Incidental Mutation 'R6930:Vmn2r61'
| ID |
539945 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn2r61
|
| Ensembl Gene |
ENSMUSG00000090967 |
| Gene Name |
vomeronasal 2, receptor 61 |
| Synonyms |
Gprc2a-rs2, Casr-rs2, EG637873 |
| MMRRC Submission |
045046-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.099)
|
| Stock # |
R6930 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Validated
|
| Chromosome |
7 |
| Chromosomal Location |
41909477-41950179 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 41949364 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Threonine to Alanine
at position 595
(T595A)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000129576
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000166131]
|
| AlphaFold |
L7N2B8 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000166131
AA Change: T595A
PolyPhen 2
Score 0.017 (Sensitivity: 0.95; Specificity: 0.80)
|
| SMART Domains |
Protein: ENSMUSP00000129576
Gene: ENSMUSG00000090967
AA Change: T595A
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
18 |
N/A |
INTRINSIC |
|
Pfam:ANF_receptor
|
77 |
471 |
4e-42 |
PFAM |
|
Pfam:NCD3G
|
514 |
567 |
1.9e-21 |
PFAM |
|
Pfam:7tm_3
|
600 |
835 |
6.2e-52 |
PFAM |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.8%
- 10x: 99.0%
- 20x: 96.5%
|
| Validation Efficiency |
100% (63/63) |
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 62 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 1700093K21Rik |
A |
T |
11: 23,466,563 (GRCm39) |
D156E |
probably benign |
Het |
| Adam17 |
A |
T |
12: 21,403,949 (GRCm39) |
V99E |
probably damaging |
Het |
| Akr1e1 |
T |
C |
13: 4,652,714 (GRCm39) |
D41G |
probably damaging |
Het |
| Alcam |
T |
C |
16: 52,126,018 (GRCm39) |
I100V |
probably benign |
Het |
| Atr |
T |
C |
9: 95,748,688 (GRCm39) |
I411T |
probably benign |
Het |
| Bbs4 |
T |
C |
9: 59,230,764 (GRCm39) |
S453G |
probably benign |
Het |
| Brdt |
C |
T |
5: 107,507,081 (GRCm39) |
L494F |
probably benign |
Het |
| Ccser1 |
T |
C |
6: 62,357,009 (GRCm39) |
S816P |
probably benign |
Het |
| Cdk10 |
T |
C |
8: 123,957,347 (GRCm39) |
I157T |
probably damaging |
Het |
| Ceacam5 |
G |
A |
7: 17,484,759 (GRCm39) |
|
probably null |
Het |
| Chst15 |
T |
C |
7: 131,870,759 (GRCm39) |
I259V |
possibly damaging |
Het |
| Cracdl |
A |
T |
1: 37,664,026 (GRCm39) |
I624N |
possibly damaging |
Het |
| Csmd1 |
A |
T |
8: 16,142,409 (GRCm39) |
M1498K |
probably damaging |
Het |
| D630045J12Rik |
T |
C |
6: 38,135,151 (GRCm39) |
D1343G |
probably damaging |
Het |
| Denr |
T |
C |
5: 124,046,250 (GRCm39) |
Y27H |
probably benign |
Het |
| Dop1a |
T |
C |
9: 86,413,825 (GRCm39) |
|
probably null |
Het |
| Epg5 |
T |
C |
18: 78,057,378 (GRCm39) |
F1819S |
probably damaging |
Het |
| Flg2 |
T |
A |
3: 93,108,642 (GRCm39) |
Y223* |
probably null |
Het |
| Fry |
T |
C |
5: 150,351,695 (GRCm39) |
L1733P |
probably benign |
Het |
| Gabrb2 |
T |
C |
11: 42,488,440 (GRCm39) |
V302A |
probably damaging |
Het |
| Gimap9 |
G |
A |
6: 48,654,601 (GRCm39) |
D53N |
probably damaging |
Het |
| Gje1 |
G |
T |
10: 14,593,886 (GRCm39) |
L3I |
possibly damaging |
Het |
| Gm49383 |
G |
T |
12: 69,239,586 (GRCm39) |
A645E |
probably damaging |
Het |
| Gm8947 |
G |
A |
1: 151,068,347 (GRCm39) |
G60D |
probably damaging |
Het |
| Gpatch2l |
G |
A |
12: 86,290,958 (GRCm39) |
R47H |
probably damaging |
Het |
| Gys2 |
A |
G |
6: 142,405,106 (GRCm39) |
|
probably null |
Het |
| Hace1 |
A |
G |
10: 45,494,598 (GRCm39) |
H136R |
probably damaging |
Het |
| Herc3 |
T |
G |
6: 58,893,444 (GRCm39) |
V902G |
probably damaging |
Het |
| Hspbp1 |
T |
C |
7: 4,687,606 (GRCm39) |
R2G |
probably benign |
Het |
| Iqch |
T |
A |
9: 63,387,856 (GRCm39) |
K811N |
possibly damaging |
Het |
| Kmt2a |
A |
G |
9: 44,753,962 (GRCm39) |
|
probably benign |
Het |
| Lonrf2 |
A |
T |
1: 38,843,417 (GRCm39) |
V372D |
probably benign |
Het |
| Lpin2 |
T |
C |
17: 71,551,786 (GRCm39) |
Y729H |
probably damaging |
Het |
| Lrrc32 |
A |
G |
7: 98,148,471 (GRCm39) |
N417S |
possibly damaging |
Het |
| Malrd1 |
T |
A |
2: 15,802,478 (GRCm39) |
C1064S |
unknown |
Het |
| Mast3 |
G |
A |
8: 71,252,115 (GRCm39) |
R20* |
probably null |
Het |
| Mypn |
A |
C |
10: 62,952,718 (GRCm39) |
I174S |
probably damaging |
Het |
| Nrg1 |
G |
A |
8: 32,308,534 (GRCm39) |
T505M |
probably damaging |
Het |
| Or13p8 |
A |
G |
4: 118,584,338 (GRCm39) |
K298R |
probably damaging |
Het |
| Or6y1 |
A |
G |
1: 174,276,677 (GRCm39) |
I163V |
probably damaging |
Het |
| Or7a42 |
A |
G |
10: 78,791,615 (GRCm39) |
D192G |
possibly damaging |
Het |
| Or7e178 |
A |
G |
9: 20,225,395 (GRCm39) |
Y266H |
probably damaging |
Het |
| Phf3 |
T |
C |
1: 30,850,958 (GRCm39) |
E1132G |
probably damaging |
Het |
| Pla2g4d |
A |
T |
2: 120,101,114 (GRCm39) |
M521K |
probably damaging |
Het |
| Plekhg1 |
A |
G |
10: 3,913,770 (GRCm39) |
H1164R |
possibly damaging |
Het |
| Plxnb2 |
A |
G |
15: 89,044,592 (GRCm39) |
V1218A |
probably benign |
Het |
| Pold1 |
A |
G |
7: 44,191,630 (GRCm39) |
S119P |
probably benign |
Het |
| Pole |
T |
A |
5: 110,441,156 (GRCm39) |
D203E |
probably benign |
Het |
| Rapgefl1 |
T |
A |
11: 98,737,947 (GRCm39) |
L387Q |
probably damaging |
Het |
| Rbm33 |
T |
C |
5: 28,557,504 (GRCm39) |
I199T |
probably benign |
Het |
| Rsrc1 |
C |
T |
3: 66,901,982 (GRCm39) |
P44L |
unknown |
Het |
| Rufy1 |
C |
A |
11: 50,289,207 (GRCm39) |
R545L |
probably benign |
Het |
| Ryr3 |
T |
A |
2: 112,690,699 (GRCm39) |
D1117V |
probably damaging |
Het |
| Sap130 |
T |
C |
18: 31,815,141 (GRCm39) |
V621A |
possibly damaging |
Het |
| Sparcl1 |
T |
A |
5: 104,234,940 (GRCm39) |
Y525F |
probably damaging |
Het |
| Spon2 |
A |
G |
5: 33,373,771 (GRCm39) |
V180A |
probably benign |
Het |
| Trav10n |
G |
A |
14: 53,359,947 (GRCm39) |
V75M |
probably benign |
Het |
| Ttc34 |
T |
C |
4: 154,923,543 (GRCm39) |
L84P |
probably damaging |
Het |
| Vmn1r23 |
C |
T |
6: 57,903,130 (GRCm39) |
R216K |
probably benign |
Het |
| Vmn2r66 |
T |
A |
7: 84,661,216 (GRCm39) |
I5F |
possibly damaging |
Het |
| Zfp879 |
C |
T |
11: 50,723,839 (GRCm39) |
G406R |
probably damaging |
Het |
| Zic2 |
A |
T |
14: 122,713,869 (GRCm39) |
D261V |
probably damaging |
Het |
|
| Other mutations in Vmn2r61 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00158:Vmn2r61
|
APN |
7 |
41,950,175 (GRCm39) |
missense |
possibly damaging |
0.96 |
|
IGL00824:Vmn2r61
|
APN |
7 |
41,916,438 (GRCm39) |
missense |
probably benign |
0.03 |
|
IGL00903:Vmn2r61
|
APN |
7 |
41,949,935 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01125:Vmn2r61
|
APN |
7 |
41,909,550 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01393:Vmn2r61
|
APN |
7 |
41,916,258 (GRCm39) |
missense |
probably benign |
0.08 |
|
IGL01712:Vmn2r61
|
APN |
7 |
41,909,661 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL01822:Vmn2r61
|
APN |
7 |
41,950,130 (GRCm39) |
missense |
probably benign |
0.18 |
|
IGL01835:Vmn2r61
|
APN |
7 |
41,950,015 (GRCm39) |
missense |
probably benign |
0.12 |
|
IGL01844:Vmn2r61
|
APN |
7 |
41,909,639 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01953:Vmn2r61
|
APN |
7 |
41,949,613 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02032:Vmn2r61
|
APN |
7 |
41,949,466 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL02054:Vmn2r61
|
APN |
7 |
41,926,158 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL02569:Vmn2r61
|
APN |
7 |
41,926,070 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02697:Vmn2r61
|
APN |
7 |
41,924,892 (GRCm39) |
missense |
possibly damaging |
0.55 |
|
IGL02958:Vmn2r61
|
APN |
7 |
41,949,361 (GRCm39) |
missense |
probably benign |
|
|
IGL03290:Vmn2r61
|
APN |
7 |
41,915,408 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL03337:Vmn2r61
|
APN |
7 |
41,916,509 (GRCm39) |
missense |
possibly damaging |
0.58 |
|
IGL03369:Vmn2r61
|
APN |
7 |
41,909,517 (GRCm39) |
missense |
probably benign |
|
|
IGL03402:Vmn2r61
|
APN |
7 |
41,909,679 (GRCm39) |
missense |
probably benign |
|
|
R0026:Vmn2r61
|
UTSW |
7 |
41,924,898 (GRCm39) |
missense |
possibly damaging |
0.64 |
|
R0319:Vmn2r61
|
UTSW |
7 |
41,949,941 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0433:Vmn2r61
|
UTSW |
7 |
41,915,335 (GRCm39) |
missense |
probably benign |
0.02 |
|
R0555:Vmn2r61
|
UTSW |
7 |
41,915,442 (GRCm39) |
missense |
probably benign |
0.02 |
|
R0691:Vmn2r61
|
UTSW |
7 |
41,949,844 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1701:Vmn2r61
|
UTSW |
7 |
41,949,935 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1718:Vmn2r61
|
UTSW |
7 |
41,950,121 (GRCm39) |
missense |
probably benign |
|
|
R1835:Vmn2r61
|
UTSW |
7 |
41,916,076 (GRCm39) |
nonsense |
probably null |
|
|
R1920:Vmn2r61
|
UTSW |
7 |
41,949,710 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R2069:Vmn2r61
|
UTSW |
7 |
41,949,425 (GRCm39) |
missense |
probably benign |
0.06 |
|
R2326:Vmn2r61
|
UTSW |
7 |
41,916,287 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2402:Vmn2r61
|
UTSW |
7 |
41,949,529 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R3103:Vmn2r61
|
UTSW |
7 |
41,916,067 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R3107:Vmn2r61
|
UTSW |
7 |
41,916,491 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R4426:Vmn2r61
|
UTSW |
7 |
41,950,159 (GRCm39) |
missense |
probably benign |
|
|
R4426:Vmn2r61
|
UTSW |
7 |
41,950,157 (GRCm39) |
missense |
probably benign |
|
|
R4484:Vmn2r61
|
UTSW |
7 |
41,950,120 (GRCm39) |
missense |
probably benign |
|
|
R4748:Vmn2r61
|
UTSW |
7 |
41,916,565 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R4835:Vmn2r61
|
UTSW |
7 |
41,916,459 (GRCm39) |
missense |
possibly damaging |
0.52 |
|
R4863:Vmn2r61
|
UTSW |
7 |
41,950,132 (GRCm39) |
missense |
probably benign |
0.03 |
|
R4923:Vmn2r61
|
UTSW |
7 |
41,916,520 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4968:Vmn2r61
|
UTSW |
7 |
41,949,478 (GRCm39) |
missense |
probably benign |
0.14 |
|
R5114:Vmn2r61
|
UTSW |
7 |
41,949,953 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R5297:Vmn2r61
|
UTSW |
7 |
41,909,646 (GRCm39) |
missense |
probably benign |
|
|
R5497:Vmn2r61
|
UTSW |
7 |
41,924,906 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R5508:Vmn2r61
|
UTSW |
7 |
41,916,242 (GRCm39) |
missense |
possibly damaging |
0.52 |
|
R5587:Vmn2r61
|
UTSW |
7 |
41,949,911 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5615:Vmn2r61
|
UTSW |
7 |
41,949,917 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5615:Vmn2r61
|
UTSW |
7 |
41,916,677 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5782:Vmn2r61
|
UTSW |
7 |
41,949,253 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6136:Vmn2r61
|
UTSW |
7 |
41,916,455 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6207:Vmn2r61
|
UTSW |
7 |
41,909,616 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6265:Vmn2r61
|
UTSW |
7 |
41,915,915 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6272:Vmn2r61
|
UTSW |
7 |
41,949,242 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6355:Vmn2r61
|
UTSW |
7 |
41,916,659 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6469:Vmn2r61
|
UTSW |
7 |
41,915,283 (GRCm39) |
nonsense |
probably null |
|
|
R6554:Vmn2r61
|
UTSW |
7 |
41,926,139 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6699:Vmn2r61
|
UTSW |
7 |
41,949,580 (GRCm39) |
missense |
probably benign |
|
|
R6768:Vmn2r61
|
UTSW |
7 |
41,949,748 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6824:Vmn2r61
|
UTSW |
7 |
41,949,403 (GRCm39) |
missense |
probably benign |
0.10 |
|
R7053:Vmn2r61
|
UTSW |
7 |
41,916,557 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R7238:Vmn2r61
|
UTSW |
7 |
41,916,629 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R7332:Vmn2r61
|
UTSW |
7 |
41,909,534 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7359:Vmn2r61
|
UTSW |
7 |
41,915,407 (GRCm39) |
missense |
probably benign |
0.11 |
|
R7553:Vmn2r61
|
UTSW |
7 |
41,916,205 (GRCm39) |
missense |
not run |
|
|
R7710:Vmn2r61
|
UTSW |
7 |
41,916,472 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7732:Vmn2r61
|
UTSW |
7 |
41,916,097 (GRCm39) |
missense |
probably benign |
|
|
R7839:Vmn2r61
|
UTSW |
7 |
41,916,032 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R7916:Vmn2r61
|
UTSW |
7 |
41,949,935 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8026:Vmn2r61
|
UTSW |
7 |
41,916,141 (GRCm39) |
missense |
probably benign |
0.02 |
|
R8440:Vmn2r61
|
UTSW |
7 |
41,916,080 (GRCm39) |
missense |
probably benign |
0.02 |
|
R8499:Vmn2r61
|
UTSW |
7 |
41,949,700 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8771:Vmn2r61
|
UTSW |
7 |
41,916,194 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8847:Vmn2r61
|
UTSW |
7 |
41,950,010 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8986:Vmn2r61
|
UTSW |
7 |
41,915,325 (GRCm39) |
nonsense |
probably null |
|
|
R9290:Vmn2r61
|
UTSW |
7 |
41,915,385 (GRCm39) |
missense |
probably benign |
0.27 |
|
R9311:Vmn2r61
|
UTSW |
7 |
41,950,092 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R9324:Vmn2r61
|
UTSW |
7 |
41,916,619 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9476:Vmn2r61
|
UTSW |
7 |
41,949,593 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9521:Vmn2r61
|
UTSW |
7 |
41,916,626 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9619:Vmn2r61
|
UTSW |
7 |
41,926,136 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R9729:Vmn2r61
|
UTSW |
7 |
41,949,917 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1088:Vmn2r61
|
UTSW |
7 |
41,949,388 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
Z1176:Vmn2r61
|
UTSW |
7 |
41,916,166 (GRCm39) |
missense |
probably benign |
0.00 |
|
Z1176:Vmn2r61
|
UTSW |
7 |
41,909,585 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
| Predicted Primers |
PCR Primer
(F):5'- GGGAACACCTAAGGATTGACAC -3'
(R):5'- ATAGCTTTGGCCAACACTGTG -3'
Sequencing Primer
(F):5'- GGATTGACACACGATCACTTTC -3'
(R):5'- CTTTGGCCAACACTGTGGAGAG -3'
|
| Posted On |
2018-11-06 |
Incidental Mutation