Incidental Mutation 'R6889:Or6c74'
ID 537121
Institutional Source Beutler Lab
Gene Symbol Or6c74
Ensembl Gene ENSMUSG00000044897
Gene Name olfactory receptor family 6 subfamily C member 74
Synonyms GA_x6K02T2PULF-11704843-11705775, Olfr821, MOR109-1
MMRRC Submission 044983-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.244) question?
Stock # R6889 (G1)
Quality Score 225.009
Status Not validated
Chromosome 10
Chromosomal Location 129869497-129870429 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 129870401 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Methionine to Threonine at position 302 (M302T)
Ref Sequence ENSEMBL: ENSMUSP00000149027 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000054364] [ENSMUST00000205181] [ENSMUST00000214177]
AlphaFold Q8VG45
Predicted Effect probably benign
Transcript: ENSMUST00000054364
AA Change: M302T

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000056626
Gene: ENSMUSG00000044897
AA Change: M302T

DomainStartEndE-ValueType
Pfam:7tm_4 29 305 5.2e-50 PFAM
Pfam:7tm_1 39 288 3.4e-24 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000205181
AA Change: M302T

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000144938
Gene: ENSMUSG00000044897
AA Change: M302T

DomainStartEndE-ValueType
Pfam:7tm_4 29 305 5.2e-50 PFAM
Pfam:7tm_1 39 288 3.4e-24 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000214177
AA Change: M302T

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.4%
  • 20x: 98.1%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 60 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2310002L09Rik A T 4: 73,861,290 (GRCm39) D103E probably benign Het
Abcc3 A T 11: 94,266,381 (GRCm39) S70T possibly damaging Het
Atp6v0a1 A G 11: 100,920,009 (GRCm39) Y214C possibly damaging Het
Azi2 A G 9: 117,878,963 (GRCm39) probably null Het
Cacnb2 T A 2: 14,990,826 (GRCm39) V636E possibly damaging Het
Cd8a A C 6: 71,351,546 (GRCm39) T169P probably damaging Het
Cfap44 G A 16: 44,224,495 (GRCm39) V68I probably benign Het
Cspg4b C A 13: 113,454,912 (GRCm39) S319R probably damaging Het
Dnaaf10 G A 11: 17,172,309 (GRCm39) V133M probably damaging Het
Eea1 G T 10: 95,873,340 (GRCm39) C1134F probably benign Het
Ehmt2 T G 17: 35,131,748 (GRCm39) F1192V probably damaging Het
Emc1 T C 4: 139,092,661 (GRCm39) F531L probably damaging Het
Eme1 G A 11: 94,541,303 (GRCm39) T173I probably benign Het
Gli2 A T 1: 118,772,146 (GRCm39) C520S probably damaging Het
Gm43302 T C 5: 105,428,004 (GRCm39) K186E probably benign Het
Gpr108 A T 17: 57,543,990 (GRCm39) N405K probably damaging Het
Hmgcl C A 4: 135,682,953 (GRCm39) T135N probably benign Het
Hydin G A 8: 111,259,488 (GRCm39) D2487N possibly damaging Het
Igfl3 G T 7: 17,913,725 (GRCm39) R25L probably benign Het
Igsf10 A C 3: 59,239,354 (GRCm39) S276A probably benign Het
Kctd1 A G 18: 15,107,045 (GRCm39) S211P probably damaging Het
Kctd7 A T 5: 130,181,342 (GRCm39) Q255L probably benign Het
Lrig1 A G 6: 94,602,044 (GRCm39) Y270H probably benign Het
Muc5ac C T 7: 141,363,481 (GRCm39) probably benign Het
Myh15 A G 16: 48,973,474 (GRCm39) N1248S possibly damaging Het
Nod1 A G 6: 54,921,094 (GRCm39) F408S probably benign Het
Nrp1 T C 8: 129,219,538 (GRCm39) F652S probably damaging Het
Opa1 G T 16: 29,439,686 (GRCm39) R792L probably benign Het
Or10ak14 G A 4: 118,611,504 (GRCm39) T79I probably damaging Het
Or51t4 A T 7: 102,597,975 (GRCm39) H91L possibly damaging Het
Or5p63 A T 7: 107,811,125 (GRCm39) F204I probably benign Het
Pcdha6 G T 18: 37,101,396 (GRCm39) L196F probably damaging Het
Pdia2 A T 17: 26,415,944 (GRCm39) Y347* probably null Het
Pdpr G T 8: 111,851,245 (GRCm39) probably null Het
Pigt T A 2: 164,349,251 (GRCm39) L518Q probably damaging Het
Ppfibp2 A C 7: 107,337,188 (GRCm39) D591A possibly damaging Het
Prrg2 G A 7: 44,709,413 (GRCm39) T97M possibly damaging Het
Qars1 A G 9: 108,390,382 (GRCm39) T428A probably damaging Het
Rai1 T C 11: 60,076,541 (GRCm39) F202L probably damaging Het
Rars1 A T 11: 35,699,313 (GRCm39) M660K probably damaging Het
Rsf1 GCGGCGGCG GCGGCGGCGTCGGCGGCG 7: 97,229,132 (GRCm39) probably benign Het
Slc16a6 A C 11: 109,345,866 (GRCm39) F382V probably damaging Het
Slc30a7 T C 3: 115,747,802 (GRCm39) T330A probably damaging Het
Smc1b A T 15: 84,951,960 (GRCm39) L1157Q probably damaging Het
Snx4 G T 16: 33,071,840 (GRCm39) A4S possibly damaging Het
Sv2b A C 7: 74,775,515 (GRCm39) probably null Het
Syt9 A T 7: 107,024,493 (GRCm39) I129L probably damaging Het
Ttbk2 T C 2: 120,603,834 (GRCm39) E198G probably damaging Het
Ubr3 A T 2: 69,774,644 (GRCm39) D488V possibly damaging Het
Ush2a T A 1: 188,530,068 (GRCm39) C3286S probably damaging Het
Vill A G 9: 118,894,950 (GRCm39) D56G possibly damaging Het
Vmn1r41 A T 6: 89,724,352 (GRCm39) I298F probably damaging Het
Vmn2r2 A T 3: 64,024,688 (GRCm39) V631D probably damaging Het
Vmn2r32 A G 7: 7,475,573 (GRCm39) S437P possibly damaging Het
Vmn2r53 A G 7: 12,335,069 (GRCm39) V197A probably benign Het
Wasf1 A T 10: 40,796,365 (GRCm39) I32F probably damaging Het
Wasf2 G T 4: 132,922,041 (GRCm39) A387S unknown Het
Zbtb14 G A 17: 69,694,674 (GRCm39) C124Y probably damaging Het
Zfp462 G T 4: 55,007,671 (GRCm39) A37S probably damaging Het
Zfp532 A G 18: 65,820,061 (GRCm39) E882G possibly damaging Het
Other mutations in Or6c74
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01093:Or6c74 APN 10 129,869,761 (GRCm39) missense probably benign 0.01
IGL01554:Or6c74 APN 10 129,870,052 (GRCm39) missense probably damaging 1.00
R1960:Or6c74 UTSW 10 129,870,187 (GRCm39) nonsense probably null
R1968:Or6c74 UTSW 10 129,869,602 (GRCm39) missense probably damaging 1.00
R6894:Or6c74 UTSW 10 129,870,178 (GRCm39) missense probably damaging 1.00
R6960:Or6c74 UTSW 10 129,869,972 (GRCm39) missense probably benign 0.34
R7140:Or6c74 UTSW 10 129,870,083 (GRCm39) missense possibly damaging 0.89
R7828:Or6c74 UTSW 10 129,869,756 (GRCm39) missense probably damaging 0.99
R9722:Or6c74 UTSW 10 129,869,500 (GRCm39) missense probably benign 0.01
Z1088:Or6c74 UTSW 10 129,869,657 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- ATCAGGACTATTCTGAGAATCCCATC -3'
(R):5'- TGGATATTACTACAGACTCAGAAGC -3'

Sequencing Primer
(F):5'- GACTATTCTGAGAATCCCATCTTCTC -3'
(R):5'- CAGACTCAGAAGCTTTTCAGTC -3'
Posted On 2018-10-18