Incidental Mutation 'R6939:Fus'
ID 540439
Institutional Source Beutler Lab
Gene Symbol Fus
Ensembl Gene ENSMUSG00000030795
Gene Name fused in sarcoma
Synonyms D930039C12Rik, translocated in liposarcoma, pigpen, hnRNP P2, Tls, D430004D17Rik
MMRRC Submission 045053-MU
Accession Numbers
Essential gene? Essential (E-score: 1.000) question?
Stock # R6939 (G1)
Quality Score 225.009
Status Validated
Chromosome 7
Chromosomal Location 127565276-127581204 bp(+) (GRCm39)
Type of Mutation unclassified
DNA Base Change (assembly) A to T at 127571741 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Gene Model predicted gene model for transcript(s): [ENSMUST00000077609] [ENSMUST00000106251] [ENSMUST00000121616]
AlphaFold P56959
Predicted Effect unknown
Transcript: ENSMUST00000077609
AA Change: D180V
SMART Domains Protein: ENSMUSP00000076801
Gene: ENSMUSG00000030795
AA Change: D180V

DomainStartEndE-ValueType
low complexity region 20 44 N/A INTRINSIC
low complexity region 48 67 N/A INTRINSIC
low complexity region 72 104 N/A INTRINSIC
low complexity region 110 179 N/A INTRINSIC
low complexity region 185 253 N/A INTRINSIC
RRM 278 359 3.85e-16 SMART
ZnF_RBZ 416 442 9e-4 SMART
Predicted Effect unknown
Transcript: ENSMUST00000106251
AA Change: D181V
SMART Domains Protein: ENSMUSP00000101858
Gene: ENSMUSG00000030795
AA Change: D181V

DomainStartEndE-ValueType
low complexity region 20 44 N/A INTRINSIC
low complexity region 47 63 N/A INTRINSIC
low complexity region 73 105 N/A INTRINSIC
low complexity region 111 180 N/A INTRINSIC
low complexity region 186 254 N/A INTRINSIC
RRM 279 360 3.85e-16 SMART
ZnF_RBZ 417 443 9e-4 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000121616
SMART Domains Protein: ENSMUSP00000112721
Gene: ENSMUSG00000030795

DomainStartEndE-ValueType
low complexity region 20 44 N/A INTRINSIC
low complexity region 47 63 N/A INTRINSIC
low complexity region 73 105 N/A INTRINSIC
low complexity region 111 176 N/A INTRINSIC
ZnF_RBZ 179 205 9e-4 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000174632
SMART Domains Protein: ENSMUSP00000133820
Gene: ENSMUSG00000030795

DomainStartEndE-ValueType
Pfam:RRM_1 6 56 6.6e-9 PFAM
ZnF_RBZ 77 103 9e-4 SMART
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.3%
  • 20x: 97.9%
Validation Efficiency 99% (66/67)
MGI Phenotype PHENOTYPE: Homozygotes for targeted null mutations exhibit impaired lymphocyte development, chromosomal instability, increased cellular radiation sensitivity, high neonatal mortality, and male sterility associated with lack of chromosomal pairing. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 66 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
A1bg G A 15: 60,792,244 (GRCm39) P128L probably damaging Het
Acsm3 T C 7: 119,377,678 (GRCm39) V401A probably damaging Het
Arhgef11 C A 3: 87,594,227 (GRCm39) N93K probably damaging Het
C1ra G A 6: 124,489,760 (GRCm39) probably null Het
Camk2a A G 18: 61,091,226 (GRCm39) E236G probably damaging Het
Cav2 C A 6: 17,281,410 (GRCm39) D17E possibly damaging Het
Ccdc149 T C 5: 52,533,607 (GRCm39) S520G probably benign Het
Chd4 C A 6: 125,083,501 (GRCm39) H674Q probably damaging Het
Clrn2 A T 5: 45,611,096 (GRCm39) probably benign Het
Cntnap1 A C 11: 101,077,337 (GRCm39) I1000L probably damaging Het
Cyp2c67 T C 19: 39,631,778 (GRCm39) T140A possibly damaging Het
D7Ertd443e T C 7: 133,966,208 (GRCm39) probably null Het
Dcdc2c G T 12: 28,591,496 (GRCm39) Q131K probably benign Het
Dmpk T A 7: 18,822,149 (GRCm39) V369E probably damaging Het
Dnah11 A T 12: 118,070,297 (GRCm39) W1503R probably damaging Het
Dnai7 A G 6: 145,120,945 (GRCm39) F625L possibly damaging Het
Dok2 T C 14: 71,013,045 (GRCm39) V71A probably benign Het
Dqx1 A T 6: 83,036,446 (GRCm39) Q150L probably damaging Het
Extl3 A G 14: 65,304,189 (GRCm39) I740T possibly damaging Het
Fan1 T A 7: 64,022,234 (GRCm39) N340Y probably damaging Het
Fat2 C T 11: 55,143,300 (GRCm39) W4183* probably null Het
Fkrp C T 7: 16,545,751 (GRCm39) R37Q probably benign Het
Frem3 A G 8: 81,341,774 (GRCm39) K1356E probably benign Het
Gabarapl2 C A 8: 112,669,201 (GRCm39) S53* probably null Het
Gjd3 A C 11: 102,691,733 (GRCm39) M90R probably damaging Het
Gm30083 C T 14: 33,725,557 (GRCm39) probably null Het
Gm7356 T A 17: 14,221,387 (GRCm39) Y214F probably benign Het
Hexd A T 11: 121,113,164 (GRCm39) D533V probably benign Het
Ift172 G A 5: 31,414,930 (GRCm39) A1364V probably damaging Het
Ighmbp2 A T 19: 3,326,907 (GRCm39) F186Y probably damaging Het
Inpp5e C A 2: 26,297,774 (GRCm39) probably null Het
Iqcb1 A G 16: 36,660,274 (GRCm39) T146A possibly damaging Het
Kcnmb2 A G 3: 32,252,465 (GRCm39) Y222C probably damaging Het
Kdm6b A G 11: 69,297,588 (GRCm39) W284R probably damaging Het
Khdc4 T A 3: 88,593,824 (GRCm39) M71K probably damaging Het
Ksr2 T A 5: 117,903,626 (GRCm39) *952R probably null Het
Ldlrap1 C A 4: 134,495,285 (GRCm39) probably benign Het
Mpdu1 G A 11: 69,548,881 (GRCm39) probably benign Het
Mrgprh A T 17: 13,095,822 (GRCm39) T21S probably benign Het
Muc16 T A 9: 18,549,833 (GRCm39) T5487S probably benign Het
Mydgf A G 17: 56,490,737 (GRCm39) probably null Het
Napa T C 7: 15,849,182 (GRCm39) C241R possibly damaging Het
Or10ab4 C A 7: 107,654,312 (GRCm39) A41E possibly damaging Het
Or10n7-ps1 T C 9: 39,598,187 (GRCm39) T18A possibly damaging Het
Or5k17 A T 16: 58,746,648 (GRCm39) Y95* probably null Het
Pla2g4f A T 2: 120,137,782 (GRCm39) L326Q probably damaging Het
Pramel16 T C 4: 143,675,366 (GRCm39) T487A probably benign Het
Psme4 T A 11: 30,787,291 (GRCm39) Y1029N probably damaging Het
Ptprj T C 2: 90,289,858 (GRCm39) T707A possibly damaging Het
Raet1e T A 10: 22,050,256 (GRCm39) M13K possibly damaging Het
Rftn2 T C 1: 55,233,508 (GRCm39) probably null Het
Rmi1 A G 13: 58,557,169 (GRCm39) I473V probably benign Het
Rps6ka4 A G 19: 6,815,437 (GRCm39) F186L probably damaging Het
Ryr1 T A 7: 28,751,751 (GRCm39) M3672L possibly damaging Het
Smarca5 A T 8: 81,431,949 (GRCm39) C890S possibly damaging Het
Spata31d1e T A 13: 59,889,872 (GRCm39) K231N possibly damaging Het
Tdrd12 C T 7: 35,185,024 (GRCm39) probably null Het
Tecta T C 9: 42,259,293 (GRCm39) N1530S probably damaging Het
Tenm4 G A 7: 96,202,703 (GRCm39) R106H probably benign Het
Tmem94 A G 11: 115,676,656 (GRCm39) S54G possibly damaging Het
Tnk2 T C 16: 32,482,696 (GRCm39) V41A probably damaging Het
Trpm1 A G 7: 63,918,045 (GRCm39) T462A probably benign Het
Tsg101 T C 7: 46,556,847 (GRCm39) T61A probably benign Het
Usp42 T C 5: 143,713,724 (GRCm39) N17D probably damaging Het
Zfp607a T A 7: 27,578,473 (GRCm39) C514* probably null Het
Zfp866 G T 8: 70,218,871 (GRCm39) Q250K probably damaging Het
Other mutations in Fus
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02505:Fus APN 7 127,580,679 (GRCm39) missense possibly damaging 0.53
IGL02622:Fus APN 7 127,584,794 (GRCm39) missense probably damaging 0.99
IGL02951:Fus APN 7 127,581,009 (GRCm39) unclassified probably benign
IGL03029:Fus APN 7 127,584,712 (GRCm39) unclassified probably benign
R0588:Fus UTSW 7 127,584,746 (GRCm39) missense probably damaging 0.99
R0674:Fus UTSW 7 127,571,948 (GRCm39) unclassified probably benign
R0686:Fus UTSW 7 127,571,935 (GRCm39) unclassified probably benign
R0746:Fus UTSW 7 127,584,596 (GRCm39) unclassified probably benign
R1562:Fus UTSW 7 127,579,094 (GRCm39) missense probably damaging 1.00
R1733:Fus UTSW 7 127,580,717 (GRCm39) missense probably benign 0.01
R2186:Fus UTSW 7 127,584,706 (GRCm39) unclassified probably benign
R2200:Fus UTSW 7 127,576,400 (GRCm39) missense probably damaging 0.99
R4537:Fus UTSW 7 127,575,087 (GRCm39) missense probably damaging 0.99
R4981:Fus UTSW 7 127,566,727 (GRCm39) start gained probably benign
R5206:Fus UTSW 7 127,568,969 (GRCm39) missense unknown
R5283:Fus UTSW 7 127,584,719 (GRCm39) unclassified probably benign
R5614:Fus UTSW 7 127,573,543 (GRCm39) unclassified probably benign
R6182:Fus UTSW 7 127,576,465 (GRCm39) missense probably damaging 0.97
R6239:Fus UTSW 7 127,580,606 (GRCm39) missense possibly damaging 0.91
R7130:Fus UTSW 7 127,573,585 (GRCm39) missense unknown
R7340:Fus UTSW 7 127,581,123 (GRCm39) splice site probably null
R8293:Fus UTSW 7 127,571,749 (GRCm39) missense unknown
R8440:Fus UTSW 7 127,568,998 (GRCm39) missense unknown
R9154:Fus UTSW 7 127,580,440 (GRCm39) missense unknown
X0061:Fus UTSW 7 127,584,605 (GRCm39) unclassified probably benign
Predicted Primers PCR Primer
(F):5'- ATGTTTACTGTCCTTTCAGTGGTAC -3'
(R):5'- CCTGGCTTATGAGACACCTAC -3'

Sequencing Primer
(F):5'- TTCAGTGGTACCATTGACCC -3'
(R):5'- GGCTTATGAGACACCTACCCCATG -3'
Posted On 2018-11-06