Incidental Mutation 'R6925:Kcns2'
ID 541121
Institutional Source Beutler Lab
Gene Symbol Kcns2
Ensembl Gene ENSMUSG00000050963
Gene Name K+ voltage-gated channel, subfamily S, 2
Synonyms Kv9.2, E130006J24Rik
MMRRC Submission 045043-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R6925 (G1)
Quality Score 225.009
Status Validated
Chromosome 15
Chromosomal Location 34837501-34843553 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 34840059 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Aspartic acid to Glycine at position 474 (D474G)
Ref Sequence ENSEMBL: ENSMUSP00000153984 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000072868] [ENSMUST00000228725]
AlphaFold O35174
Predicted Effect unknown
Transcript: ENSMUST00000072868
AA Change: D474G
SMART Domains Protein: ENSMUSP00000072645
Gene: ENSMUSG00000050963
AA Change: D474G

DomainStartEndE-ValueType
BTB 17 126 3.35e-8 SMART
Pfam:Ion_trans 186 421 1.2e-44 PFAM
Pfam:Ion_trans_2 330 415 4e-15 PFAM
low complexity region 463 476 N/A INTRINSIC
Predicted Effect unknown
Transcript: ENSMUST00000228725
AA Change: D474G
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.4%
  • 20x: 98.0%
Validation Efficiency 100% (91/91)
MGI Phenotype PHENOTYPE: Homozygous mutation of this gene results in no obvious phenotype. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 90 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acat1 A T 9: 53,503,329 (GRCm39) V170E probably benign Het
Atp2b2 T A 6: 113,737,681 (GRCm39) I902F probably damaging Het
Cacna1d A G 14: 29,773,594 (GRCm39) V1697A probably benign Het
Ccdc14 T A 16: 34,511,119 (GRCm39) F31Y probably benign Het
Ccdc17 T A 4: 116,455,407 (GRCm39) V250E probably damaging Het
Cct7 A G 6: 85,436,164 (GRCm39) N25S probably damaging Het
Cdcp3 A G 7: 130,824,436 (GRCm39) Q177R possibly damaging Het
Cep19 G C 16: 31,922,760 (GRCm39) G9R probably damaging Het
Ces5a A T 8: 94,249,685 (GRCm39) probably null Het
Chd1l T G 3: 97,490,142 (GRCm39) E471A probably damaging Het
Chd6 A G 2: 160,855,047 (GRCm39) I787T probably damaging Het
Cntnap5c A C 17: 58,702,261 (GRCm39) T1194P probably benign Het
Col6a3 T A 1: 90,743,724 (GRCm39) M208L probably benign Het
Coro7 A T 16: 4,446,538 (GRCm39) probably null Het
Csrnp2 T C 15: 100,379,839 (GRCm39) K484R probably benign Het
Cyp2c39 T A 19: 39,501,639 (GRCm39) V64E probably damaging Het
Ddr2 T C 1: 169,825,701 (GRCm39) K300E probably benign Het
Ddx56 T C 11: 6,213,980 (GRCm39) E393G probably damaging Het
Diaph1 A C 18: 37,986,732 (GRCm39) Y1084* probably null Het
Disp1 A T 1: 182,868,042 (GRCm39) F1459L probably benign Het
Dnajc8 G A 4: 132,271,424 (GRCm39) A80T probably damaging Het
Elfn1 T A 5: 139,957,440 (GRCm39) M148K probably benign Het
Emcn T A 3: 137,124,763 (GRCm39) I154N probably damaging Het
Enah T A 1: 181,733,464 (GRCm39) probably null Het
Enah C G 1: 181,733,463 (GRCm39) probably null Het
Ep300 C A 15: 81,534,182 (GRCm39) Q2080K probably benign Het
Epha2 T A 4: 141,036,068 (GRCm39) M168K probably benign Het
Ercc6 T A 14: 32,284,565 (GRCm39) I776N probably damaging Het
Fan1 T A 7: 64,022,234 (GRCm39) N340Y probably damaging Het
Fat4 G T 3: 39,050,353 (GRCm39) probably null Het
G3bp1 A G 11: 55,388,786 (GRCm39) R333G possibly damaging Het
Gm3604 A G 13: 62,517,204 (GRCm39) F385L probably benign Het
Gm5800 T C 14: 51,951,157 (GRCm39) I147M possibly damaging Het
Hipk1 A G 3: 103,685,561 (GRCm39) F18S unknown Het
Ighv3-8 A T 12: 114,285,950 (GRCm39) C131S probably benign Het
Il23r T G 6: 67,400,477 (GRCm39) T618P probably damaging Het
Il31ra G A 13: 112,664,063 (GRCm39) T538I possibly damaging Het
Klc4 T C 17: 46,947,155 (GRCm39) T407A possibly damaging Het
Klra5 C T 6: 129,888,420 (GRCm39) S2N probably benign Het
Krt10 T C 11: 99,279,677 (GRCm39) Y161C probably damaging Het
Kxd1 A T 8: 70,975,928 (GRCm39) M1K probably null Het
Lgals1 A C 15: 78,812,240 (GRCm39) D27A possibly damaging Het
Lgr5 T C 10: 115,302,251 (GRCm39) S308G probably benign Het
Lrp1 G A 10: 127,392,857 (GRCm39) S2736L probably benign Het
Lrpap1 G T 5: 35,259,880 (GRCm39) H73N probably benign Het
Mcpt1 C A 14: 56,256,522 (GRCm39) T86K probably damaging Het
Megf6 A T 4: 154,339,044 (GRCm39) D527V probably damaging Het
Mical3 A T 6: 120,936,351 (GRCm39) S1392T probably benign Het
Mmp2 A T 8: 93,566,010 (GRCm39) D437V probably damaging Het
Mob4 T A 1: 55,191,881 (GRCm39) Y166* probably null Het
Mrap2 G A 9: 87,064,527 (GRCm39) M89I possibly damaging Het
Mug1 G A 6: 121,858,746 (GRCm39) A1155T probably damaging Het
Myh2 G T 11: 67,084,044 (GRCm39) A1556S probably benign Het
Nfatc3 A G 8: 106,845,954 (GRCm39) D1028G probably benign Het
Ngef T G 1: 87,430,985 (GRCm39) probably null Het
Nlrp1a A T 11: 70,983,339 (GRCm39) L1209Q probably null Het
Npr2 C T 4: 43,647,553 (GRCm39) R819C probably damaging Het
Nsd2 A T 5: 34,036,454 (GRCm39) D646V probably damaging Het
Nsun7 A G 5: 66,434,415 (GRCm39) H252R probably damaging Het
Or2a25 T A 6: 42,888,791 (GRCm39) C111* probably null Het
Or2k2 A T 4: 58,785,647 (GRCm39) I25N possibly damaging Het
Or51a10 C T 7: 103,698,947 (GRCm39) V205I probably benign Het
Or8g32 A T 9: 39,305,156 (GRCm39) Q20L probably benign Het
Or8g32 G T 9: 39,305,157 (GRCm39) Q20H probably benign Het
Pcdhga2 A T 18: 37,803,638 (GRCm39) D494V probably damaging Het
Pcsk2 A G 2: 143,655,667 (GRCm39) E617G probably damaging Het
Pdc T C 1: 150,208,931 (GRCm39) I138T probably damaging Het
Phc2 T A 4: 128,641,927 (GRCm39) S750T probably damaging Het
Pkd2l1 T A 19: 44,179,947 (GRCm39) N88Y possibly damaging Het
Plcl1 C T 1: 55,445,757 (GRCm39) R71* probably null Het
Prag1 C A 8: 36,571,048 (GRCm39) L544M probably damaging Het
Prkg2 A G 5: 99,114,369 (GRCm39) probably null Het
Psd2 G A 18: 36,112,764 (GRCm39) S153N probably damaging Het
Rab11fip1 A T 8: 27,643,000 (GRCm39) S600T probably damaging Het
Rbms1 T G 2: 60,592,648 (GRCm39) T222P probably benign Het
Slfn8 A T 11: 82,904,243 (GRCm39) Y382* probably null Het
Socs4 T A 14: 47,527,195 (GRCm39) C43* probably null Het
Sorl1 T A 9: 41,944,922 (GRCm39) T868S probably damaging Het
St6gal1 A G 16: 23,174,963 (GRCm39) Y267C probably damaging Het
Syne1 A G 10: 5,076,682 (GRCm39) V6879A probably benign Het
Syne2 C A 12: 75,900,906 (GRCm39) H22N possibly damaging Het
Tmeff2 T A 1: 50,967,180 (GRCm39) L25Q probably damaging Het
Tmprss11g G T 5: 86,635,285 (GRCm39) D396E probably benign Het
Tmprss11g T A 5: 86,635,295 (GRCm39) H393L probably benign Het
Vmn2r23 A G 6: 123,681,512 (GRCm39) E140G probably damaging Het
Wapl T C 14: 34,399,320 (GRCm39) S130P probably benign Het
Zeb2 T A 2: 44,884,541 (GRCm39) K982M probably damaging Het
Zfhx3 C G 8: 109,683,453 (GRCm39) H3631D unknown Het
Zfp719 T C 7: 43,240,130 (GRCm39) S573P probably damaging Het
Zfp979 A T 4: 147,697,999 (GRCm39) C237S possibly damaging Het
Other mutations in Kcns2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02524:Kcns2 APN 15 34,838,981 (GRCm39) missense probably benign 0.25
IGL02723:Kcns2 APN 15 34,838,961 (GRCm39) missense probably damaging 1.00
R0380:Kcns2 UTSW 15 34,839,318 (GRCm39) missense possibly damaging 0.57
R0927:Kcns2 UTSW 15 34,839,242 (GRCm39) missense probably benign 0.31
R1673:Kcns2 UTSW 15 34,838,966 (GRCm39) missense probably damaging 1.00
R1754:Kcns2 UTSW 15 34,839,663 (GRCm39) missense possibly damaging 0.62
R1829:Kcns2 UTSW 15 34,838,949 (GRCm39) missense probably damaging 1.00
R1913:Kcns2 UTSW 15 34,839,855 (GRCm39) missense probably damaging 1.00
R2290:Kcns2 UTSW 15 34,838,655 (GRCm39) missense possibly damaging 0.95
R4983:Kcns2 UTSW 15 34,839,751 (GRCm39) missense probably damaging 1.00
R5024:Kcns2 UTSW 15 34,839,683 (GRCm39) missense probably benign 0.26
R5195:Kcns2 UTSW 15 34,839,677 (GRCm39) missense possibly damaging 0.90
R5641:Kcns2 UTSW 15 34,839,199 (GRCm39) missense possibly damaging 0.82
R5771:Kcns2 UTSW 15 34,839,068 (GRCm39) missense probably benign 0.06
R5788:Kcns2 UTSW 15 34,839,000 (GRCm39) missense probably benign 0.01
R5970:Kcns2 UTSW 15 34,839,930 (GRCm39) missense probably benign 0.03
R6032:Kcns2 UTSW 15 34,839,080 (GRCm39) missense probably benign 0.02
R6032:Kcns2 UTSW 15 34,839,080 (GRCm39) missense probably benign 0.02
R6157:Kcns2 UTSW 15 34,839,504 (GRCm39) missense possibly damaging 0.95
R7059:Kcns2 UTSW 15 34,838,981 (GRCm39) missense probably damaging 0.97
R7378:Kcns2 UTSW 15 34,839,849 (GRCm39) nonsense probably null
R7572:Kcns2 UTSW 15 34,839,318 (GRCm39) missense possibly damaging 0.57
R7854:Kcns2 UTSW 15 34,839,917 (GRCm39) missense probably benign 0.00
R8041:Kcns2 UTSW 15 34,839,291 (GRCm39) missense probably benign 0.01
Predicted Primers PCR Primer
(F):5'- TTCTATCGGCGCCAAAAGC -3'
(R):5'- CTTCACTGAGAGGTGCAAAGG -3'

Sequencing Primer
(F):5'- CAACTTGAGAGTGCTATGCGC -3'
(R):5'- GGCATGTTATTAGACACACCATC -3'
Posted On 2018-11-28