Incidental Mutation 'R6913:Lipo3'
ID 539212
Institutional Source Beutler Lab
Gene Symbol Lipo3
Ensembl Gene ENSMUSG00000024766
Gene Name lipase, member O3
Synonyms Lipo1
MMRRC Submission 045034-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.054) question?
Stock # R6913 (G1)
Quality Score 225.009
Status Validated
Chromosome 19
Chromosomal Location 33532560-33568069 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to T at 33757705 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Isoleucine at position 255 (V255I)
Ref Sequence ENSEMBL: ENSMUSP00000136249 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000178735]
AlphaFold Q3UT41
Predicted Effect probably benign
Transcript: ENSMUST00000148137
SMART Domains Protein: ENSMUSP00000118385
Gene: ENSMUSG00000079342

DomainStartEndE-ValueType
signal peptide 1 19 N/A INTRINSIC
Pfam:Abhydro_lipase 37 99 2.8e-21 PFAM
Pfam:Hydrolase_4 76 239 4.3e-8 PFAM
Pfam:Abhydrolase_1 80 219 2.2e-17 PFAM
Pfam:Abhydrolase_5 80 233 8.7e-8 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000178735
AA Change: V255I

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
SMART Domains Protein: ENSMUSP00000136249
Gene: ENSMUSG00000079342
AA Change: V255I

DomainStartEndE-ValueType
Pfam:Abhydro_lipase 33 95 1.3e-20 PFAM
Pfam:Hydrolase_4 72 231 3.5e-8 PFAM
Pfam:Abhydrolase_5 76 370 3.7e-10 PFAM
Pfam:Abhydrolase_1 76 376 6.8e-21 PFAM
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.1%
  • 20x: 96.9%
Validation Efficiency 97% (74/76)
Allele List at MGI
Other mutations in this stock
Total: 76 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcc5 A T 16: 20,197,494 (GRCm39) I619N possibly damaging Het
Accsl T C 2: 93,696,488 (GRCm39) K41E possibly damaging Het
Actr6 T C 10: 89,562,558 (GRCm39) E107G probably damaging Het
Adam7 T A 14: 68,771,100 (GRCm39) M9L probably benign Het
Adamts12 T A 15: 11,215,778 (GRCm39) H266Q probably damaging Het
Adamts16 A G 13: 70,877,017 (GRCm39) F1208S possibly damaging Het
Ankrd11 T C 8: 123,621,650 (GRCm39) D734G probably benign Het
Ap1b1 T C 11: 4,962,972 (GRCm39) V43A possibly damaging Het
Asnsd1 A G 1: 53,387,390 (GRCm39) V79A probably damaging Het
Aste1 T A 9: 105,274,607 (GRCm39) S221R probably benign Het
Ccndbp1 G A 2: 120,840,347 (GRCm39) E94K probably benign Het
Cdc34 G A 10: 79,520,937 (GRCm39) probably null Het
Cdh16 T C 8: 105,348,896 (GRCm39) D67G probably benign Het
Chd8 T C 14: 52,451,951 (GRCm39) E1348G probably damaging Het
Chl1 C T 6: 103,642,909 (GRCm39) Q216* probably null Het
Cse1l G A 2: 166,771,797 (GRCm39) V353I possibly damaging Het
Ctbp2 G A 7: 132,616,455 (GRCm39) S160F possibly damaging Het
Cyp1a1 C A 9: 57,607,576 (GRCm39) T68K probably damaging Het
Dennd11 T C 6: 40,383,851 (GRCm39) N397S possibly damaging Het
Dlgap2 T A 8: 14,828,374 (GRCm39) M594K probably benign Het
Dnah6 C T 6: 73,189,505 (GRCm39) E48K probably benign Het
Dock2 A G 11: 34,647,049 (GRCm39) V35A probably damaging Het
Edem2 A T 2: 155,568,594 (GRCm39) S73R probably damaging Het
Eps15 T C 4: 109,218,427 (GRCm39) V430A probably benign Het
Frem2 T C 3: 53,424,242 (GRCm39) N3065S probably damaging Het
Gal3st4 A T 5: 138,269,090 (GRCm39) S123R possibly damaging Het
Garnl3 T A 2: 32,876,841 (GRCm39) I937F possibly damaging Het
Gfod2 C T 8: 106,443,995 (GRCm39) V183M possibly damaging Het
Glipr1l1 T C 10: 111,898,339 (GRCm39) probably null Het
Gm7145 T G 1: 117,913,711 (GRCm39) C198G probably damaging Het
Gvin2 G A 7: 105,551,187 (GRCm39) Q622* probably null Het
H2-Eb2 G A 17: 34,552,523 (GRCm39) A123T possibly damaging Het
Ighv1-55 T C 12: 115,172,129 (GRCm39) I7V probably benign Het
Itpripl2 G T 7: 118,090,332 (GRCm39) P76T possibly damaging Het
Kat6a C A 8: 23,393,215 (GRCm39) A231E possibly damaging Het
Mamstr A T 7: 45,292,662 (GRCm39) M141L probably benign Het
Med13 A G 11: 86,210,702 (GRCm39) V480A probably benign Het
Mei1 A G 15: 81,973,810 (GRCm39) N523S probably benign Het
Mill2 A G 7: 18,590,351 (GRCm39) T144A probably null Het
Muc16 C A 9: 18,553,959 (GRCm39) L4111F unknown Het
Mylk2 G A 2: 152,755,610 (GRCm39) G258E possibly damaging Het
Myom2 T G 8: 15,115,710 (GRCm39) S42A probably benign Het
Nab1 C A 1: 52,503,995 (GRCm39) G401C possibly damaging Het
Nifk T C 1: 118,260,592 (GRCm39) V244A possibly damaging Het
Nipsnap2 C A 5: 129,830,357 (GRCm39) Q224K probably benign Het
Nop16 T G 13: 54,737,553 (GRCm39) K47Q probably damaging Het
Nup153 A T 13: 46,853,192 (GRCm39) S548R probably damaging Het
Or2at1 A C 7: 99,416,924 (GRCm39) D185A probably damaging Het
Or4g17 A G 2: 111,209,347 (GRCm39) M1V probably null Het
Or5b111 A G 19: 13,290,998 (GRCm39) I217T probably benign Het
Pard6g G A 18: 80,160,534 (GRCm39) V216I possibly damaging Het
Pcdh20 C T 14: 88,706,038 (GRCm39) V421I probably benign Het
Pcif1 G A 2: 164,726,224 (GRCm39) probably null Het
Pde11a C A 2: 76,168,084 (GRCm39) V290F probably damaging Het
Pisd T C 5: 32,894,773 (GRCm39) Y511C probably damaging Het
Polg A T 7: 79,110,405 (GRCm39) D276E probably damaging Het
Polr3b T C 10: 84,549,496 (GRCm39) V906A probably damaging Het
Prkcg C T 7: 3,362,335 (GRCm39) P270S probably benign Het
Rapgef2 T A 3: 78,993,281 (GRCm39) I884F probably damaging Het
Rpl13 C A 8: 123,830,014 (GRCm39) N113K possibly damaging Het
Rxra T A 2: 27,631,186 (GRCm39) I139N probably damaging Het
Sf3b5 T A 10: 12,884,487 (GRCm39) C41S probably benign Het
Spata31e3 G T 13: 50,399,293 (GRCm39) P1011H probably damaging Het
Stk24 C T 14: 121,540,221 (GRCm39) R126Q probably damaging Het
Taar8b T C 10: 23,967,963 (GRCm39) D77G possibly damaging Het
Tbc1d1 T A 5: 64,468,452 (GRCm39) C566S probably benign Het
Tenm3 A T 8: 48,751,972 (GRCm39) M948K probably damaging Het
Thbs4 T A 13: 92,894,444 (GRCm39) Q693L possibly damaging Het
Tnfrsf26 A T 7: 143,172,126 (GRCm39) C61* probably null Het
Trp63 A G 16: 25,707,918 (GRCm39) E636G probably damaging Het
Try5 T C 6: 41,288,266 (GRCm39) Y121C probably damaging Het
Ttn G T 2: 76,660,755 (GRCm39) probably benign Het
Vamp1 T A 6: 125,195,908 (GRCm39) V55D probably damaging Het
Vmn2r117 T C 17: 23,698,537 (GRCm39) N12S probably damaging Het
Vmn2r90 G A 17: 17,924,323 (GRCm39) G41S probably damaging Het
Zfp462 T A 4: 55,007,775 (GRCm39) D71E probably benign Het
Other mutations in Lipo3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01521:Lipo3 APN 19 33,763,083 (GRCm39) missense probably damaging 1.00
IGL01697:Lipo3 APN 19 33,536,965 (GRCm39) missense probably damaging 1.00
IGL01916:Lipo3 APN 19 33,762,182 (GRCm39) missense probably damaging 1.00
IGL02027:Lipo3 APN 19 33,557,919 (GRCm39) nonsense probably null
IGL02047:Lipo3 APN 19 33,534,562 (GRCm39) missense probably benign 0.00
IGL02586:Lipo3 APN 19 33,559,539 (GRCm39) missense possibly damaging 0.95
IGL03005:Lipo3 APN 19 33,763,136 (GRCm39) missense possibly damaging 0.65
IGL03111:Lipo3 APN 19 33,559,637 (GRCm39) missense probably damaging 0.96
IGL03404:Lipo3 APN 19 33,560,440 (GRCm39) splice site probably benign
R0122:Lipo3 UTSW 19 33,600,086 (GRCm39) intron probably benign
R0128:Lipo3 UTSW 19 33,534,506 (GRCm39) critical splice donor site probably null
R0540:Lipo3 UTSW 19 33,536,967 (GRCm39) missense possibly damaging 0.62
R0551:Lipo3 UTSW 19 33,557,951 (GRCm39) missense probably damaging 1.00
R0568:Lipo3 UTSW 19 33,559,442 (GRCm39) splice site probably benign
R0646:Lipo3 UTSW 19 33,762,169 (GRCm39) nonsense probably null
R0669:Lipo3 UTSW 19 33,537,025 (GRCm39) missense probably benign 0.05
R1704:Lipo3 UTSW 19 33,757,743 (GRCm39) missense possibly damaging 0.87
R1772:Lipo3 UTSW 19 33,764,821 (GRCm39) missense probably benign 0.45
R1862:Lipo3 UTSW 19 33,762,092 (GRCm39) missense probably damaging 1.00
R1863:Lipo3 UTSW 19 33,762,092 (GRCm39) missense probably damaging 1.00
R2911:Lipo3 UTSW 19 33,556,767 (GRCm39) missense probably benign 0.00
R3801:Lipo3 UTSW 19 33,762,257 (GRCm39) missense probably damaging 0.99
R3802:Lipo3 UTSW 19 33,762,257 (GRCm39) missense probably damaging 0.99
R3803:Lipo3 UTSW 19 33,762,257 (GRCm39) missense probably damaging 0.99
R3973:Lipo3 UTSW 19 33,535,723 (GRCm39) missense probably damaging 1.00
R4020:Lipo3 UTSW 19 33,764,804 (GRCm39) missense probably benign 0.00
R4648:Lipo3 UTSW 19 33,760,860 (GRCm39) missense probably damaging 1.00
R4660:Lipo3 UTSW 19 33,598,360 (GRCm39) intron probably benign
R4775:Lipo3 UTSW 19 33,757,795 (GRCm39) missense probably damaging 1.00
R4787:Lipo3 UTSW 19 33,757,749 (GRCm39) missense probably benign 0.00
R4820:Lipo3 UTSW 19 33,560,497 (GRCm39) missense probably damaging 1.00
R4830:Lipo3 UTSW 19 33,753,987 (GRCm39) missense probably damaging 0.99
R4951:Lipo3 UTSW 19 33,759,621 (GRCm39) missense probably benign 0.01
R5117:Lipo3 UTSW 19 33,536,952 (GRCm39) missense probably benign
R5258:Lipo3 UTSW 19 33,591,243 (GRCm39) intron probably benign
R5799:Lipo3 UTSW 19 33,755,093 (GRCm39) intron probably benign
R5853:Lipo3 UTSW 19 33,759,630 (GRCm39) missense probably benign 0.37
R6235:Lipo3 UTSW 19 33,760,963 (GRCm39) missense probably damaging 0.96
R6296:Lipo3 UTSW 19 33,757,737 (GRCm39) missense probably benign 0.10
R6383:Lipo3 UTSW 19 33,533,831 (GRCm39) missense probably benign 0.02
R6659:Lipo3 UTSW 19 33,533,828 (GRCm39) missense possibly damaging 0.55
R6915:Lipo3 UTSW 19 33,562,293 (GRCm39) missense probably damaging 1.00
R7092:Lipo3 UTSW 19 33,591,092 (GRCm39) splice site probably null
R7444:Lipo3 UTSW 19 33,535,663 (GRCm39) critical splice donor site probably null
R7532:Lipo3 UTSW 19 33,560,464 (GRCm39) missense possibly damaging 0.90
R7672:Lipo3 UTSW 19 33,757,785 (GRCm39) missense probably benign 0.23
R7796:Lipo3 UTSW 19 33,759,634 (GRCm39) missense possibly damaging 0.75
R7945:Lipo3 UTSW 19 33,533,831 (GRCm39) missense probably benign 0.02
R8683:Lipo3 UTSW 19 33,759,604 (GRCm39) missense probably benign 0.04
R8936:Lipo3 UTSW 19 33,557,880 (GRCm39) missense probably damaging 1.00
R9062:Lipo3 UTSW 19 33,757,714 (GRCm39) missense probably damaging 1.00
R9086:Lipo3 UTSW 19 33,534,529 (GRCm39) missense probably benign 0.44
R9432:Lipo3 UTSW 19 33,533,864 (GRCm39) missense probably damaging 1.00
R9615:Lipo3 UTSW 19 33,754,047 (GRCm39) missense probably benign 0.02
R9620:Lipo3 UTSW 19 33,559,629 (GRCm39) nonsense probably null
Z1176:Lipo3 UTSW 19 33,562,328 (GRCm39) missense probably null 0.97
Predicted Primers PCR Primer
(F):5'- CCTGTGCTCTTATGGTGAGAAC -3'
(R):5'- CCTTTCAGCAGCACACAGTAG -3'

Sequencing Primer
(F):5'- CTCTTATGGTGAGAACTTGGAAAGC -3'
(R):5'- CCTTTCAGCAGCACACAGTAGTTTAG -3'
Posted On 2018-11-06