Incidental Mutation 'R6893:Tmprss11b'
ID 538153
Institutional Source Beutler Lab
Gene Symbol Tmprss11b
Ensembl Gene ENSMUSG00000035861
Gene Name transmembrane protease, serine 11B
Synonyms Tmprss11bnl, 9930019B18Rik
MMRRC Submission 044987-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R6893 (G1)
Quality Score 225.009
Status Validated
Chromosome 5
Chromosomal Location 86806326-86824221 bp(-) (GRCm39)
Type of Mutation critical splice donor site (2 bp from exon)
DNA Base Change (assembly) A to G at 86811245 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000042406 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000038448] [ENSMUST00000038448]
AlphaFold Q14C59
Predicted Effect probably null
Transcript: ENSMUST00000038448
SMART Domains Protein: ENSMUSP00000042406
Gene: ENSMUSG00000035861

DomainStartEndE-ValueType
transmembrane domain 12 34 N/A INTRINSIC
Pfam:SEA 46 148 2.3e-26 PFAM
Tryp_SPc 184 410 6.19e-89 SMART
Predicted Effect probably null
Transcript: ENSMUST00000038448
SMART Domains Protein: ENSMUSP00000042406
Gene: ENSMUSG00000035861

DomainStartEndE-ValueType
transmembrane domain 12 34 N/A INTRINSIC
Pfam:SEA 46 148 2.3e-26 PFAM
Tryp_SPc 184 410 6.19e-89 SMART
Meta Mutation Damage Score 0.9755 question?
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.8%
  • 10x: 98.7%
  • 20x: 95.2%
Validation Efficiency 100% (49/49)
Allele List at MGI
Other mutations in this stock
Total: 48 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adam32 T A 8: 25,368,770 (GRCm39) D538V probably damaging Het
Akap9 T C 5: 4,011,709 (GRCm39) I804T probably benign Het
Amy1 T C 3: 113,357,281 (GRCm39) E186G probably benign Het
Best1 A G 19: 9,974,446 (GRCm39) Y33H probably damaging Het
Cacna1s C A 1: 136,005,431 (GRCm39) N405K probably benign Het
Casp7 T C 19: 56,421,741 (GRCm39) Y60H probably damaging Het
Ccdc61 T C 7: 18,626,488 (GRCm39) N367S possibly damaging Het
Cnksr3 A T 10: 7,085,129 (GRCm39) probably null Het
Col14a1 A C 15: 55,308,044 (GRCm39) probably benign Het
Cyp3a57 A T 5: 145,323,784 (GRCm39) K424* probably null Het
Dnai3 T C 3: 145,786,184 (GRCm39) E366G probably damaging Het
Dpep3 T C 8: 106,700,474 (GRCm39) K411E probably benign Het
Ebf2 T A 14: 67,475,008 (GRCm39) V81E probably benign Het
Ehbp1 G T 11: 21,964,945 (GRCm39) T1084K probably damaging Het
Fastkd2 C T 1: 63,770,953 (GRCm39) A103V possibly damaging Het
Gtf3c2 T C 5: 31,323,722 (GRCm39) K525E probably benign Het
Hdac2 A G 10: 36,873,003 (GRCm39) E287G probably damaging Het
Ifi207 T A 1: 173,555,208 (GRCm39) T832S possibly damaging Het
Igf1 G C 10: 87,700,722 (GRCm39) V49L probably damaging Het
Lef1 A G 3: 130,909,149 (GRCm39) D55G possibly damaging Het
Lipo2 G T 19: 33,698,407 (GRCm39) Y323* probably null Het
Mettl24 C T 10: 40,613,794 (GRCm39) R178C probably damaging Het
Naa80 A G 9: 107,460,225 (GRCm39) E40G probably damaging Het
Ndrg4 C A 8: 96,433,229 (GRCm39) C66* probably null Het
Nemf A G 12: 69,399,110 (GRCm39) V140A probably benign Het
Nid2 T A 14: 19,839,855 (GRCm39) F815I probably benign Het
Or4c108 A G 2: 88,804,143 (GRCm39) F31L probably benign Het
Or5b106 A C 19: 13,123,106 (GRCm39) S306A probably benign Het
Or8b12c A C 9: 37,716,141 (GRCm39) *311C probably null Het
Or8b3b A T 9: 38,584,355 (GRCm39) N141K possibly damaging Het
Or8k30 A G 2: 86,339,136 (GRCm39) E111G probably damaging Het
Pcdhga3 T C 18: 37,809,598 (GRCm39) S684P probably benign Het
Plch1 A T 3: 63,660,562 (GRCm39) C352* probably null Het
Plscr2 G A 9: 92,172,757 (GRCm39) V139I probably benign Het
Ppa1 T A 10: 61,508,182 (GRCm39) C270S probably benign Het
Ryr2 T A 13: 11,844,540 (GRCm39) M399L possibly damaging Het
Scn3a A G 2: 65,356,098 (GRCm39) V212A possibly damaging Het
Serpina3b A G 12: 104,099,285 (GRCm39) K267E probably benign Het
Shroom3 A G 5: 93,090,063 (GRCm39) T938A probably damaging Het
Specc1 A C 11: 62,023,279 (GRCm39) S115R probably benign Het
Stim2 C T 5: 54,210,787 (GRCm39) T74I probably benign Het
Sult6b2 T A 6: 142,750,025 (GRCm39) D31V possibly damaging Het
Tbc1d24 A T 17: 24,401,492 (GRCm39) W406R probably damaging Het
Trappc9 A G 15: 72,797,499 (GRCm39) Y575H possibly damaging Het
Trim63 C T 4: 134,050,412 (GRCm39) T232M probably damaging Het
Ttn A T 2: 76,598,180 (GRCm39) S19578T probably damaging Het
Vmn2r111 T C 17: 22,778,032 (GRCm39) N549S possibly damaging Het
Xpo4 T A 14: 57,819,767 (GRCm39) E1139D probably benign Het
Other mutations in Tmprss11b
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01122:Tmprss11b APN 5 86,811,376 (GRCm39) missense probably benign
IGL02340:Tmprss11b APN 5 86,810,090 (GRCm39) missense probably benign
IGL02500:Tmprss11b APN 5 86,815,182 (GRCm39) critical splice donor site probably null
demolished UTSW 5 86,812,173 (GRCm39) missense probably damaging 1.00
R0356:Tmprss11b UTSW 5 86,808,326 (GRCm39) makesense probably null
R0506:Tmprss11b UTSW 5 86,809,499 (GRCm39) missense probably damaging 1.00
R0528:Tmprss11b UTSW 5 86,819,753 (GRCm39) missense probably damaging 1.00
R1424:Tmprss11b UTSW 5 86,812,832 (GRCm39) missense probably benign 0.09
R1471:Tmprss11b UTSW 5 86,808,355 (GRCm39) missense possibly damaging 0.76
R1554:Tmprss11b UTSW 5 86,809,490 (GRCm39) missense probably benign 0.01
R3436:Tmprss11b UTSW 5 86,815,443 (GRCm39) nonsense probably null
R3829:Tmprss11b UTSW 5 86,809,449 (GRCm39) missense probably damaging 0.98
R4409:Tmprss11b UTSW 5 86,812,137 (GRCm39) missense probably benign 0.26
R4495:Tmprss11b UTSW 5 86,812,922 (GRCm39) nonsense probably null
R4624:Tmprss11b UTSW 5 86,812,895 (GRCm39) missense probably benign 0.04
R4834:Tmprss11b UTSW 5 86,811,418 (GRCm39) missense probably damaging 1.00
R5436:Tmprss11b UTSW 5 86,810,092 (GRCm39) missense probably benign 0.10
R5812:Tmprss11b UTSW 5 86,812,957 (GRCm39) missense possibly damaging 0.67
R6262:Tmprss11b UTSW 5 86,810,119 (GRCm39) missense probably benign 0.07
R6882:Tmprss11b UTSW 5 86,819,530 (GRCm39) splice site probably null
R7312:Tmprss11b UTSW 5 86,812,173 (GRCm39) missense probably damaging 1.00
R7771:Tmprss11b UTSW 5 86,809,554 (GRCm39) splice site probably null
R8101:Tmprss11b UTSW 5 86,812,821 (GRCm39) critical splice donor site probably null
X0067:Tmprss11b UTSW 5 86,810,059 (GRCm39) missense probably damaging 1.00
Z1177:Tmprss11b UTSW 5 86,809,472 (GRCm39) missense probably benign 0.13
Z1177:Tmprss11b UTSW 5 86,808,400 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- TCTGAAGTATACAGCGATGAGG -3'
(R):5'- ACTTCTGAAGGCTGTGGGAG -3'

Sequencing Primer
(F):5'- TATACAGCGATGAGGAAATAAGACTC -3'
(R):5'- CTTCTGAAGGCTGTGGGAGAAGAC -3'
Posted On 2018-11-06