Incidental Mutation 'R6925:Kcns2'
ID541121
Institutional Source Beutler Lab
Gene Symbol Kcns2
Ensembl Gene ENSMUSG00000050963
Gene NameK+ voltage-gated channel, subfamily S, 2
SynonymsE130006J24Rik, Kv9.2
MMRRC Submission
Accession Numbers
Is this an essential gene? Non essential (E-score: 0.000) question?
Stock #R6925 (G1)
Quality Score225.009
Status Validated
Chromosome15
Chromosomal Location34837355-34843407 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to G at 34839913 bp
ZygosityHeterozygous
Amino Acid Change Aspartic acid to Glycine at position 474 (D474G)
Ref Sequence ENSEMBL: ENSMUSP00000153984 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000072868] [ENSMUST00000228725]
Predicted Effect unknown
Transcript: ENSMUST00000072868
AA Change: D474G
SMART Domains Protein: ENSMUSP00000072645
Gene: ENSMUSG00000050963
AA Change: D474G

DomainStartEndE-ValueType
BTB 17 126 3.35e-8 SMART
Pfam:Ion_trans 186 421 1.2e-44 PFAM
Pfam:Ion_trans_2 330 415 4e-15 PFAM
low complexity region 463 476 N/A INTRINSIC
Predicted Effect unknown
Transcript: ENSMUST00000228725
AA Change: D474G
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.4%
  • 20x: 98.0%
Validation Efficiency 100% (91/91)
MGI Phenotype PHENOTYPE: Homozygous mutation of this gene results in no obvious phenotype. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 90 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
5430419D17Rik A G 7: 131,222,707 Q177R possibly damaging Het
Acat1 A T 9: 53,592,029 V170E probably benign Het
Atp2b2 T A 6: 113,760,720 I902F probably damaging Het
Cacna1d A G 14: 30,051,637 V1697A probably benign Het
Ccdc14 T A 16: 34,690,749 F31Y probably benign Het
Ccdc17 T A 4: 116,598,210 V250E probably damaging Het
Cct7 A G 6: 85,459,182 N25S probably damaging Het
Cep19 G C 16: 32,103,942 G9R probably damaging Het
Ces5a A T 8: 93,523,057 probably null Het
Chd1l T G 3: 97,582,826 E471A probably damaging Het
Chd6 A G 2: 161,013,127 I787T probably damaging Het
Cntnap5c A C 17: 58,395,266 T1194P probably benign Het
Col6a3 T A 1: 90,816,002 M208L probably benign Het
Coro7 A T 16: 4,628,674 probably null Het
Csrnp2 T C 15: 100,481,958 K484R probably benign Het
Cyp2c39 T A 19: 39,513,195 V64E probably damaging Het
Ddr2 T C 1: 169,998,132 K300E probably benign Het
Ddx56 T C 11: 6,263,980 E393G probably damaging Het
Diaph1 A C 18: 37,853,679 Y1084* probably null Het
Disp1 A T 1: 183,086,478 F1459L probably benign Het
Dnajc8 G A 4: 132,544,113 A80T probably damaging Het
Elfn1 T A 5: 139,971,685 M148K probably benign Het
Emcn T A 3: 137,419,002 I154N probably damaging Het
Enah C G 1: 181,905,898 probably null Het
Enah T A 1: 181,905,899 probably null Het
Ep300 C A 15: 81,649,981 Q2080K probably benign Het
Epha2 T A 4: 141,308,757 M168K probably benign Het
Ercc6 T A 14: 32,562,608 I776N probably damaging Het
Fan1 T A 7: 64,372,486 N340Y probably damaging Het
Fat4 G T 3: 38,996,204 probably null Het
G3bp1 A G 11: 55,497,960 R333G possibly damaging Het
Gm3604 A G 13: 62,369,390 F385L probably benign Het
Gm5800 T C 14: 51,713,700 I147M possibly damaging Het
Hipk1 A G 3: 103,778,245 F18S unknown Het
Ighv3-8 A T 12: 114,322,330 C131S probably benign Het
Il23r T G 6: 67,423,493 T618P probably damaging Het
Il31ra G A 13: 112,527,529 T538I possibly damaging Het
Klc4 T C 17: 46,636,229 T407A possibly damaging Het
Klra5 C T 6: 129,911,457 S2N probably benign Het
Krt10 T C 11: 99,388,851 Y161C probably damaging Het
Kxd1 A T 8: 70,523,278 M1K probably null Het
Lgals1 A C 15: 78,928,040 D27A possibly damaging Het
Lgr5 T C 10: 115,466,346 S308G probably benign Het
Lrp1 G A 10: 127,556,988 S2736L probably benign Het
Lrpap1 G T 5: 35,102,536 H73N probably benign Het
Mcpt1 C A 14: 56,019,065 T86K probably damaging Het
Megf6 A T 4: 154,254,587 D527V probably damaging Het
Mical3 A T 6: 120,959,390 S1392T probably benign Het
Mmp2 A T 8: 92,839,382 D437V probably damaging Het
Mob4 T A 1: 55,152,722 Y166* probably null Het
Mrap2 G A 9: 87,182,474 M89I possibly damaging Het
Mug1 G A 6: 121,881,787 A1155T probably damaging Het
Myh2 G T 11: 67,193,218 A1556S probably benign Het
Nfatc3 A G 8: 106,119,322 D1028G probably benign Het
Ngef T G 1: 87,503,263 probably null Het
Nlrp1a A T 11: 71,092,513 L1209Q probably null Het
Npr2 C T 4: 43,647,553 R819C probably damaging Het
Nsd2 A T 5: 33,879,110 D646V probably damaging Het
Nsun7 A G 5: 66,277,072 H252R probably damaging Het
Olfr267 A T 4: 58,785,647 I25N possibly damaging Het
Olfr447 T A 6: 42,911,857 C111* probably null Het
Olfr642 C T 7: 104,049,740 V205I probably benign Het
Olfr951 A T 9: 39,393,860 Q20L probably benign Het
Olfr951 G T 9: 39,393,861 Q20H probably benign Het
Pcdhga2 A T 18: 37,670,585 D494V probably damaging Het
Pcsk2 A G 2: 143,813,747 E617G probably damaging Het
Pdc T C 1: 150,333,180 I138T probably damaging Het
Phc2 T A 4: 128,748,134 S750T probably damaging Het
Pkd2l1 T A 19: 44,191,508 N88Y possibly damaging Het
Plcl1 C T 1: 55,406,598 R71* probably null Het
Prag1 C A 8: 36,103,894 L544M probably damaging Het
Prkg2 A G 5: 98,966,510 probably null Het
Psd2 G A 18: 35,979,711 S153N probably damaging Het
Rab11fip1 A T 8: 27,152,972 S600T probably damaging Het
Rbms1 T G 2: 60,762,304 T222P probably benign Het
Slfn8 A T 11: 83,013,417 Y382* probably null Het
Socs4 T A 14: 47,289,738 C43* probably null Het
Sorl1 T A 9: 42,033,626 T868S probably damaging Het
St6gal1 A G 16: 23,356,213 Y267C probably damaging Het
Syne1 A G 10: 5,126,682 V6879A probably benign Het
Syne2 C A 12: 75,854,132 H22N possibly damaging Het
Tmeff2 T A 1: 50,928,021 L25Q probably damaging Het
Tmprss11g G T 5: 86,487,426 D396E probably benign Het
Tmprss11g T A 5: 86,487,436 H393L probably benign Het
Vmn2r23 A G 6: 123,704,553 E140G probably damaging Het
Wapl T C 14: 34,677,363 S130P probably benign Het
Zeb2 T A 2: 44,994,529 K982M probably damaging Het
Zfhx3 C G 8: 108,956,821 H3631D unknown Het
Zfp719 T C 7: 43,590,706 S573P probably damaging Het
Zfp979 A T 4: 147,613,542 C237S possibly damaging Het
Other mutations in Kcns2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02524:Kcns2 APN 15 34838835 missense probably benign 0.25
IGL02723:Kcns2 APN 15 34838815 missense probably damaging 1.00
R0380:Kcns2 UTSW 15 34839172 missense possibly damaging 0.57
R0927:Kcns2 UTSW 15 34839096 missense probably benign 0.31
R1673:Kcns2 UTSW 15 34838820 missense probably damaging 1.00
R1754:Kcns2 UTSW 15 34839517 missense possibly damaging 0.62
R1829:Kcns2 UTSW 15 34838803 missense probably damaging 1.00
R1913:Kcns2 UTSW 15 34839709 missense probably damaging 1.00
R2290:Kcns2 UTSW 15 34838509 missense possibly damaging 0.95
R4983:Kcns2 UTSW 15 34839605 missense probably damaging 1.00
R5024:Kcns2 UTSW 15 34839537 missense probably benign 0.26
R5195:Kcns2 UTSW 15 34839531 missense possibly damaging 0.90
R5641:Kcns2 UTSW 15 34839053 missense possibly damaging 0.82
R5771:Kcns2 UTSW 15 34838922 missense probably benign 0.06
R5788:Kcns2 UTSW 15 34838854 missense probably benign 0.01
R5970:Kcns2 UTSW 15 34839784 missense probably benign 0.03
R6032:Kcns2 UTSW 15 34838934 missense probably benign 0.02
R6032:Kcns2 UTSW 15 34838934 missense probably benign 0.02
R6157:Kcns2 UTSW 15 34839358 missense possibly damaging 0.95
R7059:Kcns2 UTSW 15 34838835 missense probably damaging 0.97
R7378:Kcns2 UTSW 15 34839703 nonsense probably null
Predicted Primers PCR Primer
(F):5'- TTCTATCGGCGCCAAAAGC -3'
(R):5'- CTTCACTGAGAGGTGCAAAGG -3'

Sequencing Primer
(F):5'- CAACTTGAGAGTGCTATGCGC -3'
(R):5'- GGCATGTTATTAGACACACCATC -3'
Posted On2018-11-28