Incidental Mutation 'R6955:Or4p4'
ID 541405
Institutional Source Beutler Lab
Gene Symbol Or4p4
Ensembl Gene ENSMUSG00000111590
Gene Name olfactory receptor family 4 subfamily P member 4
Synonyms GA_x6K02T2Q125-50131417-50131917, Olfr1192, MOR225-11
Accession Numbers
Essential gene? Probably non essential (E-score: 0.088) question?
Stock # R6955 (G1)
Quality Score 92.0077
Status Not validated
Chromosome 2
Chromosomal Location 88482498-88483424 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 88483348 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Asparagine at position 284 (I284N)
Ref Sequence ENSEMBL: ENSMUSP00000149414 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000120518] [ENSMUST00000217379]
AlphaFold A0A1L1SRD7
Predicted Effect probably damaging
Transcript: ENSMUST00000120518
AA Change: I284N

PolyPhen 2 Score 0.996 (Sensitivity: 0.55; Specificity: 0.98)
Predicted Effect probably benign
Transcript: ENSMUST00000217379
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.4%
  • 20x: 97.8%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 40 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca13 T A 11: 9,244,307 (GRCm39) F2057I probably benign Het
Abl2 A G 1: 156,450,219 (GRCm39) T108A probably damaging Het
Amfr A T 8: 94,727,004 (GRCm39) W70R probably damaging Het
Cacna1h T C 17: 25,607,030 (GRCm39) T963A probably damaging Het
Cdca2 A G 14: 67,952,453 (GRCm39) M1T probably null Het
Chd2 A G 7: 73,125,171 (GRCm39) V62A probably damaging Het
Cpeb4 T A 11: 31,858,864 (GRCm39) L87Q possibly damaging Het
Ddx17 T C 15: 79,414,668 (GRCm39) M500V probably benign Het
Emilin1 T C 5: 31,075,253 (GRCm39) L498P probably damaging Het
Fhod1 C T 8: 106,059,639 (GRCm39) C682Y probably benign Het
Fshr A T 17: 89,292,894 (GRCm39) S595T probably benign Het
Gpt2 G A 8: 86,244,681 (GRCm39) E325K probably benign Het
Inf2 T C 12: 112,577,165 (GRCm39) V1003A unknown Het
Itpr3 A G 17: 27,340,441 (GRCm39) E2651G probably damaging Het
Kalrn A G 16: 34,040,506 (GRCm39) W735R probably damaging Het
Kif5b T C 18: 6,211,070 (GRCm39) N798S probably benign Het
Klb T A 5: 65,536,431 (GRCm39) L587* probably null Het
Krt82 T A 15: 101,451,284 (GRCm39) D375V probably damaging Het
Lig4 A T 8: 10,023,384 (GRCm39) V132D probably damaging Het
Lrpprc T C 17: 85,084,417 (GRCm39) I99V probably damaging Het
Ly75 T C 2: 60,158,217 (GRCm39) I1023V possibly damaging Het
Mcam T A 9: 44,050,566 (GRCm39) I286N probably damaging Het
Myh15 G T 16: 48,901,598 (GRCm39) probably null Het
Nup210 T C 6: 91,064,909 (GRCm39) E197G probably damaging Het
Nup93 T A 8: 95,036,301 (GRCm39) Y702N probably damaging Het
Osbpl8 T C 10: 111,105,305 (GRCm39) probably null Het
Pdzd2 A G 15: 12,401,550 (GRCm39) S767P probably damaging Het
Plcd1 A T 9: 118,900,924 (GRCm39) N765K probably benign Het
Poglut2 A T 1: 44,156,257 (GRCm39) L110Q probably damaging Het
Rnf208 T C 2: 25,133,414 (GRCm39) V36A probably benign Het
Rpl5 G A 5: 108,049,912 (GRCm39) R33Q probably benign Het
Selp A T 1: 163,972,478 (GRCm39) I706F possibly damaging Het
Sfmbt1 A G 14: 30,487,991 (GRCm39) probably benign Het
Slc25a39 T C 11: 102,294,344 (GRCm39) I328V probably benign Het
Smc4 G A 3: 68,931,642 (GRCm39) E604K possibly damaging Het
Sorcs3 A G 19: 48,737,782 (GRCm39) Y733C possibly damaging Het
Ttll5 T C 12: 85,911,353 (GRCm39) V237A possibly damaging Het
Uimc1 T A 13: 55,188,359 (GRCm39) R567W possibly damaging Het
Wbp4 A T 14: 79,709,800 (GRCm39) I145N probably benign Het
Xbp1 A G 11: 5,472,018 (GRCm39) E32G probably null Het
Other mutations in Or4p4
AlleleSourceChrCoordTypePredicted EffectPPH Score
R4984:Or4p4 UTSW 2 88,242,921 (GRCm39) missense probably damaging 0.99
R7468:Or4p4 UTSW 2 88,482,622 (GRCm39) missense probably damaging 1.00
R8117:Or4p4 UTSW 2 88,482,729 (GRCm39) missense probably damaging 1.00
R8359:Or4p4 UTSW 2 88,483,332 (GRCm39) missense probably benign 0.08
R8701:Or4p4 UTSW 2 88,482,831 (GRCm39) missense possibly damaging 0.49
R8942:Or4p4 UTSW 2 88,483,308 (GRCm39) missense possibly damaging 0.94
Predicted Primers PCR Primer
(F):5'- ATTCTGCAGAAAGCCGGAGC -3'
(R):5'- TGGCAGAATAGAGTCCCAATG -3'

Sequencing Primer
(F):5'- GCAAAGCTCTATCTACTTGCAG -3'
(R):5'- GGCTTTTGTGCAATAATGTCCC -3'
Posted On 2018-11-28