0.00
R4898:Or10g3b UTSW 14 52,586,999 (GRCm39) missense probably damaging 1.00
R5018:Or10g3b UTSW 14 52,586,736 (GRCm39) missense possibly damaging 0.81
R5134:Or10g3b UTSW 14 52,587,248 (GRCm39) missense probably benign 0.03
R5485:Or10g3b UTSW 14 52,586,776 (GRCm39) nonsense probably null
R6819:Or10g3b UTSW 14 52,587,156 (GRCm39) missense probably damaging 1.00
R7583:Or10g3b UTSW 14 52,587,360 (GRCm39) missense possibly damaging 0.93
R7606:Or10g3b UTSW 14 52,587,420 (GRCm39) missense probably benign 0.33
R7653:Or10g3b UTSW 14 52,586,889 (GRCm39) nonsense probably null
R8111:Or10g3b UTSW 14 52,587,344 (GRCm39) missense possibly damaging 0.70
R8262:Or10g3b UTSW 14 52,586,625 (GRCm39) missense probably damaging 1.00
R8487:Or10g3b UTSW 14 52,586,696 (GRCm39) missense probably damaging 1.00
R8786:Or10g3b UTSW 14 52,587,021 (GRCm39) missense possibly damaging 0.74
R9003:Or10g3b UTSW 14 52,586,768 (GRCm39) missense probably damaging 1.00
R9507:Or10g3b UTSW 14 52,586,678 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- TACTCAACTTAGCAGACATGAGGAC -3'
(R):5'- ACTGAGTTCATCCTCACAGGG -3'

Sequencing Primer
(F):5'- CTTAGCAGACATGAGGACTGGGTAAC -3'
(R):5'- GTTCATCCTCACAGGGGTCCC -3'
Posted On 2018-10-18