Incidental Mutation 'R6806:Zfp978'
ID 540716
Institutional Source Beutler Lab
Gene Symbol Zfp978
Ensembl Gene ENSMUSG00000078497
Gene Name zinc finger protein 978
Synonyms Gm13145
MMRRC Submission 044919-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.075) question?
Stock # R6806 (G1)
Quality Score 84.0076
Status Not validated
Chromosome 4
Chromosomal Location 147445760-147475461 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to A at 147475284 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Arginine to Lysine at position 277 (R277K)
Ref Sequence ENSEMBL: ENSMUSP00000114248 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000154154]
AlphaFold A2A7I1
Predicted Effect probably benign
Transcript: ENSMUST00000154154
AA Change: R277K

PolyPhen 2 Score 0.435 (Sensitivity: 0.89; Specificity: 0.90)
SMART Domains Protein: ENSMUSP00000114248
Gene: ENSMUSG00000078497
AA Change: R277K

DomainStartEndE-ValueType
KRAB 28 88 5.93e-17 SMART
low complexity region 104 116 N/A INTRINSIC
internal_repeat_1 129 223 3.63e-6 PROSPERO
ZnF_C2H2 257 279 7.9e-4 SMART
ZnF_C2H2 285 307 3.49e-5 SMART
ZnF_C2H2 313 335 1.03e-2 SMART
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.5%
  • 20x: 98.4%
Validation Efficiency 95% (39/41)
Allele List at MGI
Other mutations in this stock
Total: 40 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Agbl1 A G 7: 76,075,669 (GRCm39) Y437C probably damaging Het
Apba2 T A 7: 64,345,207 (GRCm39) D132E probably damaging Het
Atp13a4 A G 16: 29,288,098 (GRCm39) S258P probably damaging Het
Bach2 T A 4: 32,575,301 (GRCm39) M509K possibly damaging Het
Ccdc186 T A 19: 56,788,561 (GRCm39) K549N probably damaging Het
Chrna3 C T 9: 54,923,094 (GRCm39) R238H probably damaging Het
Cntnap5b G A 1: 99,868,374 (GRCm39) C30Y probably damaging Het
Cplane1 A G 15: 8,216,342 (GRCm39) Q520R possibly damaging Het
Dnah11 T C 12: 117,951,411 (GRCm39) probably null Het
Ebna1bp2 T C 4: 118,478,174 (GRCm39) C16R probably benign Het
Grin2b A G 6: 135,751,826 (GRCm39) Y579H possibly damaging Het
Ifi206 C T 1: 173,309,137 (GRCm39) M286I probably benign Het
Itpr1 G A 6: 108,492,908 (GRCm39) V2478I probably benign Het
Lrrc37 T C 11: 103,511,950 (GRCm39) E6G unknown Het
Ltbp2 T C 12: 84,856,012 (GRCm39) S744G possibly damaging Het
Magi3 T A 3: 103,954,285 (GRCm39) N684I possibly damaging Het
Muc16 A G 9: 18,449,206 (GRCm39) probably null Het
Nphp4 G T 4: 152,622,558 (GRCm39) Q614H probably benign Het
Nprl3 A G 11: 32,217,509 (GRCm39) I11T probably damaging Het
Or51q1 G T 7: 103,628,771 (GRCm39) R124L possibly damaging Het
Pank2 T C 2: 131,104,627 (GRCm39) probably benign Het
Prss58 A T 6: 40,874,666 (GRCm39) N58K probably damaging Het
Ptk7 C T 17: 46,884,454 (GRCm39) V759M probably damaging Het
Rassf7 A G 7: 140,796,722 (GRCm39) T28A probably damaging Het
Rbm45 C T 2: 76,210,804 (GRCm39) T445I probably benign Het
Rsf1 ATGGCG ATGGCGACGGTGGCG 7: 97,229,111 (GRCm39) probably benign Het
Rsrc2 T G 5: 123,877,594 (GRCm39) probably benign Het
Saxo2 A T 7: 82,284,240 (GRCm39) I206N probably benign Het
Sh3d19 T A 3: 86,011,640 (GRCm39) Y409N probably damaging Het
Spata31d1a A T 13: 59,851,032 (GRCm39) N365K probably benign Het
Stkld1 C G 2: 26,833,922 (GRCm39) N136K probably benign Het
Tenm4 A G 7: 96,461,166 (GRCm39) D904G possibly damaging Het
Tmf1 G A 6: 97,138,408 (GRCm39) R837* probably null Het
Tnn T C 1: 159,948,278 (GRCm39) T812A possibly damaging Het
Trgj4 T C 13: 19,526,365 (GRCm39) L15P probably damaging Het
Trp53bp1 T C 2: 121,059,147 (GRCm39) I905V probably damaging Het
Ubr3 T C 2: 69,786,308 (GRCm39) probably benign Het
Zfp446 T C 7: 12,713,043 (GRCm39) L27P probably damaging Het
Zfp719 A G 7: 43,235,809 (GRCm39) D57G possibly damaging Het
Zfp747l1 T C 7: 126,985,766 (GRCm39) probably benign Het
Other mutations in Zfp978
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00473:Zfp978 APN 4 147,475,317 (GRCm39) missense probably benign
FR4449:Zfp978 UTSW 4 147,475,401 (GRCm39) missense probably benign 0.00
R5157:Zfp978 UTSW 4 147,475,437 (GRCm39) missense probably damaging 1.00
R7778:Zfp978 UTSW 4 147,469,760 (GRCm39) critical splice donor site probably null
Predicted Primers PCR Primer
(F):5'- TCAATCAAGGAACCCACGTAGA -3'
(R):5'- TTCTCTGATGAACTCTCAGACTG -3'

Sequencing Primer
(F):5'- GTGAGATGAACACTTACACTTGTGG -3'
(R):5'- CAGACTGCCTTTGTCAGTAAAGC -3'
Posted On 2018-11-16