Incidental Mutation 'R6933:Taok1'
ID 540173
Institutional Source Beutler Lab
Gene Symbol Taok1
Ensembl Gene ENSMUSG00000017291
Gene Name TAO kinase 1
Synonyms 2810468K05Rik, D130018F14Rik
MMRRC Submission 045048-MU
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.455) question?
Stock # R6933 (G1)
Quality Score 225.009
Status Validated
Chromosome 11
Chromosomal Location 77419988-77498641 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 77446479 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Serine to Threonine at position 417 (S417T)
Ref Sequence ENSEMBL: ENSMUSP00000055470 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000017435] [ENSMUST00000058496]
AlphaFold Q5F2E8
Predicted Effect probably benign
Transcript: ENSMUST00000017435
AA Change: S417T

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000017435
Gene: ENSMUSG00000017291
AA Change: S417T

DomainStartEndE-ValueType
S_TKc 28 281 3.26e-87 SMART
low complexity region 327 335 N/A INTRINSIC
low complexity region 350 370 N/A INTRINSIC
coiled coil region 458 651 N/A INTRINSIC
coiled coil region 792 878 N/A INTRINSIC
low complexity region 914 930 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000058496
AA Change: S417T

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000055470
Gene: ENSMUSG00000017291
AA Change: S417T

DomainStartEndE-ValueType
S_TKc 28 281 3.26e-87 SMART
low complexity region 327 335 N/A INTRINSIC
low complexity region 350 370 N/A INTRINSIC
coiled coil region 458 651 N/A INTRINSIC
coiled coil region 792 878 N/A INTRINSIC
low complexity region 914 930 N/A INTRINSIC
Meta Mutation Damage Score 0.0592 question?
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.2%
  • 20x: 97.7%
Validation Efficiency 93% (41/44)
Allele List at MGI
Other mutations in this stock
Total: 44 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Ank3 G T 10: 69,740,042 (GRCm39) K814N probably damaging Het
Anks1b A G 10: 89,905,352 (GRCm39) H231R probably damaging Het
Anks6 A G 4: 47,049,164 (GRCm39) V247A probably benign Het
Antxrl A G 14: 33,797,728 (GRCm39) N568D possibly damaging Het
Ccnl1 T C 3: 65,855,373 (GRCm39) T366A probably benign Het
Ccr2 T G 9: 123,906,161 (GRCm39) L147R probably damaging Het
Cdc40 A G 10: 40,720,992 (GRCm39) V318A probably damaging Het
Cfap61 T A 2: 145,792,970 (GRCm39) probably null Het
Cfap97d2 CA CAA 8: 13,784,865 (GRCm39) probably null Het
Clk3 A T 9: 57,669,132 (GRCm39) Y31N probably damaging Het
Cmya5 T C 13: 93,231,644 (GRCm39) Y1148C probably benign Het
Cntnap5b T C 1: 100,311,175 (GRCm39) V927A probably benign Het
Dync1i1 A C 6: 5,913,333 (GRCm39) T217P probably damaging Het
Elovl4 A G 9: 83,667,153 (GRCm39) V68A probably damaging Het
Ep400 C A 5: 110,813,728 (GRCm39) K2890N probably damaging Het
Fam114a2 T C 11: 57,374,897 (GRCm39) I481V probably benign Het
Fam83e A G 7: 45,371,818 (GRCm39) T72A probably benign Het
Fnip2 A T 3: 79,425,418 (GRCm39) M59K probably benign Het
Lrpprc T C 17: 85,030,131 (GRCm39) K1089R probably benign Het
Mndal T A 1: 173,703,249 (GRCm39) E52V probably damaging Het
Myom1 C A 17: 71,359,666 (GRCm39) T446K probably damaging Het
Nbea A T 3: 55,631,031 (GRCm39) F2199I possibly damaging Het
Nr1h2 A T 7: 44,199,437 (GRCm39) L438Q probably damaging Het
Or52n2c A G 7: 104,574,330 (GRCm39) C214R probably benign Het
Pet117 T A 2: 144,211,019 (GRCm39) V13E possibly damaging Het
Pnpla8 A G 12: 44,330,210 (GRCm39) E254G probably benign Het
Polr2a T C 11: 69,627,003 (GRCm39) E1485G probably damaging Het
Polr2a C T 11: 69,630,293 (GRCm39) R1258Q probably benign Het
Ptpn4 T C 1: 119,700,878 (GRCm39) probably benign Het
Rapgef2 A T 3: 78,993,266 (GRCm39) Y889N probably damaging Het
Sbf1 G A 15: 89,184,572 (GRCm39) R1115C probably damaging Het
Sfpq GCCGCCGCAGCAGCCTCCGCCGCAGCAGCC GCCGCCGCAGCAGCC 4: 126,915,419 (GRCm39) probably benign Het
Shank2 A T 7: 143,645,515 (GRCm39) T366S probably benign Het
Slc22a23 T C 13: 34,489,163 (GRCm39) I241V probably benign Het
Sox11 G T 12: 27,391,493 (GRCm39) S305R probably damaging Het
Sox21 T C 14: 118,472,725 (GRCm39) H108R possibly damaging Het
Tg C T 15: 66,636,158 (GRCm39) R582C possibly damaging Het
Traf3 T C 12: 111,221,658 (GRCm39) V273A possibly damaging Het
Tspyl3 T C 2: 153,067,203 (GRCm39) T12A probably benign Het
Vmn2r86 A T 10: 130,282,126 (GRCm39) I830N probably damaging Het
Vps26b A T 9: 26,926,613 (GRCm39) F129I possibly damaging Het
Washc3 A G 10: 88,037,714 (GRCm39) N24S probably damaging Het
Xirp2 C A 2: 67,345,201 (GRCm39) Q2481K probably benign Het
Zfhx4 T C 3: 5,478,047 (GRCm39) V3554A probably damaging Het
Other mutations in Taok1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01598:Taok1 APN 11 77,462,510 (GRCm39) missense probably damaging 1.00
IGL01629:Taok1 APN 11 77,429,030 (GRCm39) missense possibly damaging 0.63
IGL02198:Taok1 APN 11 77,466,503 (GRCm39) splice site probably benign
IGL02392:Taok1 APN 11 77,440,178 (GRCm39) missense probably benign 0.13
IGL02415:Taok1 APN 11 77,431,066 (GRCm39) unclassified probably benign
IGL02428:Taok1 APN 11 77,440,103 (GRCm39) missense probably benign 0.01
IGL02972:Taok1 APN 11 77,450,584 (GRCm39) missense probably benign 0.04
IGL03200:Taok1 APN 11 77,466,478 (GRCm39) nonsense probably null
IGL03203:Taok1 APN 11 77,430,911 (GRCm39) missense probably damaging 0.96
IGL03292:Taok1 APN 11 77,430,962 (GRCm39) missense probably benign 0.07
IGL03351:Taok1 APN 11 77,451,154 (GRCm39) missense probably damaging 0.96
R7569_taok1_653 UTSW 11 77,446,440 (GRCm39) missense probably benign 0.06
R0070:Taok1 UTSW 11 77,444,543 (GRCm39) missense probably benign
R0497:Taok1 UTSW 11 77,464,630 (GRCm39) missense probably damaging 0.97
R0535:Taok1 UTSW 11 77,444,530 (GRCm39) missense probably benign 0.00
R0558:Taok1 UTSW 11 77,450,670 (GRCm39) missense possibly damaging 0.89
R0653:Taok1 UTSW 11 77,469,550 (GRCm39) critical splice donor site probably null
R1249:Taok1 UTSW 11 77,462,463 (GRCm39) missense probably damaging 1.00
R1424:Taok1 UTSW 11 77,440,190 (GRCm39) missense probably benign 0.00
R1597:Taok1 UTSW 11 77,470,626 (GRCm39) missense probably benign 0.31
R2112:Taok1 UTSW 11 77,462,472 (GRCm39) missense probably benign 0.01
R3716:Taok1 UTSW 11 77,432,636 (GRCm39) missense probably benign 0.09
R4013:Taok1 UTSW 11 77,450,659 (GRCm39) missense possibly damaging 0.95
R4058:Taok1 UTSW 11 77,440,264 (GRCm39) missense probably benign 0.05
R4831:Taok1 UTSW 11 77,444,500 (GRCm39) missense probably null 0.34
R5036:Taok1 UTSW 11 77,440,157 (GRCm39) missense probably benign 0.01
R5917:Taok1 UTSW 11 77,451,144 (GRCm39) missense probably damaging 0.99
R6271:Taok1 UTSW 11 77,464,609 (GRCm39) missense probably damaging 1.00
R6286:Taok1 UTSW 11 77,444,599 (GRCm39) missense probably benign 0.00
R6860:Taok1 UTSW 11 77,432,627 (GRCm39) missense probably benign 0.01
R7139:Taok1 UTSW 11 77,462,459 (GRCm39) missense probably damaging 1.00
R7143:Taok1 UTSW 11 77,428,814 (GRCm39) missense probably benign
R7305:Taok1 UTSW 11 77,432,500 (GRCm39) nonsense probably null
R7340:Taok1 UTSW 11 77,470,643 (GRCm39) missense possibly damaging 0.89
R7508:Taok1 UTSW 11 77,436,152 (GRCm39) missense probably damaging 0.97
R7569:Taok1 UTSW 11 77,446,440 (GRCm39) missense probably benign 0.06
R7753:Taok1 UTSW 11 77,428,725 (GRCm39) missense probably benign 0.29
R8064:Taok1 UTSW 11 77,440,130 (GRCm39) nonsense probably null
R8130:Taok1 UTSW 11 77,470,659 (GRCm39) missense possibly damaging 0.84
R8332:Taok1 UTSW 11 77,432,545 (GRCm39) missense possibly damaging 0.93
R8768:Taok1 UTSW 11 77,444,712 (GRCm39) missense probably damaging 1.00
R8775:Taok1 UTSW 11 77,470,632 (GRCm39) missense probably benign 0.42
R8775-TAIL:Taok1 UTSW 11 77,470,632 (GRCm39) missense probably benign 0.42
Z1176:Taok1 UTSW 11 77,450,752 (GRCm39) missense probably benign 0.00
Predicted Primers PCR Primer
(F):5'- CCTTGCTTTCTTCAAATAGGGAA -3'
(R):5'- AGCTTCTATTTCTGCTTTGTTGAATT -3'

Sequencing Primer
(F):5'- GAACTGAGTGATACGTACCAG -3'
(R):5'- GTCTTTTCCTTGAATGCTCAAA -3'
Posted On 2018-11-06