Incidental Mutation 'IGL01016:Vmn1r223'
| ID |
53938 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Vmn1r223
|
| Ensembl Gene |
ENSMUSG00000069280 |
| Gene Name |
vomeronasal 1 receptor 223 |
| Synonyms |
Gm11330 |
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.053)
|
| Stock # |
IGL01016
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
13 |
| Chromosomal Location |
23433408-23434493 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to T
at 23434237 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Tyrosine to Phenylalanine
at position 277
(Y277F)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000089312
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000091719]
|
| AlphaFold |
Q5SSA0 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000091719
AA Change: Y277F
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000089312
Gene: ENSMUSG00000069280
AA Change: Y277F
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
46 |
59 |
N/A |
INTRINSIC |
|
Pfam:TAS2R
|
63 |
355 |
6.6e-10 |
PFAM |
|
Pfam:V1R
|
94 |
357 |
2.1e-39 |
PFAM |
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 30 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Cdh20 |
G |
A |
1: 110,036,686 (GRCm39) |
|
probably null |
Het |
| Dennd1c |
T |
C |
17: 57,373,839 (GRCm39) |
I575V |
probably damaging |
Het |
| Focad |
G |
A |
4: 88,310,252 (GRCm39) |
V1394I |
possibly damaging |
Het |
| Gldc |
G |
A |
19: 30,110,893 (GRCm39) |
S570F |
possibly damaging |
Het |
| Gm12695 |
T |
A |
4: 96,646,184 (GRCm39) |
Y286F |
probably benign |
Het |
| Grid1 |
C |
T |
14: 34,544,596 (GRCm39) |
Q56* |
probably null |
Het |
| Il7r |
A |
T |
15: 9,510,294 (GRCm39) |
V253E |
probably damaging |
Het |
| Iqgap3 |
T |
C |
3: 88,014,867 (GRCm39) |
L861P |
probably damaging |
Het |
| Kcnc3 |
C |
T |
7: 44,244,810 (GRCm39) |
R367W |
probably damaging |
Het |
| Lipt1 |
T |
C |
1: 37,914,264 (GRCm39) |
Y107H |
probably damaging |
Het |
| Mep1a |
T |
C |
17: 43,789,975 (GRCm39) |
E445G |
probably benign |
Het |
| Mpo |
A |
G |
11: 87,688,436 (GRCm39) |
|
probably null |
Het |
| Nme5 |
T |
C |
18: 34,711,712 (GRCm39) |
|
probably null |
Het |
| Or52n2 |
A |
T |
7: 104,542,243 (GRCm39) |
N197K |
probably damaging |
Het |
| Or8b54 |
T |
A |
9: 38,686,737 (GRCm39) |
F62Y |
probably damaging |
Het |
| Or8s8 |
T |
A |
15: 98,354,186 (GRCm39) |
|
probably benign |
Het |
| Papolg |
A |
T |
11: 23,835,570 (GRCm39) |
N83K |
possibly damaging |
Het |
| Picalm |
A |
T |
7: 89,810,526 (GRCm39) |
D111V |
probably damaging |
Het |
| Ppargc1a |
T |
A |
5: 51,655,373 (GRCm39) |
|
probably null |
Het |
| Rnh1 |
G |
T |
7: 140,744,409 (GRCm39) |
|
probably benign |
Het |
| Rpgrip1 |
T |
C |
14: 52,383,293 (GRCm39) |
Y576H |
probably damaging |
Het |
| Sobp |
T |
A |
10: 42,898,874 (GRCm39) |
Y237F |
probably damaging |
Het |
| Spink5 |
T |
C |
18: 44,140,711 (GRCm39) |
Y637H |
probably damaging |
Het |
| St18 |
G |
T |
1: 6,914,547 (GRCm39) |
G797V |
probably damaging |
Het |
| Tbx20 |
T |
C |
9: 24,661,617 (GRCm39) |
D293G |
probably damaging |
Het |
| Tcl1b1 |
A |
T |
12: 105,130,663 (GRCm39) |
R49* |
probably null |
Het |
| Tnfsf13b |
A |
G |
8: 10,081,612 (GRCm39) |
Q258R |
probably damaging |
Het |
| Wdr62 |
T |
C |
7: 29,953,676 (GRCm39) |
T146A |
probably benign |
Het |
| Zfp236 |
G |
A |
18: 82,686,815 (GRCm39) |
A241V |
probably benign |
Het |
| Zfp318 |
T |
C |
17: 46,711,003 (GRCm39) |
S909P |
probably damaging |
Het |
|
| Other mutations in Vmn1r223 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00661:Vmn1r223
|
APN |
13 |
23,434,254 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01353:Vmn1r223
|
APN |
13 |
23,433,426 (GRCm39) |
missense |
unknown |
|
|
IGL01941:Vmn1r223
|
APN |
13 |
23,434,407 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
IGL02976:Vmn1r223
|
APN |
13 |
23,434,165 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03064:Vmn1r223
|
APN |
13 |
23,434,153 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03136:Vmn1r223
|
APN |
13 |
23,433,933 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
PIT4812001:Vmn1r223
|
UTSW |
13 |
23,434,060 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1468:Vmn1r223
|
UTSW |
13 |
23,434,038 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R1468:Vmn1r223
|
UTSW |
13 |
23,434,038 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R1592:Vmn1r223
|
UTSW |
13 |
23,433,837 (GRCm39) |
missense |
possibly damaging |
0.57 |
|
R1640:Vmn1r223
|
UTSW |
13 |
23,434,348 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2116:Vmn1r223
|
UTSW |
13 |
23,433,832 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3076:Vmn1r223
|
UTSW |
13 |
23,434,335 (GRCm39) |
missense |
probably benign |
0.15 |
|
R4229:Vmn1r223
|
UTSW |
13 |
23,433,585 (GRCm39) |
missense |
probably benign |
0.08 |
|
R4230:Vmn1r223
|
UTSW |
13 |
23,433,585 (GRCm39) |
missense |
probably benign |
0.08 |
|
R5420:Vmn1r223
|
UTSW |
13 |
23,433,675 (GRCm39) |
missense |
probably benign |
0.02 |
|
R6412:Vmn1r223
|
UTSW |
13 |
23,433,825 (GRCm39) |
missense |
probably benign |
0.05 |
|
R6424:Vmn1r223
|
UTSW |
13 |
23,434,345 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6607:Vmn1r223
|
UTSW |
13 |
23,433,919 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6944:Vmn1r223
|
UTSW |
13 |
23,433,483 (GRCm39) |
missense |
unknown |
|
|
R7256:Vmn1r223
|
UTSW |
13 |
23,434,036 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8241:Vmn1r223
|
UTSW |
13 |
23,433,982 (GRCm39) |
missense |
probably benign |
0.38 |
|
R8315:Vmn1r223
|
UTSW |
13 |
23,434,339 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8347:Vmn1r223
|
UTSW |
13 |
23,434,020 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8975:Vmn1r223
|
UTSW |
13 |
23,434,248 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
R9075:Vmn1r223
|
UTSW |
13 |
23,433,600 (GRCm39) |
missense |
possibly damaging |
0.50 |
|
| Posted On |
2013-06-28 |
Incidental Mutation