Incidental Mutation 'R6883:Or10ag58'
ID 536878
Institutional Source Beutler Lab
Gene Symbol Or10ag58
Ensembl Gene ENSMUSG00000050772
Gene Name olfactory receptor family 10 subfamily AG member 58
Synonyms GA_x6K02T2Q125-48936945-48937901, Olfr1124, GA_x6K02T2Q125-48935224-48935664, Olfr1125, MOR264-24, MOR264-3
MMRRC Submission 044978-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.085) question?
Stock # R6883 (G1)
Quality Score 225.009
Status Validated
Chromosome 2
Chromosomal Location 87264833-87265789 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to A at 87265623 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Lysine at position 264 (T264K)
Ref Sequence ENSEMBL: ENSMUSP00000150244 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000062494] [ENSMUST00000215909]
AlphaFold A2AT86
Predicted Effect probably damaging
Transcript: ENSMUST00000062494
AA Change: T264K

PolyPhen 2 Score 0.988 (Sensitivity: 0.73; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000062513
Gene: ENSMUSG00000050772
AA Change: T264K

DomainStartEndE-ValueType
Pfam:7tm_4 37 314 4.2e-52 PFAM
Pfam:7tm_1 47 296 2.4e-21 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000215909
AA Change: T264K

PolyPhen 2 Score 0.988 (Sensitivity: 0.73; Specificity: 0.96)
Meta Mutation Damage Score 0.6467 question?
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.4%
  • 20x: 98.2%
Validation Efficiency 92% (45/49)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 48 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acaa1b A G 9: 118,985,728 (GRCm39) S66P possibly damaging Het
Adh7 A T 3: 137,929,825 (GRCm39) E167V probably damaging Het
Ano6 T C 15: 95,859,992 (GRCm39) S705P probably damaging Het
Arpc1b T C 5: 145,063,739 (GRCm39) V329A probably benign Het
Btla C T 16: 45,063,092 (GRCm39) H152Y probably benign Het
Cadps T C 14: 12,465,883 (GRCm38) E1009G probably damaging Het
Cttnbp2nl A G 3: 104,918,507 (GRCm39) probably null Het
Cyp4a12a G T 4: 115,159,221 (GRCm39) V164F probably damaging Het
Duox1 G T 2: 122,155,065 (GRCm39) probably null Het
Fcgbpl1 A T 7: 27,852,260 (GRCm39) H1261L possibly damaging Het
Fmo6 A G 1: 162,757,461 (GRCm39) I104T probably damaging Het
Fnbp4 T C 2: 90,576,172 (GRCm39) probably null Het
Garem1 T C 18: 21,262,769 (GRCm39) T682A probably benign Het
Gm49358 A G 10: 86,651,762 (GRCm39) E188G probably benign Het
Gm5773 T C 3: 93,681,162 (GRCm39) I278T probably benign Het
Ifi27l2a A G 12: 103,409,756 (GRCm39) probably benign Het
Inpp5d A C 1: 87,627,412 (GRCm39) K308T probably damaging Het
Irf6 A T 1: 192,849,774 (GRCm39) Y232F probably damaging Het
Kcnmb4 T C 10: 116,309,248 (GRCm39) Q60R probably benign Het
Klri2 T C 6: 129,709,985 (GRCm39) D205G probably benign Het
Mcm9 A T 10: 53,492,110 (GRCm39) W352R probably damaging Het
Nat8 A G 6: 85,807,650 (GRCm39) V161A possibly damaging Het
Nlrp9c A T 7: 26,077,556 (GRCm39) M742K probably benign Het
Or13j1 T C 4: 43,705,723 (GRCm39) T282A possibly damaging Het
Or5an10 C A 19: 12,275,934 (GRCm39) Q187H probably damaging Het
Pcdha11 A T 18: 37,144,242 (GRCm39) D111V probably damaging Het
Pcdhb6 A T 18: 37,468,198 (GRCm39) D373V probably damaging Het
Pcolce2 A T 9: 95,560,396 (GRCm39) probably null Het
Pik3cb T C 9: 98,983,453 (GRCm39) M52V probably benign Het
Pipox T C 11: 77,774,729 (GRCm39) E118G probably benign Het
Pou4f2 T C 8: 79,162,307 (GRCm39) S99G probably benign Het
Ptpn12 T A 5: 21,260,711 (GRCm39) Q12L probably benign Het
Sim2 G T 16: 93,926,395 (GRCm39) A540S probably benign Het
Smg1 A T 7: 117,767,403 (GRCm39) probably benign Het
Sntb1 A G 15: 55,769,719 (GRCm39) V90A probably benign Het
Spns2 T C 11: 72,347,196 (GRCm39) probably null Het
Syne1 G T 10: 5,181,704 (GRCm39) C4210* probably null Het
Tek T C 4: 94,725,426 (GRCm39) I564T possibly damaging Het
Tmem94 T G 11: 115,687,287 (GRCm39) C1135W probably damaging Het
Tnxb T A 17: 34,937,493 (GRCm39) D3827E probably damaging Het
Ttl A G 2: 128,923,992 (GRCm39) D235G possibly damaging Het
Tuba4a A G 1: 75,194,066 (GRCm39) S5P probably damaging Het
Uaca T A 9: 60,777,173 (GRCm39) V518D probably damaging Het
Unc80 A T 1: 66,685,563 (GRCm39) Q2229L probably benign Het
Unkl C T 17: 25,449,307 (GRCm39) A78V probably damaging Het
Uroc1 C T 6: 90,315,574 (GRCm39) Q152* probably null Het
Vmn2r51 G T 7: 9,834,025 (GRCm39) Q338K possibly damaging Het
Vps50 C T 6: 3,498,513 (GRCm39) probably benign Het
Other mutations in Or10ag58
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00162:Or10ag58 APN 2 87,265,407 (GRCm39) missense probably benign 0.00
IGL01655:Or10ag58 APN 2 87,265,229 (GRCm39) missense probably damaging 1.00
IGL01878:Or10ag58 APN 2 87,265,314 (GRCm39) missense possibly damaging 0.55
IGL02265:Or10ag58 APN 2 87,265,688 (GRCm39) missense probably benign 0.00
IGL02379:Or10ag58 APN 2 87,265,668 (GRCm39) missense probably benign 0.07
IGL02512:Or10ag58 APN 2 87,265,402 (GRCm39) missense possibly damaging 0.59
IGL02578:Or10ag58 APN 2 87,265,401 (GRCm39) missense probably damaging 0.96
R0617:Or10ag58 UTSW 2 87,265,005 (GRCm39) missense probably damaging 1.00
R1376:Or10ag58 UTSW 2 87,264,903 (GRCm39) missense possibly damaging 0.62
R1376:Or10ag58 UTSW 2 87,264,903 (GRCm39) missense possibly damaging 0.62
R4993:Or10ag58 UTSW 2 87,265,496 (GRCm39) missense probably benign 0.00
R5045:Or10ag58 UTSW 2 87,265,490 (GRCm39) missense probably damaging 1.00
R6119:Or10ag58 UTSW 2 87,265,733 (GRCm39) nonsense probably null
R6146:Or10ag58 UTSW 2 87,265,662 (GRCm39) missense possibly damaging 0.78
R6699:Or10ag58 UTSW 2 87,265,160 (GRCm39) missense probably benign
R6966:Or10ag58 UTSW 2 87,265,623 (GRCm39) missense probably damaging 0.98
R7383:Or10ag58 UTSW 2 87,265,721 (GRCm39) missense possibly damaging 0.91
R8069:Or10ag58 UTSW 2 87,265,364 (GRCm39) missense possibly damaging 0.89
R9294:Or10ag58 UTSW 2 87,265,010 (GRCm39) missense probably benign 0.24
R9325:Or10ag58 UTSW 2 87,265,290 (GRCm39) missense possibly damaging 0.67
Z1088:Or10ag58 UTSW 2 87,265,503 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- CAATGAGATGATGGTTTTCCTAGG -3'
(R):5'- TTCTGCAAACTTAGACACATACAAAGG -3'

Sequencing Primer
(F):5'- AGATGATGGTTTTCCTAGGTGCTTTC -3'
(R):5'- TCACTCTGTAGACCAAGCTGG -3'
Posted On 2018-10-18