Incidental Mutation 'R6859:Mrgpra3'
ID 537806
Institutional Source Beutler Lab
Gene Symbol Mrgpra3
Ensembl Gene ENSMUSG00000078698
Gene Name MAS-related GPR, member A3
Synonyms G protein-coupled receptor, MrgA3
MMRRC Submission 044961-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.048) question?
Stock # R6859 (G1)
Quality Score 225.009
Status Validated
Chromosome 7
Chromosomal Location 47238698-47251120 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to C at 47239781 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Methionine at position 48 (I48M)
Ref Sequence ENSEMBL: ENSMUSP00000135437 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000176369]
AlphaFold no structure available at present
Predicted Effect probably benign
Transcript: ENSMUST00000176369
AA Change: I48M

PolyPhen 2 Score 0.043 (Sensitivity: 0.94; Specificity: 0.83)
SMART Domains Protein: ENSMUSP00000135437
Gene: ENSMUSG00000078698
AA Change: I48M

DomainStartEndE-ValueType
low complexity region 14 31 N/A INTRINSIC
Pfam:7TM_GPCR_Srx 48 234 6.3e-7 PFAM
Pfam:7tm_1 57 286 2.7e-9 PFAM
Meta Mutation Damage Score 0.1250 question?
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.5%
  • 20x: 98.5%
Validation Efficiency 100% (42/42)
Allele List at MGI
Other mutations in this stock
Total: 42 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930562C15Rik T C 16: 4,669,799 (GRCm39) V788A possibly damaging Het
Abca15 A T 7: 120,002,217 (GRCm39) K1577* probably null Het
Arhgap12 T C 18: 6,111,803 (GRCm39) E187G probably damaging Het
Arhgef10 T A 8: 15,025,005 (GRCm39) Y398N probably damaging Het
Baz2b C T 2: 59,731,874 (GRCm39) V2055I probably benign Het
Btnl4 T C 17: 34,688,353 (GRCm39) D475G probably damaging Het
C1qtnf12 T A 4: 156,050,070 (GRCm39) F190Y probably damaging Het
Cacul1 A G 19: 60,522,683 (GRCm39) S284P probably damaging Het
Ccdc166 C A 15: 75,853,820 (GRCm39) V87L possibly damaging Het
Ceacam13 C T 7: 17,747,032 (GRCm39) P162S probably damaging Het
Cep250 T A 2: 155,834,446 (GRCm39) S2124T probably benign Het
Chd5 T C 4: 152,462,664 (GRCm39) S1372P probably damaging Het
Chil3 C A 3: 106,067,730 (GRCm39) R145L probably benign Het
Cyp4f40 T C 17: 32,894,923 (GRCm39) S454P probably benign Het
Defa3 T A 8: 21,778,213 (GRCm39) C66S probably damaging Het
Fan1 T A 7: 64,022,234 (GRCm39) N340Y probably damaging Het
Glmp C A 3: 88,235,349 (GRCm39) N260K probably benign Het
Gsap T A 5: 21,486,016 (GRCm39) L653Q probably damaging Het
Il18rap T A 1: 40,564,255 (GRCm39) Y124* probably null Het
Lao1 A C 4: 118,820,948 (GRCm39) K58T probably damaging Het
Lepr T A 4: 101,622,487 (GRCm39) probably null Het
Nck2 T G 1: 43,593,511 (GRCm39) N239K probably benign Het
Optc A T 1: 133,825,554 (GRCm39) V324E possibly damaging Het
Or12k7 A T 2: 36,958,794 (GRCm39) Y159F probably damaging Het
Or4p8 A G 2: 88,727,278 (GRCm39) I221T probably benign Het
Or51b6 G A 7: 103,555,908 (GRCm39) W84* probably null Het
Otog T C 7: 45,923,205 (GRCm39) S1027P probably damaging Het
Plbd2 A G 5: 120,641,407 (GRCm39) F84L probably benign Het
Plxnb1 T C 9: 108,935,838 (GRCm39) L110P probably damaging Het
Prnp T C 2: 131,778,708 (GRCm39) V120A possibly damaging Het
Ptprh C A 7: 4,552,370 (GRCm39) E965* probably null Het
Reln T C 5: 22,239,568 (GRCm39) T900A probably damaging Het
Stt3a A G 9: 36,646,682 (GRCm39) Y644H probably damaging Het
Sulf2 A G 2: 165,929,039 (GRCm39) Y311H probably damaging Het
Tbc1d32 A T 10: 56,056,626 (GRCm39) I438N probably damaging Het
Tbcd T C 11: 121,387,937 (GRCm39) V356A possibly damaging Het
Tecta T C 9: 42,303,425 (GRCm39) N69S probably damaging Het
Topaz1 T C 9: 122,631,023 (GRCm39) V1618A probably benign Het
Usp48 C T 4: 137,352,587 (GRCm39) T627I possibly damaging Het
Vcl T C 14: 21,037,143 (GRCm39) V247A probably damaging Het
Vmn2r59 A G 7: 41,693,277 (GRCm39) L441P probably damaging Het
Zfp869 C T 8: 70,159,175 (GRCm39) G466D probably damaging Het
Other mutations in Mrgpra3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00162:Mrgpra3 APN 7 47,239,267 (GRCm39) missense probably benign 0.00
IGL02097:Mrgpra3 APN 7 47,239,204 (GRCm39) missense possibly damaging 0.94
IGL02101:Mrgpra3 APN 7 47,239,300 (GRCm39) missense probably damaging 0.99
IGL03071:Mrgpra3 APN 7 47,238,929 (GRCm39) utr 3 prime probably benign
PIT4445001:Mrgpra3 UTSW 7 47,239,908 (GRCm39) missense possibly damaging 0.88
R0828:Mrgpra3 UTSW 7 47,239,884 (GRCm39) missense probably benign 0.12
R1118:Mrgpra3 UTSW 7 47,239,039 (GRCm39) missense possibly damaging 0.83
R1835:Mrgpra3 UTSW 7 47,239,694 (GRCm39) nonsense probably null
R2258:Mrgpra3 UTSW 7 47,239,842 (GRCm39) missense probably benign 0.35
R2393:Mrgpra3 UTSW 7 47,239,365 (GRCm39) missense possibly damaging 0.92
R3437:Mrgpra3 UTSW 7 47,239,314 (GRCm39) missense probably damaging 1.00
R3973:Mrgpra3 UTSW 7 47,239,414 (GRCm39) missense probably benign 0.22
R4273:Mrgpra3 UTSW 7 47,239,180 (GRCm39) missense probably benign 0.01
R4495:Mrgpra3 UTSW 7 47,239,813 (GRCm39) missense probably benign 0.00
R4768:Mrgpra3 UTSW 7 47,239,476 (GRCm39) missense possibly damaging 0.94
R4822:Mrgpra3 UTSW 7 47,239,716 (GRCm39) missense possibly damaging 0.69
R4967:Mrgpra3 UTSW 7 47,239,267 (GRCm39) missense probably benign 0.33
R5207:Mrgpra3 UTSW 7 47,239,909 (GRCm39) missense probably benign 0.06
R5569:Mrgpra3 UTSW 7 47,239,759 (GRCm39) missense probably benign 0.00
R5763:Mrgpra3 UTSW 7 47,239,355 (GRCm39) nonsense probably null
R6102:Mrgpra3 UTSW 7 47,239,897 (GRCm39) missense possibly damaging 0.92
R6612:Mrgpra3 UTSW 7 47,239,783 (GRCm39) missense probably benign 0.00
R6718:Mrgpra3 UTSW 7 47,239,444 (GRCm39) missense probably benign 0.25
R7029:Mrgpra3 UTSW 7 47,239,290 (GRCm39) missense probably benign 0.00
R7034:Mrgpra3 UTSW 7 47,239,838 (GRCm39) missense possibly damaging 0.49
R7036:Mrgpra3 UTSW 7 47,239,838 (GRCm39) missense possibly damaging 0.49
R7097:Mrgpra3 UTSW 7 47,239,389 (GRCm39) missense probably benign
R7475:Mrgpra3 UTSW 7 47,239,695 (GRCm39) missense probably damaging 1.00
R8289:Mrgpra3 UTSW 7 47,239,468 (GRCm39) missense possibly damaging 0.76
R8315:Mrgpra3 UTSW 7 47,251,051 (GRCm39) start codon destroyed probably null 0.93
R9500:Mrgpra3 UTSW 7 47,239,400 (GRCm39) nonsense probably null
Z1177:Mrgpra3 UTSW 7 47,251,049 (GRCm39) nonsense probably null
Predicted Primers PCR Primer
(F):5'- GCCTGTGATATAGAGAACCCTTTTG -3'
(R):5'- GTGGTCATAGTAAAGGCCTCACTTC -3'

Sequencing Primer
(F):5'- GCAAAAATTCCTTTGGGTAGGG -3'
(R):5'- ATAGTAAAGGCCTCACTTCTTCTTTG -3'
Posted On 2018-10-18