Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01016:Tcl1b1'

53910

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Tcl1b1

Ensembl Gene

ENSMUSG00000066359

Gene Name

T cell leukemia/lymphoma 1B, 1

Synonyms

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.088) question?

Stock #

IGL01016

Quality Score

Status

Chromosome

Chromosomal Location

105125963-105132884 bp(+) (GRCm39)

Type of Mutation

nonsense

DNA Base Change (assembly)

A to T at 105130663 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Arginine to Stop codon at position 49 (R49*)

Ref Sequence

ENSEMBL: ENSMUSP00000152806 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000085043] [ENSMUST00000222342]

AlphaFold

P56840

Predicted Effect

probably null
Transcript: ENSMUST00000085043
AA Change: R49*

SMART Domains

Protein: ENSMUSP00000082118
Gene: ENSMUSG00000066359
AA Change: R49*

Domain	Start	End	E-Value	Type
Pfam:TCL1_MTCP1	1	115	4.1e-38	PFAM

Predicted Effect

probably null
Transcript: ENSMUST00000222342
AA Change: R49*

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 30 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Cdh20	G	A	1: 110,036,686 (GRCm39)		probably null	Het
Dennd1c	T	C	17: 57,373,839 (GRCm39)	I575V	probably damaging	Het
Focad	G	A	4: 88,310,252 (GRCm39)	V1394I	possibly damaging	Het
Gldc	G	A	19: 30,110,893 (GRCm39)	S570F	possibly damaging	Het
Gm12695	T	A	4: 96,646,184 (GRCm39)	Y286F	probably benign	Het
Grid1	C	T	14: 34,544,596 (GRCm39)	Q56*	probably null	Het
Il7r	A	T	15: 9,510,294 (GRCm39)	V253E	probably damaging	Het
Iqgap3	T	C	3: 88,014,867 (GRCm39)	L861P	probably damaging	Het
Kcnc3	C	T	7: 44,244,810 (GRCm39)	R367W	probably damaging	Het
Lipt1	T	C	1: 37,914,264 (GRCm39)	Y107H	probably damaging	Het
Mep1a	T	C	17: 43,789,975 (GRCm39)	E445G	probably benign	Het
Mpo	A	G	11: 87,688,436 (GRCm39)		probably null	Het
Nme5	T	C	18: 34,711,712 (GRCm39)		probably null	Het
Or52n2	A	T	7: 104,542,243 (GRCm39)	N197K	probably damaging	Het
Or8b54	T	A	9: 38,686,737 (GRCm39)	F62Y	probably damaging	Het
Or8s8	T	A	15: 98,354,186 (GRCm39)		probably benign	Het
Papolg	A	T	11: 23,835,570 (GRCm39)	N83K	possibly damaging	Het
Picalm	A	T	7: 89,810,526 (GRCm39)	D111V	probably damaging	Het
Ppargc1a	T	A	5: 51,655,373 (GRCm39)		probably null	Het
Rnh1	G	T	7: 140,744,409 (GRCm39)		probably benign	Het
Rpgrip1	T	C	14: 52,383,293 (GRCm39)	Y576H	probably damaging	Het
Sobp	T	A	10: 42,898,874 (GRCm39)	Y237F	probably damaging	Het
Spink5	T	C	18: 44,140,711 (GRCm39)	Y637H	probably damaging	Het
St18	G	T	1: 6,914,547 (GRCm39)	G797V	probably damaging	Het
Tbx20	T	C	9: 24,661,617 (GRCm39)	D293G	probably damaging	Het
Tnfsf13b	A	G	8: 10,081,612 (GRCm39)	Q258R	probably damaging	Het
Vmn1r223	A	T	13: 23,434,237 (GRCm39)	Y277F	probably damaging	Het
Wdr62	T	C	7: 29,953,676 (GRCm39)	T146A	probably benign	Het
Zfp236	G	A	18: 82,686,815 (GRCm39)	A241V	probably benign	Het
Zfp318	T	C	17: 46,711,003 (GRCm39)	S909P	probably damaging	Het

Other mutations in Tcl1b1

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
R0781:Tcl1b1	UTSW	12	105,126,074 (GRCm39)	missense	probably damaging	0.97
R1110:Tcl1b1	UTSW	12	105,126,074 (GRCm39)	missense	probably damaging	0.97
R1962:Tcl1b1	UTSW	12	105,130,727 (GRCm39)	missense	probably benign	0.24
R2300:Tcl1b1	UTSW	12	105,130,783 (GRCm39)	missense	probably benign	0.13
R6548:Tcl1b1	UTSW	12	105,130,663 (GRCm39)	missense	probably benign	0.01
R7068:Tcl1b1	UTSW	12	105,125,952 (GRCm39)	unclassified	probably benign
R7257:Tcl1b1	UTSW	12	105,130,790 (GRCm39)	missense	probably damaging	1.00
R9493:Tcl1b1	UTSW	12	105,130,823 (GRCm39)	missense	probably damaging	0.97

Posted On

2013-06-28