Incidental Mutation 'R6899:Bag2'
ID 540993
Institutional Source Beutler Lab
Gene Symbol Bag2
Ensembl Gene ENSMUSG00000042215
Gene Name BCL2-associated athanogene 2
Synonyms 2610042A13Rik
MMRRC Submission 044993-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.194) question?
Stock # R6899 (G1)
Quality Score 225.009
Status Validated
Chromosome 1
Chromosomal Location 33784565-33796831 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 33785912 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Serine to Proline at position 137 (S137P)
Ref Sequence ENSEMBL: ENSMUSP00000042009 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000044691] [ENSMUST00000088287] [ENSMUST00000115174] [ENSMUST00000138024] [ENSMUST00000187602]
AlphaFold Q91YN9
PDB Structure Chaperone Complex [X-RAY DIFFRACTION]
Structure of the BNB domain of the Hsp70 cochaperone Bag2 [X-RAY DIFFRACTION]
Predicted Effect possibly damaging
Transcript: ENSMUST00000044691
AA Change: S137P

PolyPhen 2 Score 0.865 (Sensitivity: 0.83; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000042009
Gene: ENSMUSG00000042215
AA Change: S137P

DomainStartEndE-ValueType
coiled coil region 20 60 N/A INTRINSIC
BAG 109 189 4.18e-16 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000088287
SMART Domains Protein: ENSMUSP00000085625
Gene: ENSMUSG00000004768

DomainStartEndE-ValueType
RAB 10 172 7.79e-58 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000115174
SMART Domains Protein: ENSMUSP00000110828
Gene: ENSMUSG00000004768

DomainStartEndE-ValueType
RAB 10 172 7.79e-58 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000138024
SMART Domains Protein: ENSMUSP00000137896
Gene: ENSMUSG00000004768

DomainStartEndE-ValueType
Pfam:Miro 11 59 1.9e-6 PFAM
Pfam:Ras 11 61 6.3e-14 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000155484
Predicted Effect probably benign
Transcript: ENSMUST00000187602
Predicted Effect noncoding transcript
Transcript: ENSMUST00000195310
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.0%
  • 20x: 95.9%
Validation Efficiency 98% (56/57)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] BAG proteins compete with Hip for binding to the Hsc70/Hsp70 ATPase domain and promote substrate release. All the BAG proteins have an approximately 45-amino acid BAG domain near the C terminus but differ markedly in their N-terminal regions. The predicted BAG2 protein contains 211 amino acids. The BAG domains of BAG1, BAG2, and BAG3 interact specifically with the Hsc70 ATPase domain in vitro and in mammalian cells. All 3 proteins bind with high affinity to the ATPase domain of Hsc70 and inhibit its chaperone activity in a Hip-repressible manner. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 56 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca16 A G 7: 120,126,264 (GRCm39) Y1140C probably damaging Het
Actl9 G A 17: 33,652,533 (GRCm39) G198S probably damaging Het
Adcy2 A T 13: 69,130,500 (GRCm39) M129K probably damaging Het
Apmap T A 2: 150,436,228 (GRCm39) I107F probably benign Het
Arrdc3 T C 13: 81,037,330 (GRCm39) I162T probably damaging Het
Asprv1 T C 6: 86,605,742 (GRCm39) L196P probably damaging Het
Atpsckmt A G 15: 31,617,257 (GRCm39) S163G probably benign Het
Borcs5 T A 6: 134,687,173 (GRCm39) M177K probably benign Het
C8b A T 4: 104,644,071 (GRCm39) K246M probably benign Het
Cdo1 A G 18: 46,856,407 (GRCm39) C76R probably damaging Het
Ces2b T A 8: 105,563,398 (GRCm39) probably null Het
Csf2rb G A 15: 78,224,902 (GRCm39) S194N probably benign Het
Dap3 A G 3: 88,840,907 (GRCm39) F77L probably benign Het
Dars1 A G 1: 128,341,483 (GRCm39) V44A possibly damaging Het
Dhtkd1 T A 2: 5,922,776 (GRCm39) D461V possibly damaging Het
Ero1a A C 14: 45,530,396 (GRCm39) H345Q probably benign Het
Fzd8 T A 18: 9,214,729 (GRCm39) S604T probably damaging Het
Gpatch2l G A 12: 86,290,958 (GRCm39) R47H probably damaging Het
Gramd1c T A 16: 43,860,505 (GRCm39) Y64F probably benign Het
Heatr5b T A 17: 79,110,938 (GRCm39) Y970F probably benign Het
Hoxc10 A G 15: 102,875,942 (GRCm39) E217G possibly damaging Het
Hsd17b14 A T 7: 45,212,352 (GRCm39) H128L possibly damaging Het
Idh2 TCCCAGG T 7: 79,748,079 (GRCm39) probably benign Het
Ifna9 A G 4: 88,510,300 (GRCm39) F108S probably damaging Het
Ikbke A G 1: 131,203,499 (GRCm39) V58A probably damaging Het
Inpp5e G A 2: 26,290,060 (GRCm39) R462C possibly damaging Het
Junb A G 8: 85,704,353 (GRCm39) F236L probably benign Het
Klhl36 T C 8: 120,596,881 (GRCm39) V194A probably benign Het
Lsg1 A T 16: 30,400,906 (GRCm39) D134E probably benign Het
Megf8 G T 7: 25,060,138 (GRCm39) C2343F probably damaging Het
Mtres1 T C 10: 43,408,780 (GRCm39) E121G possibly damaging Het
Myom3 G A 4: 135,530,603 (GRCm39) G1172R probably damaging Het
Nasp A T 4: 116,461,530 (GRCm39) V548E probably damaging Het
Nubpl T A 12: 52,357,536 (GRCm39) S317T probably benign Het
Nup210l A G 3: 90,075,204 (GRCm39) D838G possibly damaging Het
Oxsr1 C T 9: 119,076,188 (GRCm39) A373T probably benign Het
Psat1 C T 19: 15,895,569 (GRCm39) probably null Het
Rsrc1 C T 3: 66,901,982 (GRCm39) P44L unknown Het
Slain1 C T 14: 103,888,215 (GRCm39) P45L possibly damaging Het
Slc16a8 A G 15: 79,137,949 (GRCm39) V20A possibly damaging Het
Slc22a13 A T 9: 119,025,473 (GRCm39) M145K probably damaging Het
Slc22a4 G A 11: 53,879,739 (GRCm39) T440I probably damaging Het
Slc39a12 C T 2: 14,394,352 (GRCm39) P74L probably damaging Het
Sod3 A G 5: 52,526,050 (GRCm39) T250A unknown Het
Syne2 A G 12: 76,142,503 (GRCm39) probably null Het
Tctn1 A G 5: 122,387,019 (GRCm39) Y299H probably damaging Het
Tfcp2l1 A G 1: 118,603,305 (GRCm39) M448V probably benign Het
Tfpi C T 2: 84,275,153 (GRCm39) G152S probably damaging Het
Thap4 A G 1: 93,678,691 (GRCm39) S32P probably damaging Het
Tmem132c T A 5: 127,628,744 (GRCm39) W549R probably damaging Het
Vmn2r29 T C 7: 7,244,641 (GRCm39) E411G probably damaging Het
Washc4 C A 10: 83,411,919 (GRCm39) D683E probably benign Het
Wdr3 A T 3: 100,057,217 (GRCm39) V462D possibly damaging Het
Wdr5b T C 16: 35,862,150 (GRCm39) S90P probably damaging Het
Zfp407 A G 18: 84,579,559 (GRCm39) L518P possibly damaging Het
Zfp53 A G 17: 21,728,707 (GRCm39) I247V possibly damaging Het
Other mutations in Bag2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01635:Bag2 APN 1 33,786,013 (GRCm39) missense possibly damaging 0.86
R0568:Bag2 UTSW 1 33,786,059 (GRCm39) missense probably benign 0.01
R2144:Bag2 UTSW 1 33,785,912 (GRCm39) missense possibly damaging 0.87
R3712:Bag2 UTSW 1 33,785,997 (GRCm39) missense probably benign 0.11
R4663:Bag2 UTSW 1 33,786,074 (GRCm39) missense probably damaging 1.00
R4745:Bag2 UTSW 1 33,787,417 (GRCm39) splice site probably null
R4828:Bag2 UTSW 1 33,785,968 (GRCm39) missense probably damaging 0.99
R4859:Bag2 UTSW 1 33,786,022 (GRCm39) missense probably damaging 1.00
R4911:Bag2 UTSW 1 33,787,357 (GRCm39) missense probably benign
R5643:Bag2 UTSW 1 33,786,034 (GRCm39) missense probably damaging 0.99
R5644:Bag2 UTSW 1 33,786,034 (GRCm39) missense probably damaging 0.99
R8518:Bag2 UTSW 1 33,787,358 (GRCm39) missense probably benign
R9025:Bag2 UTSW 1 33,785,905 (GRCm39) missense
Predicted Primers PCR Primer
(F):5'- AGCATGCTCTAGGAGTTTAATGGC -3'
(R):5'- ACGTGGGAAGTTTCTGCCTC -3'

Sequencing Primer
(F):5'- CTCTAGGAGTTTAATGGCCTTGTC -3'
(R):5'- GGGAAGTTTCTGCCTCATACTGAC -3'
Posted On 2018-11-28