Incidental Mutation 'R6904:Zfp456'
ID 538699
Institutional Source Beutler Lab
Gene Symbol Zfp456
Ensembl Gene ENSMUSG00000078995
Gene Name zinc finger protein 456
Synonyms Rslcan-13
MMRRC Submission 045033-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.133) question?
Stock # R6904 (G1)
Quality Score 225.009
Status Not validated
Chromosome 13
Chromosomal Location 67511700-67523872 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 67514384 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Serine to Threonine at position 441 (S441T)
Ref Sequence ENSEMBL: ENSMUSP00000059686 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000057070] [ENSMUST00000166080] [ENSMUST00000172266]
AlphaFold B2RUK9
Predicted Effect probably benign
Transcript: ENSMUST00000057070
AA Change: S441T

PolyPhen 2 Score 0.439 (Sensitivity: 0.89; Specificity: 0.90)
SMART Domains Protein: ENSMUSP00000059686
Gene: ENSMUSG00000078995
AA Change: S441T

DomainStartEndE-ValueType
KRAB 2 62 3.07e-33 SMART
ZnF_C2H2 106 128 1.92e-2 SMART
ZnF_C2H2 134 156 5.77e0 SMART
ZnF_C2H2 162 184 1.28e-3 SMART
ZnF_C2H2 190 212 2.36e-2 SMART
ZnF_C2H2 246 268 2.17e-1 SMART
ZnF_C2H2 274 296 7.37e-4 SMART
ZnF_C2H2 302 324 6.32e-3 SMART
ZnF_C2H2 330 352 2.4e-3 SMART
ZnF_C2H2 358 380 8.94e-3 SMART
ZnF_C2H2 386 408 1.92e-2 SMART
ZnF_C2H2 414 436 7.9e-4 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000166080
SMART Domains Protein: ENSMUSP00000126669
Gene: ENSMUSG00000098692

DomainStartEndE-ValueType
KRAB 2 62 3.07e-33 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000172266
SMART Domains Protein: ENSMUSP00000130928
Gene: ENSMUSG00000078995

DomainStartEndE-ValueType
KRAB 2 62 3.07e-33 SMART
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.2%
  • 20x: 97.2%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 46 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2610021A01Rik T A 7: 41,275,516 (GRCm39) Y406* probably null Het
Acadvl T C 11: 69,905,159 (GRCm39) D109G probably benign Het
Adam24 G A 8: 41,134,542 (GRCm39) G670E probably damaging Het
Angpt1 T C 15: 42,323,136 (GRCm39) M378V probably benign Het
Ankrd33 G A 15: 101,014,993 (GRCm39) probably null Het
Apol7b G A 15: 77,307,625 (GRCm39) T290I probably benign Het
Atg4a-ps A G 3: 103,553,180 (GRCm39) W54R probably damaging Het
B3glct A G 5: 149,663,069 (GRCm39) probably null Het
Bmp7 A G 2: 172,714,706 (GRCm39) S368P probably damaging Het
Boc A G 16: 44,312,154 (GRCm39) V636A probably damaging Het
Cacna1i G A 15: 80,259,002 (GRCm39) R1237H probably damaging Het
Cdcp1 T C 9: 123,002,980 (GRCm39) D697G probably benign Het
Cep85l T C 10: 53,225,194 (GRCm39) T132A probably benign Het
Ces1b T A 8: 93,787,038 (GRCm39) Y447F probably damaging Het
Cfhr4 T G 1: 139,659,391 (GRCm39) N642H possibly damaging Het
Cntn4 A T 6: 106,674,544 (GRCm39) T1015S probably benign Het
Eea1 T G 10: 95,838,741 (GRCm39) probably null Het
Fcgbpl1 C T 7: 27,836,638 (GRCm39) R186C probably damaging Het
Hipk1 A T 3: 103,684,828 (GRCm39) N262K possibly damaging Het
Jmjd8 G A 17: 26,048,026 (GRCm39) R41H possibly damaging Het
Klhl3 T A 13: 58,178,259 (GRCm39) T344S probably damaging Het
Krt39 T C 11: 99,410,647 (GRCm39) D175G probably damaging Het
Map4k1 A G 7: 28,686,227 (GRCm39) Y81C probably damaging Het
Mpdu1 T A 11: 69,549,411 (GRCm39) T95S probably benign Het
Myl12b A T 17: 71,284,135 (GRCm39) I31N probably damaging Het
Ndufaf5 T A 2: 140,030,700 (GRCm39) Y195* probably null Het
Or4c119 G A 2: 88,987,157 (GRCm39) R121C possibly damaging Het
Or4d5 T C 9: 40,012,652 (GRCm39) I45V probably benign Het
Or51v15-ps1 A T 7: 103,278,790 (GRCm39) F126I probably benign Het
Or52z12 T A 7: 103,233,727 (GRCm39) I166N possibly damaging Het
Or5w17 A G 2: 87,584,223 (GRCm39) V38A probably benign Het
Oxgr1 T A 14: 120,259,431 (GRCm39) I259F possibly damaging Het
Pcdhb9 T A 18: 37,534,970 (GRCm39) D321E probably benign Het
Pi4kb G T 3: 94,900,461 (GRCm39) R392L probably damaging Het
Pramel18 G A 4: 101,767,291 (GRCm39) C180Y possibly damaging Het
Prss41 T C 17: 24,056,622 (GRCm39) K151R probably benign Het
Rev3l T A 10: 39,697,477 (GRCm39) V658D probably benign Het
Snx4 A G 16: 33,115,108 (GRCm39) I430V probably damaging Het
Tanc2 C T 11: 105,726,056 (GRCm39) H407Y possibly damaging Het
Tcf25 G A 8: 124,127,437 (GRCm39) probably null Het
Tsc22d1 A T 14: 76,743,923 (GRCm39) K24* probably null Het
Vmn2r30 A G 7: 7,315,547 (GRCm39) F762S probably damaging Het
Xrcc6 A G 15: 81,913,323 (GRCm39) T319A probably benign Het
Zbtb1 C T 12: 76,432,985 (GRCm39) R324* probably null Het
Zc3h7a A G 16: 10,963,535 (GRCm39) Y729H probably damaging Het
Zfp329 C A 7: 12,540,457 (GRCm39) probably benign Het
Other mutations in Zfp456
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01769:Zfp456 APN 13 67,515,272 (GRCm39) missense probably benign 0.06
IGL03200:Zfp456 APN 13 67,514,596 (GRCm39) missense probably benign
IGL03406:Zfp456 APN 13 67,514,450 (GRCm39) missense probably damaging 0.98
R0667:Zfp456 UTSW 13 67,514,861 (GRCm39) missense probably benign 0.00
R0729:Zfp456 UTSW 13 67,514,663 (GRCm39) missense probably damaging 1.00
R1731:Zfp456 UTSW 13 67,514,674 (GRCm39) missense probably benign 0.39
R1832:Zfp456 UTSW 13 67,515,482 (GRCm39) missense probably benign 0.09
R2011:Zfp456 UTSW 13 67,514,993 (GRCm39) nonsense probably null
R2022:Zfp456 UTSW 13 67,514,616 (GRCm39) nonsense probably null
R2023:Zfp456 UTSW 13 67,514,616 (GRCm39) nonsense probably null
R2438:Zfp456 UTSW 13 67,515,073 (GRCm39) missense probably damaging 1.00
R2516:Zfp456 UTSW 13 67,510,491 (GRCm39) missense probably benign 0.00
R2896:Zfp456 UTSW 13 67,515,416 (GRCm39) missense possibly damaging 0.52
R3964:Zfp456 UTSW 13 67,514,900 (GRCm39) missense probably benign 0.03
R4930:Zfp456 UTSW 13 67,515,065 (GRCm39) missense probably benign
R4971:Zfp456 UTSW 13 67,514,995 (GRCm39) missense probably benign 0.31
R5357:Zfp456 UTSW 13 67,520,328 (GRCm39) missense possibly damaging 0.71
R5754:Zfp456 UTSW 13 67,514,359 (GRCm39) missense probably benign 0.40
R5795:Zfp456 UTSW 13 67,515,039 (GRCm39) missense probably benign
R6339:Zfp456 UTSW 13 67,510,483 (GRCm39) nonsense probably null
R7071:Zfp456 UTSW 13 67,520,896 (GRCm39) missense probably damaging 1.00
R7690:Zfp456 UTSW 13 67,514,913 (GRCm39) missense probably damaging 1.00
R8228:Zfp456 UTSW 13 67,514,533 (GRCm39) missense probably damaging 1.00
R8410:Zfp456 UTSW 13 67,520,915 (GRCm39) missense probably damaging 1.00
R8507:Zfp456 UTSW 13 67,515,108 (GRCm39) missense probably damaging 1.00
R8745:Zfp456 UTSW 13 67,515,373 (GRCm39) missense possibly damaging 0.77
R8928:Zfp456 UTSW 13 67,514,603 (GRCm39) missense probably benign 0.00
R9331:Zfp456 UTSW 13 67,514,389 (GRCm39) missense probably damaging 0.98
Predicted Primers PCR Primer
(F):5'- AACAGTTCTGCTTTATGCCTGTAG -3'
(R):5'- GAAGACTGTGGCAGATGTTTC -3'

Sequencing Primer
(F):5'- CACACTATAGAACACATTGGTTGGG -3'
(R):5'- TGCAAGTCTTCAGGAGCATC -3'
Posted On 2018-11-06