Incidental Mutation 'R6821:Ccnt2'
ID 537597
Institutional Source Beutler Lab
Gene Symbol Ccnt2
Ensembl Gene ENSMUSG00000026349
Gene Name cyclin T2
Synonyms 2900041I18Rik, CycT2
MMRRC Submission 044933-MU
Accession Numbers
Essential gene? Essential (E-score: 1.000) question?
Stock # R6821 (G1)
Quality Score 225.009
Status Validated
Chromosome 1
Chromosomal Location 127701901-127732574 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 127731072 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Serine to Proline at position 650 (S650P)
Ref Sequence ENSEMBL: ENSMUSP00000027587 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000027587] [ENSMUST00000112570]
AlphaFold Q7TQK0
Predicted Effect probably damaging
Transcript: ENSMUST00000027587
AA Change: S650P

PolyPhen 2 Score 0.990 (Sensitivity: 0.72; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000027587
Gene: ENSMUSG00000026349
AA Change: S650P

DomainStartEndE-ValueType
CYCLIN 42 141 4.27e-14 SMART
CYCLIN 154 242 4.51e0 SMART
low complexity region 531 543 N/A INTRINSIC
low complexity region 621 653 N/A INTRINSIC
low complexity region 658 664 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000112570
SMART Domains Protein: ENSMUSP00000108189
Gene: ENSMUSG00000026349

DomainStartEndE-ValueType
CYCLIN 42 141 4.27e-14 SMART
CYCLIN 154 242 4.51e0 SMART
low complexity region 531 543 N/A INTRINSIC
low complexity region 621 634 N/A INTRINSIC
Meta Mutation Damage Score 0.1028 question?
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.6%
  • 20x: 98.7%
Validation Efficiency 97% (63/65)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin and its kinase partner CDK9 were found to be subunits of the transcription elongation factor p-TEFb. The p-TEFb complex containing this cyclin was reported to interact with, and act as a negative regulator of human immunodeficiency virus type 1 (HIV-1) Tat protein. A pseudogene of this gene is found on chromosome 1. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Dec 2010]
PHENOTYPE: Mice homozygous for a gene trap allele die prior to the 4-cell stage. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 64 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acsl5 T C 19: 55,277,268 (GRCm39) I417T probably benign Het
Adamts12 A C 15: 11,152,134 (GRCm39) K208T probably benign Het
Adamts8 T A 9: 30,867,922 (GRCm39) L582Q probably benign Het
Aim2 C G 1: 173,291,546 (GRCm39) T317R probably damaging Het
Ano9 A T 7: 140,687,169 (GRCm39) F357I possibly damaging Het
Aox3 T C 1: 58,189,547 (GRCm39) V416A probably benign Het
Arhgap21 A C 2: 20,853,659 (GRCm39) F1901C probably benign Het
Atp8b2 A T 3: 89,855,480 (GRCm39) F506I probably damaging Het
Atp9b A T 18: 80,890,463 (GRCm39) L292H probably damaging Het
C2cd5 A G 6: 142,963,712 (GRCm39) V891A probably damaging Het
Cdhr3 T A 12: 33,085,044 (GRCm39) N791Y probably damaging Het
Cmtm1 TCCGGGTACTGAAGGTCCCTGGCTGGCTGGTGTCCCGGGTACTGAAGGTCCCTGGCTGGCTGGTGTCCCGGGTACTGAAGGTCCCTGGCTGGCTGGTGTCCCGGGTACTGAAGGTCCCTGGCTGGCTGGTGTCCCGGGTACTGAAGGTCCCTGG TCCGGGTACTGAAGGTCCCTGGCTGGCTGGTGTCCCGGGTACTGAAGGTCCCTGGCTGGCTGGTGTCCCGGGTACTGAAGGTCCCTGGCTGGCTGGTGTCCCGGGTACTGAAGGTCCCTGG 8: 105,036,334 (GRCm39) probably null Het
D630003M21Rik A C 2: 158,046,694 (GRCm39) L761R probably damaging Het
Draxin G T 4: 148,200,148 (GRCm39) Q101K possibly damaging Het
Dtx3l A T 16: 35,753,430 (GRCm39) L392Q probably damaging Het
Eif3d A G 15: 77,845,855 (GRCm39) S389P possibly damaging Het
Enpp5 G A 17: 44,396,155 (GRCm39) G356S probably damaging Het
Epha4 T C 1: 77,359,582 (GRCm39) N757S possibly damaging Het
Fam228b T C 12: 4,813,083 (GRCm39) I96V probably benign Het
Gars1 A G 6: 55,056,323 (GRCm39) E728G probably benign Het
Gldn T C 9: 54,246,054 (GRCm39) M535T probably benign Het
Gm47985 A G 1: 151,058,787 (GRCm39) T143A possibly damaging Het
Gpr6 T C 10: 40,947,004 (GRCm39) T193A probably benign Het
Grik5 C T 7: 24,745,780 (GRCm39) R431Q possibly damaging Het
Hecw1 T A 13: 14,438,719 (GRCm39) Y1315F probably damaging Het
Hs3st2 A G 7: 121,099,745 (GRCm39) D197G possibly damaging Het
Igsf9 T C 1: 172,312,060 (GRCm39) I2T probably benign Het
Ints9 A G 14: 65,274,907 (GRCm39) E621G probably benign Het
Itm2b G A 14: 73,603,907 (GRCm39) P47S probably benign Het
Map10 A G 8: 126,397,138 (GRCm39) K177R probably benign Het
Mdh2 T C 5: 135,818,525 (GRCm39) F260S possibly damaging Het
Mtmr11 A G 3: 96,077,723 (GRCm39) T573A probably benign Het
Mycbp2 A T 14: 103,376,845 (GRCm39) I3812N probably damaging Het
Myo15a A G 11: 60,415,301 (GRCm39) N3403S probably damaging Het
Nvl G A 1: 180,954,535 (GRCm39) Q343* probably null Het
Ocstamp A T 2: 165,239,842 (GRCm39) S115T probably benign Het
Or51ai2 A T 7: 103,586,793 (GRCm39) I69F probably benign Het
Otoa G A 7: 120,692,070 (GRCm39) probably null Het
Pcdhb20 A T 18: 37,639,175 (GRCm39) N567I probably damaging Het
Pgm5 A T 19: 24,839,011 (GRCm39) V48E possibly damaging Het
Phlpp1 T A 1: 106,314,174 (GRCm39) S1182R probably damaging Het
Pik3r4 T A 9: 105,527,805 (GRCm39) L386Q probably damaging Het
Pop1 A G 15: 34,508,785 (GRCm39) K287E possibly damaging Het
Pramel23 A T 4: 143,425,874 (GRCm39) L23* probably null Het
Rad54b A G 4: 11,612,777 (GRCm39) D803G probably damaging Het
Rbm26 G A 14: 105,354,400 (GRCm39) probably benign Het
Rspry1 C T 8: 95,362,059 (GRCm39) Q113* probably null Het
Siah2 T A 3: 58,599,191 (GRCm39) S16C probably benign Het
Sirpa C A 2: 129,472,017 (GRCm39) D481E probably damaging Het
Slc38a7 A C 8: 96,571,548 (GRCm39) D227E probably benign Het
Smc5 A G 19: 23,220,151 (GRCm39) V438A probably benign Het
Spast A G 17: 74,658,957 (GRCm39) E108G probably benign Het
Speg A G 1: 75,394,547 (GRCm39) E1752G possibly damaging Het
Tanc2 T G 11: 105,777,316 (GRCm39) probably null Het
Tgfbi T C 13: 56,773,950 (GRCm39) I243T possibly damaging Het
Tlr12 T C 4: 128,510,685 (GRCm39) S522G possibly damaging Het
Trav14-3 A G 14: 54,000,929 (GRCm39) I47V probably benign Het
Tsc22d4 T C 5: 137,760,906 (GRCm39) V109A possibly damaging Het
Ttl G A 2: 128,910,835 (GRCm39) R73H probably damaging Het
Usp34 C T 11: 23,317,491 (GRCm39) T850I possibly damaging Het
Vdac3 T C 8: 23,070,491 (GRCm39) Y140C probably damaging Het
Vmn2r120 T C 17: 57,843,659 (GRCm39) R62G probably benign Het
Vmn2r17 T A 5: 109,577,331 (GRCm39) Y461N probably damaging Het
Wt1 T A 2: 105,002,612 (GRCm39) F493I probably damaging Het
Other mutations in Ccnt2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00807:Ccnt2 APN 1 127,725,628 (GRCm39) splice site probably benign
IGL01370:Ccnt2 APN 1 127,731,250 (GRCm39) missense possibly damaging 0.49
IGL02055:Ccnt2 APN 1 127,719,447 (GRCm39) missense possibly damaging 0.46
IGL02169:Ccnt2 APN 1 127,702,126 (GRCm39) splice site probably benign
R0526:Ccnt2 UTSW 1 127,727,182 (GRCm39) missense probably damaging 1.00
R0538:Ccnt2 UTSW 1 127,730,902 (GRCm39) missense probably damaging 0.98
R0744:Ccnt2 UTSW 1 127,730,131 (GRCm39) missense probably benign 0.42
R0833:Ccnt2 UTSW 1 127,730,131 (GRCm39) missense probably benign 0.42
R0836:Ccnt2 UTSW 1 127,730,131 (GRCm39) missense probably benign 0.42
R1763:Ccnt2 UTSW 1 127,727,143 (GRCm39) missense possibly damaging 0.94
R2037:Ccnt2 UTSW 1 127,731,136 (GRCm39) missense probably damaging 1.00
R2159:Ccnt2 UTSW 1 127,702,891 (GRCm39) missense probably benign 0.00
R4585:Ccnt2 UTSW 1 127,730,766 (GRCm39) missense probably damaging 0.99
R5342:Ccnt2 UTSW 1 127,719,470 (GRCm39) splice site silent
R5527:Ccnt2 UTSW 1 127,730,401 (GRCm39) missense probably benign 0.00
R5698:Ccnt2 UTSW 1 127,730,965 (GRCm39) missense probably benign 0.00
R6606:Ccnt2 UTSW 1 127,730,978 (GRCm39) missense probably benign 0.00
R6979:Ccnt2 UTSW 1 127,702,873 (GRCm39) missense probably damaging 0.97
R7512:Ccnt2 UTSW 1 127,730,031 (GRCm39) missense possibly damaging 0.85
R8743:Ccnt2 UTSW 1 127,702,020 (GRCm39) missense probably damaging 1.00
R9334:Ccnt2 UTSW 1 127,723,046 (GRCm39) missense probably damaging 0.99
R9722:Ccnt2 UTSW 1 127,729,925 (GRCm39) missense probably damaging 1.00
X0019:Ccnt2 UTSW 1 127,702,877 (GRCm39) missense probably damaging 1.00
X0027:Ccnt2 UTSW 1 127,702,025 (GRCm39) missense probably damaging 0.98
Z1177:Ccnt2 UTSW 1 127,730,795 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- GCCACAAGTATTTGCACATGC -3'
(R):5'- TGTAGTCCATATGCTGGCTG -3'

Sequencing Primer
(F):5'- ACAGCGGATGGAATGCCTC -3'
(R):5'- CATATGCTGGCTGCTTGTACTGTAC -3'
Posted On 2018-10-18