Incidental Mutation 'R6966:Or10ag58'
ID 541982
Institutional Source Beutler Lab
Gene Symbol Or10ag58
Ensembl Gene ENSMUSG00000050772
Gene Name olfactory receptor family 10 subfamily AG member 58
Synonyms GA_x6K02T2Q125-48936945-48937901, Olfr1124, GA_x6K02T2Q125-48935224-48935664, Olfr1125, MOR264-24, MOR264-3
MMRRC Submission 045076-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.085) question?
Stock # R6966 (G1)
Quality Score 225.009
Status Not validated
Chromosome 2
Chromosomal Location 87264833-87265789 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to T at 87265623 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Isoleucine at position 264 (T264I)
Ref Sequence ENSEMBL: ENSMUSP00000150244 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000062494] [ENSMUST00000215909]
AlphaFold A2AT86
Predicted Effect probably damaging
Transcript: ENSMUST00000062494
AA Change: T264I

PolyPhen 2 Score 0.976 (Sensitivity: 0.76; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000062513
Gene: ENSMUSG00000050772
AA Change: T264I

DomainStartEndE-ValueType
Pfam:7tm_4 37 314 4.2e-52 PFAM
Pfam:7tm_1 47 296 2.4e-21 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000215909
AA Change: T264I

PolyPhen 2 Score 0.976 (Sensitivity: 0.76; Specificity: 0.96)
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.2%
  • 20x: 97.3%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 51 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adam26b G A 8: 43,974,472 (GRCm39) R177C possibly damaging Het
Adgrb2 CG C 4: 129,908,155 (GRCm39) probably null Het
Bahcc1 G A 11: 120,173,985 (GRCm39) V1582M probably damaging Het
Baiap2 A T 11: 119,897,231 (GRCm39) R529* probably null Het
Bcl9l C T 9: 44,420,685 (GRCm39) Q1327* probably null Het
Brsk2 T A 7: 141,538,270 (GRCm39) C139S possibly damaging Het
Catsper3 T A 13: 55,946,672 (GRCm39) I123N probably damaging Het
Cd84 A G 1: 171,713,976 (GRCm39) N325D possibly damaging Het
Chid1 T A 7: 141,076,297 (GRCm39) Y357F possibly damaging Het
Clstn2 A T 9: 97,408,459 (GRCm39) Y416* probably null Het
Cnot1 A T 8: 96,451,160 (GRCm39) L2189Q probably damaging Het
Csnk2b T A 17: 35,336,758 (GRCm39) I170L probably benign Het
Dnah3 T C 7: 119,631,977 (GRCm39) Q1326R probably damaging Het
Drd1 T C 13: 54,207,564 (GRCm39) I210V probably damaging Het
Eef1d G T 15: 75,775,558 (GRCm39) Q34K probably benign Het
Fam184a T C 10: 53,531,095 (GRCm39) T760A probably benign Het
Fnip1 G T 11: 54,373,385 (GRCm39) V199F probably benign Het
Glyatl3 T C 17: 41,215,829 (GRCm39) K226E probably damaging Het
Gm19410 C T 8: 36,285,127 (GRCm39) T2093I possibly damaging Het
Herc1 A T 9: 66,318,347 (GRCm39) E1206D probably benign Het
Hs6st1 G A 1: 36,143,299 (GRCm39) W411* probably null Het
Hsf2 C A 10: 57,372,080 (GRCm39) S60R probably damaging Het
Hyal5 C A 6: 24,891,291 (GRCm39) N368K probably damaging Het
Itgb2l A T 16: 96,231,843 (GRCm39) F308I probably benign Het
Kdm7a G A 6: 39,129,773 (GRCm39) L468F probably damaging Het
Lamp3 A T 16: 19,518,403 (GRCm39) L278* probably null Het
Ly6c1 A T 15: 74,917,289 (GRCm39) probably benign Het
Mark3 A G 12: 111,606,458 (GRCm39) N524D probably damaging Het
Met T G 6: 17,531,531 (GRCm39) L603R possibly damaging Het
Mical1 A T 10: 41,355,750 (GRCm39) Q198L probably damaging Het
Nacad T A 11: 6,552,634 (GRCm39) I186F possibly damaging Het
Nt5c3b A T 11: 100,320,750 (GRCm39) M257K probably benign Het
Nuak2 T C 1: 132,252,770 (GRCm39) M108T possibly damaging Het
Nub1 T A 5: 24,894,470 (GRCm39) Y51N probably damaging Het
Nxpe5 T C 5: 138,237,679 (GRCm39) S68P probably damaging Het
Or5d44 A G 2: 88,141,835 (GRCm39) S102P probably benign Het
Or6c66 A G 10: 129,461,633 (GRCm39) V99A probably benign Het
Pias3 A G 3: 96,609,511 (GRCm39) D276G probably damaging Het
Setd7 A G 3: 51,437,605 (GRCm39) Y217H probably damaging Het
Slc23a1 A T 18: 35,758,114 (GRCm39) I142N probably damaging Het
Slx4ip T C 2: 136,910,144 (GRCm39) S310P probably damaging Het
Tcp11l2 G A 10: 84,427,133 (GRCm39) R199Q possibly damaging Het
Tgm4 T A 9: 122,880,207 (GRCm39) D226E possibly damaging Het
Tspyl4 C A 10: 34,173,673 (GRCm39) A55E probably benign Het
Uap1l1 A G 2: 25,254,950 (GRCm39) I146T probably damaging Het
Ush2a G A 1: 188,308,441 (GRCm39) G2030D probably damaging Het
Uts2r G A 11: 121,052,213 (GRCm39) G359D possibly damaging Het
Vwa7 T C 17: 35,236,072 (GRCm39) S9P probably benign Het
Zbtb16 A G 9: 48,568,654 (GRCm39) C604R probably damaging Het
Zfp804b A G 5: 6,821,615 (GRCm39) S483P probably damaging Het
Zfpm1 G A 8: 123,058,904 (GRCm39) A175T probably damaging Het
Other mutations in Or10ag58
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00162:Or10ag58 APN 2 87,265,407 (GRCm39) missense probably benign 0.00
IGL01655:Or10ag58 APN 2 87,265,229 (GRCm39) missense probably damaging 1.00
IGL01878:Or10ag58 APN 2 87,265,314 (GRCm39) missense possibly damaging 0.55
IGL02265:Or10ag58 APN 2 87,265,688 (GRCm39) missense probably benign 0.00
IGL02379:Or10ag58 APN 2 87,265,668 (GRCm39) missense probably benign 0.07
IGL02512:Or10ag58 APN 2 87,265,402 (GRCm39) missense possibly damaging 0.59
IGL02578:Or10ag58 APN 2 87,265,401 (GRCm39) missense probably damaging 0.96
R0617:Or10ag58 UTSW 2 87,265,005 (GRCm39) missense probably damaging 1.00
R1376:Or10ag58 UTSW 2 87,264,903 (GRCm39) missense possibly damaging 0.62
R1376:Or10ag58 UTSW 2 87,264,903 (GRCm39) missense possibly damaging 0.62
R4993:Or10ag58 UTSW 2 87,265,496 (GRCm39) missense probably benign 0.00
R5045:Or10ag58 UTSW 2 87,265,490 (GRCm39) missense probably damaging 1.00
R6119:Or10ag58 UTSW 2 87,265,733 (GRCm39) nonsense probably null
R6146:Or10ag58 UTSW 2 87,265,662 (GRCm39) missense possibly damaging 0.78
R6699:Or10ag58 UTSW 2 87,265,160 (GRCm39) missense probably benign
R6883:Or10ag58 UTSW 2 87,265,623 (GRCm39) missense probably damaging 0.99
R7383:Or10ag58 UTSW 2 87,265,721 (GRCm39) missense possibly damaging 0.91
R8069:Or10ag58 UTSW 2 87,265,364 (GRCm39) missense possibly damaging 0.89
R9294:Or10ag58 UTSW 2 87,265,010 (GRCm39) missense probably benign 0.24
R9325:Or10ag58 UTSW 2 87,265,290 (GRCm39) missense possibly damaging 0.67
Z1088:Or10ag58 UTSW 2 87,265,503 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- CAATGAGATGATGGTTTTCCTAGG -3'
(R):5'- TTCTGCAAACTTAGACACATACAAAGG -3'

Sequencing Primer
(F):5'- AGATGATGGTTTTCCTAGGTGCTTTC -3'
(R):5'- TCACTCTGTAGACCAAGCTGG -3'
Posted On 2018-11-28