Incidental Mutation 'R6838:Tmem161b'
| ID |
537977 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Tmem161b
|
| Ensembl Gene |
ENSMUSG00000035762 |
| Gene Name |
transmembrane protein 161B |
| Synonyms |
2810446P07Rik |
| MMRRC Submission |
044946-MU
|
| Accession Numbers |
|
| Essential gene? |
Essential
(E-score: 1.000)
|
| Stock # |
R6838 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Validated
|
| Chromosome |
13 |
| Chromosomal Location |
84370415-84444085 bp(+) (GRCm39) |
| Type of Mutation |
start gained |
| DNA Base Change (assembly) |
C to A
at 84370537 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000152891
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000057495]
[ENSMUST00000223827]
[ENSMUST00000223862]
[ENSMUST00000224525]
[ENSMUST00000225069]
|
| AlphaFold |
Q8C2L6 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000057495
AA Change: -1
|
| SMART Domains |
Protein: ENSMUSP00000055208
Gene: ENSMUSG00000035762
AA Change: -1
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:Tmemb_161AB
|
2 |
485 |
1.3e-213 |
PFAM |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000180894
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000185973
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000223827
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000223862
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000224501
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000224525
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000225069
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000225126
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000225212
|
| Meta Mutation Damage Score |
0.0898 |
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.5%
- 20x: 98.7%
|
| Validation Efficiency |
97% (64/66) |
| MGI Phenotype |
PHENOTYPE: Homozygous mice exhibit lethality before genotyping age. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 66 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Aim2 |
C |
G |
1: 173,291,546 (GRCm39) |
T317R |
probably damaging |
Het |
| Aqp9 |
T |
A |
9: 71,019,498 (GRCm39) |
M321L |
probably benign |
Het |
| Avil |
G |
A |
10: 126,849,431 (GRCm39) |
D576N |
probably benign |
Het |
| Bbs1 |
C |
T |
19: 4,953,880 (GRCm39) |
M94I |
possibly damaging |
Het |
| Bms1 |
A |
G |
6: 118,393,455 (GRCm39) |
V139A |
probably benign |
Het |
| Bscl2 |
A |
T |
19: 8,818,745 (GRCm39) |
M57L |
probably damaging |
Het |
| C2cd5 |
A |
G |
6: 142,975,364 (GRCm39) |
I794T |
possibly damaging |
Het |
| Cacna1s |
C |
T |
1: 136,012,175 (GRCm39) |
T539I |
possibly damaging |
Het |
| Cand1 |
T |
C |
10: 119,045,935 (GRCm39) |
K990R |
probably benign |
Het |
| Capn7 |
A |
G |
14: 31,076,130 (GRCm39) |
I311V |
possibly damaging |
Het |
| Cd180 |
A |
G |
13: 102,839,239 (GRCm39) |
N41D |
probably benign |
Het |
| Cdin1 |
T |
C |
2: 115,607,471 (GRCm39) |
F275L |
possibly damaging |
Het |
| Celsr1 |
G |
A |
15: 85,823,395 (GRCm39) |
T1671I |
probably benign |
Het |
| Cep135 |
A |
T |
5: 76,780,062 (GRCm39) |
Q798L |
probably damaging |
Het |
| Cfap65 |
T |
C |
1: 74,971,180 (GRCm39) |
D46G |
probably benign |
Het |
| Cracd |
A |
T |
5: 77,006,056 (GRCm39) |
T806S |
unknown |
Het |
| Ddx46 |
G |
T |
13: 55,787,748 (GRCm39) |
|
probably null |
Het |
| Dnah7b |
T |
C |
1: 46,230,948 (GRCm39) |
L1402P |
probably damaging |
Het |
| Dnah8 |
A |
G |
17: 30,929,525 (GRCm39) |
E1402G |
probably damaging |
Het |
| Dock9 |
A |
G |
14: 121,784,008 (GRCm39) |
Y1989H |
possibly damaging |
Het |
| Ereg |
A |
G |
5: 91,236,323 (GRCm39) |
D50G |
probably benign |
Het |
| Evi5 |
G |
T |
5: 107,990,027 (GRCm39) |
T64K |
possibly damaging |
Het |
| Frem3 |
A |
C |
8: 81,338,660 (GRCm39) |
T318P |
probably damaging |
Het |
| Gpx1 |
A |
G |
9: 108,217,139 (GRCm39) |
D81G |
possibly damaging |
Het |
| Gramd1a |
T |
C |
7: 30,833,929 (GRCm39) |
I499V |
probably benign |
Het |
| H4c12 |
A |
T |
13: 21,934,375 (GRCm39) |
F101I |
probably damaging |
Het |
| Herc2 |
T |
A |
7: 55,758,526 (GRCm39) |
D804E |
probably damaging |
Het |
| Hk1 |
T |
C |
10: 62,107,437 (GRCm39) |
E846G |
probably damaging |
Het |
| Iars2 |
G |
A |
1: 185,061,342 (GRCm39) |
A48V |
probably damaging |
Het |
| Invs |
C |
T |
4: 48,283,278 (GRCm39) |
T10M |
possibly damaging |
Het |
| Ism2 |
A |
T |
12: 87,326,975 (GRCm39) |
D321E |
probably benign |
Het |
| Itpr1 |
T |
C |
6: 108,448,152 (GRCm39) |
S231P |
possibly damaging |
Het |
| Kif17 |
A |
T |
4: 138,005,710 (GRCm39) |
|
probably null |
Het |
| Lvrn |
A |
G |
18: 47,023,947 (GRCm39) |
I765V |
possibly damaging |
Het |
| Map4k4 |
T |
A |
1: 40,015,882 (GRCm39) |
C108S |
probably damaging |
Het |
| Mapk13 |
G |
T |
17: 28,996,535 (GRCm39) |
|
probably null |
Het |
| Mapkapk2 |
T |
A |
1: 130,985,740 (GRCm39) |
K95* |
probably null |
Het |
| Mau2 |
A |
T |
8: 70,491,947 (GRCm39) |
|
probably null |
Het |
| Mex3a |
A |
G |
3: 88,444,084 (GRCm39) |
T387A |
probably benign |
Het |
| Myo5a |
T |
C |
9: 75,061,165 (GRCm39) |
|
probably null |
Het |
| Ncbp3 |
A |
T |
11: 72,964,300 (GRCm39) |
M417L |
possibly damaging |
Het |
| Nod2 |
A |
C |
8: 89,397,086 (GRCm39) |
E810A |
possibly damaging |
Het |
| Nol3 |
A |
T |
8: 106,006,207 (GRCm39) |
E152V |
probably damaging |
Het |
| Obox6 |
T |
C |
7: 15,567,664 (GRCm39) |
E261G |
possibly damaging |
Het |
| Or2h1 |
A |
T |
17: 37,404,058 (GRCm39) |
L236* |
probably null |
Het |
| Or8b12b |
A |
C |
9: 37,684,348 (GRCm39) |
Y131S |
possibly damaging |
Het |
| P3h2 |
T |
C |
16: 25,924,034 (GRCm39) |
S134G |
possibly damaging |
Het |
| Plxna2 |
A |
T |
1: 194,487,222 (GRCm39) |
R1592S |
possibly damaging |
Het |
| Ppp1r12a |
C |
T |
10: 108,097,137 (GRCm39) |
S250L |
possibly damaging |
Het |
| Rab38 |
A |
G |
7: 88,099,917 (GRCm39) |
D144G |
possibly damaging |
Het |
| Septin1 |
T |
C |
7: 126,815,894 (GRCm39) |
M176V |
probably benign |
Het |
| Spata22 |
C |
T |
11: 73,236,759 (GRCm39) |
T355M |
probably benign |
Het |
| Tango6 |
A |
G |
8: 107,468,706 (GRCm39) |
N734S |
probably benign |
Het |
| Tbc1d17 |
C |
A |
7: 44,493,738 (GRCm39) |
R295L |
probably damaging |
Het |
| Thsd7a |
G |
T |
6: 12,504,074 (GRCm39) |
P360Q |
probably damaging |
Het |
| Tnnt1 |
T |
C |
7: 4,510,406 (GRCm39) |
N239S |
possibly damaging |
Het |
| Tpst1 |
A |
T |
5: 130,131,279 (GRCm39) |
M250L |
probably benign |
Het |
| Urb1 |
T |
A |
16: 90,578,994 (GRCm39) |
D689V |
possibly damaging |
Het |
| Usp28 |
T |
A |
9: 48,911,730 (GRCm39) |
|
probably null |
Het |
| Vldlr |
G |
A |
19: 27,225,370 (GRCm39) |
D816N |
probably damaging |
Het |
| Vmn1r257 |
T |
A |
7: 22,391,142 (GRCm39) |
M201L |
probably benign |
Het |
| Wdr1 |
A |
G |
5: 38,687,374 (GRCm39) |
V219A |
probably damaging |
Het |
| Xndc1 |
T |
C |
7: 101,722,476 (GRCm39) |
V47A |
possibly damaging |
Het |
| Zfp366 |
C |
T |
13: 99,365,015 (GRCm39) |
P59S |
possibly damaging |
Het |
| Zfp366 |
A |
G |
13: 99,382,685 (GRCm39) |
E616G |
possibly damaging |
Het |
| Zfp937 |
T |
A |
2: 150,081,266 (GRCm39) |
I432K |
probably benign |
Het |
|
| Other mutations in Tmem161b |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00666:Tmem161b
|
APN |
13 |
84,442,715 (GRCm39) |
splice site |
probably benign |
|
|
IGL01086:Tmem161b
|
APN |
13 |
84,370,541 (GRCm39) |
utr 5 prime |
probably benign |
|
|
IGL01150:Tmem161b
|
APN |
13 |
84,440,526 (GRCm39) |
nonsense |
probably null |
|
|
IGL01566:Tmem161b
|
APN |
13 |
84,442,881 (GRCm39) |
missense |
probably benign |
0.35 |
|
IGL02183:Tmem161b
|
APN |
13 |
84,420,373 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02481:Tmem161b
|
APN |
13 |
84,432,112 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL02519:Tmem161b
|
APN |
13 |
84,442,863 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03207:Tmem161b
|
APN |
13 |
84,442,714 (GRCm39) |
splice site |
probably benign |
|
|
R6836_Tmem161b_587
|
UTSW |
13 |
84,370,537 (GRCm39) |
start gained |
probably benign |
|
|
R0015:Tmem161b
|
UTSW |
13 |
84,370,533 (GRCm39) |
splice site |
probably null |
|
|
R0376:Tmem161b
|
UTSW |
13 |
84,440,502 (GRCm39) |
missense |
probably benign |
0.43 |
|
R0613:Tmem161b
|
UTSW |
13 |
84,399,439 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1925:Tmem161b
|
UTSW |
13 |
84,408,348 (GRCm39) |
missense |
probably benign |
0.07 |
|
R1935:Tmem161b
|
UTSW |
13 |
84,441,585 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1936:Tmem161b
|
UTSW |
13 |
84,441,585 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2325:Tmem161b
|
UTSW |
13 |
84,442,887 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R2988:Tmem161b
|
UTSW |
13 |
84,440,574 (GRCm39) |
nonsense |
probably null |
|
|
R4327:Tmem161b
|
UTSW |
13 |
84,399,359 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4525:Tmem161b
|
UTSW |
13 |
84,405,921 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4558:Tmem161b
|
UTSW |
13 |
84,399,363 (GRCm39) |
missense |
possibly damaging |
0.50 |
|
R5133:Tmem161b
|
UTSW |
13 |
84,442,887 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R5134:Tmem161b
|
UTSW |
13 |
84,442,887 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R5727:Tmem161b
|
UTSW |
13 |
84,434,909 (GRCm39) |
missense |
possibly damaging |
0.63 |
|
R5875:Tmem161b
|
UTSW |
13 |
84,442,977 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6217:Tmem161b
|
UTSW |
13 |
84,399,363 (GRCm39) |
missense |
possibly damaging |
0.50 |
|
R6527:Tmem161b
|
UTSW |
13 |
84,420,383 (GRCm39) |
missense |
probably benign |
0.06 |
|
R6550:Tmem161b
|
UTSW |
13 |
84,370,537 (GRCm39) |
start gained |
probably benign |
|
|
R6551:Tmem161b
|
UTSW |
13 |
84,370,537 (GRCm39) |
start gained |
probably benign |
|
|
R6553:Tmem161b
|
UTSW |
13 |
84,370,537 (GRCm39) |
start gained |
probably benign |
|
|
R6554:Tmem161b
|
UTSW |
13 |
84,370,537 (GRCm39) |
start gained |
probably benign |
|
|
R6640:Tmem161b
|
UTSW |
13 |
84,370,537 (GRCm39) |
start gained |
probably benign |
|
|
R6641:Tmem161b
|
UTSW |
13 |
84,370,537 (GRCm39) |
start gained |
probably benign |
|
|
R6685:Tmem161b
|
UTSW |
13 |
84,370,537 (GRCm39) |
start gained |
probably benign |
|
|
R6836:Tmem161b
|
UTSW |
13 |
84,370,537 (GRCm39) |
start gained |
probably benign |
|
|
R6837:Tmem161b
|
UTSW |
13 |
84,370,537 (GRCm39) |
start gained |
probably benign |
|
|
R7077:Tmem161b
|
UTSW |
13 |
84,370,537 (GRCm39) |
start gained |
probably benign |
|
|
R7078:Tmem161b
|
UTSW |
13 |
84,370,537 (GRCm39) |
start gained |
probably benign |
|
|
R7386:Tmem161b
|
UTSW |
13 |
84,370,537 (GRCm39) |
start gained |
probably benign |
|
|
R7388:Tmem161b
|
UTSW |
13 |
84,370,537 (GRCm39) |
start gained |
probably benign |
|
|
R7429:Tmem161b
|
UTSW |
13 |
84,430,866 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R7430:Tmem161b
|
UTSW |
13 |
84,430,866 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R7547:Tmem161b
|
UTSW |
13 |
84,370,537 (GRCm39) |
start gained |
probably benign |
|
|
R7548:Tmem161b
|
UTSW |
13 |
84,370,537 (GRCm39) |
start gained |
probably benign |
|
|
R7634:Tmem161b
|
UTSW |
13 |
84,370,537 (GRCm39) |
start gained |
probably benign |
|
|
R7636:Tmem161b
|
UTSW |
13 |
84,370,537 (GRCm39) |
start gained |
probably benign |
|
|
R8094:Tmem161b
|
UTSW |
13 |
84,370,537 (GRCm39) |
start gained |
probably benign |
|
|
R8095:Tmem161b
|
UTSW |
13 |
84,370,537 (GRCm39) |
start gained |
probably benign |
|
|
R8255:Tmem161b
|
UTSW |
13 |
84,370,537 (GRCm39) |
start gained |
probably benign |
|
|
R8257:Tmem161b
|
UTSW |
13 |
84,370,537 (GRCm39) |
start gained |
probably benign |
|
|
R8669:Tmem161b
|
UTSW |
13 |
84,420,288 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R9049:Tmem161b
|
UTSW |
13 |
84,442,754 (GRCm39) |
missense |
probably benign |
|
|
R9092:Tmem161b
|
UTSW |
13 |
84,440,503 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
R9316:Tmem161b
|
UTSW |
13 |
84,430,855 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
R9326:Tmem161b
|
UTSW |
13 |
84,440,602 (GRCm39) |
nonsense |
probably null |
|
|
| Predicted Primers |
PCR Primer
(F):5'- GGCTTTAGAGAACGCCTTGC -3'
(R):5'- TAGACTGGGTACTCCGACAGAC -3'
Sequencing Primer
(F):5'- TCCTCTCTGCGTGGCGTG -3'
(R):5'- TCCCTCGGCTGTCTGGAAC -3'
|
| Posted On |
2018-10-18 |
Incidental Mutation