Incidental Mutation 'R6965:Fcmr'
ID 541920
Institutional Source Beutler Lab
Gene Symbol Fcmr
Ensembl Gene ENSMUSG00000042474
Gene Name Fc fragment of IgM receptor
Synonyms 1810037B05Rik, FcmuR, Faim3
MMRRC Submission 045075-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R6965 (G1)
Quality Score 225.009
Status Not validated
Chromosome 1
Chromosomal Location 130793514-130808528 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to C at 130803724 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glutamic Acid to Alanine at position 176 (E176A)
Ref Sequence ENSEMBL: ENSMUSP00000048303 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000038829]
AlphaFold no structure available at present
Predicted Effect possibly damaging
Transcript: ENSMUST00000038829
AA Change: E176A

PolyPhen 2 Score 0.654 (Sensitivity: 0.87; Specificity: 0.91)
SMART Domains Protein: ENSMUSP00000048303
Gene: ENSMUSG00000042474
AA Change: E176A

DomainStartEndE-ValueType
signal peptide 1 16 N/A INTRINSIC
Pfam:V-set 21 122 1.3e-10 PFAM
low complexity region 212 223 N/A INTRINSIC
transmembrane domain 264 283 N/A INTRINSIC
low complexity region 285 311 N/A INTRINSIC
low complexity region 344 363 N/A INTRINSIC
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.3%
  • 20x: 97.3%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Fc receptors specifically bind to the Fc region of immunoglobulins (Igs) to mediate the unique functions of each Ig class. FAIM3 encodes an Fc receptor for IgM (see MIM 147020) (Kubagawa et al., 2009 [PubMed 19858324]; Shima et al., 2010 [PubMed 20042454]).[supplied by OMIM, Jul 2010]
PHENOTYPE: Mice homozygous for knock-out alleles exhibit a slight decrease in B cell numbers reduced sensitivity to Gal-induced liver damage, increased granulocyte production of ROS and increased sensitivity to infection by Listeria monocytogenes. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 59 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca14 C T 7: 119,882,452 (GRCm39) Q1205* probably null Het
Als2 A G 1: 59,209,716 (GRCm39) F1422S possibly damaging Het
Anapc4 T C 5: 52,993,093 (GRCm39) V68A possibly damaging Het
Atmin T C 8: 117,683,777 (GRCm39) F479S probably damaging Het
Atp7b T C 8: 22,518,101 (GRCm39) T234A probably benign Het
Bpifa1 G A 2: 153,987,581 (GRCm39) G144S probably damaging Het
Brf2 A T 8: 27,614,586 (GRCm39) M200K probably benign Het
C1ql2 G A 1: 120,268,944 (GRCm39) C33Y probably damaging Het
Cdk18 A G 1: 132,045,319 (GRCm39) V269A probably damaging Het
Clcc1 T C 3: 108,580,625 (GRCm39) V313A probably damaging Het
Cntrl A T 2: 35,052,845 (GRCm39) T1117S probably benign Het
Col15a1 G A 4: 47,247,533 (GRCm39) E236K probably damaging Het
Comp T C 8: 70,829,164 (GRCm39) L278P probably damaging Het
Csnk2a1-ps3 C T 1: 156,352,119 (GRCm39) R107* probably null Het
Dlg5 C A 14: 24,199,498 (GRCm39) D1469Y probably damaging Het
Efna1 A T 3: 89,186,782 (GRCm39) V23D probably damaging Het
Enpp5 G A 17: 44,396,155 (GRCm39) G356S probably damaging Het
Epb41l4b T C 4: 57,040,915 (GRCm39) Y516C probably damaging Het
Esr2 T C 12: 76,168,631 (GRCm39) D526G probably damaging Het
Fam184b T C 5: 45,712,477 (GRCm39) T514A probably benign Het
Fry T A 5: 150,339,685 (GRCm39) N1485K possibly damaging Het
Fut2 A G 7: 45,300,305 (GRCm39) C156R probably damaging Het
Gm5431 T C 11: 48,786,027 (GRCm39) Y116C probably benign Het
Gm5493 T A 17: 22,967,047 (GRCm39) V61E possibly damaging Het
Golga4 A T 9: 118,377,847 (GRCm39) Q456L probably damaging Het
Gpam T C 19: 55,063,041 (GRCm39) Y757C probably damaging Het
Iqcg C T 16: 32,851,174 (GRCm39) A266T probably benign Het
Lta4h G T 10: 93,307,759 (GRCm39) G331* probably null Het
Macf1 C A 4: 123,302,538 (GRCm39) V655F probably benign Het
Map3k13 T A 16: 21,740,900 (GRCm39) D742E probably benign Het
Mrgprb2 G A 7: 48,202,597 (GRCm39) L43F probably damaging Het
N4bp1 T C 8: 87,571,461 (GRCm39) R846G probably damaging Het
Nbn T C 4: 15,970,863 (GRCm39) I282T probably benign Het
Ncor1 C T 11: 62,244,059 (GRCm39) probably null Het
Or4a77 G T 2: 89,487,009 (GRCm39) P259T probably damaging Het
Or4d10c A G 19: 12,066,120 (GRCm39) F12S possibly damaging Het
Or8b12 T A 9: 37,657,433 (GRCm39) M1K probably null Het
Pclo A G 5: 14,731,976 (GRCm39) probably benign Het
Pde9a G T 17: 31,662,861 (GRCm39) V97L probably benign Het
Ptch1 T C 13: 63,672,881 (GRCm39) Y771C possibly damaging Het
R3hcc1l G A 19: 42,551,284 (GRCm39) D94N probably damaging Het
Rnpep T A 1: 135,190,858 (GRCm39) K602* probably null Het
Rph3al T C 11: 75,745,276 (GRCm39) Y156C probably damaging Het
Rundc1 A T 11: 101,324,737 (GRCm39) Y481F possibly damaging Het
Serpinb9f A G 13: 33,509,859 (GRCm39) K17R possibly damaging Het
Smpd3 T C 8: 106,986,513 (GRCm39) H459R probably damaging Het
Spata31 A C 13: 65,070,648 (GRCm39) Q932P possibly damaging Het
Srgap3 C T 6: 112,700,090 (GRCm39) A963T probably damaging Het
Syne1 A T 10: 5,179,120 (GRCm39) F4451L possibly damaging Het
Tbc1d19 T A 5: 54,014,266 (GRCm39) probably null Het
Thap12 T A 7: 98,364,669 (GRCm39) V279D probably damaging Het
Tmprss6 T C 15: 78,328,328 (GRCm39) D544G probably damaging Het
Tox2 A G 2: 163,164,930 (GRCm39) *523W probably null Het
Txnrd1 T C 10: 82,717,652 (GRCm39) I212T probably benign Het
Unc80 T C 1: 66,685,725 (GRCm39) I2283T probably benign Het
Vmn1r176 A G 7: 23,535,099 (GRCm39) I18T possibly damaging Het
Vmn2r101 C T 17: 19,811,284 (GRCm39) T456I probably benign Het
Vmn2r79 T A 7: 86,651,100 (GRCm39) H166Q probably benign Het
Zer1 A G 2: 29,991,059 (GRCm39) V723A possibly damaging Het
Other mutations in Fcmr
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01638:Fcmr APN 1 130,802,859 (GRCm39) missense probably benign 0.06
IGL01652:Fcmr APN 1 130,806,244 (GRCm39) missense probably benign 0.25
IGL02106:Fcmr APN 1 130,802,872 (GRCm39) missense probably benign
IGL03270:Fcmr APN 1 130,803,779 (GRCm39) missense possibly damaging 0.63
R1635:Fcmr UTSW 1 130,803,922 (GRCm39) splice site probably null
R1651:Fcmr UTSW 1 130,805,988 (GRCm39) missense probably benign
R1728:Fcmr UTSW 1 130,806,006 (GRCm39) missense probably benign 0.00
R1728:Fcmr UTSW 1 130,803,711 (GRCm39) missense probably benign
R1729:Fcmr UTSW 1 130,806,006 (GRCm39) missense probably benign 0.00
R1729:Fcmr UTSW 1 130,803,711 (GRCm39) missense probably benign
R1730:Fcmr UTSW 1 130,806,006 (GRCm39) missense probably benign 0.00
R1730:Fcmr UTSW 1 130,803,711 (GRCm39) missense probably benign
R1739:Fcmr UTSW 1 130,806,006 (GRCm39) missense probably benign 0.00
R1739:Fcmr UTSW 1 130,803,711 (GRCm39) missense probably benign
R1762:Fcmr UTSW 1 130,806,006 (GRCm39) missense probably benign 0.00
R1762:Fcmr UTSW 1 130,803,711 (GRCm39) missense probably benign
R1783:Fcmr UTSW 1 130,806,006 (GRCm39) missense probably benign 0.00
R1783:Fcmr UTSW 1 130,803,711 (GRCm39) missense probably benign
R1784:Fcmr UTSW 1 130,806,006 (GRCm39) missense probably benign 0.00
R1784:Fcmr UTSW 1 130,803,711 (GRCm39) missense probably benign
R1785:Fcmr UTSW 1 130,806,006 (GRCm39) missense probably benign 0.00
R1785:Fcmr UTSW 1 130,803,711 (GRCm39) missense probably benign
R2037:Fcmr UTSW 1 130,806,070 (GRCm39) missense possibly damaging 0.61
R6111:Fcmr UTSW 1 130,805,566 (GRCm39) missense probably damaging 0.96
R6217:Fcmr UTSW 1 130,806,060 (GRCm39) missense probably damaging 0.96
R6538:Fcmr UTSW 1 130,802,762 (GRCm39) missense possibly damaging 0.72
R6712:Fcmr UTSW 1 130,805,588 (GRCm39) missense probably damaging 0.99
R7765:Fcmr UTSW 1 130,802,025 (GRCm39) missense probably damaging 1.00
R8770:Fcmr UTSW 1 130,803,799 (GRCm39) missense probably benign
R9343:Fcmr UTSW 1 130,802,072 (GRCm39) missense
R9468:Fcmr UTSW 1 130,801,951 (GRCm39) missense possibly damaging 0.65
X0025:Fcmr UTSW 1 130,802,004 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- GCACTATAAAGGCATTTGTGGC -3'
(R):5'- AACATAGAAGCCCTTCTTACCTTTG -3'

Sequencing Primer
(F):5'- TTGTGGCCACAAGGACTAC -3'
(R):5'- ACCTTTGCTCATGAAGTCTGG -3'
Posted On 2018-11-28