Incidental Mutation 'R6937:Or7g28'
ID 540346
Institutional Source Beutler Lab
Gene Symbol Or7g28
Ensembl Gene ENSMUSG00000058692
Gene Name olfactory receptor family 7 subfamily G member 28
Synonyms GA_x6K02T2PVTD-13098546-13097608, MOR149-3, Olfr846
MMRRC Submission 045051-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.139) question?
Stock # R6937 (G1)
Quality Score 225.009
Status Validated
Chromosome 9
Chromosomal Location 19271711-19272652 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 19271985 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Aspartic acid at position 222 (V222D)
Ref Sequence ENSEMBL: ENSMUSP00000150672 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000078774] [ENSMUST00000214810]
AlphaFold Q8VET8
Predicted Effect probably damaging
Transcript: ENSMUST00000078774
AA Change: V222D

PolyPhen 2 Score 0.992 (Sensitivity: 0.70; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000077830
Gene: ENSMUSG00000058692
AA Change: V222D

DomainStartEndE-ValueType
Pfam:7tm_4 31 308 3.2e-54 PFAM
Pfam:7tm_1 41 290 4.7e-23 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000214810
AA Change: V222D

PolyPhen 2 Score 0.992 (Sensitivity: 0.70; Specificity: 0.97)
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.1%
  • 20x: 97.1%
Validation Efficiency 98% (42/43)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 44 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Ankrd52 T C 10: 128,222,889 (GRCm39) V613A probably benign Het
Cdh23 A T 10: 60,322,893 (GRCm39) L337Q probably damaging Het
Chrna6 A G 8: 27,897,055 (GRCm39) L274P probably damaging Het
Ciita G A 16: 10,330,355 (GRCm39) probably null Het
Csnka2ip A T 16: 64,299,058 (GRCm39) probably benign Het
Ddx60 G A 8: 62,490,103 (GRCm39) D1691N probably damaging Het
Dnah7b T C 1: 46,234,280 (GRCm39) I1441T probably damaging Het
Dock4 T C 12: 40,884,634 (GRCm39) S1713P probably benign Het
Ep400 T C 5: 110,859,018 (GRCm39) probably benign Het
Epn1 T C 7: 5,092,943 (GRCm39) I85T probably damaging Het
Eri2 T C 7: 119,386,012 (GRCm39) K228E probably damaging Het
Garem1 C T 18: 21,280,827 (GRCm39) A510T probably benign Het
Gfm2 T A 13: 97,299,572 (GRCm39) probably null Het
Hnrnpd T C 5: 100,111,629 (GRCm39) T321A probably benign Het
Htr2a A T 14: 74,882,604 (GRCm39) I197F probably damaging Het
Krtap2-4 T A 11: 99,505,299 (GRCm39) probably benign Het
Lcn3 C A 2: 25,657,823 (GRCm39) Y179* probably null Het
Mak A T 13: 41,201,578 (GRCm39) M261K probably damaging Het
Marchf7 A G 2: 60,071,310 (GRCm39) T605A probably damaging Het
Mcm4 A C 16: 15,454,199 (GRCm39) F83V probably benign Het
Myo18b T C 5: 112,950,258 (GRCm39) N1546S probably benign Het
Nckap1 T A 2: 80,339,060 (GRCm39) K989N probably damaging Het
Ndufaf5 A G 2: 140,023,522 (GRCm39) D119G probably damaging Het
Pcdh1 T C 18: 38,336,528 (GRCm39) T36A possibly damaging Het
Pitpna C T 11: 75,494,557 (GRCm39) T100I possibly damaging Het
Pmf1 A T 3: 88,306,496 (GRCm39) L102Q probably damaging Het
Rftn2 T C 1: 55,233,508 (GRCm39) probably null Het
Robo3 A G 9: 37,341,176 (GRCm39) L10P probably benign Het
Serpinb6a T C 13: 34,102,801 (GRCm39) I241V possibly damaging Het
St14 A T 9: 31,040,956 (GRCm39) probably null Het
Stat6 T C 10: 127,494,571 (GRCm39) probably null Het
Tdpoz6 T C 3: 93,599,523 (GRCm39) N282S probably benign Het
Tdpoz8 A G 3: 92,981,417 (GRCm39) H145R probably benign Het
Tenm4 G A 7: 96,202,703 (GRCm39) R106H probably benign Het
Tgfbrap1 A T 1: 43,091,064 (GRCm39) V687E probably damaging Het
Trim30d A T 7: 104,132,634 (GRCm39) S68T probably damaging Het
Ttn A G 2: 76,663,253 (GRCm39) probably benign Het
Ugt3a1 A T 15: 9,292,158 (GRCm39) D97V probably benign Het
Ugt8a G A 3: 125,709,250 (GRCm39) probably benign Het
Vmn1r184 A T 7: 25,966,750 (GRCm39) K165N probably benign Het
Vmn2r86 T A 10: 130,284,523 (GRCm39) I523F probably damaging Het
Wapl G A 14: 34,444,311 (GRCm39) V588I probably benign Het
Wdr7 C T 18: 63,924,938 (GRCm39) P974S probably benign Het
Zfp975 T C 7: 42,314,480 (GRCm39) D31G possibly damaging Het
Other mutations in Or7g28
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01560:Or7g28 APN 9 19,271,842 (GRCm39) missense probably benign 0.00
IGL01677:Or7g28 APN 9 19,272,441 (GRCm39) missense probably damaging 1.00
PIT4378001:Or7g28 UTSW 9 19,272,471 (GRCm39) missense probably damaging 1.00
R0471:Or7g28 UTSW 9 19,272,177 (GRCm39) nonsense probably null
R2381:Or7g28 UTSW 9 19,271,753 (GRCm39) missense probably benign 0.01
R4320:Or7g28 UTSW 9 19,272,254 (GRCm39) nonsense probably null
R5093:Or7g28 UTSW 9 19,272,274 (GRCm39) missense probably damaging 1.00
R5109:Or7g28 UTSW 9 19,272,438 (GRCm39) missense probably damaging 1.00
R5130:Or7g28 UTSW 9 19,272,369 (GRCm39) missense possibly damaging 0.81
R6049:Or7g28 UTSW 9 19,272,640 (GRCm39) nonsense probably null
R7024:Or7g28 UTSW 9 19,272,579 (GRCm39) missense possibly damaging 0.64
R8139:Or7g28 UTSW 9 19,272,504 (GRCm39) missense probably damaging 0.99
R9211:Or7g28 UTSW 9 19,271,824 (GRCm39) missense possibly damaging 0.53
R9476:Or7g28 UTSW 9 19,272,383 (GRCm39) missense probably benign 0.23
Predicted Primers PCR Primer
(F):5'- GGGTTCAACATTTGAGGGAGC -3'
(R):5'- TGTGAACAGCTTATTACAGTGTCTG -3'

Sequencing Primer
(F):5'- CAACATTTGAGGGAGCACTGTGTAC -3'
(R):5'- AGTGTCTGATGATACTGCGACTATC -3'
Posted On 2018-11-06