Incidental Mutation 'R6818:Vmn2r97'
| ID |
537455 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn2r97
|
| Ensembl Gene |
ENSMUSG00000091491 |
| Gene Name |
vomeronasal 2, receptor 97 |
| Synonyms |
EG627367 |
| MMRRC Submission |
044930-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.071)
|
| Stock # |
R6818 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Validated
|
| Chromosome |
17 |
| Chromosomal Location |
19134584-19168333 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to T
at 19168193 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Isoleucine to Phenylalanine
at position 816
(I816F)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000129313
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000168710]
[ENSMUST00000232219]
|
| AlphaFold |
K7N6Z2 |
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000168710
AA Change: I816F
PolyPhen 2
Score 0.955 (Sensitivity: 0.79; Specificity: 0.95)
|
| SMART Domains |
Protein: ENSMUSP00000129313
Gene: ENSMUSG00000091491
AA Change: I816F
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
21 |
N/A |
INTRINSIC |
|
Pfam:ANF_receptor
|
82 |
442 |
2.9e-36 |
PFAM |
|
Pfam:NCD3G
|
513 |
566 |
4.9e-21 |
PFAM |
|
Pfam:7tm_3
|
599 |
834 |
1.7e-52 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000232219
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.6%
- 20x: 98.6%
|
| Validation Efficiency |
97% (59/61) |
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 60 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Abcb5 |
T |
A |
12: 118,865,089 (GRCm39) |
|
probably null |
Het |
| Acot4 |
A |
C |
12: 84,088,783 (GRCm39) |
E210D |
probably damaging |
Het |
| Adamts9 |
A |
C |
6: 92,882,172 (GRCm39) |
S476A |
probably damaging |
Het |
| Ajm1 |
C |
CTCTA |
2: 25,469,733 (GRCm39) |
|
probably null |
Het |
| Ak1 |
T |
A |
2: 32,520,385 (GRCm39) |
M61K |
probably damaging |
Het |
| Ambp |
G |
T |
4: 63,072,243 (GRCm39) |
S17* |
probably null |
Het |
| Anxa6 |
T |
A |
11: 54,870,326 (GRCm39) |
M662L |
probably benign |
Het |
| Atp11b |
T |
C |
3: 35,868,329 (GRCm39) |
I467T |
possibly damaging |
Het |
| B3gat1 |
G |
T |
9: 26,662,998 (GRCm39) |
|
probably benign |
Het |
| Bccip |
T |
G |
7: 133,319,488 (GRCm39) |
I193S |
probably damaging |
Het |
| Ccdc170 |
A |
G |
10: 4,491,782 (GRCm39) |
E401G |
probably damaging |
Het |
| Cldn16 |
A |
G |
16: 26,296,257 (GRCm39) |
T78A |
probably damaging |
Het |
| Cldn24 |
G |
T |
8: 48,275,757 (GRCm39) |
A194S |
probably benign |
Het |
| Cltc |
A |
G |
11: 86,595,054 (GRCm39) |
V1348A |
possibly damaging |
Het |
| Clvs1 |
T |
C |
4: 9,282,014 (GRCm39) |
|
probably null |
Het |
| Csmd1 |
C |
T |
8: 16,235,341 (GRCm39) |
D1161N |
probably damaging |
Het |
| Cuzd1 |
A |
G |
7: 130,918,394 (GRCm39) |
V181A |
probably damaging |
Het |
| Dhx30 |
A |
G |
9: 109,917,099 (GRCm39) |
I435T |
probably damaging |
Het |
| Dip2b |
T |
C |
15: 100,091,835 (GRCm39) |
V858A |
probably benign |
Het |
| Dnmt3b |
C |
T |
2: 153,528,204 (GRCm39) |
T822M |
probably damaging |
Het |
| Dock10 |
A |
T |
1: 80,593,082 (GRCm39) |
F97I |
possibly damaging |
Het |
| Dock8 |
T |
C |
19: 25,146,865 (GRCm39) |
|
probably null |
Het |
| Dvl2 |
T |
C |
11: 69,900,099 (GRCm39) |
L631P |
probably damaging |
Het |
| Faf2 |
T |
A |
13: 54,789,419 (GRCm39) |
|
probably null |
Het |
| Fat2 |
T |
A |
11: 55,200,167 (GRCm39) |
H969L |
probably benign |
Het |
| Fsip2 |
T |
A |
2: 82,815,544 (GRCm39) |
V3759E |
probably benign |
Het |
| Gm10985 |
A |
C |
3: 53,752,674 (GRCm39) |
Y19S |
probably damaging |
Het |
| Gm973 |
T |
C |
1: 59,669,328 (GRCm39) |
L793P |
probably damaging |
Het |
| H2-M1 |
A |
G |
17: 36,981,327 (GRCm39) |
I236T |
probably damaging |
Het |
| Hif1a |
A |
T |
12: 73,992,337 (GRCm39) |
R765* |
probably null |
Het |
| Htt |
A |
G |
5: 34,940,111 (GRCm39) |
K77E |
probably damaging |
Het |
| Ift172 |
G |
T |
5: 31,423,304 (GRCm39) |
Q826K |
probably benign |
Het |
| Inafm1 |
C |
T |
7: 16,007,086 (GRCm39) |
A44T |
probably damaging |
Het |
| Kctd4 |
A |
G |
14: 76,200,748 (GRCm39) |
T240A |
probably damaging |
Het |
| Klk1 |
A |
T |
7: 43,878,883 (GRCm39) |
I124F |
probably damaging |
Het |
| Krbox5 |
A |
G |
13: 67,981,986 (GRCm39) |
Q66R |
possibly damaging |
Het |
| Kremen1 |
T |
C |
11: 5,145,051 (GRCm39) |
T442A |
probably benign |
Het |
| Mei4 |
T |
A |
9: 81,907,574 (GRCm39) |
D202E |
probably benign |
Het |
| Mest |
T |
A |
6: 30,746,286 (GRCm39) |
D284E |
probably damaging |
Het |
| Nsfl1c |
T |
A |
2: 151,344,940 (GRCm39) |
Y95* |
probably null |
Het |
| Or10al5 |
T |
A |
17: 38,063,315 (GRCm39) |
V190D |
possibly damaging |
Het |
| Or10am5 |
T |
C |
7: 6,517,550 (GRCm39) |
M293V |
probably damaging |
Het |
| Or2ak4 |
T |
A |
11: 58,648,783 (GRCm39) |
C97* |
probably null |
Het |
| Or4k38 |
T |
G |
2: 111,165,659 (GRCm39) |
I255L |
probably benign |
Het |
| Pgm1 |
T |
A |
4: 99,820,763 (GRCm39) |
I220N |
probably damaging |
Het |
| Pirt |
T |
A |
11: 66,816,719 (GRCm39) |
V10E |
possibly damaging |
Het |
| Prl7d1 |
C |
A |
13: 27,898,454 (GRCm39) |
M19I |
probably benign |
Het |
| Samhd1 |
T |
C |
2: 156,949,417 (GRCm39) |
N490D |
probably benign |
Het |
| Scn2a |
C |
A |
2: 65,519,013 (GRCm39) |
S413* |
probably null |
Het |
| Serpinb6e |
A |
T |
13: 34,016,337 (GRCm39) |
|
probably null |
Het |
| Slitrk5 |
A |
G |
14: 111,917,726 (GRCm39) |
D450G |
probably benign |
Het |
| Tchh |
A |
G |
3: 93,350,718 (GRCm39) |
T53A |
probably damaging |
Het |
| Tmem44 |
A |
T |
16: 30,362,039 (GRCm39) |
|
probably null |
Het |
| Tpm3-rs7 |
A |
G |
14: 113,552,448 (GRCm39) |
E114G |
possibly damaging |
Het |
| Treml2 |
A |
G |
17: 48,609,925 (GRCm39) |
Y119C |
probably damaging |
Het |
| Ubxn1 |
T |
A |
19: 8,851,245 (GRCm39) |
|
probably null |
Het |
| Vmn2r84 |
A |
T |
10: 130,222,147 (GRCm39) |
M691K |
probably benign |
Het |
| Was |
GCCTCCTCCTCCTCCTCCTCCTCCTCCTCCTCCTCCTCCTCCTCCTCCTCCTCCTC |
GCCTCCTCCTCCTCCTCCTCCTCCTCCTCCTCCTCCTCCTCCTCCTCCTCCTC |
X: 7,952,450 (GRCm39) |
|
probably benign |
Het |
| Wfdc2 |
T |
C |
2: 164,405,070 (GRCm39) |
|
probably null |
Het |
| Zscan4-ps3 |
T |
C |
7: 11,346,986 (GRCm39) |
S341P |
probably damaging |
Het |
|
| Other mutations in Vmn2r97 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00897:Vmn2r97
|
APN |
17 |
19,167,921 (GRCm39) |
missense |
probably benign |
0.37 |
|
IGL00962:Vmn2r97
|
APN |
17 |
19,149,490 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01704:Vmn2r97
|
APN |
17 |
19,168,073 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01888:Vmn2r97
|
APN |
17 |
19,149,286 (GRCm39) |
nonsense |
probably null |
|
|
IGL02429:Vmn2r97
|
APN |
17 |
19,150,596 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
IGL02742:Vmn2r97
|
APN |
17 |
19,149,432 (GRCm39) |
missense |
probably damaging |
0.97 |
|
IGL02934:Vmn2r97
|
APN |
17 |
19,149,947 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02978:Vmn2r97
|
APN |
17 |
19,168,298 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL03230:Vmn2r97
|
APN |
17 |
19,149,668 (GRCm39) |
missense |
probably benign |
0.10 |
|
IGL03241:Vmn2r97
|
APN |
17 |
19,148,438 (GRCm39) |
missense |
probably benign |
0.11 |
|
IGL03050:Vmn2r97
|
UTSW |
17 |
19,167,900 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
PIT4469001:Vmn2r97
|
UTSW |
17 |
19,149,878 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0482:Vmn2r97
|
UTSW |
17 |
19,167,930 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0514:Vmn2r97
|
UTSW |
17 |
19,134,734 (GRCm39) |
missense |
probably benign |
0.25 |
|
R0944:Vmn2r97
|
UTSW |
17 |
19,167,665 (GRCm39) |
missense |
probably benign |
0.13 |
|
R1061:Vmn2r97
|
UTSW |
17 |
19,148,440 (GRCm39) |
nonsense |
probably null |
|
|
R1546:Vmn2r97
|
UTSW |
17 |
19,168,110 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1725:Vmn2r97
|
UTSW |
17 |
19,149,397 (GRCm39) |
missense |
probably benign |
0.43 |
|
R1860:Vmn2r97
|
UTSW |
17 |
19,167,648 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1938:Vmn2r97
|
UTSW |
17 |
19,149,593 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1944:Vmn2r97
|
UTSW |
17 |
19,160,500 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2027:Vmn2r97
|
UTSW |
17 |
19,149,944 (GRCm39) |
missense |
unknown |
|
|
R2106:Vmn2r97
|
UTSW |
17 |
19,168,100 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2151:Vmn2r97
|
UTSW |
17 |
19,167,584 (GRCm39) |
nonsense |
probably null |
|
|
R2153:Vmn2r97
|
UTSW |
17 |
19,167,584 (GRCm39) |
nonsense |
probably null |
|
|
R2154:Vmn2r97
|
UTSW |
17 |
19,167,584 (GRCm39) |
nonsense |
probably null |
|
|
R2516:Vmn2r97
|
UTSW |
17 |
19,167,814 (GRCm39) |
missense |
probably benign |
|
|
R3739:Vmn2r97
|
UTSW |
17 |
19,148,413 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3744:Vmn2r97
|
UTSW |
17 |
19,149,890 (GRCm39) |
missense |
probably benign |
|
|
R3885:Vmn2r97
|
UTSW |
17 |
19,148,596 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R3899:Vmn2r97
|
UTSW |
17 |
19,167,873 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R4115:Vmn2r97
|
UTSW |
17 |
19,148,332 (GRCm39) |
missense |
probably benign |
0.01 |
|
R4247:Vmn2r97
|
UTSW |
17 |
19,167,542 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R4287:Vmn2r97
|
UTSW |
17 |
19,168,337 (GRCm39) |
intron |
probably benign |
|
|
R4439:Vmn2r97
|
UTSW |
17 |
19,150,616 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4523:Vmn2r97
|
UTSW |
17 |
19,149,333 (GRCm39) |
missense |
probably benign |
0.03 |
|
R4783:Vmn2r97
|
UTSW |
17 |
19,149,550 (GRCm39) |
missense |
probably benign |
|
|
R4948:Vmn2r97
|
UTSW |
17 |
19,167,561 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R4981:Vmn2r97
|
UTSW |
17 |
19,160,436 (GRCm39) |
nonsense |
probably null |
|
|
R5029:Vmn2r97
|
UTSW |
17 |
19,168,173 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5200:Vmn2r97
|
UTSW |
17 |
19,148,615 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5541:Vmn2r97
|
UTSW |
17 |
19,148,617 (GRCm39) |
nonsense |
probably null |
|
|
R5637:Vmn2r97
|
UTSW |
17 |
19,167,628 (GRCm39) |
nonsense |
probably null |
|
|
R5765:Vmn2r97
|
UTSW |
17 |
19,167,442 (GRCm39) |
nonsense |
probably null |
|
|
R5885:Vmn2r97
|
UTSW |
17 |
19,168,035 (GRCm39) |
missense |
possibly damaging |
0.50 |
|
R6272:Vmn2r97
|
UTSW |
17 |
19,167,861 (GRCm39) |
missense |
possibly damaging |
0.70 |
|
R6553:Vmn2r97
|
UTSW |
17 |
19,150,566 (GRCm39) |
nonsense |
probably null |
|
|
R6880:Vmn2r97
|
UTSW |
17 |
19,134,770 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7012:Vmn2r97
|
UTSW |
17 |
19,167,756 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7023:Vmn2r97
|
UTSW |
17 |
19,134,663 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7044:Vmn2r97
|
UTSW |
17 |
19,134,629 (GRCm39) |
missense |
probably benign |
0.05 |
|
R7191:Vmn2r97
|
UTSW |
17 |
19,150,548 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7503:Vmn2r97
|
UTSW |
17 |
19,148,470 (GRCm39) |
missense |
probably benign |
|
|
R7862:Vmn2r97
|
UTSW |
17 |
19,167,416 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7876:Vmn2r97
|
UTSW |
17 |
19,149,326 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R7890:Vmn2r97
|
UTSW |
17 |
19,149,802 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7936:Vmn2r97
|
UTSW |
17 |
19,150,662 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7978:Vmn2r97
|
UTSW |
17 |
19,167,854 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8405:Vmn2r97
|
UTSW |
17 |
19,134,802 (GRCm39) |
critical splice donor site |
probably null |
|
|
R8755:Vmn2r97
|
UTSW |
17 |
19,168,104 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8790:Vmn2r97
|
UTSW |
17 |
19,160,472 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8850:Vmn2r97
|
UTSW |
17 |
19,149,607 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9060:Vmn2r97
|
UTSW |
17 |
19,134,585 (GRCm39) |
start codon destroyed |
probably null |
0.94 |
|
R9079:Vmn2r97
|
UTSW |
17 |
19,149,640 (GRCm39) |
missense |
probably benign |
|
|
R9252:Vmn2r97
|
UTSW |
17 |
19,167,849 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9278:Vmn2r97
|
UTSW |
17 |
19,134,762 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9342:Vmn2r97
|
UTSW |
17 |
19,149,368 (GRCm39) |
missense |
probably benign |
|
|
R9422:Vmn2r97
|
UTSW |
17 |
19,149,333 (GRCm39) |
missense |
probably benign |
0.03 |
|
R9496:Vmn2r97
|
UTSW |
17 |
19,149,227 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9571:Vmn2r97
|
UTSW |
17 |
19,149,919 (GRCm39) |
missense |
probably benign |
|
|
R9601:Vmn2r97
|
UTSW |
17 |
19,134,770 (GRCm39) |
missense |
probably benign |
|
|
R9672:Vmn2r97
|
UTSW |
17 |
19,149,442 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9773:Vmn2r97
|
UTSW |
17 |
19,168,221 (GRCm39) |
missense |
probably benign |
0.01 |
|
R9795:Vmn2r97
|
UTSW |
17 |
19,167,561 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- CCTTGGGAGTTATGCTATGGCC -3'
(R):5'- GGAGCCATCAGGTCTTAGAC -3'
Sequencing Primer
(F):5'- GGCCTTCTTGTCTAGAAATTTGCCAG -3'
(R):5'- GCCATCAGGTCTTAGACTCAGAG -3'
|
| Posted On |
2018-10-18 |
Incidental Mutation