Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01019:Usp32'

53882

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Usp32

Ensembl Gene

ENSMUSG00000000804

Gene Name

ubiquitin specific peptidase 32

Synonyms

2900074J03Rik, 6430526O11Rik

Accession Numbers

Essential gene?

Essential (E-score: 1.000) question?

Stock #

IGL01019

Quality Score

Status

Chromosome

Chromosomal Location

84875268-85030987 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 84930091 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Valine to Alanine at position 562 (V562A)

Ref Sequence

ENSEMBL: ENSMUSP00000103710 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000108075] [ENSMUST00000172515]

AlphaFold

F8VPZ3

Predicted Effect

probably damaging
Transcript: ENSMUST00000108075
AA Change: V562A

PolyPhen 2 Score 0.972 (Sensitivity: 0.77; Specificity: 0.96)

SMART Domains

Protein: ENSMUSP00000103710
Gene: ENSMUSG00000000804
AA Change: V562A

Domain	Start	End	E-Value	Type
EFh	232	260	4.66e0	SMART
EFh	268	296	5.8e-1	SMART
Blast:EFh	318	346	5e-7	BLAST
DUSP	389	588	2.32e-16	SMART
Pfam:Ubiquitin_3	628	711	2.4e-9	PFAM
Pfam:UCH	733	1564	2.4e-83	PFAM
Pfam:UCH_1	1202	1547	2.9e-12	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000172515

SMART Domains

Protein: ENSMUSP00000133781
Gene: ENSMUSG00000000804

Domain	Start	End	E-Value	Type
Blast:DUSP	1	52	7e-30	BLAST
low complexity region	53	65	N/A	INTRINSIC

Predicted Effect

unknown
Transcript: ENSMUST00000174602
AA Change: V40A

SMART Domains

Protein: ENSMUSP00000134476
Gene: ENSMUSG00000000804
AA Change: V40A

Domain	Start	End	E-Value	Type
Pfam:DUSP	1	65	6.5e-17	PFAM
Pfam:Ubiquitin_3	122	216	8e-10	PFAM
Pfam:UCH	238	257	1.2e-7	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 50 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
9930022D16Rik	T	C	11: 109,308,737 (GRCm39)		probably benign	Het
Aatk	T	C	11: 119,903,101 (GRCm39)	S375G	probably benign	Het
Abcg8	T	C	17: 84,999,423 (GRCm39)	M173T	probably benign	Het
B3galt2	A	C	1: 143,522,495 (GRCm39)	R210S	probably benign	Het
Bltp1	G	T	3: 37,061,133 (GRCm39)		probably null	Het
Capn5	C	T	7: 97,784,971 (GRCm39)	A168T	probably damaging	Het
Cbx7	C	T	15: 79,814,829 (GRCm39)	G24D	probably damaging	Het
Ccdc7a	A	T	8: 129,788,099 (GRCm39)	S77T	probably benign	Het
Cd200r2	T	A	16: 44,729,832 (GRCm39)		probably benign	Het
Cdh11	T	C	8: 103,406,377 (GRCm39)	H32R	probably benign	Het
Chdh	A	T	14: 29,753,289 (GRCm39)	N66I	probably benign	Het
Clca3a2	G	A	3: 144,519,388 (GRCm39)	Q263*	probably null	Het
Dcc	T	C	18: 71,942,161 (GRCm39)	I319V	probably benign	Het
Depdc5	G	T	5: 33,050,745 (GRCm39)	M170I	probably damaging	Het
Dop1b	T	A	16: 93,607,117 (GRCm39)	L2140Q	probably benign	Het
Frem3	G	A	8: 81,341,763 (GRCm39)	G1352E	probably benign	Het
Fsd1l	T	A	4: 53,694,742 (GRCm39)	C389S	probably damaging	Het
Grin2c	C	T	11: 115,148,936 (GRCm39)	A221T	possibly damaging	Het
Gstz1	C	A	12: 87,210,575 (GRCm39)	P153T	probably damaging	Het
Itgb2	T	C	10: 77,378,237 (GRCm39)	S22P	possibly damaging	Het
Krt87	G	T	15: 101,336,312 (GRCm39)	Q114K	possibly damaging	Het
Krtap5-4	A	C	7: 141,857,647 (GRCm39)	S106R	unknown	Het
Lats1	T	C	10: 7,581,435 (GRCm39)	V740A	probably damaging	Het
Mcm9	C	A	10: 53,506,041 (GRCm39)	G78C	probably damaging	Het
Mn1	G	A	5: 111,569,413 (GRCm39)	E1128K	possibly damaging	Het
Myo1f	G	A	17: 33,811,977 (GRCm39)	R592H	possibly damaging	Het
Nfat5	G	T	8: 108,094,146 (GRCm39)	A277S	probably damaging	Het
Nfkbia	T	A	12: 55,537,327 (GRCm39)	Y254F	probably damaging	Het
Nr3c2	A	T	8: 77,635,843 (GRCm39)	N315Y	probably damaging	Het
Otof	T	C	5: 30,562,560 (GRCm39)	M258V	probably benign	Het
Panx3	C	T	9: 37,572,767 (GRCm39)	C261Y	probably damaging	Het
Pdia2	C	A	17: 26,417,896 (GRCm39)	G38W	probably damaging	Het
Psg19	G	T	7: 18,527,971 (GRCm39)	Y257*	probably null	Het
Ptpre	A	T	7: 135,280,054 (GRCm39)	K586*	probably null	Het
Reps1	A	G	10: 18,000,643 (GRCm39)	R752G	probably damaging	Het
Rpgrip1	T	A	14: 52,368,633 (GRCm39)	D277E	possibly damaging	Het
Rpl21-ps6	A	G	17: 56,222,671 (GRCm39)		noncoding transcript	Het
Serpinf2	T	A	11: 75,327,333 (GRCm39)	E198V	possibly damaging	Het
Sh3tc1	A	G	5: 35,860,719 (GRCm39)	L1046P	probably damaging	Het
Snw1	T	C	12: 87,497,711 (GRCm39)	E426G	probably benign	Het
Sord	T	A	2: 122,094,564 (GRCm39)	N317K	probably benign	Het
Taar3	A	T	10: 23,826,330 (GRCm39)	D292V	probably damaging	Het
Tdrd3	C	A	14: 87,709,618 (GRCm39)	T94K	probably damaging	Het
Ttn	C	A	2: 76,687,165 (GRCm39)	E736*	probably null	Het
Vmn1r169	T	G	7: 23,276,611 (GRCm39)	M1R	probably null	Het
Vmn2r3	C	T	3: 64,167,304 (GRCm39)	C609Y	probably damaging	Het
Vmn2r69	T	C	7: 85,055,739 (GRCm39)	T800A	probably benign	Het
Vmn2r72	G	A	7: 85,387,542 (GRCm39)	T674I	probably benign	Het
Zfp160	T	A	17: 21,241,088 (GRCm39)	M52K	possibly damaging	Het
Zfp607a	T	A	7: 27,578,042 (GRCm39)	C371S	probably damaging	Het

Other mutations in Usp32

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00529:Usp32	APN	11	84,885,252 (GRCm39)	missense	probably damaging	1.00
IGL00701:Usp32	APN	11	84,949,951 (GRCm39)	splice site	probably null
IGL00848:Usp32	APN	11	84,942,007 (GRCm39)	splice site	probably benign
IGL00934:Usp32	APN	11	84,897,902 (GRCm39)	missense	probably damaging	1.00
IGL01302:Usp32	APN	11	84,879,308 (GRCm39)	missense	probably benign	0.05
IGL01444:Usp32	APN	11	84,949,990 (GRCm39)	missense	probably damaging	0.97
IGL01575:Usp32	APN	11	84,913,628 (GRCm39)	missense	probably damaging	1.00
IGL01981:Usp32	APN	11	84,927,350 (GRCm39)	missense	probably benign	0.02
IGL02118:Usp32	APN	11	84,923,003 (GRCm39)	nonsense	probably null
IGL02159:Usp32	APN	11	84,896,628 (GRCm39)	splice site	probably null
IGL02227:Usp32	APN	11	84,877,307 (GRCm39)	missense	probably damaging	1.00
IGL02363:Usp32	APN	11	84,935,613 (GRCm39)	missense	probably benign	0.01
IGL02524:Usp32	APN	11	84,900,837 (GRCm39)	nonsense	probably null
IGL02613:Usp32	APN	11	84,930,896 (GRCm39)	missense	probably damaging	0.99
IGL02720:Usp32	APN	11	84,897,817 (GRCm39)	critical splice donor site	probably null
IGL02738:Usp32	APN	11	84,974,632 (GRCm39)	missense	probably damaging	1.00
IGL02929:Usp32	APN	11	84,879,198 (GRCm39)	missense	probably benign	0.01
IGL03303:Usp32	APN	11	84,913,658 (GRCm39)	missense	probably damaging	1.00
BB010:Usp32	UTSW	11	84,897,885 (GRCm39)	missense	probably damaging	1.00
BB020:Usp32	UTSW	11	84,897,885 (GRCm39)	missense	probably damaging	1.00
PIT4812001:Usp32	UTSW	11	84,900,900 (GRCm39)	missense	probably damaging	1.00
R0026:Usp32	UTSW	11	84,922,900 (GRCm39)	missense	possibly damaging	0.48
R0295:Usp32	UTSW	11	84,944,518 (GRCm39)	missense	probably damaging	0.98
R1320:Usp32	UTSW	11	84,908,619 (GRCm39)	missense	probably damaging	0.98
R1712:Usp32	UTSW	11	84,933,406 (GRCm39)	missense	probably benign	0.12
R1922:Usp32	UTSW	11	84,897,830 (GRCm39)	nonsense	probably null
R1973:Usp32	UTSW	11	84,994,757 (GRCm39)	missense	probably benign	0.09
R2010:Usp32	UTSW	11	84,930,830 (GRCm39)	missense	probably damaging	0.98
R2082:Usp32	UTSW	11	84,921,338 (GRCm39)	missense	probably damaging	0.99
R2355:Usp32	UTSW	11	84,896,735 (GRCm39)	missense	probably benign	0.34
R3147:Usp32	UTSW	11	84,919,913 (GRCm39)	missense	probably damaging	1.00
R3160:Usp32	UTSW	11	84,916,362 (GRCm39)	missense	probably damaging	0.97
R3162:Usp32	UTSW	11	84,916,362 (GRCm39)	missense	probably damaging	0.97
R3716:Usp32	UTSW	11	84,933,389 (GRCm39)	missense	probably damaging	1.00
R3816:Usp32	UTSW	11	84,885,210 (GRCm39)	critical splice donor site	probably null
R3870:Usp32	UTSW	11	84,897,881 (GRCm39)	nonsense	probably null
R3871:Usp32	UTSW	11	84,971,982 (GRCm39)	missense	probably null	0.81
R4041:Usp32	UTSW	11	84,908,565 (GRCm39)	missense	probably benign	0.40
R4079:Usp32	UTSW	11	84,930,055 (GRCm39)	missense	probably damaging	0.98
R4332:Usp32	UTSW	11	84,994,804 (GRCm39)	missense	possibly damaging	0.79
R4396:Usp32	UTSW	11	84,944,801 (GRCm39)	missense	probably benign
R4580:Usp32	UTSW	11	84,949,953 (GRCm39)	critical splice donor site	probably null
R4620:Usp32	UTSW	11	84,949,953 (GRCm39)	critical splice donor site	probably null
R4744:Usp32	UTSW	11	84,885,219 (GRCm39)	missense	probably damaging	1.00
R4909:Usp32	UTSW	11	84,946,598 (GRCm39)	nonsense	probably null
R5056:Usp32	UTSW	11	84,917,621 (GRCm39)	missense	probably benign	0.07
R5111:Usp32	UTSW	11	84,968,157 (GRCm39)	missense	possibly damaging	0.95
R5213:Usp32	UTSW	11	84,913,085 (GRCm39)	missense	probably damaging	1.00
R5308:Usp32	UTSW	11	84,908,544 (GRCm39)	missense	probably benign	0.12
R5381:Usp32	UTSW	11	84,949,953 (GRCm39)	critical splice donor site	probably benign
R5538:Usp32	UTSW	11	84,908,612 (GRCm39)	missense	possibly damaging	0.65
R5659:Usp32	UTSW	11	84,968,240 (GRCm39)	missense	possibly damaging	0.94
R6006:Usp32	UTSW	11	84,883,277 (GRCm39)	critical splice donor site	probably null
R6011:Usp32	UTSW	11	84,922,923 (GRCm39)	missense	possibly damaging	0.70
R6029:Usp32	UTSW	11	84,916,408 (GRCm39)	missense	probably damaging	0.99
R6074:Usp32	UTSW	11	84,885,399 (GRCm39)	missense	probably benign	0.00
R6331:Usp32	UTSW	11	84,877,402 (GRCm39)	missense	possibly damaging	0.92
R6353:Usp32	UTSW	11	84,913,107 (GRCm39)	missense	probably benign
R6714:Usp32	UTSW	11	84,917,696 (GRCm39)	missense	probably damaging	0.99
R6778:Usp32	UTSW	11	84,916,512 (GRCm39)	missense	probably benign	0.00
R6988:Usp32	UTSW	11	84,900,969 (GRCm39)	missense	probably benign	0.35
R6992:Usp32	UTSW	11	84,922,914 (GRCm39)	missense	probably damaging	0.99
R7182:Usp32	UTSW	11	84,930,996 (GRCm39)	missense	probably benign	0.34
R7186:Usp32	UTSW	11	84,942,060 (GRCm39)	missense	probably benign	0.45
R7198:Usp32	UTSW	11	84,913,681 (GRCm39)	frame shift	probably null
R7201:Usp32	UTSW	11	84,913,681 (GRCm39)	frame shift	probably null
R7469:Usp32	UTSW	11	84,879,379 (GRCm39)	missense	possibly damaging	0.94
R7502:Usp32	UTSW	11	84,913,724 (GRCm39)	missense	possibly damaging	0.48
R7513:Usp32	UTSW	11	84,917,938 (GRCm39)	nonsense	probably null
R7629:Usp32	UTSW	11	84,910,681 (GRCm39)	frame shift	probably null
R7703:Usp32	UTSW	11	84,968,153 (GRCm39)	missense	probably damaging	0.99
R7741:Usp32	UTSW	11	84,878,107 (GRCm39)	missense	probably damaging	0.99
R7765:Usp32	UTSW	11	84,885,234 (GRCm39)	missense	probably damaging	1.00
R7933:Usp32	UTSW	11	84,897,885 (GRCm39)	missense	probably damaging	1.00
R7973:Usp32	UTSW	11	84,913,634 (GRCm39)	missense	probably damaging	0.99
R7989:Usp32	UTSW	11	84,925,126 (GRCm39)	missense
R7998:Usp32	UTSW	11	84,885,252 (GRCm39)	missense	probably damaging	1.00
R8292:Usp32	UTSW	11	84,968,227 (GRCm39)	missense	probably damaging	0.99
R8305:Usp32	UTSW	11	84,923,011 (GRCm39)	missense	possibly damaging	0.83
R8548:Usp32	UTSW	11	84,908,653 (GRCm39)	missense	possibly damaging	0.52
R8924:Usp32	UTSW	11	84,916,370 (GRCm39)	missense	probably damaging	0.98
R9002:Usp32	UTSW	11	84,944,777 (GRCm39)	missense	probably damaging	0.96
R9145:Usp32	UTSW	11	84,913,118 (GRCm39)	missense	probably damaging	1.00
R9209:Usp32	UTSW	11	84,930,838 (GRCm39)	missense	probably damaging	0.98
R9211:Usp32	UTSW	11	84,913,559 (GRCm39)	missense	probably damaging	1.00
R9296:Usp32	UTSW	11	84,908,478 (GRCm39)	missense	probably damaging	1.00
R9310:Usp32	UTSW	11	84,942,028 (GRCm39)	missense	probably benign	0.29
R9417:Usp32	UTSW	11	84,885,369 (GRCm39)	missense	probably damaging	1.00
R9514:Usp32	UTSW	11	84,913,560 (GRCm39)	missense	probably damaging	0.99
R9652:Usp32	UTSW	11	84,921,317 (GRCm39)	missense	probably damaging	0.97
R9723:Usp32	UTSW	11	84,935,536 (GRCm39)	nonsense	probably null
R9757:Usp32	UTSW	11	84,968,155 (GRCm39)	nonsense	probably null
X0028:Usp32	UTSW	11	84,883,432 (GRCm39)	missense	probably benign	0.05
Z1177:Usp32	UTSW	11	84,879,438 (GRCm39)	nonsense	probably null

Posted On

2013-06-28