Incidental Mutation 'R6922:Prokr1'
ID 539678
Institutional Source Beutler Lab
Gene Symbol Prokr1
Ensembl Gene ENSMUSG00000049409
Gene Name prokineticin receptor 1
Synonyms Pkr1, Gpr73, EG-VEGFR1
MMRRC Submission 045041-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R6922 (G1)
Quality Score 225.009
Status Not validated
Chromosome 6
Chromosomal Location 87555573-87567725 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to A at 87565455 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tryptophan to Leucine at position 130 (W130L)
Ref Sequence ENSEMBL: ENSMUSP00000144999 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000050887] [ENSMUST00000203636] [ENSMUST00000204682]
AlphaFold Q9JKL1
Predicted Effect probably damaging
Transcript: ENSMUST00000050887
AA Change: W130L

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000059034
Gene: ENSMUSG00000049409
AA Change: W130L

DomainStartEndE-ValueType
Pfam:7TM_GPCR_Srsx 73 360 8.8e-8 PFAM
Pfam:7tm_1 79 342 7.2e-47 PFAM
Predicted Effect unknown
Transcript: ENSMUST00000203636
AA Change: G92W
SMART Domains Protein: ENSMUSP00000145476
Gene: ENSMUSG00000049409
AA Change: G92W

DomainStartEndE-ValueType
low complexity region 100 113 N/A INTRINSIC
Predicted Effect probably damaging
Transcript: ENSMUST00000204682
AA Change: W130L

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000144999
Gene: ENSMUSG00000049409
AA Change: W130L

DomainStartEndE-ValueType
Pfam:7TM_GPCR_Srsx 73 360 8.8e-8 PFAM
Pfam:7tm_1 79 342 7.2e-47 PFAM
Meta Mutation Damage Score 0.9554 question?
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.3%
  • 20x: 97.7%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the G-protein-coupled receptor family. The encoded protein binds to prokineticins (1 and 2), leading to the activation of MAPK and STAT signaling pathways. Prokineticins are protein ligands involved in angiogenesis and inflammation. The encoded protein is expressed in peripheral tissues such as those comprising the circulatory system, lungs, reproductive system, endocrine system and the gastrointestinal system. The protein may be involved in signaling in human fetal ovary during initiation of primordial follicle formation. Sequence variants in this gene may be associated with recurrent miscarriage. [provided by RefSeq, Aug 2016]
PHENOTYPE: Mice homozygous for one null allele exhibit abnormal nociceptions and hypoalgesia. Mice homozygous for another null allele exhibit decreased capillary density in the heart. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 44 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Ago2 T C 15: 72,985,601 (GRCm39) I665V probably benign Het
Aoc1l3 T G 6: 48,964,508 (GRCm39) F172C probably damaging Het
Arhgap32 A T 9: 32,063,983 (GRCm39) M74L possibly damaging Het
Asb4 T C 6: 5,398,304 (GRCm39) C90R possibly damaging Het
B3galt4 T A 17: 34,169,821 (GRCm39) D139V probably damaging Het
Camta2 A C 11: 70,564,964 (GRCm39) I852S probably benign Het
Cd200l1 A T 16: 45,264,294 (GRCm39) M88K probably benign Het
Cox4i2 G T 2: 152,599,015 (GRCm39) E57D probably benign Het
Dip2b T C 15: 100,091,724 (GRCm39) I1055T probably benign Het
Eif1ad18 T A 12: 88,050,602 (GRCm39) W46R probably benign Het
Eif4g3 C T 4: 137,824,646 (GRCm39) P284S probably damaging Het
Ephb1 C A 9: 101,806,463 (GRCm39) probably null Het
Fbxw7 A T 3: 84,879,723 (GRCm39) probably null Het
Frem1 C A 4: 82,840,506 (GRCm39) D1789Y probably damaging Het
Gm29106 A T 1: 118,127,524 (GRCm39) R405S probably damaging Het
Greb1l G A 18: 10,547,482 (GRCm39) V1567M possibly damaging Het
Hapstr1 A G 16: 8,648,553 (GRCm39) probably null Het
Heatr1 C A 13: 12,449,956 (GRCm39) D1983E probably benign Het
Lhfpl2 G T 13: 94,311,029 (GRCm39) A100S probably damaging Het
Lrp5 A T 19: 3,655,301 (GRCm39) V1073D probably damaging Het
Naip6 G A 13: 100,438,706 (GRCm39) L364F possibly damaging Het
Nek9 A G 12: 85,350,311 (GRCm39) L921P probably damaging Het
Nim1k C T 13: 120,189,263 (GRCm39) E49K probably damaging Het
Nsun5 A C 5: 135,399,046 (GRCm39) N32T probably damaging Het
Nuggc T C 14: 65,855,092 (GRCm39) S325P probably damaging Het
Or2d36 A G 7: 106,747,290 (GRCm39) I256V probably damaging Het
Or5w12 T A 2: 87,501,797 (GRCm39) K305* probably null Het
Pcdhga7 A G 18: 37,848,710 (GRCm39) D239G probably damaging Het
Pld2 A G 11: 70,444,273 (GRCm39) D523G probably benign Het
Prpf8 A G 11: 75,381,562 (GRCm39) N266S probably damaging Het
Rdh10 T C 1: 16,176,255 (GRCm39) V5A probably benign Het
Rp1l1 T C 14: 64,267,834 (GRCm39) L1140P possibly damaging Het
Sacs A G 14: 61,448,874 (GRCm39) D3640G probably damaging Het
Smarca2 A G 19: 26,668,749 (GRCm39) E916G probably damaging Het
Steap3 A T 1: 120,171,624 (GRCm39) H160Q probably damaging Het
Tlk2 T C 11: 105,147,779 (GRCm39) probably null Het
Tmprss4 A G 9: 45,097,220 (GRCm39) V15A probably benign Het
Togaram2 T C 17: 72,014,129 (GRCm39) L559P probably damaging Het
Topbp1 T A 9: 103,213,045 (GRCm39) L990H probably damaging Het
Ttll7 A G 3: 146,615,369 (GRCm39) T278A possibly damaging Het
Ttn G A 2: 76,604,780 (GRCm39) L18385F probably damaging Het
Upf3a G T 8: 13,841,911 (GRCm39) A149S probably damaging Het
Vmn2r111 T C 17: 22,778,032 (GRCm39) N549S possibly damaging Het
Zfp316 A T 5: 143,239,280 (GRCm39) F913Y probably damaging Het
Other mutations in Prokr1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00336:Prokr1 APN 6 87,565,593 (GRCm39) missense probably damaging 1.00
IGL00838:Prokr1 APN 6 87,565,675 (GRCm39) missense possibly damaging 0.94
IGL01083:Prokr1 APN 6 87,565,766 (GRCm39) missense probably benign 0.41
IGL02677:Prokr1 APN 6 87,565,350 (GRCm39) splice site probably benign
IGL03344:Prokr1 APN 6 87,565,482 (GRCm39) missense possibly damaging 0.95
R1953:Prokr1 UTSW 6 87,565,575 (GRCm39) missense probably benign 0.18
R2065:Prokr1 UTSW 6 87,565,695 (GRCm39) missense probably damaging 0.98
R3161:Prokr1 UTSW 6 87,565,413 (GRCm39) missense probably damaging 1.00
R4777:Prokr1 UTSW 6 87,565,842 (GRCm39) start codon destroyed probably null 0.98
R4828:Prokr1 UTSW 6 87,558,224 (GRCm39) missense probably benign 0.07
R4890:Prokr1 UTSW 6 87,565,678 (GRCm39) missense probably benign 0.00
R4943:Prokr1 UTSW 6 87,558,806 (GRCm39) missense possibly damaging 0.90
R6134:Prokr1 UTSW 6 87,565,837 (GRCm39) missense possibly damaging 0.54
R6183:Prokr1 UTSW 6 87,565,834 (GRCm39) missense possibly damaging 0.94
R6329:Prokr1 UTSW 6 87,558,774 (GRCm39) missense possibly damaging 0.94
R6794:Prokr1 UTSW 6 87,565,675 (GRCm39) missense possibly damaging 0.94
R8428:Prokr1 UTSW 6 87,565,756 (GRCm39) missense probably benign
R8478:Prokr1 UTSW 6 87,558,330 (GRCm39) missense probably benign 0.01
R9369:Prokr1 UTSW 6 87,558,407 (GRCm39) missense possibly damaging 0.95
Predicted Primers PCR Primer
(F):5'- CAGTAGGCTTTTGAGTCCCC -3'
(R):5'- CATGCTAGTGTGTGGCATCG -3'

Sequencing Primer
(F):5'- GGGTAATACAGTCACATGTCATCAGC -3'
(R):5'- GTGGCATCGGCAACTTCATC -3'
Posted On 2018-11-06