Incidental Mutation 'R6956:Mphosph9'
ID 541454
Institutional Source Beutler Lab
Gene Symbol Mphosph9
Ensembl Gene ENSMUSG00000038126
Gene Name M-phase phosphoprotein 9
Synonyms 4930548D04Rik, MPP9, B930097C17Rik, 9630025B04Rik, MPP-9
MMRRC Submission 045067-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R6956 (G1)
Quality Score 225.009
Status Validated
Chromosome 5
Chromosomal Location 124389022-124466001 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 124435621 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Aspartic acid to Glycine at position 604 (D604G)
Ref Sequence ENSEMBL: ENSMUSP00000138982 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000031344] [ENSMUST00000130502] [ENSMUST00000141203] [ENSMUST00000147737] [ENSMUST00000184951]
AlphaFold no structure available at present
Predicted Effect possibly damaging
Transcript: ENSMUST00000031344
AA Change: D574G

PolyPhen 2 Score 0.904 (Sensitivity: 0.82; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000031344
Gene: ENSMUSG00000038126
AA Change: D574G

DomainStartEndE-ValueType
low complexity region 102 119 N/A INTRINSIC
low complexity region 128 140 N/A INTRINSIC
low complexity region 414 428 N/A INTRINSIC
coiled coil region 574 736 N/A INTRINSIC
low complexity region 879 898 N/A INTRINSIC
low complexity region 957 971 N/A INTRINSIC
coiled coil region 1040 1105 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000130502
SMART Domains Protein: ENSMUSP00000120827
Gene: ENSMUSG00000038126

DomainStartEndE-ValueType
low complexity region 47 74 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000141203
Predicted Effect probably benign
Transcript: ENSMUST00000147737
Predicted Effect probably damaging
Transcript: ENSMUST00000184951
AA Change: D604G

PolyPhen 2 Score 0.996 (Sensitivity: 0.55; Specificity: 0.98)
SMART Domains Protein: ENSMUSP00000138982
Gene: ENSMUSG00000038126
AA Change: D604G

DomainStartEndE-ValueType
coiled coil region 102 130 N/A INTRINSIC
low complexity region 132 149 N/A INTRINSIC
low complexity region 158 170 N/A INTRINSIC
low complexity region 444 458 N/A INTRINSIC
coiled coil region 604 766 N/A INTRINSIC
low complexity region 909 928 N/A INTRINSIC
low complexity region 987 1001 N/A INTRINSIC
coiled coil region 1070 1135 N/A INTRINSIC
Meta Mutation Damage Score 0.1573 question?
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.3%
  • 20x: 97.7%
Validation Efficiency 100% (43/43)
Allele List at MGI
Other mutations in this stock
Total: 45 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aars1 G A 8: 111,781,762 (GRCm39) V945M probably benign Het
Amotl2 A G 9: 102,601,967 (GRCm39) T371A probably damaging Het
Bmpr1a A G 14: 34,163,132 (GRCm39) I86T possibly damaging Het
C9 A T 15: 6,474,945 (GRCm39) M35L probably benign Het
Cc2d1a G T 8: 84,862,528 (GRCm39) P661T probably damaging Het
Ccdc202 T A 14: 96,119,869 (GRCm39) W209R probably damaging Het
Dcdc2a T A 13: 25,303,349 (GRCm39) S293R probably benign Het
Dchs2 T A 3: 83,261,233 (GRCm39) N2500K probably benign Het
Dicer1 A G 12: 104,697,282 (GRCm39) S92P probably damaging Het
Dnah7a T A 1: 53,616,446 (GRCm39) I1172F probably benign Het
Dnajc6 A G 4: 101,471,470 (GRCm39) S364G probably damaging Het
Dpp6 A T 5: 27,803,819 (GRCm39) N255I probably damaging Het
Eif2ak4 T C 2: 118,252,748 (GRCm39) I440T probably damaging Het
Fam184b T C 5: 45,688,099 (GRCm39) T937A probably damaging Het
Fam229b T A 10: 39,009,843 (GRCm39) probably null Het
Gbp11 A G 5: 105,476,241 (GRCm39) probably null Het
Gipc2 A G 3: 151,799,885 (GRCm39) F282L probably benign Het
Gpt2 G A 8: 86,244,681 (GRCm39) E325K probably benign Het
H2-T3 T A 17: 36,500,263 (GRCm39) Y144F probably damaging Het
Kel T G 6: 41,664,907 (GRCm39) D7A probably damaging Het
Lrrc7 A G 3: 157,994,668 (GRCm39) V166A probably benign Het
Mapt T C 11: 104,209,081 (GRCm39) probably null Het
Marchf3 A G 18: 56,909,053 (GRCm39) V244A probably benign Het
Mboat1 T C 13: 30,422,059 (GRCm39) V396A possibly damaging Het
Muc16 T C 9: 18,556,322 (GRCm39) T3324A unknown Het
Nalf1 T A 8: 9,820,744 (GRCm39) Q92L probably benign Het
Nat10 T C 2: 103,564,757 (GRCm39) I495V probably benign Het
Or6c208 A T 10: 129,224,166 (GRCm39) K221N probably benign Het
Pfkfb2 T C 1: 130,635,337 (GRCm39) N75D probably damaging Het
Psmd3 T A 11: 98,586,377 (GRCm39) L515Q probably damaging Het
Rpgrip1l A C 8: 92,012,941 (GRCm39) probably null Het
Scube1 T C 15: 83,606,077 (GRCm39) Y65C probably damaging Het
Slc12a4 A G 8: 106,680,484 (GRCm39) F211L probably damaging Het
Socs7 T C 11: 97,267,849 (GRCm39) S327P probably benign Het
Spef2 A T 15: 9,685,021 (GRCm39) D591E probably damaging Het
Sult2a6 T A 7: 13,988,748 (GRCm39) D4V possibly damaging Het
Tdpoz8 T C 3: 92,981,279 (GRCm39) V25A possibly damaging Het
Tdrd9 A G 12: 112,002,788 (GRCm39) probably benign Het
Tgm4 G T 9: 122,893,768 (GRCm39) M155I possibly damaging Het
Togaram2 T C 17: 72,036,183 (GRCm39) V891A probably benign Het
Usp1 A G 4: 98,819,243 (GRCm39) E235G probably damaging Het
Usp2 T A 9: 44,004,053 (GRCm39) V533E probably damaging Het
Vcan T A 13: 89,837,550 (GRCm39) I2665F probably damaging Het
Vmn2r31 G A 7: 7,397,505 (GRCm39) S251L probably benign Het
Vmn2r84 C A 10: 130,225,136 (GRCm39) C458F probably damaging Het
Other mutations in Mphosph9
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01363:Mphosph9 APN 5 124,400,084 (GRCm39) missense probably damaging 1.00
IGL01527:Mphosph9 APN 5 124,421,687 (GRCm39) splice site probably benign
IGL01784:Mphosph9 APN 5 124,403,373 (GRCm39) splice site probably benign
IGL01958:Mphosph9 APN 5 124,463,053 (GRCm39) utr 5 prime probably benign
IGL02020:Mphosph9 APN 5 124,397,013 (GRCm39) missense probably damaging 0.99
IGL02190:Mphosph9 APN 5 124,403,488 (GRCm39) missense possibly damaging 0.92
IGL02261:Mphosph9 APN 5 124,398,150 (GRCm39) missense probably damaging 1.00
IGL02569:Mphosph9 APN 5 124,435,634 (GRCm39) nonsense probably null
IGL02640:Mphosph9 APN 5 124,453,563 (GRCm39) missense possibly damaging 0.66
IGL02702:Mphosph9 APN 5 124,398,052 (GRCm39) missense probably damaging 1.00
IGL02793:Mphosph9 APN 5 124,421,800 (GRCm39) critical splice acceptor site probably null
IGL02813:Mphosph9 APN 5 124,453,691 (GRCm39) missense probably benign 0.37
IGL02875:Mphosph9 APN 5 124,421,800 (GRCm39) critical splice acceptor site probably null
IGL03149:Mphosph9 APN 5 124,401,074 (GRCm39) missense probably damaging 1.00
PIT4445001:Mphosph9 UTSW 5 124,436,853 (GRCm39) missense possibly damaging 0.82
R0304:Mphosph9 UTSW 5 124,436,892 (GRCm39) missense probably benign 0.01
R0437:Mphosph9 UTSW 5 124,453,631 (GRCm39) missense probably benign 0.27
R0483:Mphosph9 UTSW 5 124,445,033 (GRCm39) nonsense probably null
R0811:Mphosph9 UTSW 5 124,436,822 (GRCm39) missense probably damaging 1.00
R0812:Mphosph9 UTSW 5 124,436,822 (GRCm39) missense probably damaging 1.00
R0942:Mphosph9 UTSW 5 124,400,100 (GRCm39) nonsense probably null
R1175:Mphosph9 UTSW 5 124,453,739 (GRCm39) missense possibly damaging 0.94
R1372:Mphosph9 UTSW 5 124,421,808 (GRCm39) splice site probably null
R1442:Mphosph9 UTSW 5 124,403,461 (GRCm39) missense possibly damaging 0.62
R1533:Mphosph9 UTSW 5 124,405,204 (GRCm39) missense probably damaging 1.00
R1959:Mphosph9 UTSW 5 124,453,764 (GRCm39) missense possibly damaging 0.92
R2036:Mphosph9 UTSW 5 124,442,274 (GRCm39) missense probably damaging 0.97
R2256:Mphosph9 UTSW 5 124,421,722 (GRCm39) missense probably benign 0.00
R2919:Mphosph9 UTSW 5 124,399,069 (GRCm39) missense probably benign 0.22
R2920:Mphosph9 UTSW 5 124,399,069 (GRCm39) missense probably benign 0.22
R4064:Mphosph9 UTSW 5 124,428,980 (GRCm39) missense probably damaging 1.00
R4272:Mphosph9 UTSW 5 124,442,266 (GRCm39) missense probably damaging 0.96
R4430:Mphosph9 UTSW 5 124,403,509 (GRCm39) missense possibly damaging 0.83
R4883:Mphosph9 UTSW 5 124,437,108 (GRCm39) missense probably damaging 1.00
R4992:Mphosph9 UTSW 5 124,442,253 (GRCm39) missense probably damaging 1.00
R5815:Mphosph9 UTSW 5 124,453,481 (GRCm39) missense probably damaging 1.00
R5993:Mphosph9 UTSW 5 124,454,161 (GRCm39) missense probably benign 0.40
R6102:Mphosph9 UTSW 5 124,435,772 (GRCm39) missense possibly damaging 0.86
R6295:Mphosph9 UTSW 5 124,458,978 (GRCm39) missense possibly damaging 0.46
R6320:Mphosph9 UTSW 5 124,463,024 (GRCm39) missense probably damaging 0.99
R6628:Mphosph9 UTSW 5 124,436,825 (GRCm39) missense probably damaging 0.98
R6692:Mphosph9 UTSW 5 124,398,179 (GRCm39) missense probably damaging 1.00
R6705:Mphosph9 UTSW 5 124,429,027 (GRCm39) missense possibly damaging 0.83
R6747:Mphosph9 UTSW 5 124,435,762 (GRCm39) missense possibly damaging 0.93
R6787:Mphosph9 UTSW 5 124,399,090 (GRCm39) missense probably damaging 0.99
R6850:Mphosph9 UTSW 5 124,399,019 (GRCm39) missense probably damaging 1.00
R7075:Mphosph9 UTSW 5 124,458,922 (GRCm39) missense probably damaging 0.99
R7604:Mphosph9 UTSW 5 124,454,180 (GRCm39) missense probably benign 0.01
R7789:Mphosph9 UTSW 5 124,453,650 (GRCm39) missense probably damaging 1.00
R7808:Mphosph9 UTSW 5 124,399,009 (GRCm39) missense probably damaging 0.99
R7823:Mphosph9 UTSW 5 124,442,319 (GRCm39) missense probably damaging 0.99
R7891:Mphosph9 UTSW 5 124,428,967 (GRCm39) missense probably damaging 1.00
R8210:Mphosph9 UTSW 5 124,405,174 (GRCm39) missense probably damaging 1.00
R8256:Mphosph9 UTSW 5 124,393,169 (GRCm39) missense probably damaging 1.00
R8385:Mphosph9 UTSW 5 124,450,785 (GRCm39) missense probably benign 0.19
R8438:Mphosph9 UTSW 5 124,430,455 (GRCm39) missense probably benign 0.19
R8692:Mphosph9 UTSW 5 124,450,875 (GRCm39) missense probably damaging 0.99
R8790:Mphosph9 UTSW 5 124,453,736 (GRCm39) missense probably damaging 1.00
R8818:Mphosph9 UTSW 5 124,463,027 (GRCm39) nonsense probably null
R8847:Mphosph9 UTSW 5 124,454,209 (GRCm39) missense possibly damaging 0.91
R9018:Mphosph9 UTSW 5 124,436,713 (GRCm39) missense probably benign 0.12
R9208:Mphosph9 UTSW 5 124,450,854 (GRCm39) missense probably damaging 0.97
R9221:Mphosph9 UTSW 5 124,403,427 (GRCm39) missense probably benign 0.10
R9603:Mphosph9 UTSW 5 124,463,015 (GRCm39) nonsense probably null
R9721:Mphosph9 UTSW 5 124,436,738 (GRCm39) missense possibly damaging 0.87
Predicted Primers PCR Primer
(F):5'- CATAAAAGGCATGGCTTTGTGTTG -3'
(R):5'- ACGGTCCTGAGAGCATCTTTC -3'

Sequencing Primer
(F):5'- AGGCATGGCTTTGTGTTGGTTATAAC -3'
(R):5'- AGAGCATCTTTCCTTCTTACTGACAG -3'
Posted On 2018-11-28