Incidental Mutation 'R6947:Fgr'
ID 540920
Institutional Source Beutler Lab
Gene Symbol Fgr
Ensembl Gene ENSMUSG00000028874
Gene Name FGR proto-oncogene, Src family tyrosine kinase
Synonyms Ali18, Mhdaali18
MMRRC Submission 045060-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.195) question?
Stock # R6947 (G1)
Quality Score 225.009
Status Validated
Chromosome 4
Chromosomal Location 132701406-132729204 bp(+) (GRCm39)
Type of Mutation critical splice donor site (2 bp from exon)
DNA Base Change (assembly) T to A at 132722380 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000128411 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000030693] [ENSMUST00000171223]
AlphaFold P14234
Predicted Effect probably null
Transcript: ENSMUST00000030693
SMART Domains Protein: ENSMUSP00000030693
Gene: ENSMUSG00000028874

DomainStartEndE-ValueType
SH3 68 125 5.39e-22 SMART
SH2 130 220 5.25e-36 SMART
TyrKc 251 500 5.5e-126 SMART
Predicted Effect probably null
Transcript: ENSMUST00000171223
SMART Domains Protein: ENSMUSP00000128411
Gene: ENSMUSG00000028874

DomainStartEndE-ValueType
SH3 68 125 5.39e-22 SMART
SH2 130 220 5.25e-36 SMART
TyrKc 251 500 5.5e-126 SMART
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.8%
  • 10x: 99.0%
  • 20x: 96.0%
Validation Efficiency 100% (46/46)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene is a member of the Src family of protein tyrosine kinases (PTKs). The encoded protein contains N-terminal sites for myristylation and palmitylation, a PTK domain, and SH2 and SH3 domains which are involved in mediating protein-protein interactions with phosphotyrosine-containing and proline-rich motifs, respectively. The protein localizes to plasma membrane ruffles, and functions as a negative regulator of cell migration and adhesion triggered by the beta-2 integrin signal transduction pathway. Infection with Epstein-Barr virus results in the overexpression of this gene. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit a partial reduction in hemorrhage following induction of a local Shwartzman reaction, and show enhanced NK-cell receptor-induced IFN-gamma production in natural killer (NK) cells. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 45 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adamts7 C A 9: 90,073,857 (GRCm39) probably null Het
Adcy4 T C 14: 56,015,848 (GRCm39) T414A possibly damaging Het
Bop1 A G 15: 76,338,188 (GRCm39) F561L probably damaging Het
Ccdc18 T C 5: 108,309,401 (GRCm39) V332A probably benign Het
Cep290 A G 10: 100,365,918 (GRCm39) T1042A probably damaging Het
Cnot8 G T 11: 58,008,331 (GRCm39) V266L probably benign Het
Cxxc4 C T 3: 133,946,277 (GRCm39) S286F possibly damaging Het
Cyp2d12 A T 15: 82,443,248 (GRCm39) I386L probably benign Het
Dgka A T 10: 128,568,884 (GRCm39) I227N probably damaging Het
Eif2d T C 1: 131,092,404 (GRCm39) V354A probably benign Het
Idnk A G 13: 58,308,055 (GRCm39) probably null Het
Kmt2e T C 5: 23,702,543 (GRCm39) S952P probably damaging Het
Kng1 A G 16: 22,896,124 (GRCm39) H343R probably benign Het
Lgals8 G A 13: 12,469,682 (GRCm39) probably benign Het
Lrit3 T A 3: 129,582,883 (GRCm39) Q368L probably benign Het
Lypd8 A T 11: 58,273,592 (GRCm39) T24S probably benign Het
Map3k4 G A 17: 12,479,456 (GRCm39) Q704* probably null Het
Mcm3ap A G 10: 76,351,500 (GRCm39) I1948V probably benign Het
Mettl25 A G 10: 105,662,053 (GRCm39) F306L probably benign Het
Mos A C 4: 3,871,585 (GRCm39) V77G probably damaging Het
Muc4 C T 16: 32,596,177 (GRCm39) R3130C possibly damaging Het
Naxd T C 8: 11,552,757 (GRCm39) V59A probably damaging Het
Nup107 A G 10: 117,593,179 (GRCm39) V833A probably benign Het
Or1p4-ps1 C T 11: 74,208,370 (GRCm39) S173L unknown Het
Or5m10b T C 2: 85,699,271 (GRCm39) F112L probably benign Het
Pcnx2 C T 8: 126,577,021 (GRCm39) probably null Het
Pde10a T A 17: 9,188,424 (GRCm39) I908N probably damaging Het
Plcb1 A G 2: 135,228,075 (GRCm39) K1058R probably benign Het
Rad17 A T 13: 100,759,383 (GRCm39) F548Y probably damaging Het
Rad54b T G 4: 11,569,859 (GRCm39) S58R possibly damaging Het
Rbm20 G A 19: 53,839,696 (GRCm39) G895D probably damaging Het
Rgs22 T C 15: 36,104,036 (GRCm39) probably null Het
Rhobtb3 A G 13: 76,058,785 (GRCm39) S338P probably benign Het
Ruvbl2 A G 7: 45,074,373 (GRCm39) probably null Het
Slc16a12 A G 19: 34,650,007 (GRCm39) F343L probably benign Het
Slc22a28 A G 19: 8,041,875 (GRCm39) L444P possibly damaging Het
Slc44a4 A T 17: 35,147,044 (GRCm39) Q358L probably null Het
Sowaha A G 11: 53,369,225 (GRCm39) F504L probably benign Het
Syne1 A G 10: 5,125,789 (GRCm39) L6035P probably damaging Het
Thbs2 A T 17: 14,910,029 (GRCm39) M190K possibly damaging Het
Tmem171 A G 13: 98,824,950 (GRCm39) F227L possibly damaging Het
Trp53 A G 11: 69,479,307 (GRCm39) K162E possibly damaging Het
Ttn T A 2: 76,724,732 (GRCm39) K2098* probably null Het
Usp30 T C 5: 114,241,821 (GRCm39) S88P probably benign Het
Zfp276 C A 8: 123,981,643 (GRCm39) D63E probably benign Het
Other mutations in Fgr
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02201:Fgr APN 4 132,722,235 (GRCm39) missense probably damaging 0.99
IGL03089:Fgr APN 4 132,713,577 (GRCm39) missense probably damaging 0.96
R1760:Fgr UTSW 4 132,725,653 (GRCm39) missense possibly damaging 0.72
R1957:Fgr UTSW 4 132,725,673 (GRCm39) missense probably benign
R2011:Fgr UTSW 4 132,724,832 (GRCm39) missense probably damaging 1.00
R2109:Fgr UTSW 4 132,725,786 (GRCm39) missense probably benign 0.32
R2351:Fgr UTSW 4 132,724,548 (GRCm39) missense probably damaging 0.99
R2941:Fgr UTSW 4 132,725,734 (GRCm39) missense probably benign
R3034:Fgr UTSW 4 132,725,807 (GRCm39) critical splice donor site probably null
R4590:Fgr UTSW 4 132,722,364 (GRCm39) missense probably damaging 1.00
R4770:Fgr UTSW 4 132,714,602 (GRCm39) missense probably damaging 0.99
R4847:Fgr UTSW 4 132,721,959 (GRCm39) missense probably damaging 1.00
R5294:Fgr UTSW 4 132,724,811 (GRCm39) missense probably benign 0.01
R5384:Fgr UTSW 4 132,713,664 (GRCm39) critical splice donor site probably null
R5388:Fgr UTSW 4 132,722,342 (GRCm39) missense probably damaging 1.00
R5650:Fgr UTSW 4 132,727,533 (GRCm39) missense probably benign 0.13
R7651:Fgr UTSW 4 132,722,324 (GRCm39) missense probably damaging 1.00
R7686:Fgr UTSW 4 132,725,324 (GRCm39) missense probably benign
R7921:Fgr UTSW 4 132,713,832 (GRCm39) splice site probably null
R8011:Fgr UTSW 4 132,725,790 (GRCm39) missense probably damaging 1.00
R8238:Fgr UTSW 4 132,724,832 (GRCm39) missense probably damaging 1.00
R8742:Fgr UTSW 4 132,724,828 (GRCm39) missense probably damaging 1.00
R8876:Fgr UTSW 4 132,726,071 (GRCm39) intron probably benign
R8884:Fgr UTSW 4 132,713,609 (GRCm39) missense probably benign 0.01
Z1176:Fgr UTSW 4 132,727,481 (GRCm39) missense probably benign 0.23
Predicted Primers PCR Primer
(F):5'- AAGCTGGGCTCTGGGAATTC -3'
(R):5'- CTTAGGCCTGGAAGCAAGATTAGG -3'

Sequencing Primer
(F):5'- GAATTCCTTTGGGGGCCTCC -3'
(R):5'- CAAGATTAGGAGGCATTGCTTG -3'
Posted On 2018-11-28