Incidental Mutation 'R6820:Or5p51'
ID 537567
Institutional Source Beutler Lab
Gene Symbol Or5p51
Ensembl Gene ENSMUSG00000109542
Gene Name olfactory receptor family 5 subfamily P member 51
Synonyms MOR204-22, Olfr470, GA_x6K02T2PBJ9-10175273-10174329
MMRRC Submission 044932-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.135) question?
Stock # R6820 (G1)
Quality Score 225.009
Status Validated
Chromosome 7
Chromosomal Location 107443994-107444938 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 107444298 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Alanine at position 214 (V214A)
Ref Sequence ENSEMBL: ENSMUSP00000151543 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000073059] [ENSMUST00000220193]
AlphaFold Q8VF65
Predicted Effect probably benign
Transcript: ENSMUST00000073059
AA Change: V214A

PolyPhen 2 Score 0.007 (Sensitivity: 0.96; Specificity: 0.75)
SMART Domains Protein: ENSMUSP00000072810
Gene: ENSMUSG00000109542
AA Change: V214A

DomainStartEndE-ValueType
Pfam:7tm_4 34 311 2e-56 PFAM
Pfam:7tm_1 44 293 2e-20 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000220193
AA Change: V214A

PolyPhen 2 Score 0.007 (Sensitivity: 0.96; Specificity: 0.75)
Meta Mutation Damage Score 0.2331 question?
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.6%
  • 20x: 98.7%
Validation Efficiency 98% (46/47)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 46 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Accs T A 2: 93,673,266 (GRCm39) N141Y probably null Het
Chkb A G 15: 89,312,379 (GRCm39) L46P probably damaging Het
Col9a3 G A 2: 180,248,927 (GRCm39) V260M probably damaging Het
Dna2 T C 10: 62,800,683 (GRCm39) I739T possibly damaging Het
Dnah17 T C 11: 117,959,826 (GRCm39) H2620R probably damaging Het
Dsel A G 1: 111,787,547 (GRCm39) V996A probably damaging Het
Dst T C 1: 34,250,337 (GRCm39) L1757S probably damaging Het
Exoc5 A T 14: 49,286,387 (GRCm39) probably null Het
Fam120a A T 13: 49,034,468 (GRCm39) V1048E possibly damaging Het
Fam50b G A 13: 34,931,084 (GRCm39) E187K possibly damaging Het
Fbxw19 T A 9: 109,311,079 (GRCm39) T377S probably benign Het
Fbxw28 A T 9: 109,167,493 (GRCm39) F88Y probably damaging Het
Grik5 C T 7: 24,745,780 (GRCm39) R431Q possibly damaging Het
Gtsf1 T C 15: 103,328,954 (GRCm39) T92A probably benign Het
Hoxc13 A G 15: 102,830,257 (GRCm39) Y212C probably damaging Het
Itih2 T C 2: 10,102,909 (GRCm39) I742V probably benign Het
Kat7 T C 11: 95,174,965 (GRCm39) T351A probably damaging Het
Mlh3 T C 12: 85,294,497 (GRCm39) D1233G probably damaging Het
Mroh2b A G 15: 4,982,756 (GRCm39) D1525G probably damaging Het
Nme5 T C 18: 34,704,626 (GRCm39) Y73C probably damaging Het
Nr3c2 T C 8: 77,969,086 (GRCm39) V957A probably damaging Het
Nup153 A G 13: 46,863,459 (GRCm39) S301P probably benign Het
Obscn T C 11: 58,942,019 (GRCm39) D5013G probably damaging Het
Or4f54 C T 2: 111,123,455 (GRCm39) P281S probably damaging Het
Or8g51 A G 9: 38,608,771 (GRCm39) V297A possibly damaging Het
Pak1 A G 7: 97,535,586 (GRCm39) N226D probably benign Het
Pak4 A G 7: 28,262,461 (GRCm39) Y384H probably benign Het
Pkp3 T C 7: 140,659,757 (GRCm39) probably null Het
Prxl2b A T 4: 154,982,623 (GRCm39) D50E probably damaging Het
Psd G T 19: 46,309,283 (GRCm39) A558E probably damaging Het
Psmd14 C A 2: 61,607,068 (GRCm39) H172N probably benign Het
Pygb G T 2: 150,658,674 (GRCm39) W366L possibly damaging Het
Rbm39 A T 2: 156,021,146 (GRCm39) M1K probably null Het
Rnf213 T C 11: 119,339,664 (GRCm39) I3421T probably damaging Het
Rsf1 ATGGCG ATGGCGACGGTGGCG 7: 97,229,111 (GRCm39) probably benign Het
Smg6 T C 11: 74,932,790 (GRCm39) V88A probably damaging Het
Tha1 T C 11: 117,762,504 (GRCm39) E80G probably benign Het
Tie1 A G 4: 118,341,583 (GRCm39) V243A probably damaging Het
Tmem215 T C 4: 40,473,926 (GRCm39) M1T probably null Het
Tpm2 A G 4: 43,518,443 (GRCm39) Y221H probably damaging Het
Ubap1 C T 4: 41,379,854 (GRCm39) P356L probably benign Het
Wbp2nl G T 15: 82,197,996 (GRCm39) A178S possibly damaging Het
Wdr54 A T 6: 83,131,601 (GRCm39) S139T probably benign Het
Wipi2 G C 5: 142,615,555 (GRCm39) Q14H probably benign Het
Zan T C 5: 137,406,106 (GRCm39) probably benign Het
Zfp735 A G 11: 73,579,783 (GRCm39) M1V probably null Het
Other mutations in Or5p51
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02034:Or5p51 APN 7 107,444,385 (GRCm39) missense probably benign 0.00
IGL02349:Or5p51 APN 7 107,444,812 (GRCm39) missense probably benign 0.03
IGL02365:Or5p51 APN 7 107,444,119 (GRCm39) missense probably damaging 1.00
R0070:Or5p51 UTSW 7 107,444,124 (GRCm39) missense probably damaging 0.99
R0540:Or5p51 UTSW 7 107,444,776 (GRCm39) missense probably damaging 0.98
R0607:Or5p51 UTSW 7 107,444,776 (GRCm39) missense probably damaging 0.98
R0624:Or5p51 UTSW 7 107,444,323 (GRCm39) missense possibly damaging 0.87
R1983:Or5p51 UTSW 7 107,444,619 (GRCm39) missense probably benign 0.36
R2420:Or5p51 UTSW 7 107,444,025 (GRCm39) missense probably benign 0.03
R2441:Or5p51 UTSW 7 107,444,185 (GRCm39) missense probably benign 0.10
R4395:Or5p51 UTSW 7 107,444,469 (GRCm39) missense probably damaging 1.00
R4734:Or5p51 UTSW 7 107,444,635 (GRCm39) missense probably benign 0.00
R4779:Or5p51 UTSW 7 107,444,755 (GRCm39) missense possibly damaging 0.96
R5874:Or5p51 UTSW 7 107,444,377 (GRCm39) missense probably benign
R6598:Or5p51 UTSW 7 107,444,470 (GRCm39) missense probably benign 0.06
R6807:Or5p51 UTSW 7 107,444,797 (GRCm39) missense possibly damaging 0.67
R7305:Or5p51 UTSW 7 107,444,572 (GRCm39) missense probably damaging 1.00
R7413:Or5p51 UTSW 7 107,444,721 (GRCm39) missense probably damaging 1.00
R7954:Or5p51 UTSW 7 107,444,119 (GRCm39) missense probably benign 0.01
R8215:Or5p51 UTSW 7 107,444,124 (GRCm39) missense probably damaging 0.99
R8255:Or5p51 UTSW 7 107,444,368 (GRCm39) missense probably damaging 1.00
R8384:Or5p51 UTSW 7 107,444,465 (GRCm39) missense possibly damaging 0.94
Predicted Primers PCR Primer
(F):5'- AGACACCACCTTGTTCTGGTC -3'
(R):5'- CTGTATCCAGTTGCTTGTAGGATC -3'

Sequencing Primer
(F):5'- CACCTTGTTCTGGTCCGTGG -3'
(R):5'- CCAGTTGCTTGTAGGATCTTATATTG -3'
Posted On 2018-10-18