Incidental Mutation 'R6928:Nynrin'
ID 539863
Institutional Source Beutler Lab
Gene Symbol Nynrin
Ensembl Gene ENSMUSG00000075592
Gene Name NYN domain and retroviral integrase containing
Synonyms
MMRRC Submission 045045-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R6928 (G1)
Quality Score 225.009
Status Validated
Chromosome 14
Chromosomal Location 56091572-56112193 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to G at 56101335 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Serine to Alanine at position 335 (S335A)
Ref Sequence ENSEMBL: ENSMUSP00000129557 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000100529] [ENSMUST00000168479] [ENSMUST00000227465]
AlphaFold Q5DTZ0
Predicted Effect probably benign
Transcript: ENSMUST00000100529
AA Change: S335A

PolyPhen 2 Score 0.202 (Sensitivity: 0.92; Specificity: 0.88)
SMART Domains Protein: ENSMUSP00000098098
Gene: ENSMUSG00000075592
AA Change: S335A

DomainStartEndE-ValueType
low complexity region 581 606 N/A INTRINSIC
Pfam:RNase_Zc3h12a 739 890 1.6e-54 PFAM
low complexity region 938 952 N/A INTRINSIC
low complexity region 1212 1228 N/A INTRINSIC
low complexity region 1390 1397 N/A INTRINSIC
PDB:3S3O|B 1478 1706 6e-8 PDB
SCOP:d1cxqa_ 1552 1646 2e-12 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000168479
AA Change: S335A

PolyPhen 2 Score 0.202 (Sensitivity: 0.92; Specificity: 0.88)
SMART Domains Protein: ENSMUSP00000129557
Gene: ENSMUSG00000075592
AA Change: S335A

DomainStartEndE-ValueType
low complexity region 581 606 N/A INTRINSIC
Pfam:RNase_Zc3h12a 739 890 5.5e-54 PFAM
low complexity region 938 952 N/A INTRINSIC
low complexity region 1212 1228 N/A INTRINSIC
low complexity region 1390 1397 N/A INTRINSIC
PDB:3S3O|B 1478 1706 6e-8 PDB
SCOP:d1cxqa_ 1552 1646 2e-12 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000227465
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.1%
  • 20x: 97.5%
Validation Efficiency 98% (62/63)
Allele List at MGI
Other mutations in this stock
Total: 60 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adcyap1r1 A G 6: 55,456,257 (GRCm39) D215G possibly damaging Het
Asb3 A T 11: 30,948,326 (GRCm39) M40L probably damaging Het
Aspg G A 12: 112,093,123 (GRCm39) V547M possibly damaging Het
Aspm T A 1: 139,407,944 (GRCm39) L2277* probably null Het
Atp7b A G 8: 22,484,828 (GRCm39) S1295P probably benign Het
Cdca2 A G 14: 67,943,193 (GRCm39) S199P probably damaging Het
Cdh1 A G 8: 107,387,642 (GRCm39) E514G possibly damaging Het
Cenpk G T 13: 104,365,500 (GRCm39) probably benign Het
Col6a5 C A 9: 105,817,118 (GRCm39) V398L unknown Het
Colec10 A T 15: 54,326,002 (GRCm39) K277N probably damaging Het
Cryzl2 T G 1: 157,298,357 (GRCm39) S249A probably benign Het
Cspg4 T A 9: 56,805,164 (GRCm39) Y1992N possibly damaging Het
Drd3 G T 16: 43,641,683 (GRCm39) R333L probably benign Het
Espl1 C T 15: 102,207,342 (GRCm39) R269C probably benign Het
Esr2 C T 12: 76,212,252 (GRCm39) C188Y probably damaging Het
Focad A G 4: 88,267,112 (GRCm39) D1041G unknown Het
Frem3 T C 8: 81,337,911 (GRCm39) F68S possibly damaging Het
Gapdh A G 6: 125,139,634 (GRCm39) V212A probably damaging Het
Gzmb T C 14: 56,497,734 (GRCm39) K169E probably benign Het
Hexd T A 11: 121,102,880 (GRCm39) F33I possibly damaging Het
Hsd3b6 T C 3: 98,718,269 (GRCm39) I32V probably benign Het
Jcad T C 18: 4,673,372 (GRCm39) V378A probably benign Het
Kcnmb2 T C 3: 32,253,190 (GRCm39) S177P probably benign Het
Lrriq1 A T 10: 103,050,800 (GRCm39) S651T possibly damaging Het
Map3k2 T C 18: 32,340,593 (GRCm39) probably null Het
Mib1 T G 18: 10,802,282 (GRCm39) S870A probably benign Het
Moap1 T A 12: 102,708,871 (GRCm39) N226I probably damaging Het
Moxd1 T A 10: 24,176,186 (GRCm39) N547K probably damaging Het
Mtmr9 A G 14: 63,781,042 (GRCm39) V16A probably benign Het
Nme1 T C 11: 93,850,229 (GRCm39) Y151C probably damaging Het
Nwd1 T C 8: 73,408,653 (GRCm39) F879L probably benign Het
Or52ac1 A T 7: 104,245,796 (GRCm39) Y197* probably null Het
Or5ac25 C A 16: 59,181,826 (GRCm39) G252C probably damaging Het
Or5b102 A T 19: 13,041,348 (GRCm39) H191L probably benign Het
Or5b99 A G 19: 12,977,202 (GRCm39) N284S probably damaging Het
Or8d23 T C 9: 38,841,862 (GRCm39) Y132H probably damaging Het
Or8g21 T C 9: 38,905,928 (GRCm39) M268V probably benign Het
Pcdhb21 A G 18: 37,647,474 (GRCm39) E201G probably damaging Het
Plscr1 T C 9: 92,152,004 (GRCm39) V301A possibly damaging Het
Psg28 A T 7: 18,157,003 (GRCm39) S411T possibly damaging Het
Rif1 T C 2: 51,985,973 (GRCm39) W653R probably damaging Het
Rnd3 T A 2: 51,022,518 (GRCm39) I175L probably benign Het
Rtn4 A G 11: 29,656,791 (GRCm39) E199G possibly damaging Het
Sgpp1 T C 12: 75,763,344 (GRCm39) Y279C probably damaging Het
Slc2a13 A G 15: 91,160,382 (GRCm39) I524T probably damaging Het
Speer4a2 A G 5: 26,290,586 (GRCm39) probably null Het
Spg11 C T 2: 121,900,385 (GRCm39) V1556I probably benign Het
Spopfm1 T A 3: 94,173,855 (GRCm39) C288S probably benign Het
Srebf2 C T 15: 82,087,924 (GRCm39) R215* probably null Het
Tdpoz8 G A 3: 92,981,267 (GRCm39) C95Y probably damaging Het
Tmem19 T C 10: 115,183,179 (GRCm39) N147S possibly damaging Het
Tpr T C 1: 150,284,536 (GRCm39) S408P possibly damaging Het
Trav13d-4 C T 14: 53,310,618 (GRCm39) T53I probably damaging Het
Trf T A 9: 103,099,307 (GRCm39) R168W possibly damaging Het
Trim11 A G 11: 58,879,669 (GRCm39) K273R probably damaging Het
Tsacc T A 3: 88,190,247 (GRCm39) M68L probably benign Het
Ttn T A 2: 76,584,869 (GRCm39) M22110L probably benign Het
Zfp160 G T 17: 21,261,724 (GRCm39) G104V probably benign Het
Zfp582 T C 7: 6,357,266 (GRCm39) Y360H probably damaging Het
Zranb1 G A 7: 132,568,323 (GRCm39) R301H possibly damaging Het
Other mutations in Nynrin
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01020:Nynrin APN 14 56,105,905 (GRCm39) missense probably benign 0.38
IGL01131:Nynrin APN 14 56,110,142 (GRCm39) missense probably damaging 1.00
IGL01357:Nynrin APN 14 56,107,874 (GRCm39) missense probably benign
IGL01537:Nynrin APN 14 56,109,502 (GRCm39) missense possibly damaging 0.87
IGL01583:Nynrin APN 14 56,107,968 (GRCm39) missense probably damaging 1.00
IGL01726:Nynrin APN 14 56,101,611 (GRCm39) missense probably benign
IGL02161:Nynrin APN 14 56,101,441 (GRCm39) missense probably damaging 1.00
IGL02167:Nynrin APN 14 56,100,792 (GRCm39) missense probably damaging 1.00
IGL02247:Nynrin APN 14 56,109,167 (GRCm39) nonsense probably null
IGL02302:Nynrin APN 14 56,105,962 (GRCm39) missense probably benign 0.43
IGL02524:Nynrin APN 14 56,108,931 (GRCm39) missense possibly damaging 0.73
IGL02600:Nynrin APN 14 56,101,449 (GRCm39) missense probably benign 0.38
IGL02639:Nynrin APN 14 56,108,112 (GRCm39) missense probably damaging 1.00
IGL02654:Nynrin APN 14 56,100,716 (GRCm39) missense possibly damaging 0.95
IGL02659:Nynrin APN 14 56,103,554 (GRCm39) unclassified probably benign
IGL02736:Nynrin APN 14 56,108,366 (GRCm39) missense probably damaging 1.00
IGL02949:Nynrin APN 14 56,109,837 (GRCm39) missense probably damaging 0.99
PIT4458001:Nynrin UTSW 14 56,101,425 (GRCm39) missense probably benign 0.39
R0017:Nynrin UTSW 14 56,109,852 (GRCm39) missense probably damaging 1.00
R0078:Nynrin UTSW 14 56,100,789 (GRCm39) missense probably damaging 1.00
R0211:Nynrin UTSW 14 56,109,255 (GRCm39) missense probably benign 0.08
R0211:Nynrin UTSW 14 56,109,255 (GRCm39) missense probably benign 0.08
R0413:Nynrin UTSW 14 56,109,648 (GRCm39) missense possibly damaging 0.90
R0609:Nynrin UTSW 14 56,110,218 (GRCm39) missense probably damaging 1.00
R0626:Nynrin UTSW 14 56,105,492 (GRCm39) missense probably damaging 1.00
R1205:Nynrin UTSW 14 56,091,646 (GRCm39) intron probably benign
R1222:Nynrin UTSW 14 56,100,998 (GRCm39) missense probably benign 0.02
R1385:Nynrin UTSW 14 56,102,356 (GRCm39) missense probably benign 0.00
R1820:Nynrin UTSW 14 56,107,835 (GRCm39) missense possibly damaging 0.95
R1829:Nynrin UTSW 14 56,110,404 (GRCm39) missense possibly damaging 0.50
R1874:Nynrin UTSW 14 56,100,950 (GRCm39) missense probably benign 0.04
R1927:Nynrin UTSW 14 56,101,049 (GRCm39) missense probably benign 0.00
R2233:Nynrin UTSW 14 56,109,524 (GRCm39) missense possibly damaging 0.83
R3018:Nynrin UTSW 14 56,100,867 (GRCm39) missense probably benign 0.00
R3154:Nynrin UTSW 14 56,101,044 (GRCm39) missense possibly damaging 0.46
R3853:Nynrin UTSW 14 56,101,562 (GRCm39) missense probably benign 0.24
R4648:Nynrin UTSW 14 56,110,351 (GRCm39) nonsense probably null
R4722:Nynrin UTSW 14 56,091,852 (GRCm39) missense probably damaging 0.97
R4735:Nynrin UTSW 14 56,107,625 (GRCm39) missense probably benign 0.03
R4736:Nynrin UTSW 14 56,101,454 (GRCm39) missense probably damaging 1.00
R4780:Nynrin UTSW 14 56,100,720 (GRCm39) missense probably damaging 1.00
R4804:Nynrin UTSW 14 56,102,326 (GRCm39) missense probably benign
R4816:Nynrin UTSW 14 56,109,458 (GRCm39) missense probably damaging 1.00
R5307:Nynrin UTSW 14 56,101,263 (GRCm39) missense probably damaging 1.00
R5372:Nynrin UTSW 14 56,105,948 (GRCm39) missense probably benign 0.01
R5432:Nynrin UTSW 14 56,101,923 (GRCm39) missense possibly damaging 0.80
R5800:Nynrin UTSW 14 56,108,088 (GRCm39) missense probably damaging 1.00
R5825:Nynrin UTSW 14 56,101,683 (GRCm39) missense probably benign 0.00
R6149:Nynrin UTSW 14 56,091,780 (GRCm39) missense possibly damaging 0.83
R6244:Nynrin UTSW 14 56,105,485 (GRCm39) missense probably damaging 1.00
R6350:Nynrin UTSW 14 56,105,533 (GRCm39) missense probably benign 0.19
R6379:Nynrin UTSW 14 56,107,848 (GRCm39) missense probably damaging 1.00
R6437:Nynrin UTSW 14 56,109,227 (GRCm39) missense probably benign 0.00
R6501:Nynrin UTSW 14 56,100,989 (GRCm39) missense probably benign
R6702:Nynrin UTSW 14 56,101,935 (GRCm39) missense possibly damaging 0.80
R6703:Nynrin UTSW 14 56,101,935 (GRCm39) missense possibly damaging 0.80
R6907:Nynrin UTSW 14 56,101,335 (GRCm39) missense probably benign 0.20
R6908:Nynrin UTSW 14 56,101,335 (GRCm39) missense probably benign 0.20
R6934:Nynrin UTSW 14 56,101,335 (GRCm39) missense probably benign 0.20
R6935:Nynrin UTSW 14 56,101,335 (GRCm39) missense probably benign 0.20
R7197:Nynrin UTSW 14 56,109,380 (GRCm39) missense probably benign 0.00
R7204:Nynrin UTSW 14 56,110,190 (GRCm39) missense probably damaging 1.00
R7272:Nynrin UTSW 14 56,107,872 (GRCm39) missense probably damaging 1.00
R7335:Nynrin UTSW 14 56,101,371 (GRCm39) missense probably benign
R7361:Nynrin UTSW 14 56,107,857 (GRCm39) missense possibly damaging 0.71
R7368:Nynrin UTSW 14 56,107,968 (GRCm39) missense probably damaging 1.00
R7443:Nynrin UTSW 14 56,108,873 (GRCm39) missense probably benign 0.18
R7584:Nynrin UTSW 14 56,109,041 (GRCm39) missense probably damaging 1.00
R7677:Nynrin UTSW 14 56,107,693 (GRCm39) missense probably benign
R7723:Nynrin UTSW 14 56,109,502 (GRCm39) missense possibly damaging 0.87
R7776:Nynrin UTSW 14 56,103,420 (GRCm39) missense probably damaging 1.00
R7787:Nynrin UTSW 14 56,107,980 (GRCm39) missense probably benign
R7842:Nynrin UTSW 14 56,102,553 (GRCm39) missense probably damaging 1.00
R7852:Nynrin UTSW 14 56,108,886 (GRCm39) missense probably damaging 0.96
R8040:Nynrin UTSW 14 56,108,982 (GRCm39) missense probably benign 0.01
R8159:Nynrin UTSW 14 56,102,517 (GRCm39) missense probably benign
R8159:Nynrin UTSW 14 56,100,587 (GRCm39) missense probably damaging 0.99
R8258:Nynrin UTSW 14 56,100,815 (GRCm39) missense possibly damaging 0.95
R8259:Nynrin UTSW 14 56,100,815 (GRCm39) missense possibly damaging 0.95
R8343:Nynrin UTSW 14 56,101,248 (GRCm39) missense probably benign
R8504:Nynrin UTSW 14 56,107,703 (GRCm39) missense probably benign 0.01
R8671:Nynrin UTSW 14 56,107,899 (GRCm39) missense possibly damaging 0.52
R8691:Nynrin UTSW 14 56,110,106 (GRCm39) missense probably damaging 1.00
R8777:Nynrin UTSW 14 56,109,120 (GRCm39) missense probably benign
R8777-TAIL:Nynrin UTSW 14 56,109,120 (GRCm39) missense probably benign
R9041:Nynrin UTSW 14 56,108,753 (GRCm39) missense possibly damaging 0.83
R9346:Nynrin UTSW 14 56,100,495 (GRCm39) missense probably benign 0.01
R9366:Nynrin UTSW 14 56,100,587 (GRCm39) missense probably damaging 0.99
R9690:Nynrin UTSW 14 56,108,204 (GRCm39) missense probably benign 0.00
RF007:Nynrin UTSW 14 56,103,658 (GRCm39) splice site probably null
Predicted Primers PCR Primer
(F):5'- GCCACGAACTTGGACTTTCTC -3'
(R):5'- AAGGGCAAAGGATTCCGTC -3'

Sequencing Primer
(F):5'- AACTTGGACTTTCTCTAGGGACCAG -3'
(R):5'- CTCTGCCAGAAGGGGAAATTTAAGC -3'
Posted On 2018-11-06