Incidental Mutation 'R6890:Tex21'
ID 537165
Institutional Source Beutler Lab
Gene Symbol Tex21
Ensembl Gene ENSMUSG00000021056
Gene Name testis expressed gene 21
Synonyms 4931406F04Rik, tsec-2, 4931412D23Rik, 4931421K24Rik
MMRRC Submission 044984-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.107) question?
Stock # R6890 (G1)
Quality Score 225.009
Status Validated
Chromosome 12
Chromosomal Location 76245460-76293520 bp(-) (GRCm39)
Type of Mutation critical splice donor site (2 bp from exon)
DNA Base Change (assembly) A to G at 76286229 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000151892 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000021453] [ENSMUST00000021453] [ENSMUST00000218426] [ENSMUST00000218426] [ENSMUST00000219327] [ENSMUST00000219327]
AlphaFold Q9R0U9
Predicted Effect probably null
Transcript: ENSMUST00000021453
SMART Domains Protein: ENSMUSP00000021453
Gene: ENSMUSG00000021056

DomainStartEndE-ValueType
coiled coil region 83 190 N/A INTRINSIC
coiled coil region 308 356 N/A INTRINSIC
coiled coil region 409 447 N/A INTRINSIC
Predicted Effect probably null
Transcript: ENSMUST00000021453
SMART Domains Protein: ENSMUSP00000021453
Gene: ENSMUSG00000021056

DomainStartEndE-ValueType
coiled coil region 83 190 N/A INTRINSIC
coiled coil region 308 356 N/A INTRINSIC
coiled coil region 409 447 N/A INTRINSIC
Predicted Effect probably null
Transcript: ENSMUST00000218426
Predicted Effect probably null
Transcript: ENSMUST00000218426
Predicted Effect probably null
Transcript: ENSMUST00000219327
Predicted Effect probably null
Transcript: ENSMUST00000219327
Meta Mutation Damage Score 0.9755 question?
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.4%
  • 20x: 98.0%
Validation Efficiency 100% (39/39)
Allele List at MGI
Other mutations in this stock
Total: 38 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Alg3 T C 16: 20,424,736 (GRCm39) T270A possibly damaging Het
Ambp G C 4: 63,068,596 (GRCm39) H140Q probably benign Het
Arhgef10 T C 8: 14,978,786 (GRCm39) C18R probably benign Het
Arhgef10l A G 4: 140,271,730 (GRCm39) F548S probably damaging Het
Armh3 A G 19: 45,948,796 (GRCm39) Y228H probably damaging Het
Cdhr1 T C 14: 36,807,602 (GRCm39) D346G probably damaging Het
Col18a1 T A 10: 76,949,318 (GRCm39) probably benign Het
Col1a2 T A 6: 4,539,587 (GRCm39) L1285Q unknown Het
Cspg5 T C 9: 110,075,852 (GRCm39) L196P probably damaging Het
Dusp10 T G 1: 183,801,393 (GRCm39) Y387D probably damaging Het
Epb41 A T 4: 131,663,140 (GRCm39) D681E probably damaging Het
Eps8 A G 6: 137,489,255 (GRCm39) V381A probably damaging Het
Fbxw16 A T 9: 109,265,810 (GRCm39) S336R probably benign Het
Gm49368 A G 7: 127,680,901 (GRCm39) R277G probably benign Het
Gsg1 C T 6: 135,214,418 (GRCm39) V320I probably benign Het
Iglc3 T A 16: 18,884,258 (GRCm39) probably benign Het
Klc4 A T 17: 46,942,769 (GRCm39) N598K probably benign Het
Malsu1 A G 6: 49,052,185 (GRCm39) Y135C probably damaging Het
Mapkbp1 T C 2: 119,846,283 (GRCm39) I477T probably damaging Het
Mtss1 G T 15: 58,823,508 (GRCm39) S286R probably damaging Het
Naip2 A C 13: 100,298,549 (GRCm39) S496A probably benign Het
Niban3 T A 8: 72,058,315 (GRCm39) V540D probably damaging Het
Npepps A T 11: 97,158,470 (GRCm39) C98* probably null Het
Nphp3 A C 9: 103,919,153 (GRCm39) Y1267S probably damaging Het
Npr3 A G 15: 11,883,478 (GRCm39) V317A possibly damaging Het
Nsun6 A G 2: 15,053,788 (GRCm39) I7T probably damaging Het
Or13p4 A G 4: 118,546,728 (GRCm39) V307A possibly damaging Het
Or51ai2 A T 7: 103,587,066 (GRCm39) T160S possibly damaging Het
Or5b121 C T 19: 13,507,445 (GRCm39) T180I probably damaging Het
Pcnx1 A G 12: 82,018,150 (GRCm39) H1330R probably benign Het
Rad17 T C 13: 100,773,592 (GRCm39) I201V probably benign Het
Slc26a4 G A 12: 31,599,950 (GRCm39) T126M possibly damaging Het
Slitrk6 A T 14: 110,988,528 (GRCm39) L393* probably null Het
Snx2 A G 18: 53,345,951 (GRCm39) H378R probably damaging Het
Trio A T 15: 27,919,374 (GRCm39) probably benign Het
Vpreb1b T C 16: 17,798,820 (GRCm39) I102T probably damaging Het
Zfp617 T G 8: 72,686,010 (GRCm39) H113Q probably benign Het
Zgpat T A 2: 181,020,304 (GRCm39) I237N probably damaging Het
Other mutations in Tex21
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00472:Tex21 APN 12 76,253,571 (GRCm39) missense probably damaging 1.00
IGL00923:Tex21 APN 12 76,291,885 (GRCm39) missense probably damaging 1.00
IGL01062:Tex21 APN 12 76,245,718 (GRCm39) missense probably benign 0.03
IGL01063:Tex21 APN 12 76,245,592 (GRCm39) missense probably benign 0.34
IGL02624:Tex21 APN 12 76,261,398 (GRCm39) missense probably damaging 1.00
IGL03349:Tex21 APN 12 76,268,365 (GRCm39) missense probably benign 0.14
IGL03387:Tex21 APN 12 76,245,694 (GRCm39) missense probably damaging 1.00
IGL03412:Tex21 APN 12 76,291,780 (GRCm39) critical splice donor site probably null
ihop UTSW 12 76,286,229 (GRCm39) critical splice donor site probably null
R0189:Tex21 UTSW 12 76,286,307 (GRCm39) missense probably benign 0.13
R0730:Tex21 UTSW 12 76,250,940 (GRCm39) missense probably benign 0.25
R1521:Tex21 UTSW 12 76,251,044 (GRCm39) missense probably benign 0.38
R1572:Tex21 UTSW 12 76,253,665 (GRCm39) missense probably benign 0.03
R1700:Tex21 UTSW 12 76,268,446 (GRCm39) missense probably damaging 0.99
R1941:Tex21 UTSW 12 76,268,458 (GRCm39) missense possibly damaging 0.68
R4654:Tex21 UTSW 12 76,263,860 (GRCm39) missense probably benign 0.32
R4943:Tex21 UTSW 12 76,268,474 (GRCm39) missense probably damaging 1.00
R6175:Tex21 UTSW 12 76,245,707 (GRCm39) missense probably benign 0.00
R6262:Tex21 UTSW 12 76,259,306 (GRCm39) missense probably damaging 0.99
R6738:Tex21 UTSW 12 76,286,283 (GRCm39) missense probably benign 0.12
R6759:Tex21 UTSW 12 76,251,086 (GRCm39) critical splice acceptor site probably null
R8910:Tex21 UTSW 12 76,263,533 (GRCm39) unclassified probably benign
R9547:Tex21 UTSW 12 76,253,591 (GRCm39) missense probably damaging 0.99
Z1176:Tex21 UTSW 12 76,250,894 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- CTGACTTCTAAAAGCACTGAATGAGG -3'
(R):5'- GGTTTTGATCCACAGGGCAC -3'

Sequencing Primer
(F):5'- CTGAATGAGGCACCATCTTCAGTAG -3'
(R):5'- TGATCCACAGGGCACATATTTCG -3'
Posted On 2018-10-18