Incidental Mutation 'R6837:Gm10267'
ID 537921
Institutional Source Beutler Lab
Gene Symbol Gm10267
Ensembl Gene ENSMUSG00000069385
Gene Name predicted gene 10267
Synonyms
MMRRC Submission 044945-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.060) question?
Stock # R6837 (G1)
Quality Score 225.009
Status Validated
Chromosome 18
Chromosomal Location 44289470-44292952 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 44291375 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Histidine to Arginine at position 32 (H32R)
Ref Sequence ENSEMBL: ENSMUSP00000137781 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000091916] [ENSMUST00000181652]
AlphaFold M0QWD8
Predicted Effect probably benign
Transcript: ENSMUST00000091916
AA Change: H32R

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000089535
Gene: ENSMUSG00000069385
AA Change: H32R

DomainStartEndE-ValueType
KAZAL 35 85 5.04e-10 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000181652
AA Change: H32R

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000137781
Gene: ENSMUSG00000069385
AA Change: H32R

DomainStartEndE-ValueType
signal peptide 1 22 N/A INTRINSIC
KAZAL 35 85 5.04e-10 SMART
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.6%
  • 20x: 98.9%
Validation Efficiency 98% (41/42)
Allele List at MGI
Other mutations in this stock
Total: 41 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Akap6 G A 12: 53,188,045 (GRCm39) E1820K probably damaging Het
Anxa8 A T 14: 33,814,511 (GRCm39) I116F probably damaging Het
Arid4a A G 12: 71,122,289 (GRCm39) D890G probably benign Het
Aup1 C T 6: 83,034,279 (GRCm39) T396I possibly damaging Het
C2cd3 G C 7: 100,097,953 (GRCm39) E594Q probably damaging Het
Colgalt2 C T 1: 152,382,579 (GRCm39) P477L probably damaging Het
Dennd3 G A 15: 73,429,542 (GRCm39) D20N probably damaging Het
Dpysl3 A G 18: 43,570,947 (GRCm39) I109T probably benign Het
Fas A T 19: 34,284,564 (GRCm39) T24S probably damaging Het
Fras1 A T 5: 96,874,832 (GRCm39) I2332F probably damaging Het
Gm57859 A G 11: 113,579,439 (GRCm39) H278R possibly damaging Het
Hcfc2 A T 10: 82,575,030 (GRCm39) I230F probably damaging Het
Hdac9 T C 12: 34,337,463 (GRCm39) T673A probably benign Het
Herc2 T G 7: 55,839,589 (GRCm39) N3366K possibly damaging Het
Hhla1 T C 15: 65,820,334 (GRCm39) N139D probably damaging Het
Hip1r A G 5: 124,136,928 (GRCm39) E632G possibly damaging Het
Kcnc2 A G 10: 112,294,407 (GRCm39) D98G probably damaging Het
Maip1 T A 1: 57,454,891 (GRCm39) *292K probably null Het
Map2 T C 1: 66,453,731 (GRCm39) F874L probably damaging Het
Myof A T 19: 37,911,404 (GRCm39) probably null Het
Notch2 A G 3: 97,978,170 (GRCm39) probably null Het
Npy5r T A 8: 67,134,392 (GRCm39) M134L probably benign Het
Ntsr2 T A 12: 16,709,710 (GRCm39) M225K probably benign Het
Nup153 G A 13: 46,847,527 (GRCm39) T634I probably damaging Het
Or51f1d T A 7: 102,700,929 (GRCm39) Y141* probably null Het
Pcsk5 T C 19: 17,416,448 (GRCm39) S1667G probably benign Het
Pex13 A G 11: 23,599,527 (GRCm39) I328T possibly damaging Het
Pkd2 T G 5: 104,624,909 (GRCm39) L235W probably damaging Het
Prune2 A T 19: 17,156,292 (GRCm39) D66V probably damaging Het
Rasal3 T C 17: 32,622,044 (GRCm39) N105S probably benign Het
Sla A T 15: 66,658,939 (GRCm39) I144N probably damaging Het
Slc5a4b A T 10: 75,898,220 (GRCm39) I498N possibly damaging Het
Snx14 C T 9: 88,262,276 (GRCm39) E872K probably benign Het
Stx16 G A 2: 173,935,795 (GRCm39) R242H probably benign Het
Tg T C 15: 66,567,984 (GRCm39) F1296S probably damaging Het
Tmem161b C A 13: 84,370,537 (GRCm39) probably benign Het
Tmf1 G A 6: 97,153,542 (GRCm39) T177M possibly damaging Het
Tuba4a T C 1: 75,194,038 (GRCm39) Q14R probably damaging Het
Vmn2r114 T C 17: 23,529,176 (GRCm39) M309V probably benign Het
Vps13c C T 9: 67,817,504 (GRCm39) P1059S probably benign Het
Yars1 T A 4: 129,103,544 (GRCm39) S298T possibly damaging Het
Other mutations in Gm10267
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01738:Gm10267 APN 18 44,292,342 (GRCm39) missense possibly damaging 0.63
R0050:Gm10267 UTSW 18 44,289,520 (GRCm39) splice site probably benign
R0050:Gm10267 UTSW 18 44,289,520 (GRCm39) splice site probably benign
R1669:Gm10267 UTSW 18 44,290,367 (GRCm39) missense probably damaging 1.00
R2084:Gm10267 UTSW 18 44,290,397 (GRCm39) missense probably benign 0.00
R4289:Gm10267 UTSW 18 44,290,331 (GRCm39) missense probably damaging 1.00
R4570:Gm10267 UTSW 18 44,289,492 (GRCm39) missense probably benign 0.03
R8910:Gm10267 UTSW 18 44,289,511 (GRCm39) missense possibly damaging 0.83
R9666:Gm10267 UTSW 18 44,291,397 (GRCm39) missense probably benign 0.00
Predicted Primers PCR Primer
(F):5'- GCCAATGGCTAGTGTTTGAG -3'
(R):5'- GAAACCTGAGGCCAGAATATTTCAC -3'

Sequencing Primer
(F):5'- CTTGTTGCAATAATAAGTTGTTTTGC -3'
(R):5'- GGCCAGAATATTTCACTGAAAATTC -3'
Posted On 2018-10-18