Mutagenetix > Incidental Mutation

Incidental Mutation 'R6921:Vmn2r73'

539640

Institutional Source

Beutler Lab

Gene Symbol

Vmn2r73

Ensembl Gene

ENSMUSG00000070458

Gene Name

vomeronasal 2, receptor 73

Synonyms

EG620928

MMRRC Submission

045006-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.141) question?

Stock #

R6921 (G1)

Quality Score

225.009

Status

Validated

Chromosome

Chromosomal Location

85506755-85525146 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to C at 85507446 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Valine to Glycine at position 622 (V622G)

Ref Sequence

ENSEMBL: ENSMUSP00000076687 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000077478]

AlphaFold

D3Z7M3

Predicted Effect

probably benign
Transcript: ENSMUST00000077478
AA Change: V622G

PolyPhen 2 Score 0.270 (Sensitivity: 0.91; Specificity: 0.88)

SMART Domains

Protein: ENSMUSP00000076687
Gene: ENSMUSG00000070458
AA Change: V622G

Domain	Start	End	E-Value	Type
signal peptide	1	18	N/A	INTRINSIC
Pfam:ANF_receptor	77	465	1.4e-30	PFAM
Pfam:NCD3G	508	560	5.9e-21	PFAM
Pfam:7tm_3	590	827	4.4e-51	PFAM

Coding Region Coverage

1x: 100.0%
3x: 99.8%
10x: 98.9%
20x: 96.4%

Validation Efficiency

96% (46/48)

Allele List at MGI

Other mutations in this stock

Total: 47 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1700017B05Rik	A	T	9: 57,166,019 (GRCm39)	H118Q	probably damaging	Het
Adgrl3	T	G	5: 81,796,560 (GRCm39)	V623G	probably damaging	Het
B9d2	A	G	7: 25,385,442 (GRCm39)	D84G	probably damaging	Het
Clec1a	A	T	6: 129,405,827 (GRCm39)	L268H	probably damaging	Het
Copa	A	T	1: 171,939,491 (GRCm39)	N576I	possibly damaging	Het
Cyp11b1	T	C	15: 74,712,798 (GRCm39)	T88A	probably benign	Het
Dis3l2	T	C	1: 86,785,063 (GRCm39)	I318T	probably benign	Het
Dmtf1	T	C	5: 9,180,654 (GRCm39)		probably benign	Het
Dnah17	C	A	11: 117,932,310 (GRCm39)	A3639S	probably damaging	Het
Dnajc8	T	A	4: 132,272,031 (GRCm39)	I89N	probably damaging	Het
Dync2h1	T	A	9: 7,102,549 (GRCm39)	H377L	probably benign	Het
Erfe	T	A	1: 91,298,054 (GRCm39)	I212N	probably benign	Het
Fam117b	A	G	1: 59,992,094 (GRCm39)	T248A	probably damaging	Het
Fbxo10	A	T	4: 45,044,849 (GRCm39)	N595K	probably damaging	Het
Fzd10	T	A	5: 128,678,646 (GRCm39)	M122K	probably damaging	Het
Gpr15	C	T	16: 58,538,144 (GRCm39)	R315H	probably benign	Het
Gvin2	G	A	7: 105,551,187 (GRCm39)	Q622*	probably null	Het
H6pd	T	C	4: 150,066,508 (GRCm39)	D626G	probably damaging	Het
Hexd	A	G	11: 121,113,107 (GRCm39)	D514G	probably damaging	Het
Hoxd4	T	C	2: 74,558,836 (GRCm39)	S220P	possibly damaging	Het
Invs	A	G	4: 48,396,260 (GRCm39)	H311R	possibly damaging	Het
Ip6k1	A	G	9: 107,901,634 (GRCm39)	T70A	probably damaging	Het
Lipt2	T	C	7: 99,809,578 (GRCm39)	C222R	probably damaging	Het
Lrrc3	T	A	10: 77,736,866 (GRCm39)	D190V	probably damaging	Het
Marchf10	T	C	11: 105,280,603 (GRCm39)	T561A	probably benign	Het
Mcm10	G	A	2: 5,005,746 (GRCm39)	T463I	probably benign	Het
Mideas	A	G	12: 84,203,233 (GRCm39)	S890P	probably damaging	Het
Mmel1	T	C	4: 154,966,134 (GRCm39)	L52P	probably damaging	Het
Nipbl	T	C	15: 8,332,969 (GRCm39)	N2218S	probably benign	Het
Nr4a3	C	T	4: 48,051,486 (GRCm39)	P80L	probably benign	Het
Nrip1	C	T	16: 76,089,476 (GRCm39)	G694R	possibly damaging	Het
Oit3	A	T	10: 59,271,767 (GRCm39)	C197S	probably damaging	Het
Or5al1	C	T	2: 85,990,196 (GRCm39)	V173M	probably benign	Het
Or8b1b	A	G	9: 38,375,543 (GRCm39)	I69V	probably benign	Het
Otol1	A	G	3: 69,935,433 (GRCm39)	E475G	possibly damaging	Het
Pes1	T	C	11: 3,923,330 (GRCm39)	F168L	probably damaging	Het
Plch1	C	T	3: 63,615,155 (GRCm39)	R780H	possibly damaging	Het
Pxdn	C	G	12: 30,065,504 (GRCm39)	P1275A	probably damaging	Het
Sgcz	T	C	8: 37,993,443 (GRCm39)	E218G	probably damaging	Het
Slc27a5	A	T	7: 12,725,135 (GRCm39)	N437K	probably damaging	Het
Sult2b1	A	G	7: 45,384,612 (GRCm39)	S155P	probably damaging	Het
Tgfbrap1	T	C	1: 43,091,056 (GRCm39)	M690V	probably benign	Het
Tmem151a	A	T	19: 5,133,119 (GRCm39)	L29Q	probably damaging	Het
Tmprss2	A	G	16: 97,369,637 (GRCm39)	I379T	probably damaging	Het
Vmn1r168	T	A	7: 23,240,323 (GRCm39)	V60E	probably damaging	Het
Wdr72	A	G	9: 74,117,928 (GRCm39)	H880R	probably benign	Het
Zfhx3	A	G	8: 109,678,024 (GRCm39)	T3025A	possibly damaging	Het

Other mutations in Vmn2r73

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00158:Vmn2r73	APN	7	85,506,795 (GRCm39)	missense
IGL01151:Vmn2r73	APN	7	85,507,086 (GRCm39)	missense	probably damaging	0.99
IGL01408:Vmn2r73	APN	7	85,521,455 (GRCm39)	missense	probably benign	0.45
IGL01505:Vmn2r73	APN	7	85,507,267 (GRCm39)	nonsense	probably null
IGL01731:Vmn2r73	APN	7	85,506,757 (GRCm39)	makesense	probably null
IGL01818:Vmn2r73	APN	7	85,519,109 (GRCm39)	splice site	probably benign
IGL02236:Vmn2r73	APN	7	85,521,902 (GRCm39)	missense	probably benign	0.00
IGL02265:Vmn2r73	APN	7	85,520,847 (GRCm39)	missense	probably benign	0.02
IGL02266:Vmn2r73	APN	7	85,525,007 (GRCm39)	missense	possibly damaging	0.52
IGL02276:Vmn2r73	APN	7	85,518,980 (GRCm39)	critical splice donor site	probably null
IGL02284:Vmn2r73	APN	7	85,507,123 (GRCm39)	missense	possibly damaging	0.92
IGL02380:Vmn2r73	APN	7	85,507,383 (GRCm39)	missense	probably benign	0.00
IGL02466:Vmn2r73	APN	7	85,522,084 (GRCm39)	missense	probably damaging	1.00
IGL03172:Vmn2r73	APN	7	85,507,495 (GRCm39)	missense	probably benign	0.01
IGL03179:Vmn2r73	APN	7	85,519,468 (GRCm39)	missense	probably benign	0.04
G1Funyon:Vmn2r73	UTSW	7	85,507,510 (GRCm39)	missense	probably benign	0.00
R0077:Vmn2r73	UTSW	7	85,525,075 (GRCm39)	missense	probably benign	0.00
R0311:Vmn2r73	UTSW	7	85,520,997 (GRCm39)	missense	probably benign
R0413:Vmn2r73	UTSW	7	85,521,087 (GRCm39)	missense	possibly damaging	0.68
R0494:Vmn2r73	UTSW	7	85,522,140 (GRCm39)	missense	probably benign
R1523:Vmn2r73	UTSW	7	85,519,486 (GRCm39)	missense	probably benign	0.02
R1618:Vmn2r73	UTSW	7	85,525,120 (GRCm39)	nonsense	probably null
R1667:Vmn2r73	UTSW	7	85,506,889 (GRCm39)	missense	probably benign	0.00
R1728:Vmn2r73	UTSW	7	85,507,086 (GRCm39)	missense	probably damaging	1.00
R1729:Vmn2r73	UTSW	7	85,507,086 (GRCm39)	missense	probably damaging	1.00
R1747:Vmn2r73	UTSW	7	85,507,375 (GRCm39)	missense	probably damaging	1.00
R1784:Vmn2r73	UTSW	7	85,507,086 (GRCm39)	missense	probably damaging	1.00
R2152:Vmn2r73	UTSW	7	85,506,936 (GRCm39)	missense	probably benign	0.03
R2395:Vmn2r73	UTSW	7	85,506,975 (GRCm39)	missense	probably damaging	1.00
R2415:Vmn2r73	UTSW	7	85,521,431 (GRCm39)	missense	probably damaging	1.00
R2926:Vmn2r73	UTSW	7	85,520,871 (GRCm39)	missense	probably benign	0.17
R3719:Vmn2r73	UTSW	7	85,519,582 (GRCm39)	missense	probably damaging	1.00
R3766:Vmn2r73	UTSW	7	85,521,198 (GRCm39)	missense	probably benign
R3838:Vmn2r73	UTSW	7	85,507,258 (GRCm39)	missense	probably benign	0.00
R3890:Vmn2r73	UTSW	7	85,507,144 (GRCm39)	missense	probably benign
R4030:Vmn2r73	UTSW	7	85,521,044 (GRCm39)	missense	possibly damaging	0.92
R4247:Vmn2r73	UTSW	7	85,521,883 (GRCm39)	missense	probably damaging	0.99
R4409:Vmn2r73	UTSW	7	85,520,768 (GRCm39)	missense	probably damaging	0.97
R4427:Vmn2r73	UTSW	7	85,506,981 (GRCm39)	missense	probably damaging	1.00
R4430:Vmn2r73	UTSW	7	85,519,449 (GRCm39)	missense	probably benign
R4552:Vmn2r73	UTSW	7	85,525,055 (GRCm39)	missense	probably benign	0.12
R4779:Vmn2r73	UTSW	7	85,520,923 (GRCm39)	nonsense	probably null
R4906:Vmn2r73	UTSW	7	85,506,829 (GRCm39)	missense	probably damaging	0.99
R4942:Vmn2r73	UTSW	7	85,519,582 (GRCm39)	missense	probably damaging	1.00
R5280:Vmn2r73	UTSW	7	85,507,155 (GRCm39)	missense	probably damaging	0.98
R5344:Vmn2r73	UTSW	7	85,525,046 (GRCm39)	missense	probably benign	0.00
R5478:Vmn2r73	UTSW	7	85,518,996 (GRCm39)	missense	probably damaging	1.00
R5527:Vmn2r73	UTSW	7	85,507,575 (GRCm39)	missense	possibly damaging	0.65
R5691:Vmn2r73	UTSW	7	85,507,299 (GRCm39)	missense	probably damaging	1.00
R5826:Vmn2r73	UTSW	7	85,524,956 (GRCm39)	missense	possibly damaging	0.77
R6018:Vmn2r73	UTSW	7	85,521,875 (GRCm39)	missense	possibly damaging	0.48
R6082:Vmn2r73	UTSW	7	85,507,429 (GRCm39)	missense	probably benign	0.00
R6111:Vmn2r73	UTSW	7	85,520,997 (GRCm39)	missense	probably benign
R6233:Vmn2r73	UTSW	7	85,519,099 (GRCm39)	missense	probably benign	0.00
R6278:Vmn2r73	UTSW	7	85,522,140 (GRCm39)	missense	probably benign
R6283:Vmn2r73	UTSW	7	85,521,049 (GRCm39)	missense	probably benign	0.00
R6307:Vmn2r73	UTSW	7	85,506,828 (GRCm39)	missense	probably damaging	1.00
R6413:Vmn2r73	UTSW	7	85,519,544 (GRCm39)	nonsense	probably null
R6782:Vmn2r73	UTSW	7	85,519,563 (GRCm39)	missense	probably benign	0.00
R6884:Vmn2r73	UTSW	7	85,507,213 (GRCm39)	missense	probably benign	0.05
R7169:Vmn2r73	UTSW	7	85,507,663 (GRCm39)	nonsense	probably null
R7206:Vmn2r73	UTSW	7	85,522,075 (GRCm39)	missense	probably benign	0.03
R7311:Vmn2r73	UTSW	7	85,521,192 (GRCm39)	missense	possibly damaging	0.80
R7650:Vmn2r73	UTSW	7	85,521,147 (GRCm39)	missense	probably benign
R7811:Vmn2r73	UTSW	7	85,524,956 (GRCm39)	missense	possibly damaging	0.77
R8263:Vmn2r73	UTSW	7	85,507,619 (GRCm39)	missense	probably benign
R8301:Vmn2r73	UTSW	7	85,507,510 (GRCm39)	missense	probably benign	0.00
R8341:Vmn2r73	UTSW	7	85,507,128 (GRCm39)	missense	probably benign	0.01
R8500:Vmn2r73	UTSW	7	85,519,638 (GRCm39)	missense	probably benign	0.01
R8673:Vmn2r73	UTSW	7	85,521,902 (GRCm39)	missense	probably benign	0.01
R8719:Vmn2r73	UTSW	7	85,521,095 (GRCm39)	missense	probably damaging	0.96
R8783:Vmn2r73	UTSW	7	85,507,668 (GRCm39)	missense	probably damaging	0.96
R8828:Vmn2r73	UTSW	7	85,521,179 (GRCm39)	missense	probably damaging	0.98
R8860:Vmn2r73	UTSW	7	85,522,149 (GRCm39)	splice site	probably benign
R9002:Vmn2r73	UTSW	7	85,507,284 (GRCm39)	missense	probably benign	0.32
R9008:Vmn2r73	UTSW	7	85,521,904 (GRCm39)	missense	probably damaging	0.96
R9159:Vmn2r73	UTSW	7	85,521,931 (GRCm39)	missense	possibly damaging	0.90
R9180:Vmn2r73	UTSW	7	85,507,123 (GRCm39)	missense	probably benign	0.07
R9198:Vmn2r73	UTSW	7	85,518,987 (GRCm39)	missense	probably benign	0.01
R9329:Vmn2r73	UTSW	7	85,519,073 (GRCm39)	missense	probably benign
R9448:Vmn2r73	UTSW	7	85,522,027 (GRCm39)	missense	probably benign	0.00
R9463:Vmn2r73	UTSW	7	85,506,795 (GRCm39)	missense
R9589:Vmn2r73	UTSW	7	85,519,659 (GRCm39)	missense	probably benign	0.03
X0023:Vmn2r73	UTSW	7	85,507,664 (GRCm39)	missense	probably benign	0.31
Z1176:Vmn2r73	UTSW	7	85,521,176 (GRCm39)	missense	probably damaging	0.99
Z1177:Vmn2r73	UTSW	7	85,521,480 (GRCm39)	missense	probably damaging	1.00

Predicted Primers

PCR Primer
(F):5'- TGGGACAGTGACCTTGAAGG -3'
(R):5'- GATATGGATCAGTGTGTGAAATGTCC -3'

Sequencing Primer
(F):5'- GTGACCTTGAAGGCCAGTACTAC -3'
(R):5'- TATGCCAATGAAGACCATACTCTCTG -3'

Posted On

2018-11-06