Incidental Mutation 'R6922:Or5w12'
ID 539668
Institutional Source Beutler Lab
Gene Symbol Or5w12
Ensembl Gene ENSMUSG00000075153
Gene Name olfactory receptor family 5 subfamily W member 12
Synonyms GA_x6K02T2Q125-49177531-49176599, MOR177-2, Olfr1135
MMRRC Submission 045041-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.070) question?
Stock # R6922 (G1)
Quality Score 225.009
Status Not validated
Chromosome 2
Chromosomal Location 87501777-87502709 bp(-) (GRCm39)
Type of Mutation nonsense
DNA Base Change (assembly) T to A at 87501797 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Lysine to Stop codon at position 305 (K305*)
Ref Sequence ENSEMBL: ENSMUSP00000150079 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000099853] [ENSMUST00000213835]
AlphaFold Q7TR42
Predicted Effect probably null
Transcript: ENSMUST00000099853
AA Change: K305*
SMART Domains Protein: ENSMUSP00000097439
Gene: ENSMUSG00000075153
AA Change: K305*

DomainStartEndE-ValueType
Pfam:7tm_4 31 307 3e-44 PFAM
Pfam:7tm_1 41 290 1.6e-17 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000213835
AA Change: K305*
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.3%
  • 20x: 97.7%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 44 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Ago2 T C 15: 72,985,601 (GRCm39) I665V probably benign Het
Aoc1l3 T G 6: 48,964,508 (GRCm39) F172C probably damaging Het
Arhgap32 A T 9: 32,063,983 (GRCm39) M74L possibly damaging Het
Asb4 T C 6: 5,398,304 (GRCm39) C90R possibly damaging Het
B3galt4 T A 17: 34,169,821 (GRCm39) D139V probably damaging Het
Camta2 A C 11: 70,564,964 (GRCm39) I852S probably benign Het
Cd200l1 A T 16: 45,264,294 (GRCm39) M88K probably benign Het
Cox4i2 G T 2: 152,599,015 (GRCm39) E57D probably benign Het
Dip2b T C 15: 100,091,724 (GRCm39) I1055T probably benign Het
Eif1ad18 T A 12: 88,050,602 (GRCm39) W46R probably benign Het
Eif4g3 C T 4: 137,824,646 (GRCm39) P284S probably damaging Het
Ephb1 C A 9: 101,806,463 (GRCm39) probably null Het
Fbxw7 A T 3: 84,879,723 (GRCm39) probably null Het
Frem1 C A 4: 82,840,506 (GRCm39) D1789Y probably damaging Het
Gm29106 A T 1: 118,127,524 (GRCm39) R405S probably damaging Het
Greb1l G A 18: 10,547,482 (GRCm39) V1567M possibly damaging Het
Hapstr1 A G 16: 8,648,553 (GRCm39) probably null Het
Heatr1 C A 13: 12,449,956 (GRCm39) D1983E probably benign Het
Lhfpl2 G T 13: 94,311,029 (GRCm39) A100S probably damaging Het
Lrp5 A T 19: 3,655,301 (GRCm39) V1073D probably damaging Het
Naip6 G A 13: 100,438,706 (GRCm39) L364F possibly damaging Het
Nek9 A G 12: 85,350,311 (GRCm39) L921P probably damaging Het
Nim1k C T 13: 120,189,263 (GRCm39) E49K probably damaging Het
Nsun5 A C 5: 135,399,046 (GRCm39) N32T probably damaging Het
Nuggc T C 14: 65,855,092 (GRCm39) S325P probably damaging Het
Or2d36 A G 7: 106,747,290 (GRCm39) I256V probably damaging Het
Pcdhga7 A G 18: 37,848,710 (GRCm39) D239G probably damaging Het
Pld2 A G 11: 70,444,273 (GRCm39) D523G probably benign Het
Prokr1 C A 6: 87,565,455 (GRCm39) W130L probably damaging Het
Prpf8 A G 11: 75,381,562 (GRCm39) N266S probably damaging Het
Rdh10 T C 1: 16,176,255 (GRCm39) V5A probably benign Het
Rp1l1 T C 14: 64,267,834 (GRCm39) L1140P possibly damaging Het
Sacs A G 14: 61,448,874 (GRCm39) D3640G probably damaging Het
Smarca2 A G 19: 26,668,749 (GRCm39) E916G probably damaging Het
Steap3 A T 1: 120,171,624 (GRCm39) H160Q probably damaging Het
Tlk2 T C 11: 105,147,779 (GRCm39) probably null Het
Tmprss4 A G 9: 45,097,220 (GRCm39) V15A probably benign Het
Togaram2 T C 17: 72,014,129 (GRCm39) L559P probably damaging Het
Topbp1 T A 9: 103,213,045 (GRCm39) L990H probably damaging Het
Ttll7 A G 3: 146,615,369 (GRCm39) T278A possibly damaging Het
Ttn G A 2: 76,604,780 (GRCm39) L18385F probably damaging Het
Upf3a G T 8: 13,841,911 (GRCm39) A149S probably damaging Het
Vmn2r111 T C 17: 22,778,032 (GRCm39) N549S possibly damaging Het
Zfp316 A T 5: 143,239,280 (GRCm39) F913Y probably damaging Het
Other mutations in Or5w12
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00952:Or5w12 APN 2 87,502,159 (GRCm39) missense probably damaging 0.99
IGL03158:Or5w12 APN 2 87,502,135 (GRCm39) missense probably benign 0.14
R0559:Or5w12 UTSW 2 87,502,244 (GRCm39) missense possibly damaging 0.54
R1288:Or5w12 UTSW 2 87,501,916 (GRCm39) missense probably benign 0.01
R2278:Or5w12 UTSW 2 87,502,289 (GRCm39) missense possibly damaging 0.63
R2304:Or5w12 UTSW 2 87,502,238 (GRCm39) missense probably benign 0.01
R4328:Or5w12 UTSW 2 87,502,008 (GRCm39) missense possibly damaging 0.52
R5094:Or5w12 UTSW 2 87,502,174 (GRCm39) missense possibly damaging 0.90
R7042:Or5w12 UTSW 2 87,501,935 (GRCm39) missense possibly damaging 0.90
R8824:Or5w12 UTSW 2 87,502,304 (GRCm39) missense possibly damaging 0.90
R8919:Or5w12 UTSW 2 87,502,567 (GRCm39) missense probably damaging 1.00
R9142:Or5w12 UTSW 2 87,502,313 (GRCm39) missense probably benign 0.00
R9394:Or5w12 UTSW 2 87,502,094 (GRCm39) missense probably benign 0.01
R9712:Or5w12 UTSW 2 87,502,105 (GRCm39) missense probably benign 0.06
Predicted Primers PCR Primer
(F):5'- AAAGCTGAACCTGTCGAAGATTC -3'
(R):5'- CATTTTCCAGGGAACACTGC -3'

Sequencing Primer
(F):5'- TCTCCAAAATTAAAGTGCCATGC -3'
(R):5'- AGGGAACACTGCTCTTCATG -3'
Posted On 2018-11-06