Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL00491:Tpra1'

5404

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Tpra1

Ensembl Gene

ENSMUSG00000002871

Gene Name

transmembrane protein, adipocyte asscociated 1

Synonyms

Tpra40, 40kDa, Gpr175

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.105) question?

Stock #

IGL00491

Quality Score

Status

Chromosome

Chromosomal Location

88879238-88889216 bp(+) (GRCm39)

Type of Mutation

splice site

DNA Base Change (assembly)

A to G at 88887390 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000145050 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000055022] [ENSMUST00000128790] [ENSMUST00000129979] [ENSMUST00000203185] [ENSMUST00000152585] [ENSMUST00000203648] [ENSMUST00000150236] [ENSMUST00000203694] [ENSMUST00000203345] [ENSMUST00000153874] [ENSMUST00000204765]

AlphaFold

Q99MU1

Predicted Effect

probably benign
Transcript: ENSMUST00000055022

SMART Domains

Protein: ENSMUSP00000063042
Gene: ENSMUSG00000002871

Domain	Start	End	E-Value	Type
Pfam:Tmemb_40	36	311	9.9e-95	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000123257

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000128171

SMART Domains

Protein: ENSMUSP00000114865
Gene: ENSMUSG00000002871

Domain	Start	End	E-Value	Type
Pfam:Tmemb_40	1	88	1.5e-31	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000128790

SMART Domains

Protein: ENSMUSP00000145116
Gene: ENSMUSG00000002871

Domain	Start	End	E-Value	Type
Pfam:Tmemb_40	36	206	2e-51	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000129979

SMART Domains

Protein: ENSMUSP00000145368
Gene: ENSMUSG00000002871

Domain	Start	End	E-Value	Type
Pfam:Tmemb_40	30	211	2e-51	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000135778

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000138415

Predicted Effect

probably benign
Transcript: ENSMUST00000203185

SMART Domains

Protein: ENSMUSP00000145168
Gene: ENSMUSG00000002871

Domain	Start	End	E-Value	Type
Pfam:Tmemb_40	36	311	9.9e-95	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000152585

Predicted Effect

probably benign
Transcript: ENSMUST00000203648

SMART Domains

Protein: ENSMUSP00000145404
Gene: ENSMUSG00000002871

Domain	Start	End	E-Value	Type
Pfam:Tmemb_40	36	222	6.6e-59	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000151379

Predicted Effect

probably benign
Transcript: ENSMUST00000150236

SMART Domains

Protein: ENSMUSP00000145098
Gene: ENSMUSG00000002871

Domain	Start	End	E-Value	Type
Pfam:Tmemb_40	30	212	1.6e-50	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000144405

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000153885

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000152045

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000141163

Predicted Effect

probably benign
Transcript: ENSMUST00000203694

Predicted Effect

probably benign
Transcript: ENSMUST00000203345

SMART Domains

Protein: ENSMUSP00000144846
Gene: ENSMUSG00000002871

Domain	Start	End	E-Value	Type
Pfam:Tmemb_40	36	170	6.2e-45	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000148874

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000203155

Predicted Effect

probably benign
Transcript: ENSMUST00000153874

SMART Domains

Protein: ENSMUSP00000118017
Gene: ENSMUSG00000002871

Domain	Start	End	E-Value	Type
Pfam:Tmemb_40	32	162	6.5e-57	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000204765

SMART Domains

Protein: ENSMUSP00000145050
Gene: ENSMUSG00000002871

Domain	Start	End	E-Value	Type
Pfam:Tmemb_40	36	311	9.9e-95	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000204584

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 25 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adamts20	G	T	15: 94,171,113 (GRCm39)	S1870Y	possibly damaging	Het
Bcorl1	T	G	X: 47,494,919 (GRCm39)	V1730G	probably damaging	Het
Ccdc7a	A	G	8: 129,753,235 (GRCm39)		probably benign	Het
Col13a1	T	A	10: 61,699,784 (GRCm39)		probably null	Het
Dgkq	A	G	5: 108,802,448 (GRCm39)	S417P	possibly damaging	Het
Dnah1	A	G	14: 30,983,796 (GRCm39)	Y4016H	probably damaging	Het
Dnajc1	A	G	2: 18,313,713 (GRCm39)	V136A	possibly damaging	Het
Fcgbp	A	G	7: 27,792,827 (GRCm39)	T944A	probably damaging	Het
Gm10351	A	T	7: 42,749,217 (GRCm39)		noncoding transcript	Het
Mettl9	T	A	7: 120,651,336 (GRCm39)	V17E	probably damaging	Het
Msh5	A	G	17: 35,249,706 (GRCm39)	V613A	probably damaging	Het
Nup54	T	A	5: 92,565,344 (GRCm39)	I458L	probably benign	Het
Oxct1	A	G	15: 4,125,996 (GRCm39)	N365D	probably damaging	Het
Patl1	T	A	19: 11,907,251 (GRCm39)	N378K	probably benign	Het
Plcl1	T	C	1: 55,752,657 (GRCm39)		probably null	Het
Polk	A	T	13: 96,633,268 (GRCm39)	D258E	probably benign	Het
Ppm1f	T	C	16: 16,741,777 (GRCm39)	L417P	probably benign	Het
Rnf133	T	C	6: 23,649,255 (GRCm39)	I225V	probably benign	Het
Robo4	A	T	9: 37,317,231 (GRCm39)	K463N	possibly damaging	Het
Slc12a2	T	A	18: 58,069,477 (GRCm39)	D1019E	probably damaging	Het
Spock1	C	A	13: 57,704,619 (GRCm39)	R116S	possibly damaging	Het
Stambp	G	T	6: 83,533,280 (GRCm39)	L328I	probably damaging	Het
Tdrd7	T	C	4: 46,010,889 (GRCm39)	C598R	probably damaging	Het
Tmem87a	A	G	2: 120,210,261 (GRCm39)		probably benign	Het
Vps13c	A	G	9: 67,800,418 (GRCm39)	E544G	probably damaging	Het

Other mutations in Tpra1

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00819:Tpra1	APN	6	88,886,318 (GRCm39)	nonsense	probably null
IGL01648:Tpra1	APN	6	88,886,653 (GRCm39)	splice site	probably benign
IGL01810:Tpra1	APN	6	88,886,324 (GRCm39)	missense	probably damaging	1.00
IGL02040:Tpra1	APN	6	88,887,164 (GRCm39)	missense	possibly damaging	0.89
IGL02864:Tpra1	APN	6	88,888,868 (GRCm39)	missense	probably damaging	1.00
R0528:Tpra1	UTSW	6	88,887,372 (GRCm39)	missense	probably benign	0.12
R1555:Tpra1	UTSW	6	88,887,185 (GRCm39)	missense	probably damaging	0.99
R1824:Tpra1	UTSW	6	88,888,805 (GRCm39)	missense	probably benign
R4774:Tpra1	UTSW	6	88,887,661 (GRCm39)	intron	probably benign
R4879:Tpra1	UTSW	6	88,888,691 (GRCm39)	missense	probably damaging	1.00
R6074:Tpra1	UTSW	6	88,888,919 (GRCm39)	missense	possibly damaging	0.93
R7017:Tpra1	UTSW	6	88,885,294 (GRCm39)	missense	probably damaging	1.00
R7097:Tpra1	UTSW	6	88,885,276 (GRCm39)	missense	probably damaging	1.00
R7122:Tpra1	UTSW	6	88,885,276 (GRCm39)	missense	probably damaging	1.00
R7639:Tpra1	UTSW	6	88,887,158 (GRCm39)	missense	probably benign	0.07
R8096:Tpra1	UTSW	6	88,888,699 (GRCm39)	nonsense	probably null
R8975:Tpra1	UTSW	6	88,888,726 (GRCm39)	missense	probably benign
R9434:Tpra1	UTSW	6	88,888,774 (GRCm39)	missense	probably benign	0.17
R9513:Tpra1	UTSW	6	88,887,221 (GRCm39)	missense	probably benign	0.00
R9516:Tpra1	UTSW	6	88,887,221 (GRCm39)	missense	probably benign	0.00
RF012:Tpra1	UTSW	6	88,886,324 (GRCm39)	missense	probably damaging	1.00

Posted On

2012-04-20