Incidental Mutation 'R6956:Togaram2'
ID 541481
Institutional Source Beutler Lab
Gene Symbol Togaram2
Ensembl Gene ENSMUSG00000045761
Gene Name TOG array regulator of axonemal microtubules 2
Synonyms Fam179a, 4632412N22Rik
MMRRC Submission 045067-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.071) question?
Stock # R6956 (G1)
Quality Score 225.009
Status Validated
Chromosome 17
Chromosomal Location 71980256-72036664 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 72036183 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Alanine at position 891 (V891A)
Ref Sequence ENSEMBL: ENSMUSP00000122691 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000097284] [ENSMUST00000144479] [ENSMUST00000153445]
AlphaFold Q3TYG6
Predicted Effect probably benign
Transcript: ENSMUST00000097284
AA Change: V891A

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
SMART Domains Protein: ENSMUSP00000094886
Gene: ENSMUSG00000045761
AA Change: V891A

DomainStartEndE-ValueType
low complexity region 49 60 N/A INTRINSIC
low complexity region 94 105 N/A INTRINSIC
low complexity region 467 474 N/A INTRINSIC
Pfam:CLASP_N 492 705 2.3e-21 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000144479
AA Change: V911A

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
SMART Domains Protein: ENSMUSP00000114359
Gene: ENSMUSG00000045761
AA Change: V911A

DomainStartEndE-ValueType
low complexity region 50 61 N/A INTRINSIC
low complexity region 95 106 N/A INTRINSIC
low complexity region 468 475 N/A INTRINSIC
Pfam:CLASP_N 493 706 2.4e-21 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000153445
AA Change: V891A

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
SMART Domains Protein: ENSMUSP00000122691
Gene: ENSMUSG00000045761
AA Change: V891A

DomainStartEndE-ValueType
low complexity region 49 60 N/A INTRINSIC
low complexity region 94 105 N/A INTRINSIC
low complexity region 467 474 N/A INTRINSIC
Pfam:CLASP_N 492 705 2.3e-21 PFAM
Meta Mutation Damage Score 0.1187 question?
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.3%
  • 20x: 97.7%
Validation Efficiency 100% (43/43)
Allele List at MGI
Other mutations in this stock
Total: 45 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aars1 G A 8: 111,781,762 (GRCm39) V945M probably benign Het
Amotl2 A G 9: 102,601,967 (GRCm39) T371A probably damaging Het
Bmpr1a A G 14: 34,163,132 (GRCm39) I86T possibly damaging Het
C9 A T 15: 6,474,945 (GRCm39) M35L probably benign Het
Cc2d1a G T 8: 84,862,528 (GRCm39) P661T probably damaging Het
Ccdc202 T A 14: 96,119,869 (GRCm39) W209R probably damaging Het
Dcdc2a T A 13: 25,303,349 (GRCm39) S293R probably benign Het
Dchs2 T A 3: 83,261,233 (GRCm39) N2500K probably benign Het
Dicer1 A G 12: 104,697,282 (GRCm39) S92P probably damaging Het
Dnah7a T A 1: 53,616,446 (GRCm39) I1172F probably benign Het
Dnajc6 A G 4: 101,471,470 (GRCm39) S364G probably damaging Het
Dpp6 A T 5: 27,803,819 (GRCm39) N255I probably damaging Het
Eif2ak4 T C 2: 118,252,748 (GRCm39) I440T probably damaging Het
Fam184b T C 5: 45,688,099 (GRCm39) T937A probably damaging Het
Fam229b T A 10: 39,009,843 (GRCm39) probably null Het
Gbp11 A G 5: 105,476,241 (GRCm39) probably null Het
Gipc2 A G 3: 151,799,885 (GRCm39) F282L probably benign Het
Gpt2 G A 8: 86,244,681 (GRCm39) E325K probably benign Het
H2-T3 T A 17: 36,500,263 (GRCm39) Y144F probably damaging Het
Kel T G 6: 41,664,907 (GRCm39) D7A probably damaging Het
Lrrc7 A G 3: 157,994,668 (GRCm39) V166A probably benign Het
Mapt T C 11: 104,209,081 (GRCm39) probably null Het
Marchf3 A G 18: 56,909,053 (GRCm39) V244A probably benign Het
Mboat1 T C 13: 30,422,059 (GRCm39) V396A possibly damaging Het
Mphosph9 T C 5: 124,435,621 (GRCm39) D604G probably damaging Het
Muc16 T C 9: 18,556,322 (GRCm39) T3324A unknown Het
Nalf1 T A 8: 9,820,744 (GRCm39) Q92L probably benign Het
Nat10 T C 2: 103,564,757 (GRCm39) I495V probably benign Het
Or6c208 A T 10: 129,224,166 (GRCm39) K221N probably benign Het
Pfkfb2 T C 1: 130,635,337 (GRCm39) N75D probably damaging Het
Psmd3 T A 11: 98,586,377 (GRCm39) L515Q probably damaging Het
Rpgrip1l A C 8: 92,012,941 (GRCm39) probably null Het
Scube1 T C 15: 83,606,077 (GRCm39) Y65C probably damaging Het
Slc12a4 A G 8: 106,680,484 (GRCm39) F211L probably damaging Het
Socs7 T C 11: 97,267,849 (GRCm39) S327P probably benign Het
Spef2 A T 15: 9,685,021 (GRCm39) D591E probably damaging Het
Sult2a6 T A 7: 13,988,748 (GRCm39) D4V possibly damaging Het
Tdpoz8 T C 3: 92,981,279 (GRCm39) V25A possibly damaging Het
Tdrd9 A G 12: 112,002,788 (GRCm39) probably benign Het
Tgm4 G T 9: 122,893,768 (GRCm39) M155I possibly damaging Het
Usp1 A G 4: 98,819,243 (GRCm39) E235G probably damaging Het
Usp2 T A 9: 44,004,053 (GRCm39) V533E probably damaging Het
Vcan T A 13: 89,837,550 (GRCm39) I2665F probably damaging Het
Vmn2r31 G A 7: 7,397,505 (GRCm39) S251L probably benign Het
Vmn2r84 C A 10: 130,225,136 (GRCm39) C458F probably damaging Het
Other mutations in Togaram2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00943:Togaram2 APN 17 72,031,999 (GRCm39) missense probably damaging 1.00
IGL01298:Togaram2 APN 17 72,023,508 (GRCm39) missense possibly damaging 0.71
IGL01625:Togaram2 APN 17 72,021,693 (GRCm39) missense probably benign 0.06
IGL01691:Togaram2 APN 17 72,036,485 (GRCm39) missense probably null 0.02
IGL02165:Togaram2 APN 17 72,004,861 (GRCm39) missense probably benign 0.00
IGL02186:Togaram2 APN 17 71,992,166 (GRCm39) missense possibly damaging 0.64
IGL02664:Togaram2 APN 17 72,036,234 (GRCm39) missense probably damaging 0.97
IGL02712:Togaram2 APN 17 72,011,749 (GRCm39) missense probably benign 0.04
IGL03000:Togaram2 APN 17 72,024,365 (GRCm39) missense probably benign 0.08
IGL03209:Togaram2 APN 17 72,002,740 (GRCm39) critical splice donor site probably null
R0211:Togaram2 UTSW 17 72,036,243 (GRCm39) missense probably damaging 1.00
R0212:Togaram2 UTSW 17 72,031,978 (GRCm39) missense probably damaging 1.00
R0219:Togaram2 UTSW 17 72,021,225 (GRCm39) splice site probably benign
R0268:Togaram2 UTSW 17 72,004,993 (GRCm39) critical splice donor site probably null
R0617:Togaram2 UTSW 17 72,007,504 (GRCm39) missense possibly damaging 0.87
R0831:Togaram2 UTSW 17 72,023,439 (GRCm39) missense probably damaging 1.00
R0972:Togaram2 UTSW 17 72,014,309 (GRCm39) missense probably damaging 1.00
R1635:Togaram2 UTSW 17 72,004,846 (GRCm39) missense probably benign 0.05
R1799:Togaram2 UTSW 17 71,998,450 (GRCm39) missense probably damaging 1.00
R2062:Togaram2 UTSW 17 72,023,360 (GRCm39) missense probably benign 0.26
R2414:Togaram2 UTSW 17 72,023,304 (GRCm39) intron probably benign
R2866:Togaram2 UTSW 17 72,016,592 (GRCm39) missense probably benign 0.00
R2867:Togaram2 UTSW 17 72,016,592 (GRCm39) missense probably benign 0.00
R2867:Togaram2 UTSW 17 72,016,592 (GRCm39) missense probably benign 0.00
R4066:Togaram2 UTSW 17 72,023,233 (GRCm39) intron probably benign
R4807:Togaram2 UTSW 17 72,004,918 (GRCm39) missense probably damaging 1.00
R5659:Togaram2 UTSW 17 71,994,667 (GRCm39) missense probably damaging 0.96
R5680:Togaram2 UTSW 17 71,996,204 (GRCm39) missense probably benign 0.00
R5975:Togaram2 UTSW 17 72,036,200 (GRCm39) missense probably damaging 1.00
R5996:Togaram2 UTSW 17 72,011,778 (GRCm39) missense probably damaging 0.99
R6619:Togaram2 UTSW 17 71,996,266 (GRCm39) missense probably damaging 0.99
R6682:Togaram2 UTSW 17 72,011,749 (GRCm39) missense probably benign 0.04
R6922:Togaram2 UTSW 17 72,014,129 (GRCm39) missense probably damaging 1.00
R6968:Togaram2 UTSW 17 72,016,608 (GRCm39) missense probably damaging 1.00
R7007:Togaram2 UTSW 17 72,016,638 (GRCm39) missense probably damaging 0.99
R7015:Togaram2 UTSW 17 72,016,563 (GRCm39) missense possibly damaging 0.62
R7140:Togaram2 UTSW 17 72,021,761 (GRCm39) missense probably benign 0.00
R7383:Togaram2 UTSW 17 72,007,512 (GRCm39) missense probably damaging 1.00
R7691:Togaram2 UTSW 17 72,023,405 (GRCm39) missense probably benign 0.16
R7778:Togaram2 UTSW 17 72,011,746 (GRCm39) missense probably benign 0.00
R7824:Togaram2 UTSW 17 72,011,746 (GRCm39) missense probably benign 0.00
R7862:Togaram2 UTSW 17 71,996,168 (GRCm39) missense probably benign 0.00
R7864:Togaram2 UTSW 17 72,007,935 (GRCm39) missense probably damaging 0.96
R7968:Togaram2 UTSW 17 72,024,428 (GRCm39) missense probably benign 0.18
R8125:Togaram2 UTSW 17 72,023,489 (GRCm39) missense probably benign 0.16
R8227:Togaram2 UTSW 17 72,021,237 (GRCm39) nonsense probably null
R8331:Togaram2 UTSW 17 72,036,221 (GRCm39) missense probably damaging 1.00
R8354:Togaram2 UTSW 17 72,004,873 (GRCm39) missense probably benign 0.00
R8454:Togaram2 UTSW 17 72,004,873 (GRCm39) missense probably benign 0.00
R9043:Togaram2 UTSW 17 71,993,699 (GRCm39) missense probably benign 0.00
R9050:Togaram2 UTSW 17 72,007,878 (GRCm39) missense probably damaging 1.00
R9303:Togaram2 UTSW 17 71,996,408 (GRCm39) missense probably damaging 0.97
R9305:Togaram2 UTSW 17 71,996,408 (GRCm39) missense probably damaging 0.97
R9458:Togaram2 UTSW 17 72,024,246 (GRCm39) missense possibly damaging 0.93
R9660:Togaram2 UTSW 17 72,024,365 (GRCm39) missense probably damaging 0.98
R9776:Togaram2 UTSW 17 72,023,508 (GRCm39) missense possibly damaging 0.94
X0063:Togaram2 UTSW 17 72,014,192 (GRCm39) missense possibly damaging 0.91
Z1088:Togaram2 UTSW 17 72,021,275 (GRCm39) missense possibly damaging 0.87
Z1177:Togaram2 UTSW 17 72,007,997 (GRCm39) missense probably damaging 0.98
Predicted Primers PCR Primer
(F):5'- ATGGACCTACCTCATTTGCATTG -3'
(R):5'- AGGCTAAAAGTCCCTGCAGC -3'

Sequencing Primer
(F):5'- GCAGACCAATATTTCTCTTCAGATG -3'
(R):5'- TGACTGGCAGCGAAGTCCTG -3'
Posted On 2018-11-28