Incidental Mutation 'R6888:Or2y15'
ID 537063
Institutional Source Beutler Lab
Gene Symbol Or2y15
Ensembl Gene ENSMUSG00000063386
Gene Name olfactory receptor family 2 subfamily Y member 15
Synonyms MOR256-22, GA_x6K02T2QP88-5975166-5974231, Olfr1387
MMRRC Submission 044982-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.108) question?
Stock # R6888 (G1)
Quality Score 225.009
Status Not validated
Chromosome 11
Chromosomal Location 49350508-49351443 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 49351087 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Serine at position 194 (T194S)
Ref Sequence ENSEMBL: ENSMUSP00000151105 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000073824] [ENSMUST00000204518] [ENSMUST00000213674] [ENSMUST00000214541]
AlphaFold Q8VFA9
Predicted Effect probably damaging
Transcript: ENSMUST00000073824
AA Change: T194S

PolyPhen 2 Score 0.970 (Sensitivity: 0.77; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000073494
Gene: ENSMUSG00000063386
AA Change: T194S

DomainStartEndE-ValueType
Pfam:7tm_4 31 306 1e-49 PFAM
Pfam:7tm_1 41 289 5.8e-20 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000204518
SMART Domains Protein: ENSMUSP00000145320
Gene: ENSMUSG00000108167

DomainStartEndE-ValueType
Pfam:7tm_4 31 306 1.2e-49 PFAM
Pfam:7TM_GPCR_Srsx 35 227 1.2e-5 PFAM
Pfam:7tm_1 41 289 7.4e-24 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000213674
Predicted Effect probably damaging
Transcript: ENSMUST00000214541
AA Change: T194S

PolyPhen 2 Score 0.970 (Sensitivity: 0.77; Specificity: 0.96)
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.4%
  • 20x: 98.1%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 62 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Actg1 T C 11: 120,238,141 (GRCm39) Y190C probably damaging Het
Adgrv1 A G 13: 81,656,788 (GRCm39) I2902T probably damaging Het
AI429214 G A 8: 37,460,987 (GRCm39) G45D possibly damaging Het
Ambra1 A G 2: 91,599,372 (GRCm39) D164G probably damaging Het
Ap3b1 A T 13: 94,545,299 (GRCm39) Q184L probably benign Het
Arhgef17 T C 7: 100,580,027 (GRCm39) D307G possibly damaging Het
AY761185 A T 8: 21,434,571 (GRCm39) Y52* probably null Het
Bfsp1 A G 2: 143,668,639 (GRCm39) S647P probably benign Het
C130073F10Rik A G 4: 101,747,453 (GRCm39) V192A probably benign Het
Cacna1g T A 11: 94,350,033 (GRCm39) D604V probably benign Het
Ccdc170 T C 10: 4,496,854 (GRCm39) V458A possibly damaging Het
Ccdc187 G A 2: 26,179,746 (GRCm39) R238W probably damaging Het
Cdh1 A G 8: 107,384,946 (GRCm39) S380G probably benign Het
Cdk5rap3 T C 11: 96,807,018 (GRCm39) H4R probably benign Het
Cftr G A 6: 18,313,729 (GRCm39) probably null Het
Cstpp1 A G 2: 91,252,239 (GRCm39) Y41H probably damaging Het
Dnajc16 A G 4: 141,504,303 (GRCm39) V219A probably benign Het
Drd3 A T 16: 43,637,502 (GRCm39) I266F probably benign Het
Dut A G 2: 125,099,044 (GRCm39) D177G probably benign Het
Esr1 A G 10: 4,807,076 (GRCm39) I331V probably benign Het
Gm11110 A G 17: 57,409,143 (GRCm39) probably benign Het
Grm7 G T 6: 111,335,314 (GRCm39) G575V possibly damaging Het
Heatr3 A G 8: 88,897,512 (GRCm39) Y531C probably damaging Het
Igfn1 A G 1: 135,910,218 (GRCm39) V122A probably benign Het
Igsf21 T C 4: 139,762,054 (GRCm39) D208G probably benign Het
Kntc1 T C 5: 123,949,373 (GRCm39) Y1915H probably damaging Het
Lamc1 A T 1: 153,138,238 (GRCm39) D205E probably damaging Het
Limch1 C T 5: 67,179,269 (GRCm39) T713I probably benign Het
Lrp1b A G 2: 41,361,138 (GRCm39) I555T probably benign Het
Lrp2 A T 2: 69,354,485 (GRCm39) F448I probably damaging Het
Marchf6 T C 15: 31,459,379 (GRCm39) K896E probably benign Het
Mroh4 T C 15: 74,485,098 (GRCm39) Y469C possibly damaging Het
Niban3 G T 8: 72,056,383 (GRCm39) R361L probably benign Het
Nos3 T C 5: 24,588,333 (GRCm39) V1060A possibly damaging Het
Nr1h4 A G 10: 89,292,404 (GRCm39) I406T probably damaging Het
Odf2l T C 3: 144,854,379 (GRCm39) probably null Het
Or5d14 A G 2: 87,880,608 (GRCm39) M120T probably damaging Het
Pals2 T G 6: 50,157,257 (GRCm39) probably null Het
Pbx2 A G 17: 34,813,081 (GRCm39) Y119C possibly damaging Het
Pdcd6ip C A 9: 113,500,905 (GRCm39) A526S probably benign Het
Prx G A 7: 27,219,059 (GRCm39) D1187N possibly damaging Het
Ptpro G A 6: 137,357,198 (GRCm39) V230I probably benign Het
Rtn3 C T 19: 7,434,614 (GRCm39) M440I probably benign Het
Sar1b T C 11: 51,679,019 (GRCm39) I96T probably damaging Het
Sds T C 5: 120,618,965 (GRCm39) probably null Het
Secisbp2 A G 13: 51,833,977 (GRCm39) T706A probably benign Het
Sorcs3 A T 19: 48,682,263 (GRCm39) M433L possibly damaging Het
Sppl2a A G 2: 126,746,912 (GRCm39) V472A probably damaging Het
Tbc1d9 A G 8: 83,998,217 (GRCm39) E1258G possibly damaging Het
Tbxas1 C A 6: 38,929,008 (GRCm39) probably benign Het
Tg T C 15: 66,568,095 (GRCm39) I1333T probably damaging Het
Tmem108 C T 9: 103,376,915 (GRCm39) G178D probably damaging Het
Tmem174 A G 13: 98,773,569 (GRCm39) L87P probably damaging Het
Tmppe T A 9: 114,233,769 (GRCm39) S23T probably damaging Het
Ttn G A 2: 76,591,447 (GRCm39) T21074I probably benign Het
Tub A G 7: 108,628,505 (GRCm39) M338V probably null Het
Vmn1r160 A T 7: 22,571,531 (GRCm39) R295* probably null Het
Vps52 T C 17: 34,182,180 (GRCm39) V518A probably benign Het
Wdr59 A G 8: 112,177,675 (GRCm39) V909A probably benign Het
Wnk1 T C 6: 119,925,742 (GRCm39) T1241A probably benign Het
Zfp882 G A 8: 72,668,130 (GRCm39) C319Y probably benign Het
Znfx1 A T 2: 166,880,860 (GRCm39) I308N possibly damaging Het
Other mutations in Or2y15
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01362:Or2y15 APN 11 49,351,270 (GRCm39) missense probably benign 0.05
IGL01511:Or2y15 APN 11 49,351,043 (GRCm39) missense probably damaging 1.00
IGL02322:Or2y15 APN 11 49,350,784 (GRCm39) missense probably benign 0.12
R1028:Or2y15 UTSW 11 49,351,047 (GRCm39) missense probably benign 0.03
R2173:Or2y15 UTSW 11 49,350,967 (GRCm39) missense probably benign 0.00
R3894:Or2y15 UTSW 11 49,350,766 (GRCm39) missense possibly damaging 0.60
R5860:Or2y15 UTSW 11 49,350,563 (GRCm39) missense probably damaging 1.00
R6279:Or2y15 UTSW 11 49,351,039 (GRCm39) missense probably damaging 1.00
R6300:Or2y15 UTSW 11 49,351,039 (GRCm39) missense probably damaging 1.00
R6621:Or2y15 UTSW 11 49,350,598 (GRCm39) missense probably benign 0.09
R6836:Or2y15 UTSW 11 49,350,904 (GRCm39) missense possibly damaging 0.90
R9238:Or2y15 UTSW 11 49,350,529 (GRCm39) missense probably benign
R9687:Or2y15 UTSW 11 49,350,518 (GRCm39) missense probably benign 0.03
Z1088:Or2y15 UTSW 11 49,351,283 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- ATGAACCCCATCCTCTGCAG -3'
(R):5'- CTTGCTTTCAGAATATCTATGGACTGG -3'

Sequencing Primer
(F):5'- ATCCTCTGCAGGGCACTGG -3'
(R):5'- CAGAATATCTATGGACTGGTTGAAG -3'
Posted On 2018-10-18