Incidental Mutation 'R6905:Flrt1'
ID 538757
Institutional Source Beutler Lab
Gene Symbol Flrt1
Ensembl Gene ENSMUSG00000047787
Gene Name fibronectin leucine rich transmembrane protein 1
Synonyms D630040I23Rik
MMRRC Submission 044997-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.194) question?
Stock # R6905 (G1)
Quality Score 225.009
Status Validated
Chromosome 19
Chromosomal Location 7069366-7083094 bp(-) (GRCm39)
Type of Mutation nonsense
DNA Base Change (assembly) T to A at 7072757 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Lysine to Stop codon at position 597 (K597*)
Ref Sequence ENSEMBL: ENSMUSP00000109010 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000040261] [ENSMUST00000113383]
AlphaFold no structure available at present
Predicted Effect probably benign
Transcript: ENSMUST00000040261
SMART Domains Protein: ENSMUSP00000039507
Gene: ENSMUSG00000036278

DomainStartEndE-ValueType
low complexity region 9 21 N/A INTRINSIC
low complexity region 25 41 N/A INTRINSIC
low complexity region 59 74 N/A INTRINSIC
A1pp 151 281 7.67e-46 SMART
Predicted Effect probably null
Transcript: ENSMUST00000113383
AA Change: K597*
SMART Domains Protein: ENSMUSP00000109010
Gene: ENSMUSG00000047787
AA Change: K597*

DomainStartEndE-ValueType
low complexity region 2 28 N/A INTRINSIC
LRRNT 53 85 4.11e-6 SMART
LRR 127 149 2.61e1 SMART
LRR 150 175 4.71e1 SMART
LRR 177 199 1.76e1 SMART
LRR 200 220 7.36e0 SMART
LRR 221 246 1.49e1 SMART
LRR 247 270 9.77e1 SMART
LRR 271 292 1.53e1 SMART
LRR_TYP 293 316 3.55e-6 SMART
LRRCT 328 379 5.19e-9 SMART
low complexity region 381 392 N/A INTRINSIC
FN3 434 515 1.49e0 SMART
transmembrane domain 556 578 N/A INTRINSIC
Meta Mutation Damage Score 0.9755 question?
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.8%
  • 10x: 99.0%
  • 20x: 96.8%
Validation Efficiency 98% (44/45)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the fibronectin leucine rich transmembrane protein (FLRT) family. The family members may function in cell adhesion and/or receptor signalling. Their protein structures resemble small leucine-rich proteoglycans found in the extracellular matrix. The encoded protein shares sequence similarity with two other family members, FLRT2 and FLRT3. This gene is expressed in kidney and brain. [provided by RefSeq, Jul 2008]
PHENOTYPE: No notable phenotype was detected in a high-throughput screen of homozygous mice. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 45 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700025G04Rik G T 1: 151,856,189 (GRCm39) N59K probably damaging Het
Abi3bp A G 16: 56,394,880 (GRCm39) D196G probably damaging Het
Ankrd44 A G 1: 54,831,653 (GRCm39) F50S probably damaging Het
Arid4a C T 12: 71,108,318 (GRCm39) A41V probably benign Het
Cdk11b A T 4: 155,726,065 (GRCm39) probably benign Het
Chrm5 C A 2: 112,309,901 (GRCm39) C405F probably benign Het
Cimip2a A G 2: 25,110,491 (GRCm39) I100V probably benign Het
Col6a4 A T 9: 105,937,517 (GRCm39) probably null Het
Copb1 A C 7: 113,853,125 (GRCm39) I24S probably benign Het
Ctsh A T 9: 89,944,819 (GRCm39) K83N probably damaging Het
Dgkd A G 1: 87,863,097 (GRCm39) E48G probably damaging Het
Dis3l2 A G 1: 86,972,561 (GRCm39) T657A probably benign Het
Ifit1bl2 T C 19: 34,596,990 (GRCm39) S209G possibly damaging Het
Ifrd2 T C 9: 107,465,089 (GRCm39) M1T probably null Het
Ighv8-12 T C 12: 115,611,705 (GRCm39) Y73C probably benign Het
Klhl21 C A 4: 152,094,184 (GRCm39) A262E probably benign Het
L3mbtl4 A T 17: 69,084,883 (GRCm39) Y598F probably benign Het
Lad1 A G 1: 135,755,618 (GRCm39) K298R probably benign Het
Map2k2 A G 10: 80,944,701 (GRCm39) D71G probably damaging Het
Megf8 T A 7: 25,037,357 (GRCm39) H752Q probably benign Het
Mms22l A T 4: 24,503,107 (GRCm39) M200L probably benign Het
Mup5 C A 4: 61,751,340 (GRCm39) D103Y possibly damaging Het
Nes C T 3: 87,885,985 (GRCm39) P1371S probably damaging Het
Or4c10b A T 2: 89,712,052 (GRCm39) D294V probably benign Het
Or4f14c A T 2: 111,940,703 (GRCm39) M298K probably damaging Het
Or52z14 A T 7: 103,253,574 (GRCm39) T238S probably benign Het
Osbpl3 T C 6: 50,328,862 (GRCm39) I114V probably damaging Het
Pank3 T C 11: 35,667,239 (GRCm39) Y119H probably benign Het
Pcdhb15 C T 18: 37,607,748 (GRCm39) L327F possibly damaging Het
Pnpla8 T C 12: 44,330,336 (GRCm39) V78A probably damaging Het
Rbm14 A G 19: 4,853,264 (GRCm39) probably benign Het
Rev3l G A 10: 39,693,323 (GRCm39) V468M probably benign Het
Ripk1 A G 13: 34,211,973 (GRCm39) I428V probably benign Het
Rps5 T C 7: 12,659,785 (GRCm39) V147A probably damaging Het
Rps6ka2 T A 17: 7,495,340 (GRCm39) I9N probably damaging Het
Samd9l A T 6: 3,375,387 (GRCm39) F625I probably damaging Het
Sh3bp1 A G 15: 78,789,230 (GRCm39) D196G probably benign Het
Slc66a1 A G 4: 139,033,752 (GRCm39) probably null Het
Smg7 A T 1: 152,725,757 (GRCm39) probably null Het
Stap1 G A 5: 86,238,781 (GRCm39) E150K possibly damaging Het
Ticrr T C 7: 79,315,598 (GRCm39) I284T probably benign Het
Tm4sf1 T C 3: 57,202,330 (GRCm39) probably benign Het
Traf4 C T 11: 78,051,268 (GRCm39) R296Q probably benign Het
Trav7d-4 G T 14: 53,007,770 (GRCm39) A88S possibly damaging Het
Vwde T C 6: 13,205,926 (GRCm39) E207G probably damaging Het
Other mutations in Flrt1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00336:Flrt1 APN 19 7,074,277 (GRCm39) missense probably damaging 1.00
IGL01082:Flrt1 APN 19 7,073,339 (GRCm39) missense probably benign
IGL02535:Flrt1 APN 19 7,074,098 (GRCm39) missense probably benign 0.00
R0240:Flrt1 UTSW 19 7,074,475 (GRCm39) intron probably benign
R0240:Flrt1 UTSW 19 7,074,475 (GRCm39) intron probably benign
R0403:Flrt1 UTSW 19 7,073,284 (GRCm39) missense probably benign 0.01
R0645:Flrt1 UTSW 19 7,074,508 (GRCm39) intron probably benign
R0677:Flrt1 UTSW 19 7,073,544 (GRCm39) nonsense probably null
R1818:Flrt1 UTSW 19 7,072,711 (GRCm39) missense probably damaging 1.00
R2191:Flrt1 UTSW 19 7,073,194 (GRCm39) missense probably damaging 0.99
R2228:Flrt1 UTSW 19 7,072,723 (GRCm39) missense probably damaging 1.00
R2471:Flrt1 UTSW 19 7,073,856 (GRCm39) missense probably damaging 1.00
R4978:Flrt1 UTSW 19 7,074,241 (GRCm39) missense probably damaging 1.00
R5460:Flrt1 UTSW 19 7,073,105 (GRCm39) missense probably damaging 0.99
R5630:Flrt1 UTSW 19 7,073,830 (GRCm39) missense probably damaging 1.00
R6326:Flrt1 UTSW 19 7,073,974 (GRCm39) missense probably damaging 1.00
R6734:Flrt1 UTSW 19 7,073,524 (GRCm39) missense possibly damaging 0.91
R7239:Flrt1 UTSW 19 7,073,329 (GRCm39) missense probably benign 0.12
R7799:Flrt1 UTSW 19 7,073,229 (GRCm39) missense possibly damaging 0.78
R8168:Flrt1 UTSW 19 7,074,002 (GRCm39) missense probably damaging 1.00
X0024:Flrt1 UTSW 19 7,073,114 (GRCm39) missense probably damaging 1.00
X0062:Flrt1 UTSW 19 7,074,244 (GRCm39) missense probably benign 0.00
Predicted Primers PCR Primer
(F):5'- GTAGTCCACATCAGGGATGC -3'
(R):5'- GCAGATAGCTATGGCCCTAC -3'

Sequencing Primer
(F):5'- CGTGTGGTGCCATAGCCAATAG -3'
(R):5'- TGGCCCTACCACCACGC -3'
Posted On 2018-11-06