Incidental Mutation 'R6919:Zbtb39'
ID539513
Institutional Source Beutler Lab
Gene Symbol Zbtb39
Ensembl Gene ENSMUSG00000044617
Gene Namezinc finger and BTB domain containing 39
Synonyms
MMRRC Submission
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.155) question?
Stock #R6919 (G1)
Quality Score225.009
Status Validated
Chromosome10
Chromosomal Location127739538-127747349 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to G at 127741842 bp
ZygosityHeterozygous
Amino Acid Change Aspartic acid to Glycine at position 95 (D95G)
Ref Sequence ENSEMBL: ENSMUSP00000052717 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000054287]
Predicted Effect probably damaging
Transcript: ENSMUST00000054287
AA Change: D95G

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000052717
Gene: ENSMUSG00000044617
AA Change: D95G

DomainStartEndE-ValueType
BTB 30 126 9.15e-24 SMART
low complexity region 197 206 N/A INTRINSIC
low complexity region 213 229 N/A INTRINSIC
ZnF_C2H2 372 394 6.4e0 SMART
ZnF_C2H2 400 420 3.21e1 SMART
ZnF_C2H2 451 474 9.31e1 SMART
ZnF_C2H2 480 502 6.92e0 SMART
ZnF_C2H2 508 530 1.79e-2 SMART
ZnF_C2H2 538 560 1.18e-2 SMART
ZnF_C2H2 605 627 2.57e-3 SMART
ZnF_C2H2 633 655 3.78e-1 SMART
ZnF_C2H2 661 683 2.49e-1 SMART
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.3%
  • 20x: 97.8%
Validation Efficiency 99% (84/85)
Allele List at MGI
Other mutations in this stock
Total: 83 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700086D15Rik A G 11: 65,152,530 probably benign Het
4931408C20Rik T C 1: 26,682,934 Y1055C probably benign Het
6430548M08Rik T C 8: 120,145,482 S50P probably damaging Het
Aacs A G 5: 125,506,163 D261G probably benign Het
Abcc4 T A 14: 118,594,894 T775S probably benign Het
Acsl6 A G 11: 54,341,756 probably null Het
Agbl5 T A 5: 30,904,717 F196I probably benign Het
Ahnak2 T C 12: 112,774,684 T985A possibly damaging Het
Ak1 A T 2: 32,631,122 D101V possibly damaging Het
Alx1 A G 10: 103,025,200 Y156H probably damaging Het
Angptl7 T A 4: 148,500,031 S87C probably benign Het
Ankrd36 A G 11: 5,629,299 T188A probably benign Het
Arhgap11a A C 2: 113,839,709 S356R possibly damaging Het
Ascc3 G T 10: 50,645,753 E455* probably null Het
Atp6v0a2 G A 5: 124,712,161 probably null Het
B3gnt7 T C 1: 86,305,694 W104R probably damaging Het
Bbs9 G A 9: 22,812,544 probably null Het
Cc2d2a T A 5: 43,703,215 D544E probably benign Het
Cic C T 7: 25,271,777 T311I probably benign Het
Cngb1 T A 8: 95,248,375 R1157W probably null Het
Cntln A G 4: 85,115,368 H1310R probably benign Het
Cntnap5c A T 17: 58,293,953 I764F probably benign Het
Col26a1 T C 5: 136,744,234 Q362R possibly damaging Het
Cyp2c29 G A 19: 39,291,141 R100K probably benign Het
D17H6S53E C G 17: 35,127,246 D44E probably damaging Het
Dap3 A G 3: 88,930,989 V65A probably damaging Het
Dna2 A T 10: 62,957,003 I266F probably damaging Het
Dnah14 G A 1: 181,585,066 G57E probably benign Het
Dock9 A T 14: 121,643,152 V333E probably benign Het
Dpm1 A G 2: 168,230,275 Y27H probably damaging Het
Dsp A T 13: 38,167,655 Y150F possibly damaging Het
Emilin3 A T 2: 160,908,098 I577N probably damaging Het
Erap1 A G 13: 74,671,433 T189A probably benign Het
Fam208a T A 14: 27,449,801 L397* probably null Het
Fat2 A G 11: 55,282,771 I2372T possibly damaging Het
Fbn2 A T 18: 58,124,187 probably null Het
Gnl1 A T 17: 35,987,533 R390* probably null Het
Hivep1 A G 13: 42,183,452 I2336V probably benign Het
Il17rb C G 14: 30,004,271 probably null Het
Itga9 T C 9: 118,887,815 W396R probably damaging Het
Katnal2 A G 18: 77,011,038 V152A probably benign Het
Kcnk3 A G 5: 30,622,400 T265A probably benign Het
Klhl1 T C 14: 96,136,594 Y672C probably benign Het
Leng8 C A 7: 4,143,626 N412K possibly damaging Het
Lrrc9 T A 12: 72,506,393 F1356L probably benign Het
Map7 A G 10: 20,171,082 probably benign Het
Mei1 T C 15: 82,081,930 F251S probably damaging Het
Mia2 A G 12: 59,129,895 E9G possibly damaging Het
Ms4a13 C A 19: 11,171,885 W182C probably benign Het
Muc16 C T 9: 18,660,299 R308K unknown Het
Olfr1195 G A 2: 88,683,684 T16I possibly damaging Het
Olfr936 A G 9: 39,047,531 probably benign Het
Pcnt A G 10: 76,385,798 V1998A probably benign Het
Pgm1 A T 5: 64,097,025 N51I probably benign Het
Piezo1 T A 8: 122,490,281 H1333L probably damaging Het
Prg2 G A 2: 84,983,256 V199M probably damaging Het
Prss51 T C 14: 64,097,488 V182A probably damaging Het
Psmb9 A T 17: 34,183,225 Y132* probably null Het
Ralyl T C 3: 13,777,031 Y76H probably damaging Het
Rnaset2a A T 17: 8,130,282 D174E probably benign Het
Rnft1 G A 11: 86,495,330 probably null Het
Robo2 T C 16: 73,961,867 Y676C probably damaging Het
Samd9l T G 6: 3,376,313 Y316S possibly damaging Het
Siah3 T A 14: 75,456,138 F28Y possibly damaging Het
Slc28a3 C T 13: 58,573,443 probably null Het
Slc8a1 A G 17: 81,388,872 F911S probably damaging Het
Speg T A 1: 75,387,908 L156* probably null Het
Spopl T G 2: 23,517,861 M269L probably benign Het
Tacr1 C T 6: 82,557,073 T360I probably benign Het
Tmem262 A G 19: 6,080,737 E95G probably benign Het
Tmem68 G T 4: 3,569,669 T7N possibly damaging Het
Top3a T A 11: 60,749,493 I460F probably damaging Het
Trafd1 G A 5: 121,384,074 R5* probably null Het
Trim16 T A 11: 62,840,869 V435D possibly damaging Het
Tspan17 A G 13: 54,796,033 D236G probably damaging Het
Tssk2 A T 16: 17,899,701 M323L probably benign Het
Ubqln5 A G 7: 104,129,008 V203A probably benign Het
Utrn A T 10: 12,693,470 L1134* probably null Het
Vmn1r37 C T 6: 66,731,720 S73F possibly damaging Het
Vps13c A G 9: 67,927,452 K1688E probably damaging Het
Zfhx3 T A 8: 108,800,528 I1019N probably damaging Het
Zfp207 C T 11: 80,395,503 probably benign Het
Zmiz1 C T 14: 25,643,638 T169M probably damaging Het
Other mutations in Zbtb39
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01935:Zbtb39 APN 10 127742366 missense probably benign 0.00
R0636:Zbtb39 UTSW 10 127742835 missense probably benign 0.01
R0959:Zbtb39 UTSW 10 127742306 missense probably benign 0.31
R0959:Zbtb39 UTSW 10 127743062 missense probably damaging 1.00
R0962:Zbtb39 UTSW 10 127742306 missense probably benign 0.31
R0964:Zbtb39 UTSW 10 127742306 missense probably benign 0.31
R1188:Zbtb39 UTSW 10 127742306 missense probably benign 0.31
R1189:Zbtb39 UTSW 10 127742306 missense probably benign 0.31
R1239:Zbtb39 UTSW 10 127743069 missense probably damaging 1.00
R1341:Zbtb39 UTSW 10 127743500 missense possibly damaging 0.91
R1838:Zbtb39 UTSW 10 127742700 missense probably damaging 1.00
R2012:Zbtb39 UTSW 10 127742834 missense probably benign 0.43
R2167:Zbtb39 UTSW 10 127742975 missense probably benign 0.03
R2346:Zbtb39 UTSW 10 127741581 missense possibly damaging 0.49
R4041:Zbtb39 UTSW 10 127743554 missense probably damaging 1.00
R4171:Zbtb39 UTSW 10 127742367 missense possibly damaging 0.51
R4409:Zbtb39 UTSW 10 127742827 missense possibly damaging 0.51
R4410:Zbtb39 UTSW 10 127742827 missense possibly damaging 0.51
R4539:Zbtb39 UTSW 10 127742192 missense possibly damaging 0.90
R5761:Zbtb39 UTSW 10 127742646 missense probably damaging 1.00
R5766:Zbtb39 UTSW 10 127742688 missense probably damaging 1.00
R5812:Zbtb39 UTSW 10 127741560 start codon destroyed probably null 0.99
R6710:Zbtb39 UTSW 10 127743636 missense probably damaging 1.00
X0024:Zbtb39 UTSW 10 127741766 missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- GCTGAAGGAACTCAACAAGTGC -3'
(R):5'- GATCTACTGAGGGACAACTGAG -3'

Sequencing Primer
(F):5'- TCAGAGACCATGTGCGATGTCAC -3'
(R):5'- TGAGAGTGACACACTGGCTGTC -3'
Posted On2018-11-06